Dr Anna Renfrew

MChem York(UK); PhD EPFL
ARC DECRA Fellow

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 2830
Fax 61 2 9351 3329

Website Contact Details
Curriculum vitae Curriculum vitae

Biographical details

  • MChem (First Class), The University of York, UK (2002 - 2006)
  • PhD, Ecole Polytechnique Federal de Lausanne, Switzerland (2006 - 2010)
  • Postdoctoral Research Associate, The University of Sydney (2011-2013)
  • Swiss National Science Foundation Postdoctoral Fellow, The University of Sydney (2011-2013)
  • ARC DECRA Fellow, The University of Sydney (2013 - 2015)
  • Lecturer (2016)

Research interests

My research focuses on using photoactive metal complexes for the selective delivery and release of anticancer agents.

  • Bioinorganic medicinal chemistry
  • Ruthenium-based anticancer agents
  • Light-activated prodrugs
  • Bioconjugation of tumour targeting groups and fluorescent tags

Selected grants

2013

  • Rational design of novel metal-based chaperones for tumour-selective drug delivery; Renfrew A; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA).

Selected publications

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Journals

  • Karaoun, N., Renfrew, A. (2015). A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging. Chemical Communications, 51(74), 14038-14041. [More Information]
  • Renfrew, A., Bryce, N., Hambley, T. (2015). Cobalt(III) chaperone complexes of curcumin: Photoreduction, cellular accumulation and light-selective toxicity towards tumour cells. Chemistry - A European Journal, 21(43), 15224-15234. [More Information]
  • Renfrew, A. (2014). Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery. Metallomics, 6(8), 1324-1335. [More Information]
  • Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information]
  • Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information]
  • Renfrew, A., Juillerat-Jeanneret, L., Dyson, P. (2011). Adding diversity to ruthenium(II)-arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains. Journal of Organometallic Chemistry, 696(3), 772-779. [More Information]
  • Govender, P., Renfrew, A., Clavel, C., Dyson, P., Therrien, B., Smith, G. (2011). Antiproliferative activity of chelating N,O-and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds. Dalton Transactions, 40(5), 1158-1167. [More Information]
  • Mattsson, J., Zava, O., Renfrew, A., Sei, Y., Yamaguchi, K., Dyson, P., Therrien, B. (2010). Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton Transactions, 39(35), 8248-8255. [More Information]
  • Egger, A., Hartinger, C., Renfrew, A., Dyson, P. (2010). Metabolization of [Ru(eta(^6)-C(6)H(5)CF(3)(pta)Cl(2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand. Journal of Biological Inorganic Chemistry, 15(6), 919-927. [More Information]
  • Schulz, J., Renfrew, A., Cisarova, I., Dyson, P., Stepnicka, P. (2010). Synthesis and anticancer activity of chalcogenide derivatives and platinum(II) and palladium(II) complexes derived from a polar ferrocene phosphanyl-carboxamide. Applied Organometallic Chemistry, 24(5), 392-397. [More Information]
  • Suss-Fink, G., Khan, F., Juillerat-Jeanneret, L., Dyson, P., Renfrew, A. (2010). Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and naoparticles. Journal of Cluster Science: including nanoclusters and nanoparticles, 21(3), 313-324. [More Information]
  • Renfrew, A., Egger, A., Scopelliti, R., Hartinger, C., Dyson, P. (2010). Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(eta(6)-cymene)(PPh(2)(o-C(6)H(4)O)-kappa(^2)-P,O)(pta)](^+) and an investigation of its cytotoxic effects (Invited publication). Academie des Sciences. Comptes Rendus. Chimie, 13(8-9), 1144-1150. [More Information]
  • Renfrew, A., Scopelliti, R., Dyson, P. (2010). Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting. Inorganic Chemistry, 49(5), 2239-2246. [More Information]
  • Govender, P., Antonels, N., Mattsson, J., Renfrew, A., Dyson, P., Moss, J., Therrien, B., Smith, G. (2009). Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds. Journal of Organometallic Chemistry, 694(21), 3470-3476. [More Information]
  • Auzias, M., Gueniat, J., Therrien, B., Suss-Fink, G., Renfrew, A., Dyson, P. (2009). Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(η6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]. Journal of Organometallic Chemistry, 694(6), 855-861. [More Information]
  • Renfrew, A., Phillips, A., Egger, A., Hartinger, C., Bosquain, S., Nazarov, A., Keppler, B., Gonsalvi, L., Peruzzini, M., Dyson, P. (2009). Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta. Organometallics, 28(4), 1165-1172. [More Information]
  • Renfrew, A. (2009). Ruthenium(II) arene compounds as versatile anticancer agents. Chimia, 63(4), 217-219. [More Information]
  • Hartl, F., Renfrew, A., Lafolet, F., Mahabiersing, T., Calhorda, M., Chardon-Noblat, S., Haukka, M., Deronzier, A. (2009). Soluble redox-active polymetallic chains [{Ruo(CO)(L)(bpy)}m]n (bpy = 2,2'-bipyridine, L = PrCN, CI-; m = O, -1): Electrosynthesis and characterization. Inorganic Chemistry, 48(17), 8233-8244. [More Information]
  • Mattsson, J., Govindaswamy, P., Renfrew, A., Dyson, P., Stepnicka, P., Suss-Fink, G., Therrien, B. (2009). Synthesis, molecular structure, and anticancer activity of cationic arene ruthenium metallarectangles. Organometallics, 28(15), 4350-4357. [More Information]
  • Renfrew, A., Phillips, A., Tapavicza, E., Scopelliti, R., Rothlisberger, U., Dyson, P. (2009). Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumor compounds with fluorinated arene ligands. Organometallics, 28(17), 5061-5071. [More Information]
  • Chardon-Noblat, S., Renfrew, A., Lafolet, F., Deronzier, A., Jakonen, M., Laurila, E., Haukka, M. (2008). An easy electrochemical and chemical synthesis of [Ru(bpy)(CH3CN)2Cl2]: a synthon for heteroleptic tris(diimine) Ru(II) complexes. Dalton Transactions, 2008, 5891-5896. [More Information]
  • Vock, C., Renfrew, A., Scopelliti, R., Juillerat-Jeanneret, L., Dyson, P. (2008). Influence of the diketonato ligand on the cytotoxicities of [Ru(η6-p-cymene)(R2acac)(PTA)]+ complexes (PTA = 1,3,5-triaza-7-phosphaadamantane). European Journal of Inorganic Chemistry, (10), 1661-1671. [More Information]
  • Therrien, B., Suss-Fink, G., Govindaswamy, P., Renfrew, A., Dyson, P. (2008). The "complex-in-a-complex" cations [(acac)2M⊂Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells. Angewandte Chemie (International Edition), 47(20), 3773-3776. [More Information]
  • Gras, M., Therrien, B., Suss-Fink, G., Stepnicka, P., Renfrew, A., Dyson, P. (2008). Water-soluble arene ruthenium complexes containing pyridinethiolato ligands: Synthesis, molecular structure, redox properties and anticancer activity of the cations [(η6-arene)Ru(p-SC5H4NH)3]2+. Journal of Organometallic Chemistry, 693(21-22), 3419-3424. [More Information]

