Protein structure, function and engineering lab Publications from Prof. Jacqui Matthews
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Recent news

24 Aug, 2015: Ana's lab baby update...

19 Aug, 2015: Welcome to new lab members - Mehdi, Jason (aka. Alex) and Taylor

19 Aug, 2015: GATA1-DNA structure published



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[Publication highlights]

[Joel - all papers] [Jacqui - all papers]

Refereed journal articles
  1. Wilkinson-White, L., Lester, K. L., Ripin, N., Jacques, D. A., Mitchell Guss, J., and Matthews, J. M. (2015)
    GATA1 directly mediates interactions with closely spaced pseudo-palindromic but not distantly spaced double GATA sites on DNA
    Protein Sci Epub ahead of print.

  2. Wienert, B., Funnell, A., Norton, L., Pearson, R., Wilkinson-White, L., Lester, K., Vadolas, J., Porteus, M., Matthews, J. M., Quinlan, K., and Crossley, M. (2015)
    Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin
    Nat Comm 8, 7058

  3. Matthews, J. M. (2015)
    Protein complex hierarchy & translocation gene products, in
    Chromosomal Translocations and Genome Rearrangements in Cancer (Rowley, J., Le Beau, M. M., and Rabbitts, T. H. eds.), Springer International Publishing. pp Accepted 29/04/2014

  4. Kazenwadel, J., Betterman, K., Chong, C.-E., Stokes, P. H., Lee, Y., Secker, G., Agalarov, Y., Demir, C. S., Lawrence, D., Sutton, D., Tabruyn, S., Miura, N., Salminen, M., Petrova, T., Matthews, J. M., Hahn, C., Scott, H., and Harvey, N. (2015)
    GATA2 haploinsufficiency predisposing to lymphedema reveals key roles in lymphatic vascular development
    J Clin Invest 128, 2979-2994

  5. Harten, S., Oey, H., Bourke, L., Bharti, V., Luke, I., Daxinger, L., Faou, P., Robertson, N. O., Matthews, J., and Whitelaw, E. (2015)
    The recently identified modifier of murine metastable epialleles, Re-arranged L-Myc Fusion, is involved in maintaining epigenetic marks at CpG island shores and enhancers
    BMC Biology MS#1980694683152788, Accepted 24 February 2015

  6. Fung, H. K., Gadd, M. S., Drury, T. A., Cheung, S., Guss, J. M., Coleman, N. V., and Matthews, J. M. (2015)
    Biochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanes
    Mol Microbiol 97, 439-453

  7. Wilkinson-White, L., and Matthews, J. M. (2014)
    The PA207 peptide inhibitor of LIM-only protein 2 (Lmo2) targets zinc finger domains in a non-specific manner.
    Prot Prot Lett 21, 132-139.

  8. Vandevenne, M., O’Connell, M., Helder, S., Shepherd, N., Matthews, J., Kwan, A., Segal, D., and Mackay, J. (2014)
    Engineering Specificity Changes on a RanBP2 Zinc Finger that binds single-stranded RNA
    Angew Chem, DOI: 10.1002/anie.201402980R201402981

  9. Joseph, J., Kwan, A. H. Y., Stokes, P. H., Mackay, J. P., Cubeddu, L., and Matthews, J. M. (2014)
    The structure of an LIM-only protein 4 (LMO4) and Deformed Epidermal Autoregulatory Factor-1 (DEAF1) complex reveals a common mode of binding to LMO4
    PLOS One, accepted 28/08/2014

  10. Joseph, J., Kwan, A. H. Y., Mackay, J. P., Cubeddu, L., and Matthews, J. M. (2014)
    Backbone and side-chain assignments of a tethered complex between LMO4 and DEAF-1
    Biol NMR Assign 8, 141-144

  11. Youngson, N., Epp, T., Roberts, A., Daxinger, L., Ashe, A., Huang, E., Lester, K. L., Harten, S., Kay, G., Cox, T., Matthews, J. M., Chong, S., and Whitelaw, E. (2013)
    No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations
    Mamm Genome 24, 206-217

