Professor Arthur Conigrave

Professor

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 3883
Fax +61 2 9351 5858

Research interests

Proteins are essential structural and functional components of our bodies. It is impossible to imagine human life without them. Amino acids are the building blocks of proteins and our bodies need a regular supply of amino acids to replace proteins that are 'worn out'. For this reason, the cells of our bodies bristle with sensing mechanisms that detect variations in amino acid levels. Reductions in amino acid levels in the brain, for example, provide a powerful stimulus to appetite. The presence of amino acids in the gut, on the other hand, promotes intestinal digestion and absorption and elevated levels in blood trigger the release of hormones that coordinate growth and the uptake of amino acids by cells for protein synthesis and tissue building. Our laboratory is concerned with the molecules that sense changes in amino acid levels and currently focusses on a subgroup of the G-protein coupled receptor superfamily ('class 3') that includes a number of broad-spectrum amino acid sensors involved in triggering both gut digestive responses as well as hormonal regulatory responses.

Keywords

Musculoskeletal diseases; Biochemistry; Endocrinology

PhD and master's project opportunities

Selected grants

2015

  • Nutrient-sensing by the calcium-sensing receptor and its partners; Conigrave A; DVC Research/Bridging Support Grant.

2013

  • Will a novel genetic mutation save large goannas from extinction?; Ujvari B, Madsen T, Conigrave A, Mun H; Ian Potter Foundation/General Research Grants.

2012

  • Allosteric modulation and biased signalling at the calcium-sensing receptor; Conigrave A, Christopoulos A; National Health and Medical Research Council (NHMRC)/Project Grants.

2011

  • Dietary nutrients, variety and the control of human energy intake; Simpson S, Conigrave A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel strategies for the treatment of bone disease by nutrient activators of calcium-sensing receptors; Mason R, Conigrave A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A solution to the parathyroid gland secretion problem; Conigrave A, Ward D; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • Applied Biosystems 7500 Fast Real Time PCR system; Campbell I, Crossley P, Brand-Miller J, Caterson I, Hall R, Weiss A, Conigrave A, Mackay J, Matthews J, Sunde M, Gell D, Bell-Anderson K, Nicholas H, Crossett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Understanding the pharmacoregulation of the extracellular calcium sending receptor; Conigrave A, Christopoulos A, Christopoulos A; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Molecular mechanism and novel activators of amino acid and calcium-sensing class 3 G-protein coupled receptors; Conigrave A, Hampson D; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • EnVision Xcite Multilabel Reader; Conigrave A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho J, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute New South Wales/Infrastructure Grant.
  • Testing the protein leverage hypothesis in humans; Simpson S, Conigrave A, Caterson I, Brand-Miller J; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Molecular determinants of amino acid-dependent signalling by the calcium-sensing receptor; Conigrave A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • University of Sydney - Bridging Support Grant; Conigrave A; University of Sydney/Bridging Support.

2005

  • Post menopausal testing: preclinical study; Mason R, Conigrave A; Institut De Recherches Internationales (France)/BLO Project.

2004

  • Development of a knock0in mouse to analyse the psychological significance of aminoacid sensing by the calcium-sensing receptor; Conigrave A; DVC Research/Research and Development Scheme: Research and Development (R&D).

2002

  • Calcium-sensing receptor: molecualr determination of structure-function relations.; Conigrave A; Eli Lilly Australia Pty Limited/Research Grant.
  • Nutrient dependent signalling in bone via calcium sensing receptors; Mason R, Conigrave A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Perkin-Elmer: Wallac Victor2 multi-label counter and injector unit upgrade; Conigrave A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2001

  • Integration of protein and calcium metabolism by the calcium sensing receptor; Conigrave A; Eli Lilly Australia Pty Limited/Research Grant.
  • Travel to Harvard Medical School and Yale University School of Medicine.; Conigrave A; Clive & Vera Ramaciotti Foundation/Research Grants.
  • L-amino acid sensing by the extracelluar calcium-sensing receptor: molecular, cellular and in vivo studies; Conigrave A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Differentiation of human myeloid leukemia cell lines by the novel P2Y11 receptor: analysis of biochemical mechanism by multiwell plate; Conigrave A, Morris M; Clive & Vera Ramaciotti Foundation/Project Support.

