Protein structure, function and engineering lab Publications from Prof. Jacqui Matthews
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[Publication highlights]

[Joel - all papers] [Jacqui - all papers] [Margie - all papers]

Refereed journal articles
  1. Cross, A. J., Jeffries, C. M., Trewhella, J., and Matthews, J. M. (2010)
    LIM domain binding proteins one and two have different oligomeric states.
    J Mol Biol, in press: 10.1016/j.jmb.2010.1004.1006

  2. Matthews, J. M., Bhati, M., Lehtomaki, E., Mansfield, R. E., Cubeddu, L., and Mackay, J. P. (2009)
    It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains.
    Curr Pharm Des 15, 3681-3696

  3. Mansfield, R. E., Cross, A. J., Matthews, J. M., and Mackay, J. P. (2009)
    Protein Recognition
    in Amino Acids, Peptides and Proteins in Organic Chemistry (Hughes, A. B., ed) Vol. Volume 2: Modified Amino Acids, Organocatalysis and Enzymes, pp. 505-532,
    Wiley-VCH, Weinheim

  4. Lowther, J., Robinson, M. W., Donnelly, S. M., Xu, W., Stack, C. M., Matthews, J. M., and Dalton, J. P. (2009)
    The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease.
    PLoS Negl Trop Dis 3, e369

  5. Lowry, J. A., Gamsjaeger, R., Thong, S. Y., Hung, W., Kwan, A. H., Broitman-Maduro, G., Matthews, J. M., Maduro, M., and Mackay, J. P. (2009)
    Structural analysis of med-1 reveals unexpected diversity in the mechanism of DNA recognition by gata-type zinc finger domains.
    J Biol Chem 284, 5827-5835

  6. Kuchel, P. W., Easterbrook-Smith, S. B., Gysbers, V., Hancock, D. P., Johnston, J. M., Jones, A. R., and Matthews, J. M. (2009)
    Schaum's Outline of Biochemistry, 3rd Ed. Schaum's Outline Series, McGraw-Hill

  7. Gadd, M. S., Langley, D. B., Guss, J. M., and Matthews, J. M. (2009)
    Crystallization and diffraction of an Lhx4-Isl2 complex.
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65, 151-153

  8. Ryan, D. P., Duncan, J. L., Lee, C., Kuchel, P. W., and Matthews, J. M. (2008)
    Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12.
    Proteins 70, 1461-1474

  9. Pilotelle-Bunner, A., Matthews, J. M., Cornelius, F., Apell, H. J., Sebban, P., and Clarke, R. J. (2008)
    ATP Binding Equilibria of the Na(+),K(+)-ATPase (dagger).
    Biochemistry 47, 13103-13114

  10. Matthews, J. M., Loughlin, F. E., and Mackay, J. P. (2008)
    Designed metal-binding sites in biomolecular and bioinorganic interactions.
    Curr Opin Struct Biol 18, 484-490

  11. Matthews, J. M., Bhati, M., Craig, V. J., Deane, J. E., Jeffries, C., Lee, C., Nancarrow, A. L., Ryan, D. P., and Sunde, M. (2008)
    Competition between LIM-binding domains.
    Biochem Soc Trans 36, 1393-1397

  12. Mackay, J. P., Sunde, M., Lowry, J. A., Crossley, M., and Matthews, J. M. (2008)
    Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?
    Trends Biochem Sci

  13. Gamsjaeger, R., Swanton, M. K., Kobus, F. J., Lehtomaki, E., Lowry, J. A., Kwan, A. H., Matthews, J. M., and Mackay, J. P. (2008)
    Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1.
    J Biol Chem 283, 5158-5167

  14. Cubeddu, L., and Matthews, J. M. (2008), Targeted Proteins Database 1

  15. Bhati, M., Lee, M., Nancarrow, A. L., Bach, I., Guss, J. M., and Matthews, J. M. (2008)
    Crystallization of an Lhx3-Isl1 complex.
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 297-299

  16. Bhati, M., Lee, C., Nancarrow, A. L., Lee, M., Craig, V. J., Bach, I., Guss, J. M., Mackay, J. P., and Matthews, J. M. (2008)
    Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes.
    EMBO J 27, 2018-2029

  17. Stokes, P. H., Thompson, L. S., Marianayagam, N. J., and Matthews, J. M. (2007)
    Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain.
    Biochem Biophys Res Commun 354, 197-202

