Dr Anna Renfrew

MChem York(UK); PhD EPFL
ARC DECRA Fellow

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 2830
Fax 61 2 9351 3329

Website Contact Details
Curriculum vitae Curriculum vitae

Biographical details

  • MChem (First Class), The University of York, UK (2002 - 2006)
  • PhD, Ecole Polytechnique Federal de Lausanne, Switzerland (2006 - 2010)
  • Postdoctoral Research Associate, The University of Sydney (2011-2013)
  • Swiss National Science Foundation Postdoctoral Fellow, The University of Sydney (2011-2013)
  • ARC DECRA Fellow, The University of Sydney (2013 - 2015)
  • Lecturer (2016)

Research interests

My research focuses on using photoactive metal complexes for the selective delivery and release of anticancer agents.

  • Bioinorganic medicinal chemistry
  • Ruthenium-based anticancer agents
  • Light-activated prodrugs
  • Bioconjugation of tumour targeting groups and fluorescent tags

Current research students

Project title Research student
Glucose Conjugation for Targeted Delivery of Metal Based Anticancer Agents Alexandra GLENISTER
Cobalt complexes as responsive MRI contrast agents Edward O'NEILL

Selected grants

2016

  • Metals in Medicine, Gordon Research Conference (26/06/16 - 01/07/16); Renfrew A; CASS Foundation Limited/Travel Support.

2015

  • Perpetual account - Renfrew; Renfrew A; Australian Synchrotron/Research Support.

2013

  • Rational design of novel metal-based chaperones for tumour-selective drug delivery; Renfrew A; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA).

Selected publications

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Journals

  • O'Neill, E., Kolanowski, J., Yin, G., Broadhouse, K., Grieve, S., Renfrew, A., Bonnitcha, P., New, E. (2016). Reversible magnetogenic cobalt complexes. RSC Advances, 6(36), 30021-30027. [More Information]
  • Karaoun, N., Renfrew, A. (2015). A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging. Chemical Communications, 51(74), 14038-14041. [More Information]
  • Renfrew, A., Bryce, N., Hambley, T. (2015). Cobalt(III) chaperone complexes of curcumin: Photoreduction, cellular accumulation and light-selective toxicity towards tumour cells. Chemistry - A European Journal, 21(43), 15224-15234. [More Information]
  • Renfrew, A. (2014). Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery. Metallomics, 6(8), 1324-1335. [More Information]
  • Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information]
  • Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information]
  • Renfrew, A., Juillerat-Jeanneret, L., Dyson, P. (2011). Adding diversity to ruthenium(II)-arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains. Journal of Organometallic Chemistry, 696(3), 772-779. [More Information]
  • Govender, P., Renfrew, A., Clavel, C., Dyson, P., Therrien, B., Smith, G. (2011). Antiproliferative activity of chelating N,O-and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds. Dalton Transactions, 40(5), 1158-1167. [More Information]
  • Mattsson, J., Zava, O., Renfrew, A., Sei, Y., Yamaguchi, K., Dyson, P., Therrien, B. (2010). Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton Transactions, 39(35), 8248-8255. [More Information]
  • Egger, A., Hartinger, C., Renfrew, A., Dyson, P. (2010). Metabolization of [Ru(eta(^6)-C(6)H(5)CF(3)(pta)Cl(2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand. Journal of Biological Inorganic Chemistry, 15(6), 919-927. [More Information]
  • Schulz, J., Renfrew, A., Cisarova, I., Dyson, P., Stepnicka, P. (2010). Synthesis and anticancer activity of chalcogenide derivatives and platinum(II) and palladium(II) complexes derived from a polar ferrocene phosphanyl-carboxamide. Applied Organometallic Chemistry, 24(5), 392-397. [More Information]
  • Suss-Fink, G., Khan, F., Juillerat-Jeanneret, L., Dyson, P., Renfrew, A. (2010). Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and naoparticles. Journal of Cluster Science: including nanoclusters and nanoparticles, 21(3), 313-324. [More Information]
  • Renfrew, A., Egger, A., Scopelliti, R., Hartinger, C., Dyson, P. (2010). Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(eta(6)-cymene)(PPh(2)(o-C(6)H(4)O)-kappa(^2)-P,O)(pta)](^+) and an investigation of its cytotoxic effects (Invited publication). Academie des Sciences. Comptes Rendus. Chimie, 13(8-9), 1144-1150. [More Information]
  • Renfrew, A., Scopelliti, R., Dyson, P. (2010). Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting. Inorganic Chemistry, 49(5), 2239-2246. [More Information]
  • Govender, P., Antonels, N., Mattsson, J., Renfrew, A., Dyson, P., Moss, J., Therrien, B., Smith, G. (2009). Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds. Journal of Organometallic Chemistry, 694(21), 3470-3476. [More Information]
  • Auzias, M., Gueniat, J., Therrien, B., Suss-Fink, G., Renfrew, A., Dyson, P. (2009). Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(η6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]. Journal of Organometallic Chemistry, 694(6), 855-861. [More Information]
  • Renfrew, A., Phillips, A., Egger, A., Hartinger, C., Bosquain, S., Nazarov, A., Keppler, B., Gonsalvi, L., Peruzzini, M., Dyson, P. (2009). Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta. Organometallics, 28(4), 1165-1172. [More Information]
  • Renfrew, A. (2009). Ruthenium(II) arene compounds as versatile anticancer agents. Chimia, 63(4), 217-219. [More Information]
  • Hartl, F., Renfrew, A., Lafolet, F., Mahabiersing, T., Calhorda, M., Chardon-Noblat, S., Haukka, M., Deronzier, A. (2009). Soluble redox-active polymetallic chains [{Ruo(CO)(L)(bpy)}m]n (bpy = 2,2'-bipyridine, L = PrCN, CI-; m = O, -1): Electrosynthesis and characterization. Inorganic Chemistry, 48(17), 8233-8244. [More Information]
  • Mattsson, J., Govindaswamy, P., Renfrew, A., Dyson, P., Stepnicka, P., Suss-Fink, G., Therrien, B. (2009). Synthesis, molecular structure, and anticancer activity of cationic arene ruthenium metallarectangles. Organometallics, 28(15), 4350-4357. [More Information]
  • Renfrew, A., Phillips, A., Tapavicza, E., Scopelliti, R., Rothlisberger, U., Dyson, P. (2009). Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumor compounds with fluorinated arene ligands. Organometallics, 28(17), 5061-5071. [More Information]
  • Chardon-Noblat, S., Renfrew, A., Lafolet, F., Deronzier, A., Jakonen, M., Laurila, E., Haukka, M. (2008). An easy electrochemical and chemical synthesis of [Ru(bpy)(CH3CN)2Cl2]: a synthon for heteroleptic tris(diimine) Ru(II) complexes. Dalton Transactions, 2008, 5891-5896. [More Information]
  • Vock, C., Renfrew, A., Scopelliti, R., Juillerat-Jeanneret, L., Dyson, P. (2008). Influence of the diketonato ligand on the cytotoxicities of [Ru(η6-p-cymene)(R2acac)(PTA)]+ complexes (PTA = 1,3,5-triaza-7-phosphaadamantane). European Journal of Inorganic Chemistry, (10), 1661-1671. [More Information]
  • Therrien, B., Suss-Fink, G., Govindaswamy, P., Renfrew, A., Dyson, P. (2008). The "complex-in-a-complex" cations [(acac)2M⊂Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells. Angewandte Chemie (International Edition), 47(20), 3773-3776. [More Information]
  • Gras, M., Therrien, B., Suss-Fink, G., Stepnicka, P., Renfrew, A., Dyson, P. (2008). Water-soluble arene ruthenium complexes containing pyridinethiolato ligands: Synthesis, molecular structure, redox properties and anticancer activity of the cations [(η6-arene)Ru(p-SC5H4NH)3]2+. Journal of Organometallic Chemistry, 693(21-22), 3419-3424. [More Information]