Selected publications

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Book Chapters

  • Quinn, S., Conigrave, A. (2003). Alternative agonists and modulators: evidence that the calcium-sensing receptor is a multi-modal sensor. In Chattopadhyay, Naibedya; Brown, Edward M (Eds.), Calcium-sensing Receptor, (pp. 203-226). Germany: Springer.

Journals

  • Leach, K., Sexton, P., Christopoulos, A., Conigrave, A. (2014). Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders. British Journal of Pharmacology, 171(5), 1142-1155. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Kuchel, P. (2014). Membrane flickering of the human erythrocyte: physical and chemical effectors. European Biophysics Journal, 43(4-5), 169-177. [More Information]
  • Gosby, A., Conigrave, A., Raubenheimer, D., Simpson, S. (2014). Protein leverage and energy intake. Obesity Reviews.
  • Gosby, A., Conigrave, A., Raubenheimer, D., Simpson, S. (2014). Protein leverage and energy intake. Obesity Reviews, 15(3), 183-191. [More Information]
  • Khan, M., Ward, J., Avlani, V., Leach, K., Christopoulos, A., Conigrave, A. (2014). Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor. FEBS Letters, 588(18), 3340-3346. [More Information]
  • Conigrave, A., Ward, D. (2013). Calcium-sensing receptor (CaSR): Pharmacological properties and signaling pathways. Best Practice and Research: Clinical Endocrinology and Metabolism, 27(3), 315-331. [More Information]
  • Avlani, V., Ma, W., Mun, H., Leach, K., Delbridge, L., Christopoulos, A., Conigrave, A. (2013). Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells. American Journal of Physiology: Endocrinology and Metabolism, 304(10), E1097-E1104. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Kuchel, P. (2013). Corrigendum to Quantitative model of NMR chemical shifts of 23Na + induced by TmDOTP: Applications in studies of Na+ transport in human erythrocytes (Journal of Inorganic Biochemistry (2012) 115 (211-219)). Journal of Inorganic Biochemistry, 121, 196.
  • Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
  • Vandenberg, J., Conigrave, A., King, G., Kirk, K. (2013). From kinetics to imaging: an NMR odyssey-a festschrift symposium in honour of Philip William Kuchel. European Biophysics Journal, 42(1), 1-2. [More Information]
  • Leach, K., Wen, A., Cook, A., Sexton, P., Conigrave, A., Christopoulos, A. (2013). Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators. Endocrinology, 154(3), 1105-1116. [More Information]
  • Ujvari, B., Mun, H., Conigrave, A., Bray (nee Adami), A., Osterkamp, J., Halling, P., Madsen, T. (2013). Isolation breeds naivety: Island living robs Australian varanid lizards of toad-toxin immunity via four-base-pair mutation. Evolution, 67(1), 289-294. [More Information]
  • Brown, E., Conigrave, A. (2013). Preface. Best Practice and Research: Clinical Endocrinology and Metabolism, 27(3), 283-284. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Grieve, S., Figtree, G., Kuchel, P. (2013). Stoichiometric relationship between Na+ ions transported and glucose consumed in human erythrocytes: Bayesian analysis of 23Na and 13C NMR time course data. Biophysical Journal, 104(8), 1676-1684. [More Information]
  • Leach, K., Wen, A., Davey, A., Sexton, P., Conigrave, A., Christopoulos, A. (2012). Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor. Endocrinology, 153(9), 4304-4316. [More Information]
  • Davey, A., Leach, K., Valant, C., Conigrave, A., Sexton, P., Christopoulos, A. (2012). Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor. Endocrinology, 153(3), 1232-1241. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Kuchel, P. (2012). Quantitative model of NMR chemical shifts of (23)Na(+) induced by TmDOTP: Applications in studies of Na(+) transport in human erythrocytes. Journal of Inorganic Biochemistry, 115, 211-219. [More Information]
  • Arulpragasam, A., Magno, A., Ingley, E., Brown, S., Conigrave, A., Ratajczak, T., Ward, B. (2012). The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor mediated rho-kinase signaling. The Biochemical Journal, 441(3), 995-1006. [More Information]
  • Lazarus, S., Pretorius, C., Khafagi, F., Campion, K., Brennan, S., Conigrave, A., Brown, E., Ward, D. (2011). A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia. European Journal of Endocrinology, 164(3), 429-435. [More Information]