  12. Vandevenne, M., Jacques, D. A., Arzur, C., Nguyen, C. D., Matthews, J. M., Crossley, M., Guss, J. M., and Mackay, J. P. (2013)
    New insights into DNA recognition by zinc fingers revealed by structural analysis of ZNF217
    J Biol Chem 288, 10616-10627

  13. Stokes, P. H., Liew, C. W., Kwan, A. H., Foo, P., Barker, H. E., Djamirze, A., O'Reilly, V., Visvader, J. E., Mackay, J. P., and Matthews, J. M. (2013)
    Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8
    J Mol Biol 425, 1101-1110

  14. Matthews, J. M., and Potts, J. R. (2013)
    The tandem β-zipper: modular binding of tandem domains and linear motifs
    FEBS Lett 587, 1164-1171

  15. Matthews, J. M., Lester, K. L., Joseph, S., and Curtis, D. J. (2013)
    LIM-domain-only proteins in cancer
    Nat Rev Cancer 12, 111-122

  16. Gamsjaeger, R., O'Connell, M. R., Cubeddu, L., Shepherd, N. E., Lowry, J. A., Kwan, A. H., Vandevenne, M., Swanton, M. K., Matthews, J. M., and Mackay, J. P. (2013)
    A structural analysis of DNA binding by Myelin Transcription Factor 1 double zinc fingers
    J Biol Chem, Oct 6. [Epub ahead of print]

  17. Gamsjaeger, R., Fernando, R., Bang, L. H., Touma, C., Nguyen, C. D., Matthews, J. M., Cubeddu, L., and Mackay, J. P. (2013)
    Semi-quantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in Surface Plasmon Resonance competition experiments
    Analytical Biochemistry 440, 178-185

  18. Gadd, M. S., Jacques, D. A., Nisevic, I., Craig, V. J., Kwan, A. H., Guss, J. M., and Matthews, J. M. (2013)
    A structural basis for the regulation of the LIM-homeodomain protein Islet 1 (Isl1) by intra- and intermolecular interactions
    J Biol Chem 288, 21924-21935

  19. Corciliusa, L., Santhakumar, G., Stone, R. S., Capicciotti, C. J., Joseph, J., Matthews, J. M., Ben, R. N., and Payne, R. J. (2013)
    Synthesis of peptides and glycopeptides with polyproline II helical topology as potential antifreeze molecules
    Bioorganic Med Chem 21, 3569-3581

  20. Campbell, A. E., Wilkinson-White, L., Mackay, J. P., Matthews, J. M., and Blobel, G. A. (2013)
    Dissecting molecular pathways that underlie disease-causing GATA1 mutations
    Blood 121, 5218-5227

  21. Yeo, G., Baldock, C., Tuukkanenc, A., Roesslec, M., Dyksterhuis, L., Wise, S., Matthews, J., Mithieux, S., and Weiss, A. (2012)
    The tropoelastin bridge region positions the cell-interactive C-terminus and contributes to elastic fiber assembly
    Proc Natl Acad Sci U S A 109, 2878-2883

  22. Wilkinson, B. L., Stone, R. S., Capicciotti, C. J., Thaysen-Andersen, M., Matthews, J. M., Packer, N. H., Ben, R. N., and Payne, R. J. (2012)
    Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins
    Angew Chem 51, 3606-3610

  23. O'Connell, M. R., Vandevenne, M., Nguyen, C. D., Matthews, J. M., Gamsjaeger, R., Segal, D. J., and Mackay, J. P. (2012)
    Modular assembly of RanBP2-type zinc finger domains to target single-stranded RNA
    Angew Chem 51, 5371-5375

  24. Matthews, J. M., and Sunde, M. (2012)
    Dimers, oligomers, everywhere
    Adv Exp Med Biol 747, 1-18
    (1)H, (1)(5)N and (1)(3)C assignments of an intramolecular LMO4-LIM1/CtIP complex
    Biomol NMR assign 6, 31-34

