Mr Alvaro Garcia

Postdoctoral Research Associate

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 3535
Fax 61 2 9351 3329

Selected publications

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Journals

  • Jiang, Q., Garcia, A., Han, M., Cornelius, F., Apell, H., Khandelia, H., Clarke, R. (2017). Electrostatic stabilization plays a central role in autoinhibitory regulation of the Na+, K+ - ATPase. Biophysical Journal, 112(2), 288-299. [More Information]
  • Garcia, A., Pratap, P., Lupfert, C., Cornelius, F., Jacquemin, D., Lev, B., Allen, T., Clarke, R. (2017). The voltage-sensitive dye RH421 detects a Na+,K+-ATPase conformational change at the membrane surface. Biochimica et Biophysica Acta-Biomembranes, 1859 (5), 813-823. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N., Hamilton, E., Hawkins, C., Figtree, G. (2016). Beta3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. Journal of the American Heart Association, 5(2), 1-17. [More Information]
  • Garcia, A., Liu, C., Cornelius, F., Clarke, R., Rasmussen, H. (2016). Glutathionylation-dependence of Na+ -K+ -pump currents can mimic reduced subsarcolemmal Na+ diffusion. Biophysical Journal, 110(5), 1099-1109. [More Information]
  • Lambropoulos, N., Garcia, A., Clarke, R. (2016). Stimulation of Na+,K+-ATPase Activity as a Possible Driving Force in Cholesterol Evolution. Journal of Membrane Biology, 249(3), 251-259. [More Information]
  • Garcia, A., Rasmussen, H., Clarke, R. (2015). A novel kinetic model based on the Albers-Post scheme that mimics the behaviour of the Na+, K+-ATPase in situ. Heart, Lung and Circulation, 24(S3), S224-S224. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Figtree, G., Rasmussen, H. (2015). Beta3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade. American Journal of Physiology: Cell Physiology, 309(5), C286-C295. [More Information]
  • Garcia, A., Eljack, N., Sani, M., Separovic, F., Rasmussen, H., Kopec, W., Khandelia, H., Cornelius, F., Clarke, R. (2015). Membrane accessibility of glutathione. Biochimica et Biophysica Acta-Biomembranes, 1848 (10 (Part A)), 2430-2436. [More Information]
  • Chia, K., Liu, C., Hamilton, E., Garcia, A., Fry, N., Hannam, W., Figtree, G., Rasmussen, H. (2015). Stimulation of the cardiac myocyte NA+-K+ pump due to reversal of its constitutive oxidative inhibition. American Journal of Physiology: Cell Physiology, 309(4), C239-C250. [More Information]
  • Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Mares, J., Garcia, A., Rasmussen, H., Cornelius, F., Mahmmoud, Y., Berlin, J., Lev, B., Allen, T., Clarke, R. (2014). Identification of Electric-Field-Dependent Steps in the Na+,K+ -Pump Cycle. Biophysical Journal, 107(6), 1352-1363. [More Information]
  • Garcia, A., Fry, N., Karimi, K., Liu, C., Apell, H., Rasmussen, H., Clarke, R. (2013). Extracellular allosteric Na+ binding to the Na+, K+-ATPase in cardiac myocytes. Biophysical Journal, 105(12), 2695-2705. [More Information]
  • Liu, C., Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]
  • Garcia, A., Rasmussen, H., Apell, H., Clarke, R. (2012). Kinetic comparisons of heart and kidney Na+, K+ -ATPases. Biophysical Journal, 103(4), 677-688. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]
  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]
  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]
  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2007). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292, C1070-C1077. [More Information]
  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2006). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292(3), C1070-C1077. [More Information]
  • Allan, C., Garcia, A., Spaliviero, J., Jimenez, M., Handelsman, D. (2006). Maintenance of spermatogenesis by the activated human (Asp567Gly) FSH receptor during testicular regression due to hormonal withdrawal. Biology Of Reproduction, 74(5), 938-944. [More Information]
  • William, M., Vien, J., Hamilton, E., Garcia, A., Bundgaard, H., Clarke, R., Rasmussen, H. (2005). The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes. The Journal of Physiology, 565.3(3), 815-825. [More Information]
  • Allan, C., Garcia, A., Spaliviero, J., Zhang, F., Jimenez, M., Huhtaniemi, I., Handelsman, D. (2004). Complete Sertoli Cell Proliferation Induced By Follicle-Stimulating Hormone (FSH) Independently Of Luteinizing Hormone Activity: Evidence From Genetic Models Of Isolated FSH Action. Endocrinology, 145(4), 1587-1593. [More Information]

Conferences

  • Liu, C., Seow, J., Hamilton, E., Garcia, A., Figtree, G., Rasmussen, H. (2009). Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation in the heart. 57th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2009, Australia: Cardiac Society of Australia and New Zealand.
  • Liu, C., Figtree, G., Hamilton, E., Garcia, A., White, C., Cornelius, F., Rasmussen, H. (2008). Oxidative signalling inhibits the cardiac Na+-K+ pump via glutathionylation. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.
  • White, C., Hamilton, E., Garcia, A., Rasmussen, H. (2006). PKA inhibits the Na+-K+ pump in cadiac myocytes via superoxide. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press.