  • Broadhead, G., Mun, H., Avlani, V., Jourdon, O., Church, W., Christopoulos, A., Delbridge, L., Conigrave, A. (2011). Allosteric Modulation of the Calcium-sensing Receptor by y-Glutamyl Peptides Inhibition of PTH Secretion, Suppression of Intracellular cAMP Levels and A Common Mechanism of Action with L-Amino Acids. Journal of Biological Chemistry, 286(11), 8786-8797. [More Information]
  • Rybchyn, M., Slater, M., Conigrave, A., Mason, R. (2011). An Akt-dependent increase in canonical Wnt Signalling and a Decrease in Sclerostin Protein Levels Are Involved in Strontium Ranelate-induced Osteogenic Effects in Human Osteoblasts. Journal of Biological Chemistry, 286(27), 23771-23779. [More Information]
  • Tharmalingam, S., Daulat, A., Antflick, J., Ahmed, S., Nemeth, E., Angers, S., Conigrave, A., Hampson, D. (2011). Calcium-sensing Receptor Modulates Cell Adhesion and Migration via Integrins. Journal of Biological Chemistry, 286(47), 40922-40933. [More Information]
  • Magno, A., Ingley, E., Brown, S., Conigrave, A., Ratajczak, T., Ward, B. (2011). Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling. Biochemical and Biophysical Research Communications, 412(4), 584-589. [More Information]
  • Gosby, A., Conigrave, A., Lau, N., Iglesias, M., Hall, R., Jebb, S., Brand-Miller, J., Caterson, I., Raubenheimer, D., Simpson, S. (2011). Testing Protein Leverage in Lean Humans: A Randomised Controlled Experimental Study. PloS One, 6(10), e25929-(11pp). [More Information]
  • Conigrave, A., Hampson, D. (2010). Broad-spectrum amino acid-sensing class C G-protein coupled receptors: Molecular mechanisms, physiological significance and options for drug development. Pharmacology and Therapeutics, 127(3), 252-260. [More Information]
  • Hannan, F., Nesbit, M., Turner, J., Stacey, J., Cianferotti, L., Christie, P., Conigrave, A., Whyte, M., Thakker, R. (2010). Comparison of human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals absence, in man, of 11.6 Mb containing four mouse calcium-sensing receptor-related sequences: relevance to familial benign hypocalciuric hypercalcaemia type 3. European Journal of Human Genetics, 18(4), 442-447. [More Information]
  • Gosby, A., Soares-Wynter, S., Campbell, C., Badaloo, A., Antonelli, M., Hall, R., Martinez-Cordero, C., Jebb, S., Brand-Miller, J., Caterson, I., Conigrave, A., Simpson, S., et al (2010). Design and testing of foods differing in protein to energy ratios. Appetite, 55(2), 367-370. [More Information]
  • McCormick, W., Atkinson-Dell, R., Campion, K., Mun, H., Conigrave, A., Ward, D. (2010). Increased Receptor Stimulation Elicits Differential Calcium-sensing Receptor(T888) Dephosphorylation. Journal of Biological Chemistry, 285(19), 14170-14177. [More Information]
  • Khan, M., Conigrave, A. (2010). Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling. British Journal of Pharmacology, 159(5), 1039-1050. [More Information]
  • Clissold, F., Tedder, B., Conigrave, A., Simpson, S. (2010). The gastrointestinal tract as a nutrient-balancing organ. Proceedings of the Royal Society B: Biological Sciences, 227(1688), 1751-1759. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Mun, H., Brennan, S., Delbridge, L., Wilkinson, M., Brown, E., Conigrave, A. (2009). Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids. Journal of Clinical Endocrinology and Metabolism, 94(9), 3567-3574. [More Information]
  • Szekely, D., Brennan, S., Mun, H., Conigrave, A., Kuchel, P. (2009). Effectors of the frequency of calcium oscillations in HEK-293 cells: wavelet analysis and a computer model. European Biophysics Journal, 39(1), 149-165. [More Information]
  • Speranza, T., Rybchyn, M., Green, W., Atwa, S., Conigrave, A., Mason, R. (2009). Osteoblasts play key roles in the mechanisms of action of strontium ranelate. British Journal of Pharmacology, 157, 1291-1300. [More Information]
  • Brennan, S., Conigrave, A. (2009). Regulation of cellular signal transduction pathways by the extracellular calcium-sensing receptor. Current Pharmaceutical Biotechnology, 10(3), 270-281. [More Information]
  • Conigrave, A., Brown, E., Rizzoli, A. (2008). Dietary Protein and Bone Health: Roles of Amino Acid-Sensing Receptors in the Control of Calcium Metabolism and Bone Homeostasis. Annual Review of Nutrition, 28, 131-155. [More Information]
  • Lu, M., Forsberg, L., Hoog, A., Juhlin, C., Vukojevic, V., Larsson, C., Conigrave, A., Delbridge, L., Gill, A., Bark, C., et al (2008). Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Molecular And Cellular Endocrinology, 287(1-2), 72-80. [More Information]