  25. Hsieh, Y. S., Wilkinson, B. L., O'Connell, M. R., Mackay, J. P., Matthews, J. M., and Payne, R. J. (2012)
    Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants
    Org Lett 14, 1910-1913

  26. Hauswirth, R., Haase, B., Blatter, M., Brooks, S. A., Burger, D., Drogemuller, C., Gerber, V., Henke, D., Janda, J., Jude, R., Magdesian, K. G., Matthews, J. M., Poncet, P. A., Svansson, V., Tozaki, T., Wilkinson-White, L., Penedo, M. C., Rieder, S., and Leeb, T. (2012)
    Mutations in MITF and PAX3 cause "splashed white" and other white spotting phenotypes in horses
    PloS Genet 8, e1002653

  27. Gadd, M. S., Jacques, D. A., Guss, J. M., and Matthews, J. M. (2012)
    Crystallization and diffraction of an Isl1-Ldb1 complex
    Acta Crystallogr Section F 68, 1398-1401

  28. Dastmalchi, S., Wilkinson-White, L., Kwan, A. H., Gamsjaeger, R., Mackay, J. P., and Matthews, J. M. (2012)
    Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex
    Prot Sci 6, 31-34

  29. Cubeddu, L., Joseph, S., Richard, D. J., and Matthews, J. M. (2012)
    Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4
    PloS One 7, e39218

  30. Bhati, M., Lee, C., Gadd, M. S., Jeffries, C. M., Kwan, A., Whitten, A. E., Trewhella, J., Mackay, J. P., and Matthews, J. M. (2012)
    Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions
    PloS One 7, e40719

  31. Wissmueller, S., Font, J., Liew, C. W., Cram, E., Schroeder, T., Turner, J., Crossley, M., Mackay, J. P., and Matthews, J. M. (2011)
    Protein-protein interactions: analysis of a false positive GST pulldown result.
    Proteins Struct Funct Gen 79, 2365-2371

  32. Wilkinson-White, L., Gamsjaeger, R., Dastmalchi, S., Wienert, B., Stokes, P. H., Crossley, M., Mackay, J. P., and Matthews, J. M. (2011)
    Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1
    Proc Natl Acad Sci U S A 108, 14443-14448

  33. Gadd, M. S., Bhati, M., Jeffries, C. M., Langley, D. B., Trewhella, J., Guss, J. M., and Matthews, J. M. (2011)
    The structural basis for partial redundancy in a class of transcription factors, the LIM homeodomain proteins, in neural cell type specification
    J Biol Chem, 42971-42980.

  34. Wilkinson-White, L. E., Dastmalchi, S., Kwan, A. H., Ryan, D. P., Mackay, J. P., and Matthews, J. M. (2010)
    (1)H, (15)N and (13)C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex
    Biomol NMR Assign.

  35. Cross, A. J., Jeffries, C. M., Trewhella, J., and Matthews, J. M. (2010)
    LIM domain binding proteins one and two have different oligomeric states
    J Mol Biol 99, 133-144

  36. Matthews, J. M., Bhati, M., Lehtomaki, E., Mansfield, R. E., Cubeddu, L., and Mackay, J. P. (2009)
    It takes two to tango: the structure and function of LIM, RING, PHD and MYND domains
    Curr Pharm Des 15, 3681-3696

  37. Mansfield, R. E., Cross, A. J., Matthews, J. M., and Mackay, J. P. (2009)
    Protein Recognition, in
    Amino Acids, Peptides and Proteins in Organic Chemistry (Hughes, A. B. ed.), Wiley-VCH, Weinheim. pp 505-532

  38. Lowther, J., Robinson, M. W., Donnelly, S. M., Xu, W., Stack, C. M., Matthews, J. M., and Dalton, J. P. (2009)
    The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease
    PLoS Negl Trop Dis 3, e369

  39. Lowry, J. A., Gamsjaeger, R., Thong, S. Y., Hung, W., Kwan, A. H., Broitman-Maduro, G., Matthews, J. M., Maduro, M., and Mackay, J. P. (2009)
    Structural analysis of med-1 reveals unexpected diversity in the mechanism of DNA recognition by gata-type zinc finger domains
    J Biol Chem 284, 5827-5835