2016

  • O'Neill, E., Kolanowski, J., Yin, G., Broadhouse, K., Grieve, S., Renfrew, A., Bonnitcha, P., New, E. (2016). Reversible magnetogenic cobalt complexes. RSC Advances, 6(36), 30021-30027. [More Information]

2015

  • Karaoun, N., Renfrew, A. (2015). A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging. Chemical Communications, 51(74), 14038-14041. [More Information]
  • Renfrew, A., Bryce, N., Hambley, T. (2015). Cobalt(III) chaperone complexes of curcumin: Photoreduction, cellular accumulation and light-selective toxicity towards tumour cells. Chemistry - A European Journal, 21(43), 15224-15234. [More Information]

2014

  • Renfrew, A. (2014). Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery. Metallomics, 6(8), 1324-1335. [More Information]

2013

  • Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information]

2012

  • Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information]

2011

  • Renfrew, A., Juillerat-Jeanneret, L., Dyson, P. (2011). Adding diversity to ruthenium(II)-arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains. Journal of Organometallic Chemistry, 696(3), 772-779. [More Information]
  • Govender, P., Renfrew, A., Clavel, C., Dyson, P., Therrien, B., Smith, G. (2011). Antiproliferative activity of chelating N,O-and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds. Dalton Transactions, 40(5), 1158-1167. [More Information]