2015

  • Karaoun, N., Renfrew, A. (2015). A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging. Chemical Communications, 51(74), 14038-14041. [More Information]
  • Renfrew, A., Bryce, N., Hambley, T. (2015). Cobalt(III) chaperone complexes of curcumin: Photoreduction, cellular accumulation and light-selective toxicity towards tumour cells. Chemistry - A European Journal, 21(43), 15224-15234. [More Information]

2014

  • Renfrew, A. (2014). Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery. Metallomics, 6(8), 1324-1335. [More Information]

2013

  • Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information]

2012

  • Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information]

2011

  • Renfrew, A., Juillerat-Jeanneret, L., Dyson, P. (2011). Adding diversity to ruthenium(II)-arene anticancer (RAPTA) compounds via click chemistry: The influence of hydrophobic chains. Journal of Organometallic Chemistry, 696(3), 772-779. [More Information]
  • Govender, P., Renfrew, A., Clavel, C., Dyson, P., Therrien, B., Smith, G. (2011). Antiproliferative activity of chelating N,O-and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds. Dalton Transactions, 40(5), 1158-1167. [More Information]

2010

  • Mattsson, J., Zava, O., Renfrew, A., Sei, Y., Yamaguchi, K., Dyson, P., Therrien, B. (2010). Drug delivery of lipophilic pyrenyl derivatives by encapsulation in a water soluble metalla-cage. Dalton Transactions, 39(35), 8248-8255. [More Information]
  • Egger, A., Hartinger, C., Renfrew, A., Dyson, P. (2010). Metabolization of [Ru(eta(^6)-C(6)H(5)CF(3)(pta)Cl(2)]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand. Journal of Biological Inorganic Chemistry, 15(6), 919-927. [More Information]
  • Schulz, J., Renfrew, A., Cisarova, I., Dyson, P., Stepnicka, P. (2010). Synthesis and anticancer activity of chalcogenide derivatives and platinum(II) and palladium(II) complexes derived from a polar ferrocene phosphanyl-carboxamide. Applied Organometallic Chemistry, 24(5), 392-397. [More Information]
  • Suss-Fink, G., Khan, F., Juillerat-Jeanneret, L., Dyson, P., Renfrew, A. (2010). Synthesis and anticancer activity of long-chain isonicotinic ester ligand-containing arene ruthenium complexes and naoparticles. Journal of Cluster Science: including nanoclusters and nanoparticles, 21(3), 313-324. [More Information]
  • Renfrew, A., Egger, A., Scopelliti, R., Hartinger, C., Dyson, P. (2010). Synthesis and characterisation of the water soluble bis-phosphine complex [Ru(eta(6)-cymene)(PPh(2)(o-C(6)H(4)O)-kappa(^2)-P,O)(pta)](^+) and an investigation of its cytotoxic effects (Invited publication). Academie des Sciences. Comptes Rendus. Chimie, 13(8-9), 1144-1150. [More Information]
  • Renfrew, A., Scopelliti, R., Dyson, P. (2010). Use of perfluorinated phosphines to provide thermomorphic anticancer complexes for heat-based tumor targeting. Inorganic Chemistry, 49(5), 2239-2246. [More Information]

