Professor Jacqueline Matthews
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Professor of Protein Chemistry and NHMRC Senior Research Fellow
G08 - Biochemistry Building |
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Research interests
The 30,000 or so genes in your genome encode proteins that work together in a coordinated fashion to regulate every biological process in the body. Jacqui Matthews' team is interested in finding out not just how proteins achieve these important biological processes, but also whether artificial regulation of these activities through the design of specific protein inhibitors is possible. In particular, they are investigating the protein-protein and protein-DNA interactions that occur during normal cellular development and comparing them with interactions that cause diseases states such as T-cell leukemia, beta-thalassaemia and breast cancer. To do this, they are using a range of techniques including:
* molecular biology
* biophysical methods
* structural methods
Current national competitive grants*
2011
LMO2-containing complexes in leukemia and blood cell development
Matthews J, Mackay J, Guss J
NHMRC Project Grant ($1,084,552 over 3 years)
Inhibiting protein-protein interactions involved in neural development and disease
Matthews J, Cubeddu L
ARC Discovery Project ($420,000 over 3 years)
2009
NHMRC Senior Research Fellowship B
Matthews J
NHMRC Research Fellowship ($587,812 over 5 years)
* Grants administered through the University of Sydney