  • Au, A., McDonald, K., Gill, A., Sywak, M., Diamond, T., Conigrave, A., Clifton-Bligh, R. (2008). PTH Mutation with Primary Hyperparathyroidism and Undetectable Intact PTH. New England Journal of Medicine, 359(11), 1184-1186. [More Information]
  • Lee, H., Mun, H., Lewis, N., Crouch, M., Culverston, E., Mason, R., Conigrave, A. (2007). Allosteric activation of the extracellular Ca2+- sensing receptor by L-amino acids enhances ERK1/2 phosphorylation. Biochemical Journal, 404(1), 141-149. [More Information]
  • Conigrave, A., Mun, H., Lok, H. (2007). Aromatic L-amino Acids activate the calcium-sensing receptor. The Journal of Nutrition, 137(Supplement), 1524S-1527S. [More Information]
  • Conigrave, A., Mun, H., Brennan, S. (2007). Physiological significance of L-amino acid sensing by extracellular Ca(2+)-sensing receptors. Biochemical Society Transactions, 35(5), 1195-1198. [More Information]
  • Conigrave, A., Hampson, D. (2006). Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors. Trends in Endocrinology and Metabolism, 17(10), 398-407. [More Information]
  • Conigrave, A., Brown, E. (2006). Taste Receptors in the Gastrointestinal Tract II. L-Amino acid sensing by calcium-sensing receptors: implications for GI physiology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 291(5), G753-G761. [More Information]
  • Mun, H., Culverston, E., Franks, A., Collyer, C., Clifton-Bligh, R., Conigrave, A. (2005). A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing. Journal of Biological Chemistry, 280(32), 29067-29072. [More Information]
  • Mun, H., Conigrave, A., Wilkinson, M., Delbridge, L. (2005). Surgery for hyperparathyroidism: does morphology or function matter most? Surgery, 138(6), 1111-1120. [More Information]
  • Conigrave, A., Lok, H. (2004). Activation Of Renal Calcium And Water Excretion By Novel Physiological And Pharmacological Activators Of The Calcium-Sensing Receptor. Clinical and Experimental Pharmacology and Physiology, 31(5), 368-371.
  • Shemon, A., Sluyter, R., Conigrave, A., Wiley, J. (2004). Chelerythrine And Other Benzophenanthridine Alkaloids Block The Human P2X(7) Receptor. British Journal of Pharmacology, 142(6), 1015-1019.
  • Conigrave, A., Mun, H., Delbridge, L., Quinn, S., Wilkinson, M., Brown, E. (2004). L-Amino Acids Regulate Parathyroid Hormone Secretion. Journal of Biological Chemistry, 279(37), 38151-38159.
  • Mun, H., Franks, A., Culverston, E., Krapcho, K., Nemeth, E., Conigrave, A. (2004). The Venus Fly Trap Domain Of The Extracellular Ca2+-Sensing Receptor Is Required For L-Amino Acid Sensing. Journal of Biological Chemistry, 279(50), 51739-51744.
  • Conigrave, A., Franks, A. (2003). Allosteric activation of plasma membrane receptors - physiological implications and structural origins. Progress in Biophysics and Molecular Biology, 81, 219-240.
  • Tan, Y., Cardinal, J., Franks, A., Mun, H., Lewis, N., Harris, L., Prins, J., Conigrave, A. (2003). Autosomal dominant hypocalcemia: a novel activating mutation (E604K) in the cysteine-rich domain of the calcium-sensing receptor. Journal of Clinical Endocrinology and Metabolism, 88(2), 605-610.
  • Rae, C., Hare, N., Bubb, W., McEwan, S., Broer, A., McQuillan, J., Balcar, V., Conigrave, A., Broer, S. (2003). Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. Journal of Neurochemistry, 85(2), 503-514.
  • Conigrave, A., Franks, A., Brown, E., Quinn, S. (2002). L-Amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? European Journal of Clinical Nutrition, 56(11), 1072-1080.
  • Bradbury, R., Cropley, J., Kifor, O., Lovicu, F., De Iongh, R., Kable, E., Brown, E., Seely, E., Peat, B., Conigrave, A. (2002). Localization of the extracellular Ca2+ -sensing receptor in the human placenta. Placenta, 23(2-3), 192-200.
  • Zhang, Z., Qiu, W., Quinn, S., Conigrave, A., Brown, E., Bai, M. (2002). Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of the receptor function. Journal of Biological Chemistry, 277(37), 33727-33735.
  • Conigrave, A. (2001). Molecular mechanisms of receptor dysfunction: implications for endocrine disorders. Current Opinion in Endocrinology, Diabetes and Obesity, 8(1), 41-46.
  • Conigrave, A., Gu, B., Zhang, W., Wiley, J., Fernando, K., Tasevski, V., Luttrell, B. (2001). P2Y11 receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors. European Journal of Pharmacology, 426, 157-163.