2017

  • Jiang, Q., Garcia, A., Han, M., Cornelius, F., Apell, H., Khandelia, H., Clarke, R. (2017). Electrostatic stabilization plays a central role in autoinhibitory regulation of the Na+, K+ - ATPase. Biophysical Journal, 112(2), 288-299. [More Information]
  • Garcia, A., Pratap, P., Lupfert, C., Cornelius, F., Jacquemin, D., Lev, B., Allen, T., Clarke, R. (2017). The voltage-sensitive dye RH421 detects a Na+,K+-ATPase conformational change at the membrane surface. Biochimica et Biophysica Acta-Biomembranes, 1859 (5), 813-823. [More Information]

2016

  • Galougahi, K., Liu, C., Garcia, A., Gentile, C., Fry, N., Hamilton, E., Hawkins, C., Figtree, G. (2016). Beta3 adrenergic stimulation restores nitric oxide/redox balance and enhances endothelial function in hyperglycemia. Journal of the American Heart Association, 5(2), 1-17. [More Information]
  • Garcia, A., Liu, C., Cornelius, F., Clarke, R., Rasmussen, H. (2016). Glutathionylation-dependence of Na+ -K+ -pump currents can mimic reduced subsarcolemmal Na+ diffusion. Biophysical Journal, 110(5), 1099-1109. [More Information]
  • Lambropoulos, N., Garcia, A., Clarke, R. (2016). Stimulation of Na+,K+-ATPase Activity as a Possible Driving Force in Cholesterol Evolution. Journal of Membrane Biology, 249(3), 251-259. [More Information]

2015

  • Garcia, A., Rasmussen, H., Clarke, R. (2015). A novel kinetic model based on the Albers-Post scheme that mimics the behaviour of the Na+, K+-ATPase in situ. Heart, Lung and Circulation, 24(S3), S224-S224. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Figtree, G., Rasmussen, H. (2015). Beta3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade. American Journal of Physiology: Cell Physiology, 309(5), C286-C295. [More Information]
  • Garcia, A., Eljack, N., Sani, M., Separovic, F., Rasmussen, H., Kopec, W., Khandelia, H., Cornelius, F., Clarke, R. (2015). Membrane accessibility of glutathione. Biochimica et Biophysica Acta-Biomembranes, 1848 (10 (Part A)), 2430-2436. [More Information]
  • Chia, K., Liu, C., Hamilton, E., Garcia, A., Fry, N., Hannam, W., Figtree, G., Rasmussen, H. (2015). Stimulation of the cardiac myocyte NA+-K+ pump due to reversal of its constitutive oxidative inhibition. American Journal of Physiology: Cell Physiology, 309(4), C239-C250. [More Information]

2014

  • Galougahi, K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N., Davies, M., Hawkins, C., Rasmussen, H., Figtree, G. (2014). Glutathionylation Mediates Angiotension II-Induced eNOS Uncoupling, Amplifying NADPH Oxidase-Dependent Endothelial Dysfunction. Journal of the American Heart Association, 3(2), 1-11. [More Information]
  • Mares, J., Garcia, A., Rasmussen, H., Cornelius, F., Mahmmoud, Y., Berlin, J., Lev, B., Allen, T., Clarke, R. (2014). Identification of Electric-Field-Dependent Steps in the Na+,K+ -Pump Cycle. Biophysical Journal, 107(6), 1352-1363. [More Information]

2013

  • Garcia, A., Fry, N., Karimi, K., Liu, C., Apell, H., Rasmussen, H., Clarke, R. (2013). Extracellular allosteric Na+ binding to the Na+, K+-ATPase in cardiac myocytes. Biophysical Journal, 105(12), 2695-2705. [More Information]
  • Liu, C., Galougahi, K., Weisbrod, R., Hansen, T., Ravaie, R., Nunez, A., Liu, Y., Fry, N., Garcia, A., Hamilton, E., Figtree, G., et al (2013). Oxidative inhibition of the vascular Na+-K+ pump via NADPH oxidase-dependent β1-subunit glutathionylation: Implications for angiotensin II-induced vascular dysfunction. Free Radical Biology and Medicine, 65(2013), 563-572. [More Information]
  • Galougahi, K., Liu, C., Garcia, A., Fry, N., Hamilton, E., Rasmussen, H., Figtree, G. (2013). Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling. The Journal of Physiology, 591(12), 2999-3015. [More Information]
  • Liu, C., Fry, N., Hamilton, E., Chia, K., Garcia, A., Galougahi, K., Figtree, G., Clarke, R., Bundgaard, H., Rasmussen, H. (2013). Redox-dependent regulation of the Na+ -K+ pump: New twists to an old target for treatment of heart failure. Journal of Molecular and Cellular Cardiology, 61, 94-101. [More Information]