2010

  • Mattsson, J., Zava, O., Renfrew, A., Sei, Y., Yamaguchi, K., Dyson, P., Therrien, B. (2010). Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton Transactions, 39(35), 8248-8255. [More Information]
  • Egger, A., Hartinger, C., Renfrew, A., Dyson, P. (2010). Metabolization of [Ru(eta(^6)-C(6)H(5)CF(3)(pta)Cl(2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand. Journal of Biological Inorganic Chemistry, 15(6), 919-927. [More Information]
  • Schulz, J., Renfrew, A., Cisarova, I., Dyson, P., Stepnicka, P. (2010). Synthesis and anticancer activity of chalcogenide derivatives and platinum(II) and palladium(II) complexes derived from a polar ferrocene phosphanyl-carboxamide. Applied Organometallic Chemistry, 24(5), 392-397. [More Information]
  • Suss-Fink, G., Khan, F., Juillerat-Jeanneret, L., Dyson, P., Renfrew, A. (2010). Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and naoparticles. Journal of Cluster Science: including nanoclusters and nanoparticles, 21(3), 313-324. [More Information]
  • Renfrew, A., Egger, A., Scopelliti, R., Hartinger, C., Dyson, P. (2010). Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(eta(6)-cymene)(PPh(2)(o-C(6)H(4)O)-kappa(^2)-P,O)(pta)](^+) and an investigation of its cytotoxic effects (Invited publication). Academie des Sciences. Comptes Rendus. Chimie, 13(8-9), 1144-1150. [More Information]
  • Renfrew, A., Scopelliti, R., Dyson, P. (2010). Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting. Inorganic Chemistry, 49(5), 2239-2246. [More Information]

2009

  • Govender, P., Antonels, N., Mattsson, J., Renfrew, A., Dyson, P., Moss, J., Therrien, B., Smith, G. (2009). Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds. Journal of Organometallic Chemistry, 694(21), 3470-3476. [More Information]
  • Auzias, M., Gueniat, J., Therrien, B., Suss-Fink, G., Renfrew, A., Dyson, P. (2009). Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(η6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]. Journal of Organometallic Chemistry, 694(6), 855-861. [More Information]
  • Renfrew, A., Phillips, A., Egger, A., Hartinger, C., Bosquain, S., Nazarov, A., Keppler, B., Gonsalvi, L., Peruzzini, M., Dyson, P. (2009). Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta. Organometallics, 28(4), 1165-1172. [More Information]
  • Renfrew, A. (2009). Ruthenium(II) arene compounds as versatile anticancer agents. Chimia, 63(4), 217-219. [More Information]
  • Hartl, F., Renfrew, A., Lafolet, F., Mahabiersing, T., Calhorda, M., Chardon-Noblat, S., Haukka, M., Deronzier, A. (2009). Soluble redox-active polymetallic chains [{Ruo(CO)(L)(bpy)}m]n (bpy = 2,2'-bipyridine, L = PrCN, CI-; m = O, -1): Electrosynthesis and characterization. Inorganic Chemistry, 48(17), 8233-8244. [More Information]
  • Mattsson, J., Govindaswamy, P., Renfrew, A., Dyson, P., Stepnicka, P., Suss-Fink, G., Therrien, B. (2009). Synthesis, molecular structure, and anticancer activity of cationic arene ruthenium metallarectangles. Organometallics, 28(15), 4350-4357. [More Information]
  • Renfrew, A., Phillips, A., Tapavicza, E., Scopelliti, R., Rothlisberger, U., Dyson, P. (2009). Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumor compounds with fluorinated arene ligands. Organometallics, 28(17), 5061-5071. [More Information]

2008

  • Chardon-Noblat, S., Renfrew, A., Lafolet, F., Deronzier, A., Jakonen, M., Laurila, E., Haukka, M. (2008). An easy electrochemical and chemical synthesis of [Ru(bpy)(CH3CN)2Cl2]: a synthon for heteroleptic tris(diimine) Ru(II) complexes. Dalton Transactions, 2008, 5891-5896. [More Information]
  • Vock, C., Renfrew, A., Scopelliti, R., Juillerat-Jeanneret, L., Dyson, P. (2008). Influence of the diketonato ligand on the cytotoxicities of [Ru(η6-p-cymene)(R2acac)(PTA)]+ complexes (PTA = 1,3,5-triaza-7-phosphaadamantane). European Journal of Inorganic Chemistry, (10), 1661-1671. [More Information]
  • Therrien, B., Suss-Fink, G., Govindaswamy, P., Renfrew, A., Dyson, P. (2008). The "complex-in-a-complex" cations [(acac)2M⊂Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells. Angewandte Chemie (International Edition), 47(20), 3773-3776. [More Information]
  • Gras, M., Therrien, B., Suss-Fink, G., Stepnicka, P., Renfrew, A., Dyson, P. (2008). Water-soluble arene ruthenium complexes containing pyridinethiolato ligands: Synthesis, molecular structure, redox properties and anticancer activity of the cations [(η6-arene)Ru(p-SC5H4NH)3]2+. Journal of Organometallic Chemistry, 693(21-22), 3419-3424. [More Information]

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