  40. Kuchel, P. W., Easterbrook-Smith, S. B., Gysbers, V., Hancock, D. P., Johnston, J. M., Jones, A. R., and Matthews, J. M. (2009)
    Schaum's Outline of Biochemistry, 3rd ed., McGraw-Hill

  41. Gadd, M. S., Langley, D. B., Guss, J. M., and Matthews, J. M. (2009)
    Crystallization and diffraction of an Lhx4-Isl2 complex
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65, 151-153

  42. Ryan, D. P., Duncan, J. L., Lee, C., Kuchel, P. W., and Matthews, J. M. (2008)
    Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12
    Proteins 70, 1461-1474

  43. Pilotelle-Bunner, A., Matthews, J. M., Cornelius, F., Apell, H. J., Sebban, P., and Clarke, R. J. (2008)
    ATP Binding Equilibria of the Na(+),K(+)-ATPase (dagger)
    Biochemistry 47, 13103-13114

  44. Matthews, J. M., Loughlin, F. E., and Mackay, J. P. (2008)
    Designed metal-binding sites in biomolecular and bioinorganic interactions
    Curr Opin Struct Biol 18, 484-490

  45. Matthews, J. M., Bhati, M., Craig, V. J., Deane, J. E., Jeffries, C., Lee, C., Nancarrow, A. L., Ryan, D. P., and Sunde, M. (2008)
    Competition between LIM-binding domains
    Biochem Soc Trans 36, 1393-1397

  46. Mackay, J. P., Sunde, M., Lowry, J. A., Crossley, M., and Matthews, J. M. (2008)
    Response to Chatr-aryamontri et al.: Protein interactions: to believe or not to believe?
    Trends Biochem Sci

  47. Gamsjaeger, R., Swanton, M. K., Kobus, F. J., Lehtomaki, E., Lowry, J. A., Kwan, A. H., Matthews, J. M., and Mackay, J. P. (2008)
    Structural and biophysical analysis of the DNA binding properties of myelin transcription factor 1
    J Biol Chem 283, 5158-5167

  48. Cubeddu, L., and Matthews, J. M. (2008) RBBP8(CtIP). Targeted Proteins Database 1

  49. Bhati, M., Lee, M., Nancarrow, A. L., Bach, I., Guss, J. M., and Matthews, J. M. (2008)
    Crystallization of an Lhx3-Isl1 complex
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 297-299

  50. Bhati, M., Lee, C., Nancarrow, A. L., Lee, M., Craig, V. J., Bach, I., Guss, J. M., Mackay, J. P., and Matthews, J. M. (2008)
    Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
    EMBO J 27, 2018-2029

  51. Stokes, P. H., Thompson, L. S., Marianayagam, N. J., and Matthews, J. M. (2007)
    Dimerization of CtIP may stabilize in vivo interactions with the Retinoblastoma-pocket domain
    Biochem Biophys Res Commun 354, 197-202

  52. Rosado, C. J., Buckle, A. M., Law, R. H., Butcher, R. E., Kan, W. T., Bird, C. H., Ung, K., Browne, K. A., Baran, K., Bashtannyk-Puhalovich, T. A., Faux, N. G., Wong, W., Porter, C. J., Pike, R. N., Ellisdon, A. M., Pearce, M. C., Bottomley, S. P., Emsley, J., Smith, A. I., Rossjohn, J., Hartland, E. L., Voskoboinik, I., Trapani, J. A., Bird, P. I., Dunstone, M. A., and Whisstock, J. C. (2007)
    A common fold mediates vertebrate defense and bacterial attack
    Science 317, 1548-1551

  53. Porter, C. J., Matthews, J. M., Mackay, J. P., Pursglove, S. E., Schmidberger, J. W., Leedman, P. J., Pero, S. C., Krag, D. N., Wilce, M. C., and Wilce, J. A. (2007)
    Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation
    BMC Struct Biol 7, 58