  18. Porter, C. J., Matthews, J. M., Mackay, J. P., Pursglove, S. E., Schmidberger, J. W., Leedman, P. J., Pero, S. C., Krag, D. N., Wilce, M. C., and Wilce, J. A. (2007)
    Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
    BMC Struct Biol 7, 58

  19. Mackay, J. P., Sunde, M., Lowry, J. A., Crossley, M., and Matthews, J. M. (2007)
    Protein interactions: is seeing believing?
    Trends Biochem Sci 32, 530-531

  20. Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., de Kretser, D., O'Bryan, M., Blewitt, M., and Whitelaw, E. (2007)
    Modifiers of epigenetic reprogramming show paternal effects in the mouse.
    Nat Genet 39, 614-622

  21. Ryan, D. P., Sunde, M., Kwan, A. H.-Y., Marianayagam, N. J., Nancarrow, A. L., vanden Hoven, R. N., Thompson, L. S., Baca, M., Mackay, J. P., Visvader, J. E., and Matthews, J. M. (2006)
    Identification of the key LMO2-binding determinants on Ldb1.
    J. Mol. Biol. 359, 66-75

  22. Kwan, A. H., Winefield, R. N., Sunde, M., Matthews, J. M., Haverkamp, R. G., Templeton, M. D., and Mackay, J. P. (2006)
    Structural basis for rodlet assembly in hydrophobins.
    Proc. Natl Acad. Sci. USA 103, 3621-3626.

  23. Jeffries, C., Graham, S., Stokes, P. H., Collyer, C. A., Guss, J. M., and Matthews, J. M. (2006)
    Stabilization of a binary protein complex through intein-mediated circularization.
    Protein Science 15, 2612-2618

  24. Ely, L. K., Beddoe, T., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., and Rossjohn, J. (2006)
    Disparate thermodynamics governing TcR-pMHCI interactions implicate extrinsic factors in guiding MHC restriction.
    Proc. Natl. Acad. Sci. USA 103, 6641-6646

  25. Begg, G. E., Holman, S. R., Stokes, P. H., Matthews, J. M., Graham, R. M., and Iismaa, S. E. (2006)
    Mutation of a critical GTP-binding arginine in transglutaminase 2 disinhibits crosslinking activity invitro and in vivo.
    J. Biol. Chem. 281, 12603-12609

  26. Begg, G. E., Carrington, L., Stokes, P. H., Matthews, J. M., Wouters, M. A., Husain, A., Lorand, L., Iismaa, S. E., and Graham, R. M. (2006)
    Mechanism of allosteric inhibition of transglutaminase 2.
    Proc. Natl Acad. Sci. USA 103, 19683-19688

  27. Williams, N., Liepinsh, E., Prosselkov, P., Watt, S. J., Matthews, J. M., Attard, P., Beck, J. L., Dixon, N. E., and Otting, G. (2005)
    Stabilization of Native Protein Fold by Intein-Mediated Covalent Cyclization.
    J. Mol. Biol. 346, 1095-1108

  28. Sharpe, B. K., Liew, C. K., Kwan, A. H., Wilce, J. A., Crossley, M., Matthews, J. M., and Mackay, J. P. (2005)
    Assessment of the robustness of a serendipitous zinc-binding fold: mutagenesis and protein grafting.
    Structure 13, 257-266

  29. Ryan, D. P., and Matthews, J. M. (2005)
    Protein:Protein Interactions in Human Disease.
    Curr Opin Struct Biol 15, 441-446

  30. Liew, C. K., Simpson, R. J. Y., Kwan, A. H., Crofts, L. A., Loughlin, F. E., Matthews, J. M., Crossley, M., and Mackay, J. P. (2005)
    Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction.
    Proc Natl Acad Sci USA 102, 583-588

  31. Lee, C., Nancarrow, A. L., Bach, I., Mackay, J. P., and Matthews, J. M. (2005)
    Letter to the Editor: 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex.
    J. Biomol. NMR 33, 198

  32. Duggin, I. G., Matthews, J. M., Wake, G., Dixon, N. E., and Mackay, J. P. (2005)
    A Complex mechanism Controls Polarity of DNA Replication Fork Arrest by the Replication Terminator Complex of Bacillus subtilis.
    J. Biol. Chem. 280, 13105-13113

