Publications list for Professor Joel Mackay

2014 | 2013 | 2012 | 2011 | 2010 | 2009


  • Mackay, J. (2014), Transcription factor seeks DNA - cognate site preferred. Journal of Molecular Biology. 426(7), 1370-1372. [Abstract]
  • Vandevenne, M., O'Connell, M., Helder, S., Shepherd, N., Matthews, J., Kwan, A., Segal, D., Mackay, J. (2014), Engineering Specificity Changes on a RanBP2 Zinc Finger that Binds Single-Stranded RNA. Angewandte Chemie. 53(30), 7848-7852. [Abstract]
  • Alqarni, S., Murthy, A., Zhang, W., Przewloka, M., Silva, A., Watson, A., Lejon, S., Pei, X., Smits, A., Kloet, S., Wang, H., Shepherd, N., Stokes, P., Blobel, G., Vermeulen, M., Glover, D., Mackay, J., Laue, E. (2014), Insight into the architecture of the NuRD complex: Structure of the RbAp48-MTA1 sub-complex. Journal of Biological Chemistry. 289(32), 21844-21855. [Abstract]
  • Blythe, A., Gunasekara, S., Walshe, J., Mackay, J., Hartzog, G., Vrielink, A. (2014), Ubiquitin fusion constructs allow the expression and purification of multi-KOW domain complexes of the Saccharomyces cerevisiae transcription elongation factor Spt4/5. Protein Expression and Purification. 100, 54-60. [Abstract]
  • Dickson, C., Kumar, K., Jacques, D., Malmirchegini, G., Spirig, T., Mackay, J., Clubb, R., Guss, J., Gell, D. (2014), Structure of the hemoglobin-IsdH complex reveals the molecular basis of iron capture by Staphylococcus aureus. Journal of Biological Chemistry. 289(10), 6728-6738. [Abstract]
  • Silva, A., Kwan, A., Mackay, J. (2014), ¹H, ¹³C and ¹⁵N resonance assignments of an n-terminal domain of chd4. Biomolecular NMR Assignments. 8(1), 137-139. [Abstract]
  • Joseph, S., Kwan, A., Mackay, J., Cubeddu, L., Matthews, J. (2014), Backbone and side-chain assignments of a tethered complex between lmo4 and deaf-1. Biomolecular NMR Assignments. 8(1), 141-144. [Abstract]
  • Joseph, S., Kwan, A., Stokes, P., Mackay, J., Cubeddu, L., Matthews, J. (2014), The Structure of an LIM-Only Protein 4 (LMO4) and Deformed Epidermal Autoregulatory Factor-1 (DEAF1) Complex Reveals a Common Mode of Binding to LMO4. PloS One. 9(10), e109108. [Abstract]
  • Clifton, M., Westman, B., Thong, S., O'Connell, M., Webster, M., Shepherd, N., Quinlan, K., Crossley, M., Blobel, G., Mackay, J. (2014), The Identification and Structure of an N-Terminal PR Domain Show that FOG1 Is a Member of the PRDM Family of Proteins. PloS One. 9(8), e106011. [Abstract]


  • Gamsjaeger, R., O'Connell, M., Cubeddu, L., Shepherd, N., Lowry, J., Kwan, A., Vandevenne, M., Swanton, M., Matthews, J., Mackay, J. (2013), A structural analysis of DNA binding by myelin transcription factor 1 double zinc fingers. The Journal of Biological Chemistry. 288(49), 35180-35191. [Abstract]
  • Mackay, J., Segal, D., Crossley, M. (2013), Is there a telltale RH fingerprint in zinc fingers that recognizes methylated CpG dinucleotides?. Trends in Biochemical Sciences. , 421-422. [Abstract]
  • Dickson, C., Rich, A., D'Avigdor, W., Collins, D., Lowry, J., Mollan, T., Khandros, E., Olson, J., Weiss, M., Mackay, J., Lay, P., Gell, D. (2013), α-Hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-α-hemoglobin and weakens the iron-oxygen bond. The Journal of Biological Chemistry. 288(27), 19986-20001. [Abstract]
  • Gamsjaeger, R., Kariawasam, R., Bang, L., Touma, C., Nguyen, C., Matthews, J., Cubeddu, L., Mackay, J. (2013), Semi-quantitative and quantitative analysis of protein-DNA interactions using steady-state measurements in Surface-Plasmon-Resonance competition experiments. Analytical Biochemistry. 440(2), 178-185. [Abstract]
  • Vandevenne, M., Jacques, D., Artuz, C., Nguyen, C., Kwan, A., Segal, D., Matthews, J., Crossley, M., Guss, J., Mackay, J. (2013), New insights into dna recognition by zinc fingers revealed by structural analysis of the oncoprotein znf217. The Journal of Biological Chemistry. 288(15), 10616-10627. [Abstract]
  • Stokes, P., Liew, C., Kwan, A., Foo, P., Barker, H., Djamirze, A., O'Reilly, V., Visvader, J., Mackay, J., Matthews, J. (2013), Structural basis of the interaction of the breast cancer oncogene lmo4 with the tumour suppressor ctip/rbbp8. Journal of Molecular Biology. 425(7), 1101-1110. [Abstract]
  • Cordina, N., Liew, C., Gell, D., Fajer, P., Mackay, J., Brown, L. (2013), Effects of calcium binding and the hypertrophic cardiomyopathy a8v mutation on the dynamic equilibrium between closed and open conformations of the regulatory n-domain of isolated cardiac troponin c. Biochemistry. 52(11), 1950-1962. [Abstract]