  54. Mackay, J. P., Sunde, M., Lowry, J. A., Crossley, M., and Matthews, J. M. (2007)
    Protein interactions: is seeing believing?
    Trends Biochem Sci 32, 530-531

  55. Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H. S., de Kretser, D., O'Bryan, M., Blewitt, M., and Whitelaw, E. (2007)
    Modifiers of epigenetic reprogramming show paternal effects in the mouse
    Nat Genet 39, 614-622

  56. Ryan, D. P., Sunde, M., Kwan, A. H.-Y., Marianayagam, N. J., Nancarrow, A. L., vanden Hoven, R. N., Thompson, L. S., Baca, M., Mackay, J. P., Visvader, J. E., and Matthews, J. M. (2006)
    Identification of the key LMO2-binding determinants on Ldb1
    J. Mol. Biol. 359, 66-75

  57. Kwan, A. H., Winefield, R. N., Sunde, M., Matthews, J. M., Haverkamp, R. G., Templeton, M. D., and Mackay, J. P. (2006)
    Structural basis for rodlet assembly in hydrophobins
    Proc. Natl Acad. Sci. USA 103, 3621-3626.

  58. Jeffries, C., Graham, S., Stokes, P. H., Collyer, C. A., Guss, J. M., and Matthews, J. M. (2006)
    Stabilization of a binary protein complex through intein-mediated circularization.
    Protein Science 15, 2612-2618

  59. Ely, L. K., Beddoe, T., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., and Rossjohn, J. (2006)
    Disparate thermodynamics governing TcR-pMHCI interactions implicate extrinsic factors in guiding MHC restriction
    Proc. Natl. Acad. Sci. USA 103, 6641-6646

  60. Begg, G. E., Holman, S. R., Stokes, P. H., Matthews, J. M., Graham, R. M., and Iismaa, S. E. (2006)
    Mutation of a critical GTP-binding arginine in transglutaminase 2 disinhibits crosslinking activity invitro and in vivo
    J. Biol. Chem. 281, 12603-12609

  61. Begg, G. E., Carrington, L., Stokes, P. H., Matthews, J. M., Wouters, M. A., Husain, A., Lorand, L., Iismaa, S. E., and Graham, R. M. (2006)
    Mechanism of allosteric inhibition of transglutaminase 2
    Proc. Natl Acad. Sci. USA 103, 19683-19688

  62. Williams, N., Liepinsh, E., Prosselkov, P., Watt, S. J., Matthews, J. M., Attard, P., Beck, J. L., Dixon, N. E., and Otting, G. (2005)
    Stabilization of Native Protein Fold by Intein-Mediated Covalent Cyclization
    J. Mol. Biol. 346, 1095-1108

  63. Sharpe, B. K., Liew, C. K., Kwan, A. H., Wilce, J. A., Crossley, M., Matthews, J. M., and Mackay, J. P. (2005)
    Assessment of the robustness of a serendipitous zinc-binding fold: mutagenesis and protein grafting
    Structure 13, 257-266

  64. Ryan, D. P., and Matthews, J. M. (2005)
    Protein:Protein Interactions in Human Disease
    Curr Opin Struct Biol 15, 441-446

  65. Liew, C. K., Simpson, R. J. Y., Kwan, A. H., Crofts, L. A., Loughlin, F. E., Matthews, J. M., Crossley, M., and Mackay, J. P. (2005)
    Zinc fingers as protein recognition motifs: structural basis for the GATA-1/Friend of GATA interaction.
    Proc Natl Acad Sci USA 102, 583-588

  66. Lee, C., Nancarrow, A. L., Bach, I., Mackay, J. P., and Matthews, J. M. (2005)
    Letter to the Editor: 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex
    J. Biomol. NMR 33, 198

  67. Duggin, I. G., Matthews, J. M., Wake, G., Dixon, N. E., and Mackay, J. P. (2005)
    A Complex mechanism Controls Polarity of DNA Replication Fork Arrest by the Replication Terminator Complex of Bacillus subtilis
    J. Biol. Chem. 280, 13105-13113