Conferences

  • Conigrave, A., Lok, H., Mun, H. (2007). Effects of specific amino acids on the calcium sensor. 6th Symposium on Nutritional Aspects of Osteoporosis 2006, United States: Elsevier.
  • Speranza, T., Rybchyn, M., Halbout, P., Conigrave, A., Mason, R. (2007). Strontium ranelate effects in human osteoblasts support its uncoupling effect on bone formation and bone resorption. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.
  • Mason, R., Conigrave, A., Rybchyn, M., Brennen, T. (2007). Strontium ranelate effects on bone formation and bone resorption: an in vitro in human osteoblasts. Seventh European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, Washington, DC: Springer UK.
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2005). Is strontium anabolic?: Mechanisms of action in human osteoblasts. 15th Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society 2005.
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2004). Functional responses of bone cells to stimulation by strontium. Australian and New Zealand Bone and Mineral Society, 14th Annual Scientific Meeting.

2014

  • Leach, K., Sexton, P., Christopoulos, A., Conigrave, A. (2014). Engendering biased signalling from the calcium-sensing receptor for the pharmacotherapy of diverse disorders. British Journal of Pharmacology, 171(5), 1142-1155. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Kuchel, P. (2014). Membrane flickering of the human erythrocyte: physical and chemical effectors. European Biophysics Journal, 43(4-5), 169-177. [More Information]
  • Gosby, A., Conigrave, A., Raubenheimer, D., Simpson, S. (2014). Protein leverage and energy intake. Obesity Reviews.
  • Gosby, A., Conigrave, A., Raubenheimer, D., Simpson, S. (2014). Protein leverage and energy intake. Obesity Reviews, 15(3), 183-191. [More Information]
  • Khan, M., Ward, J., Avlani, V., Leach, K., Christopoulos, A., Conigrave, A. (2014). Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor. FEBS Letters, 588(18), 3340-3346. [More Information]