2012

  • Garcia, A., Rasmussen, H., Apell, H., Clarke, R. (2012). Kinetic comparisons of heart and kidney Na+, K+ -ATPases. Biophysical Journal, 103(4), 677-688. [More Information]
  • Liu, C., Garcia, A., Mahmmoud, Y., Hamilton, E., Galougahi, K., Fry, N., Figtree, G., Cornelius, F., Clarke, R., Rasmussen, H. (2012). Susceptibility of β1 Na+ -K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump. Journal of Biological Chemistry, 287(15), 12353-12364. [More Information]

2011

  • Bibert, S., Liu, C., Figtree, G., Garcia, A., Hamilton, E., Marassi, F., Sweadner, K., Cornelius, F., Geering, K., Rasmussen, H. (2011). FXYD Proteins Reverse Inhibition of the Na+-K+ Pump Mediated by Glutathionylation of Its beta 1 Subunit. Journal of Biological Chemistry, 286(21), 18562-18572. [More Information]

2010

  • White, C., Liu, C., Garcia, A., Hamilton, E., Chia, K., Figtree, G., Rasmussen, H. (2010). Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity. Journal of Biological Chemistry, 285(18), 13712-13720. [More Information]
  • Bundgaard, H., Liu, C., Garcia, A., Hamilton, E., Huang, Y., Chia, K., Hunyor, S., Figtree, G., Rasmussen, H. (2010). {beta}3 Adrenergic Stimulation of the Cardiac Na+-K+ Pump by Reversal of an Inhibitory Oxidative Modification. Circulation, 122, 2699-2708. [More Information]

2009

  • White, C., Figtree, G., Liu, C., Garcia, A., Hamilton, E., Chia, K., Rasmussen, H. (2009). Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase. American Journal of Physiology: Cell Physiology, 296(4), C693-C700. [More Information]
  • Figtree, G., Liu, C., Bibert, S., Hamilton, E., Garcia, A., White, C., Chia, K., Cornelius, F., Geering, K., Rasmussen, H. (2009). Reversible oxidative modification: A key mechanism of Na+-K + pump regulation. Circulation Research, 105(2), 185-193. [More Information]
  • Liu, C., Seow, J., Hamilton, E., Garcia, A., Figtree, G., Rasmussen, H. (2009). Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation in the heart. 57th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2009, Australia: Cardiac Society of Australia and New Zealand.

2008

  • William, M., Hamilton, E., Bundgaard, H., Garcia, A., Chia, K., Figtree, G., Rasmussen, H. (2008). Natriuretic peptides stimulate the cardiac sodium pump via NPR-C coupled NOS activation. American Journal of Physiology: Cell Physiology, 294(4), C1067-C1073. [More Information]
  • White, C., Hamilton, E., Garcia, A., Wang, D., Chia, K., Figtree, G., Rasmussen, H. (2008). Opposing effects of coupled and uncoupled NOS activity on the Na+-K+ pump in cardiac myocytes. American Journal of Physiology: Cell Physiology, 294, C572-C578. [More Information]
  • Liu, C., Figtree, G., Hamilton, E., Garcia, A., White, C., Cornelius, F., Rasmussen, H. (2008). Oxidative signalling inhibits the cardiac Na+-K+ pump via glutathionylation. 12th International ATPase Conference, Aarhus, Denmark: Aarhus University.

2007

  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2007). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292, C1070-C1077. [More Information]

2006

  • Hansen, P., Clarke, R., Buhagiar, K., Hamilton, E., Garcia, A., White, C., Rasmussen, H. (2006). Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes. American Journal of Physiology: Cell Physiology, 292(3), C1070-C1077. [More Information]
  • Allan, C., Garcia, A., Spaliviero, J., Jimenez, M., Handelsman, D. (2006). Maintenance of spermatogenesis by the activated human (Asp567Gly) FSH receptor during testicular regression due to hormonal withdrawal. Biology Of Reproduction, 74(5), 938-944. [More Information]
  • White, C., Hamilton, E., Garcia, A., Rasmussen, H. (2006). PKA inhibits the Na+-K+ pump in cadiac myocytes via superoxide. 30th Annual Meeting of the Australiasian Section of the International Society of Heart Research (ISHR), United Kingdom: Academic Press.

2005

  • William, M., Vien, J., Hamilton, E., Garcia, A., Bundgaard, H., Clarke, R., Rasmussen, H. (2005). The nitric oxide donor sodium nitroprusside stimulates the Na+-K+ pump in isolated rabbit cardiac myocytes. The Journal of Physiology, 565.3(3), 815-825. [More Information]

2004

  • Allan, C., Garcia, A., Spaliviero, J., Zhang, F., Jimenez, M., Huhtaniemi, I., Handelsman, D. (2004). Complete Sertoli Cell Proliferation Induced By Follicle-Stimulating Hormone (FSH) Independently Of Luteinizing Hormone Activity: Evidence From Genetic Models Of Isolated FSH Action. Endocrinology, 145(4), 1587-1593. [More Information]

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