  68. Westman, B. J., Perdomo, J., Matthews, J. M., Crossley, M., and Mackay, J. P. (2004)
    Structural studies on a protein-binding zinc-finger domain of Eos reveal both similarities and differences to classical zinc fingers
    Biochemistry 43, 13318-13327

  69. Sunde, M., McGrath, K. C., Young, L., Matthews, J. M., Chua, E. L., Mackay, J. P., and Death, A. K. (2004)
    TC-1 is a novel tumorigenic and natively disordered protein associated with thyroid cancer
    Cancer Res. 64, 2766-2773

  70. Simpson, R. J., Lee, S. H., Bartle, N., Sum, E. Y., Visvader, J. E., Matthews, J. M., Mackay, J. P., and Crossley, M. (2004)
    A classical zinc finger from FOG mediates an interaction with the coiled-coil of TACC3
    J. Biol. Chem. 279, 39789-39797

  71. Marianayagam, N. J., Sunde, M., and Matthews, J. M. (2004)
    The power of two:protein dimerization in biology
    Trends Biochem. Sci. 29, 618-625

  72. Dubin, M. J., Stokes, P. H., Sum, E. Y. H., Williams, R. S., Valova, V. A., Robinson, P. J., Lindeman, G. J., Glover, J. N. M., Visvader, J. E., and Matthews, J. M. (2004)
    Dimerization of a BRCA1- and CtBP-interacting protein is mediated by an N-terminal coiled-coil motif.
    J. Biol. Chem. 279, 26932-26938

  73. Deane, J. E., Ryan, D. P., Sunde, M., Maher, M. J., Guss, J. M., Visvader, J. E., and Matthews, J. M. (2004)
    Tandem LIM domains provide synergistic binding in the LMO4:Ldb1 complex
    EMBO J. 23, 3589-3598

  74. Turner, J., Nicholas, H., Bishop, D., Matthews, J. M., and Crossley, M. (2003)
    The LIM protein FHL3 is a Basic Krüppel-like Factor (BKLF) co-repressor, and forms a three-way nuclear specific complex with BKLF and mCtBP2
    J. Biol. Chem. 278, 12786-12795

  75. Simpson, R., Cram, E., Czjoli, R., Matthews, J. M., Crossley, M., and Mackay, J. P. (2003)
    CCHX zinc finger derivatives retain the ability to bind Zn(II) and mediate protein-DNA interactions
    J. Biol. Chem. 278, 28011-28018

  76. Matthews, J. M., and Visvader, J. E. (2003)
    LIM domain binding protein 1 (Ldb1): a multifunctional cofactor that interacts with diverse proteins
    EMBO Reports, 1132-1137

  77. Kwan, A. H., Gell, D. A., Verger, A., Crossley, M., Matthews, J. M., and Mackay, J. P. (2003)
    Engineering a protein scaffold from a PHD finger
    Structure 11, 803-813

  78. Deane, J. E., Maher, M. J., Langley, D., Graham, S., Visvader, J. E., Guss, J. M., and Matthews, J. M. (2003)
    Crystallization of FLINC4, an intra-molecular LMO4:ldb1 complex
    Acta Crystallog D 59, 1484-1486

  79. Deane, J. E., Mackay, J. P., Kwan, A. H., Sum, E. Y., Visvader, J. E., and Matthews, J. M. (2003)
    Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4
    EMBO J 22, 2224-2233

  80. Warton, K., Tonini, R., Fairlie, W. D., Matthews, J. M., Valenzuela, S. M., Qiu, M. R., Wu, W. M., Pankhurst, S., Bauskin, A. R., Harrop, S. J., Campbell, T. J., Curmi, P. M. G., Breit, S. N., and Mazzanti, M. (2002)
    Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in CHO cells expressing CLIC1.
    J. Biol. Chem. 277, 26003-26011