  33. Westman, B. J., Perdomo, J., Matthews, J. M., Crossley, M., and Mackay, J. P. (2004)
    Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers.
    Biochemistry 43, 13318-13327

  34. Sunde, M., McGrath, K. C., Young, L., Matthews, J. M., Chua, E. L., Mackay, J. P., and Death, A. K. (2004)
    TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer.
    Cancer Res. 64, 2766-2773

  35. Simpson, R. J., Lee, S. H., Bartle, N., Sum, E. Y., Visvader, J. E., Matthews, J. M., Mackay, J. P., and Crossley, M. (2004)
    A classical zinc finger from FOG mediates an interaction with the coiled-coil of TACC3.
    J. Biol. Chem. 279, 39789-39797

  36. Marianayagam, N. J., Sunde, M., and Matthews, J. M. (2004)
    The power of two:protein dimerization in biology.
    Trends Biochem. Sci. 29, 618-625

  37. Dubin, M. J., Stokes, P. H., Sum, E. Y. H., Williams, R. S., Valova, V. A., Robinson, P. J., Lindeman, G. J., Glover, J. N. M., Visvader, J. E., and Matthews, J. M. (2004)
    Dimerization of a BRCA1- and CtBP-interacting protein is mediated by an N-terminal coiled-coil motif.
    J. Biol. Chem. 279, 26932-26938

  38. Deane, J. E., Ryan, D. P., Sunde, M., Maher, M. J., Guss, J. M., Visvader, J. E., and Matthews, J. M. (2004)
    Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex.
    EMBO J. 23, 3589-3598

  39. Turner, J., Nicholas, H., Bishop, D., Matthews, J. M., and Crossley, M. (2003)
    The LIM protein FHL3 is a Basic Krüppel-like Factor (BKLF) co-repressor, and forms a three-way nuclear specific complex with BKLF and mCtBP2.
    J. Biol. Chem. 278, 12786-12795

  40. Simpson, R., Cram, E., Czjoli, R., Matthews, J. M., Crossley, M., and Mackay, J. P. (2003)
    CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions.
    J. Biol. Chem. 278, 28011-28018

  41. Matthews, J. M., and Visvader, J. E. (2003)
    LIM domain binding protein 1 (Ldb1): a multifunctional cofactor that interacts with diverse proteins.
    EMBO Reports, 1132-1137

  42. Kwan, A. H., Gell, D. A., Verger, A., Crossley, M., Matthews, J. M., and Mackay, J. P. (2003)
    Engineering a protein scaffold from a PHD finger.
    Structure 11, 803-813

  43. Deane, J. E., Maher, M. J., Langley, D., Graham, S., Visvader, J. E., Guss, J. M., and Matthews, J. M. (2003)
    Crystallization of FLINC4, an intra-molecular LMO4:ldb1 complex.
    Acta Crystallog D 59, 1484-1486

  44. Deane, J. E., Mackay, J. P., Kwan, A. H., Sum, E. Y., Visvader, J. E., and Matthews, J. M. (2003)
    Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.
    EMBO J 22, 2224-2233

  45. Warton, K., Tonini, R., Fairlie, W. D., Matthews, J. M., Valenzuela, S. M., Qiu, M. R., Wu, W. M., Pankhurst, S., Bauskin, A. R., Harrop, S. J., Campbell, T. J., Curmi, P. M. G., Breit, S. N., and Mazzanti, M. (2002)
    Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in CHO cells expressing CLIC1.
    J. Biol. Chem. 277, 26003-26011

  46. Sharpe, B. S., Matthews, J. M., Kwan, A. H.-Y., Newton, A., Gell, D. A., Crossley, M., and Mackay, J. P. (2002)
    A new zinc-binding fold underlines the versatility of zinc-binding modules in evolution.
    Structure 10, 639-648

  47. Matthews, J. M., and Sunde, M. (2002)
    Zinc fingers--folds for many occasions.
    IUBMB Life 54, 351-355

  48. Kowalski, K., Liew, C. K., Matthews, J. M., Gell, D. A., Crossley, M., and Mackay, J. P. (2002)
    Characterization of the conserved interface between GATA- and FOG-family proteins.
    J. Biol. Chem. 277, 35720-35729

  49. Deane, J. E., Visvader, J. E., Mackay, J. P., and Matthews, J. M. (2002)
    1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.
    J. Biomol. NMR 23, 165-166

  50. Matthews, J. M., Visvader, J. E., and Mackay, J. P. (2001)
    1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex.
    J Biomol NMR 21, 385-386

  51. Mackay, J. P., Matthews, J. M., Winefield, R. D., Mackay, L. G., Haverkamp, R. G., and Templeton, M. D. (2001)
    The hydrophobin eas is largely unstructured in solution and functions by forming amyloid-like structures.
    Structure 9, 83-91.