2009

  • Govender, P., Antonels, N., Mattsson, J., Renfrew, A., Dyson, P., Moss, J., Therrien, B., Smith, G. (2009). Anticancer activity of multinuclear arene ruthenium complexes coordinated to dendritic polypyridyl scaffolds. Journal of Organometallic Chemistry, 694(21), 3470-3476. [More Information]
  • Auzias, M., Gueniat, J., Therrien, B., Suss-Fink, G., Renfrew, A., Dyson, P. (2009). Arene-ruthenium complexes with ferrocene-derived ligands: Synthesis and characterization of complexes of the type [Ru(η6-arene)(NC5H4CH2NHOC-C5H4FeC5H5)Cl2] and [Ru(η6-arene)(NC3H3N(CH2)2O2C-C5H4FeC5H5)Cl2]. Journal of Organometallic Chemistry, 694(6), 855-861. [More Information]
  • Renfrew, A., Phillips, A., Egger, A., Hartinger, C., Bosquain, S., Nazarov, A., Keppler, B., Gonsalvi, L., Peruzzini, M., Dyson, P. (2009). Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta. Organometallics, 28(4), 1165-1172. [More Information]
  • Renfrew, A. (2009). Ruthenium(II) arene compounds as versatile anticancer agents. Chimia, 63(4), 217-219. [More Information]
  • Hartl, F., Renfrew, A., Lafolet, F., Mahabiersing, T., Calhorda, M., Chardon-Noblat, S., Haukka, M., Deronzier, A. (2009). Soluble redox-active polymetallic chains [{Ruo(CO)(L)(bpy)}m]n (bpy = 2,2'-bipyridine, L = PrCN, CI-; m = O, -1): Electrosynthesis and characterization. Inorganic Chemistry, 48(17), 8233-8244. [More Information]
  • Mattsson, J., Govindaswamy, P., Renfrew, A., Dyson, P., Stepnicka, P., Suss-Fink, G., Therrien, B. (2009). Synthesis, molecular structure, and anticancer activity of cationic arene ruthenium metallarectangles. Organometallics, 28(15), 4350-4357. [More Information]
  • Renfrew, A., Phillips, A., Tapavicza, E., Scopelliti, R., Rothlisberger, U., Dyson, P. (2009). Tuning the efficacy of ruthenium(II)-arene (RAPTA) antitumor compounds with fluorinated arene ligands. Organometallics, 28(17), 5061-5071. [More Information]

2008

  • Chardon-Noblat, S., Renfrew, A., Lafolet, F., Deronzier, A., Jakonen, M., Laurila, E., Haukka, M. (2008). An easy electrochemical and chemical synthesis of [Ru(bpy)(CH3CN)2Cl2]: a synthon for heteroleptic tris(diimine) Ru(II) complexes. Dalton Transactions, 2008, 5891-5896. [More Information]
  • Vock, C., Renfrew, A., Scopelliti, R., Juillerat-Jeanneret, L., Dyson, P. (2008). Influence of the diketonato ligand on the cytotoxicities of [Ru(η6-p-cymene)(R2acac)(PTA)]+ complexes (PTA = 1,3,5-triaza-7-phosphaadamantane). European Journal of Inorganic Chemistry, (10), 1661-1671. [More Information]
  • Therrien, B., Suss-Fink, G., Govindaswamy, P., Renfrew, A., Dyson, P. (2008). The "complex-in-a-complex" cations [(acac)2M⊂Ru6-(p-iPrC6H4Me)6(tpt)2(dhbq)3]6+: a trojan horse for cancer cells. Angewandte Chemie (International Edition), 47(20), 3773-3776. [More Information]
  • Gras, M., Therrien, B., Suss-Fink, G., Stepnicka, P., Renfrew, A., Dyson, P. (2008). Water-soluble arene ruthenium complexes containing pyridinethiolato ligands: Synthesis, molecular structure, redox properties and anticancer activity of the cations [(η6-arene)Ru(p-SC5H4NH)3]2+. Journal of Organometallic Chemistry, 693(21-22), 3419-3424. [More Information]

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