  81. Sharpe, B. S., Matthews, J. M., Kwan, A. H.-Y., Newton, A., Gell, D. A., Crossley, M., and Mackay, J. P. (2002)
    A new zinc-binding fold underlines the versatility of zinc-binding modules in evolution
    Structure 10, 639-648

  82. Matthews, J. M., and Sunde, M. (2002)
    Zinc fingers--folds for many occasions
    IUBMB Life 54, 351-355

  83. Kowalski, K., Liew, C. K., Matthews, J. M., Gell, D. A., Crossley, M., and Mackay, J. P. (2002)
    Characterization of the conserved interface between GATA- and FOG-family proteins
    J. Biol. Chem. 277, 35720-35729

  84. Deane, J. E., Visvader, J. E., Mackay, J. P., and Matthews, J. M. (2002)
    1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex
    J. Biomol. NMR 23, 165-166

  85. Matthews, J. M., Visvader, J. E., and Mackay, J. P. (2001)
    1H, 15N and 13C assignments of FLIN2, an intramolecular LMO2:ldb1 complex
    J Biomol NMR 21, 385-386

  86. Mackay, J. P., Matthews, J. M., Winefield, R. D., Mackay, L. G., Haverkamp, R. G., and Templeton, M. D. (2001)
    The hydrophobin eas is largely unstructured in solution and functions by forming amyloid-like structures
    Structure 9, 83-91.

  87. Deane, J. E., Sum, E., Mackay, J. P., Lindeman, G. J., Visvader, J. E., and Matthews, J. M. (2001)
    Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes
    Protein Eng. 14, 493-499.

  88. Matthews*, J. M., Young, T. F., Tucker, S. P., and Mackay, J. P. (2000)
    The core of the respiratory syncytial virus fusion protein is a trimeric coiled coil
    J. Virol. 74, 5911-5920

  89. Matthews, J. M., Norton, R. S., Hammacher, A., and Simpson, R. J. (2000)
    The single mutation Phe173 to Ala induces a molten globule-like state in murine interleukin-6
    Biochemistry 39, 1942-1950

  90. Matthews, J. M., Kowalski, K., Liew, C. K., Sharpe, B. K., Fox, A. H., Crossley, M., and MacKay, J. P. (2000)
    A class of zinc fingers involved in protein-protein interactions biophysical characterization of CCHC fingers from fog and U-shaped
    Eur. J. Biochem. 267, 1030-1038

  91. Matthews, J. M., Hammacher, A., Howlett, G. J., and Simpson, R. J. (1998)
    Physicochemical characterization of an antagonistic human interleukin-6 dimer
    Biochemistry 37, 10671-10680

  92. Simpson, R. J., Hammacher, A., Smith, D. K., Matthews, J. M., and Ward, L. D. (1997)
    Interleukin-6: structure-function relationships
    Protein Sci 6, 929-955

  93. Matthews, J. M., Ward, L. D., Hammacher, A., Norton, R. S., and Simpson, R. J. (1997)
    Roles of histidine 31 and tryptophan 34 in the structure, self-association, and folding of murine interleukin-6
    Biochemistry 36, 6187-6196

  94. #Zhang, J. G., #Matthews, J. M., #Ward, L. D., and Simpson, R. J. (1997)
    Disruption of the disulfide bonds of recombinant murine interleukin-6 induces formation of a partially unfolded state
    Biochemistry 36, 2380-2389 #Equal First Author

  95. Ward, L. D., Hammacher, A., Howlett, G. J., Matthews, J. M., Fabri, L., Moritz, R. L., Nice, E. C., Weinstock, J., and Simpson, R. J. (1996)
    Influence of interleukin-6 (IL-6) dimerization on formation of the high affinity hexameric IL-6.receptor complex
    J Biol Chem 271, 20138-20144

  96. Matthews, J. M., Ward, L. D., J-G., Z., and Simpson, R. J. (1996)
    The association of unfolding intermediates during the equilibrium unfolding of recombinant murine interleukin-6, in
    Techniques in Protein Chemistry (Marshak, D. R. ed.), Academic Press, Inc., San Diego. pp 449-457