  • Dastmalchi, S., Wilkinson-White, L., Kwan, A., Gamsjaeger, R., Mackay, J., Matthews, J. (2012), Solution structure of a tethered Lmo2(LIM2) /Ldb1(LID) complex. Protein Science. 21(11), 1768-1774. [Abstract]
  • Cordina, N., Liew, C., Gell, D., Fajer, P., Mackay, J., Brown, L. (2012), Interdomain orientation of cardiac troponin C characterized by paramagnetic relaxation enhancement NMR reveals a compact state. Protein Science. 21(9), 1376-1387. [Abstract]
  • McKenzie, J., Duyvestyn, J., Smith, T., Bendak, K., Mackay, J., Cursons, R., Cook, G., Arcus, V. (2012), Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA. 18(6), 1267-1278. [Abstract]
  • O'Connell, M., Vandevenne, M., Nguyen, C., Matthews, J., Gamsjaeger, R., Segal, D., Mackay, J. (2012), Modular Assembly of RanBP2-Type Zinc Finger Domains to Target Single-Stranded RNA. Angewandte Chemie (International Edition). 51(22), 5371-5375. [Abstract]
  • Burdach, J., O'Connell, M., Mackay, J., Crossley, M. (2012), Two-timing zinc finger transcription factors liaising with RNA. Trends in Biochemical Sciences. 37(5), 199-205. [Abstract]
  • Hsieh, Y., Wilkinson, B., O'Connell, M., Mackay, J., Matthews, J., Payne, R. (2012), Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants. Organic Letters. 14(7), 1910-1913. [Abstract]
  • Bendak, K., Loughlin, F., Cheung, V., O'Connell, M., Crossley, M., Mackay, J. (2012), A rapid method for assessing the RNA-binding potential of a protein. Nucleic Acids Research. 40(14), e105. [Abstract]
  • Macindoe, I., Kwan, A., Ren, Q., Morris, V., Yang, W., Mackay, J., Sunde, M. (2012), Self-assembly of functional, amphipathic amyloid monolayers by the fungal hydrophobin EAS. Proceedings of the National Academy of Sciences of the United States of America. 109(14), E804-E811. [Abstract]
  • Morris, V., Kwan, A., Mackay, J., Sunde, M. (2012), Backbone and sidechain ¹H, ¹³C and ¹⁵N chemical shift assignments of the hydrophobin DewA from Aspergillus nidulans. Biomolecular NMR Assignments. 6(1), 83-86. [Abstract]
  • Liew, C., Kwan, A., Stokes, P., Mackay, J., Matthews, J. (2012), ¹H, ¹⁵N and ¹³C assignments of an intramolecular LMO4-LIM1/CtIP complex. Biomolecular NMR Assignments. 6(1), 31-34. [Abstract]
  • Musselman, C., Ramírez, J., Sims, J., Mansfield, R., Oliver, S., Denu, J., Mackay, J., Wade, P., Hagman, J., Kutateladze, T. (2012), Bivalent recognition of nucleosomes by the tandem PHD fingers of the CHD4 ATPase is required for CHD4-mediated repression. Proceedings of the National Academy of Sciences of the United States of America. 109(3), 787-792. [Abstract]
  • Gell, D., Grant, R., Mackay, J. (2012), The detection and quantitation of protein oligomerization. In: Advances in Experimental Medicine and Biology: Protein Dimerization and Oligomerization in Biology. (pp.19-41).United States: Springer Science+Business Media, LLC.
  • Bhati, M., Lee, C., Gadd, M., Jeffries, C., Kwan, A., Whitten, A., Trewhella, J., Mackay, J., Matthews, J. (2012), Solution Structure of the LIM-Homeodomain Transcription Factor Complex Lhx3/Ldb1 and the Effects of a Pituitary Mutation on Key Lhx3 Interactions. PLoS One. 7(7), e40719. [Abstract]


