Professor Joel Mackay
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Professor
G08 - Biochemistry Building |
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Research interests
The primary focus of the Mackay group is to understand protein function at the molecular level, with a particular emphasis on three areas:
*the role and nature of protein-protein interactions in the control of gene expression,
*the structural and functional diversity of zinc-binding domains, and
*the design of new proteins with tailored functions.
Experimental approaches range from molecular and cell biology and biochemistry through to biophysical methods. In-house, we have access to NMR spectroscopy (400 and 600 MHz), X-ray crystallography, CD, analytical ultracentrifugation (XL-A), a Biacore 3000, Microcal IT/DSC instruments, mass spectrometry (QSTAR and LC-MS), static and dynamic light scattering and cell culture and fermentation facilities.
Current national competitive grants*
2012
Designer DNA-binding proteins targeting methylated DNA for research and therapeutic purposes
Mackay J, Segal D, Rasko J
NHMRC Project Grants ($563,675 over 3 years)
The regulation of gene expression by post-translational modification of transcription factos
Mackay J, Blobel G
ARC Discovery Projects ($515,000 over 3 years)
Functional analysis of ZRANB2, an RNA-binding protein that is essential for mammalian development
Mackay J, Crossley M
ARC Discovery Projects ($458,000 over 3 years)
2011
LMO2-containing complexes in leukemia and blood cell development
Matthews J, Mackay J, Guss J
NHMRC Project Grant ($1,084,552 over 3 years)
Structural and functional analysis of a cancer-linked co-regulator complex
Mackay J, Blobel G
NHMRC Project Grant ($799,230 over 3 years)
2009
NHMRC Senior Research Fellowship B
Mackay J
NHMRC Research Fellowship ($618,750 over 5 years)
* Grants administered through the University of Sydney