  52. Deane, J. E., Sum, E., Mackay, J. P., Lindeman, G. J., Visvader, J. E., and Matthews, J. M. (2001)
    Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes.
    Protein Eng. 14, 493-499.

  53. Matthews*, J. M., Young, T. F., Tucker, S. P., and Mackay, J. P. (2000)
    The core of the respiratory syncytial virus fusion protein is a trimeric coiled coil.
    J. Virol. 74, 5911-5920

  54. Matthews, J. M., Norton, R. S., Hammacher, A., and Simpson, R. J. (2000)
    The single mutation Phe173 to Ala induces a molten globule-like state in murine interleukin-6.
    Biochemistry 39, 1942-1950

  55. Matthews, J. M., Kowalski, K., Liew, C. K., Sharpe, B. K., Fox, A. H., Crossley, M., and MacKay, J. P. (2000)
    A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped.
    Eur. J. Biochem. 267, 1030-1038

  56. Matthews, J. M., Hammacher, A., Howlett, G. J., and Simpson, R. J. (1998)
    Physicochemical characterization of an antagonistic human interleukin-6 dimer.
    Biochemistry 37, 10671-10680

  57. Simpson, R. J., Hammacher, A., Smith, D. K., Matthews, J. M., and Ward, L. D. (1997)
    Interleukin-6: structure-function relationships.
    Protein Sci 6, 929-955

  58. Matthews, J. M., Ward, L. D., Hammacher, A., Norton, R. S., and Simpson, R. J. (1997)
    Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6.
    Biochemistry 36, 6187-6196

  59. #Zhang, J. G., #Matthews, J. M., #Ward, L. D., and Simpson, R. J. (1997)
    Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state.
    Biochemistry 36, 2380-2389 #Equal First Author

  60. Ward, L. D., Hammacher, A., Howlett, G. J., Matthews, J. M., Fabri, L., Moritz, R. L., Nice, E. C., Weinstock, J., and Simpson, R. J. (1996)
    Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex.
    J Biol Chem 271, 20138-20144

  61. Matthews, J. M., Ward, L. D., J-G., Z., and Simpson, R. J. (1996)
    The association of unfolding intermediates during the equilibrium unfolding of recombinant murine interleukin-6
    in Techniques in Protein Chemistry (Marshak, D. R., ed) Vol. VII, pp. 449-457, Academic Press, Inc., San Diego

  62. Ward, L. D., Matthews, J. M., Zhang, J. G., and Simpson, R. J. (1995)
    Equilibrium denaturation of recombinant murine interleukin-6: effect of pH, denaturants, and salt on formation of folding intermediates.
    Biochemistry 34, 11652-11659

  63. Matthews, J. M., and Fersht, A. R. (1995)
    Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase.
    Biochemistry 34, 6805-6814

  64. Matouschek, A., Matthews, J. M., Johnson, C. M., and Fersht, A. R. (1994)
    Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions.
    Protein Eng 7, 1089-1095

  65. Fersht, A. R., Itzhaki, L. S., elMasry, N. F., Matthews, J. M., and Otzen, D. E. (1994)
    Single versus parallel pathways of protein folding and fractional formation of structure in the transition state.
    Proc Natl Acad Sci U S A 91, 10426-10429

  66. Schofield, P. J., Edwards, M. R., Matthews, J., and Wilson, J. R. (1992)
    The pathway of arginine catabolism in Giardia intestinalis.
    Mol Biochem Parasitol 51, 29-36

  67. Horovitz, A., Matthews, J. M., and Fersht, A. R. (1992)
    Alpha-helix stability in proteins. II. Factors that influence stability at an internal position.
    J Mol Biol 227, 560-568


Lastest update: "News", on 14th May 2013.


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