  • Krishna Kumar, K., Jacques, D., Pishchany, G., Caradoc-Davies, T., Spirig, T., Malmirchegini, G., Langley, D., Dickson, C., Mackay, J., Clubb, R., Skaar, E., Guss, J., Gell, D. (2011), The structural basis for hemoglobin capture by the Staphylococcus aureus cell-surface protein, IsdH. The Journal of biological chemistry. 286(44), 38439-47. [Abstract]
  • Nunez, N., Clifton, M., Funnell, A., Artuz, C., Hallal, S., Quinlan, K., Font, J., Vandevenne, M., Setiyaputra, S., Pearson, R., Mackay, J., Crossley, M. (2011), The multi-zinc finger protein ZNF217 contacts DNA through a two finger domain. The Journal of biological chemistry. 286(44), 38190-201. [Abstract]
  • Wilkinson-White, L., Gamsjaeger, R., Dastmalchi, S., Wienert, B., Stokes, P., Crossley, M., Mackay, J., Matthews, J. (2011), Structural basis of simultaneous recruitment of the transcriptional regulators LMO2 and FOG1/ZFPM1 by the transcription factor GATA1. Proceedings of the National Academy of Sciences of the United States of America. 108(35), 14443-14448. [Abstract]
  • Wissmueller, S., Font, J., Liew, C., Cram, E., Schroeder, T., Turner, J., Crossley, M., Mackay, J., Matthews, J. (2011), Protein-protein interactions: Analysis of a false positive GST pulldown result. Proteins. 79(8), 2365-71. [Abstract]
  • Gamsjaeger, R., Webb, S., Lamonica, J., Billin, A., Blobel, G., Mackay, J. (2011), Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET-family bromodomain protein Brd3. Molecular and cellular biology. 31(13), 2632-40. [Abstract]
  • Lamonica, J., Deng, W., Kadauke, S., Campbell, A., Gamsjaeger, R., Wang, H., Cheng, Y., Billin, A., Hardison, R., Mackay, J., Blobel, G. (2011), Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proceedings of the National Academy of Sciences of the United States of America. 108(22), E159-E168. [Abstract]
  • Setiyaputra, S., Mackay, J., Patrick, W. (2011), The Structure of a Truncated Phosphoribosylanthranilate Isomerase Suggests a Unified Model for Evolution of the(βα)(8) Barrel Fold. Journal of Molecular Biology. 408(2), 291-303. [Abstract]
  • Mansfield, R., Musselman, C., Kwan, A., Oliver, S., Garske, A., Davrazou, F., Denu, J., Kutateladze, T., Mackay, J. (2011), Plant Homeodomain (PHD) Fingers of CHD4 Are Histone H3-binding Modules with Preference for Unmodified H3K4 and Methylated H3K9. Journal of Biological Chemistry. 286(13), 11779-11791. [Abstract]
  • Cripps, R., Lee, B., Wing, P., Weerts, E., Mackay, J., Brown, D. (2011), A global map for traumatic spinal cord injury epidemiology: towards a living data repository for injury prevention. Spinal cord. 49(4), 493-501. [Abstract]
  • Nguyen, C., Mansfield, R., Leung, W., Vaz, P., Loughlin, F., Grant, R., Mackay, J. (2011), Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA. Journal of Molecular Biology. 407(2), 273-283. [Abstract]
  • Bieri, M., Kwan, A., Mobli, M., King, G., Mackay, J., Gooley, P. (2011), Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination. The FEBS Journal. 278(5), 704-715. [Abstract]
  • Kwan, A., Mobli, M., Gooley, P., King, G., Mackay, J. (2011), Macromolecular NMR spectroscopy for the non-spectroscopist. FEBS Journal. 278(5), 687-703. [Abstract]
  • Mackay, J., Font, J., Segal, D. (2011), The prospects for designer single-stranded RNA-binding proteins. Nature Structural & Molecular Biology. 18(3), 256-261. [Abstract]
  • Lejon, S., Thong, S., Murthy, A., Alqarni, S., Murzina, N., Blobel, G., Laue, E., Mackay, J. (2011), Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48-FOG-1 Complex. Journal of Biological Chemistry. 286(2), 1196-1203. [Abstract]