  97. Ward, L. D., Matthews, J. M., Zhang, J. G., and Simpson, R. J. (1995)
    Equilibrium denaturation of recombinant murine interleukin-6: effect of pH, denaturants, and salt on formation of folding intermediates
    Biochemistry 34, 11652-11659

  98. Matthews, J. M., and Fersht, A. R. (1995)
    Exploring the energy surface of protein folding by structure-reactivity relationships and engineered proteins: observation of Hammond behavior for the gross structure of the transition state and anti-Hammond behavior for structural elements for unfolding/folding of barnase
    Biochemistry 34, 6805-6814

  99. Matouschek, A., Matthews, J. M., Johnson, C. M., and Fersht, A. R. (1994)
    Extrapolation to water of kinetic and equilibrium data for the unfolding of barnase in urea solutions
    Protein Eng 7, 1089-1095

  100. Fersht, A. R., Itzhaki, L. S., elMasry, N. F., Matthews, J. M., and Otzen, D. E. (1994)
    Single versus parallel pathways of protein folding and fractional formation of structure in the transition state
    Proc Natl Acad Sci U S A 91, 10426-10429

  101. Schofield, P. J., Edwards, M. R., Matthews, J., and Wilson, J. R. (1992)
    The pathway of arginine catabolism in Giardia intestinalis
    Mol Biochem Parasitol 51, 29-36

  102. Horovitz, A., Matthews, J. M., and Fersht, A. R. (1992)
    Alpha-helix stability in proteins. II. Factors that influence stability at an internal position
    J Mol Biol 227, 560-568
Book chapters

  1. Matthews, J. M. (2013) Zinc finger folds and their functions. in Encyclopedia of Metalloproteins (R. Kretsinger, V. U., E. Permyakov ed., Springer

  2. Matthews, J. M. (2013) LIM Domain Proteins. in Brenner's Encyclopedia of Genetics (Hughes, S. M. a. K. ed., 2nd Ed., Elseveir, Oxford

  3. Matthews, J.M. (2012)
    Defining Protein-Protein Interactions, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer

  4. Matthews, J.M., ed. (2012)
    Protein Dimerization and Oligomerization in Biology. Adv Exp Med Biol. Vol. 747. 2012, Landes Bioscience/Springer.

  5. Matthews, J.M., Bcl-2 Inhibitors, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  6. Matthews, J.M., Mutagenic Scanning to Define Binding Hotspots, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  7. Matthews, J.M., Plasticity at Protein–Protein Interaction Interfaces, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  8. Matthews, J.M., Heteromeric Versus Homomeric Association of Protein Complexes, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer.

  9. Matthews, J.M., LIM Domain Proteins, in Brenner's Encyclopedia of Genetics, S.M.a.K. Hughes, Editor 2013, Elseveir: Oxford. p. 242-245.

  10. Matthews, J.M., Zinc finger folds and their functions, in Encyclopedia of Metalloproteins, V.U. R. Kretsinger, E. Permyakov, Editor 2013, Springer.

  11. Kuchel, P.W., Easterbrook-Smith, S.B., Gysbers, V., Hancock, D.P., Johnston, J.M., Jones, A.R., and Matthews, J.M., Schaum's Outline of Biochemistry. 3rd ed. Schaum's Outline Series 2009: McGraw-Hill.

  12. Matthews, J.M. (2012)
    Postranslational Modifications, in Encyclopedia of Biophysics, G. Roberts, Editor 2012, Springer

  13. Mansfield, R.E., Cross, A.J., Matthews, J.M., and Mackay, J.P. (2009)
    Protein Recognition, in Amino Acids, Peptides and Proteins in Organic Chemistry, A.B. Hughes, Editor 2009, Wiley-VCH: Weinheim.

  14. Matthews, J.M., Ward, L.D., J-G., Z., and Simpson, R.J. (1996)
    The association of unfolding intermediates during the equilibrium unfolding of recombinant murine interleukin-6, in Techniques in Protein Chemistry, D.R. Marshak, Editor 1996, Academic Press, Inc.: San Diego.



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