  • Krishna Kumar, K., Dickson, C., Weiss, M., Mackay, J., Gell, D. (2010), AHSP (α-haemoglobin-stabilizing protein) stabilizes apo-α-haemoglobin in a partially folded state. The Biochemical journal. 432(2), 275-82. [Abstract]
  • Wilkinson-White, L., Dastmalchi, S., Kwan, A., Ryan, D., Mackay, J., Matthews, J. (2010), (1)H, (15)N and (13)C assignments of an intramolecular Lmo2-LIM2/Ldb1-LID complex. Biomolecular NMR assignments. 4(2), 203-6. [Abstract]
  • Hynson, R., Kwan, A., Jacques, D., Mackay, J., Trewhella, J. (2010), (1)H, (13)C and (15)N backbone and side chain resonance assignments of the N-terminal domain of the histidine kinase inhibitor KipI from Bacillus subtilis. Biomolecular NMR assignments. 4(2), 167-9. [Abstract]
  • Schwalbe, M., Dutta, K., Libich, D., Venugopal, H., Claridge, J., Gell, D., Mackay, J., Edwards, P., Pascal, S. (2010), Two-state conformational equilibrium in the Par-4 leucine zipper domain. Proteins. 78(11), 2433-2449. [Abstract]
  • Font, J., Mackay, J. (2010), Beyond DNA: Zinc Finger Domains as RNA-Binding Modules. Methods in Molecular Biology. 649, 479-491. [Abstract]


  • O'Connell, M., Gamsjaeger, R., Mackay, J. (2009), The structural analysis of protein-protein interactions by NMR spectroscopy. Proteomics. 9, 5224-32. [Abstract]
  • Gell, D., Feng, L., Zhou, S., Jeffrey, P., Bendak, K., Gow, A., Weiss, M., Shi, Y., Mackay, J. (2009), A cis-proline in alpha-hemoglobin stabilizing protein directs the structural reorganization of alpha-hemoglobin. The Journal of biological chemistry. 284(43), 29462-29469. [Abstract]
  • Musselman, C., Mansfield, R., Garske, A., Davrazou, F., Kwan, A., Oliver, S., O'Leary, H., Denu, J., Mackay, J., Kutateladze, T. (2009), Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. The Biochemical journal. 423(2), 179-87. [Abstract]
  • Talib, J., Beck, J., Urathamakul, T., Nguyen, C., Aldrich-Wright, J., Mackay, J., Ralph, S. (2009), A mass spectrometric investigation of the ability of metal complexes to modulate transcription factor activity. Chemical communications (Cambridge, England). 0(37), 5546-8. [Abstract]
  • Macindoe, I., Glockner, L., Vukasin, P., Stennard, F., Costa, M., Harvey, R., Mackay, J., Sunde, M. (2009), Conformational stability and DNA binding specificity of the cardiac T-box transcription factor Tbx20. Journal of molecular biology. 389(3), 606-18. [Abstract]
  • Loughlin, F., Mansfield, R., Vaz, P., McGrath, A., Setiyaputra, S., Gamsjaeger, R., Chen, E., Morris, B., Guss, J., Mackay, J. (2009), The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences. Proceedings of the National Academy of Sciences of the United States of America. 106(14), 5581-5586. [Abstract]
  • Langley, D., Shojaei, M., Chan, C., Lok, H., Mackay, J., Traut, T., Guss, J., Christopherson, R. (2009), Structure and Inhibition of Orotidine 5'-Monophosphate Decarboxylase from Plasmodium falciparum. Biochemistry. 48(11), 2570. [Abstract]
  • Lowry, J., Gamsjaeger, R., Thong, S., Hung, W., Kwan, A., Broitman-Maduro, G., Matthews, J., Maduro, M., Mackay, J. (2009), Structural analysis of med-1 reveals unexpected diversity in the mechanism of DNA recognition by gata-type zinc finger domains. The Journal of biological chemistry. 284(0), 5827-35. [Abstract]
  • Matthews, J., Bhati, M., Lehtomaki, E., Mansfield, R., Cubeddu, L., Mackay, J. (2009), It Takes Two to Tango: The Structure and Function of LIM, RING, PHD and MYND Domains. Current pharmaceutical design. 15(31), 3681-3696. [Abstract]