2013

  • Conigrave, A., Ward, D. (2013). Calcium-sensing receptor (CaSR): Pharmacological properties and signaling pathways. Best Practice and Research: Clinical Endocrinology and Metabolism, 27(3), 315-331. [More Information]
  • Avlani, V., Ma, W., Mun, H., Leach, K., Delbridge, L., Christopoulos, A., Conigrave, A. (2013). Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells. American Journal of Physiology: Endocrinology and Metabolism, 304(10), E1097-E1104. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Kuchel, P. (2013). Corrigendum to Quantitative model of NMR chemical shifts of 23Na + induced by TmDOTP: Applications in studies of Na+ transport in human erythrocytes (Journal of Inorganic Biochemistry (2012) 115 (211-219)). Journal of Inorganic Biochemistry, 121, 196.
  • Huang, X., Hancock, D., Gosby, A., McMahon, A., Solon-Biet, S., Le Couteur, D., Conigrave, A., Raubenheimer, D., Simpson, S. (2013). Effects of dietary protein to carbohydrate balance on energy intake, fat storage and heat production in mice. Obesity, 21(1), 85-92. [More Information]
  • Vandenberg, J., Conigrave, A., King, G., Kirk, K. (2013). From kinetics to imaging: an NMR odyssey-a festschrift symposium in honour of Philip William Kuchel. European Biophysics Journal, 42(1), 1-2. [More Information]
  • Leach, K., Wen, A., Cook, A., Sexton, P., Conigrave, A., Christopoulos, A. (2013). Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators. Endocrinology, 154(3), 1105-1116. [More Information]
  • Ujvari, B., Mun, H., Conigrave, A., Bray (nee Adami), A., Osterkamp, J., Halling, P., Madsen, T. (2013). Isolation breeds naivety: Island living robs Australian varanid lizards of toad-toxin immunity via four-base-pair mutation. Evolution, 67(1), 289-294. [More Information]
  • Brown, E., Conigrave, A. (2013). Preface. Best Practice and Research: Clinical Endocrinology and Metabolism, 27(3), 283-284. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Grieve, S., Figtree, G., Kuchel, P. (2013). Stoichiometric relationship between Na+ ions transported and glucose consumed in human erythrocytes: Bayesian analysis of 23Na and 13C NMR time course data. Biophysical Journal, 104(8), 1676-1684. [More Information]

2012

  • Leach, K., Wen, A., Davey, A., Sexton, P., Conigrave, A., Christopoulos, A. (2012). Identification of Molecular Phenotypes and Biased Signaling Induced by Naturally Occurring Mutations of the Human Calcium-Sensing Receptor. Endocrinology, 153(9), 4304-4316. [More Information]
  • Davey, A., Leach, K., Valant, C., Conigrave, A., Sexton, P., Christopoulos, A. (2012). Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor. Endocrinology, 153(3), 1232-1241. [More Information]
  • Puckeridge, M., Chapman, B., Conigrave, A., Kuchel, P. (2012). Quantitative model of NMR chemical shifts of (23)Na(+) induced by TmDOTP: Applications in studies of Na(+) transport in human erythrocytes. Journal of Inorganic Biochemistry, 115, 211-219. [More Information]
  • Arulpragasam, A., Magno, A., Ingley, E., Brown, S., Conigrave, A., Ratajczak, T., Ward, B. (2012). The adaptor protein 14-3-3 binds to the calcium-sensing receptor and attenuates receptor mediated rho-kinase signaling. The Biochemical Journal, 441(3), 995-1006. [More Information]

2011

  • Lazarus, S., Pretorius, C., Khafagi, F., Campion, K., Brennan, S., Conigrave, A., Brown, E., Ward, D. (2011). A novel mutation of the primary protein kinase C phosphorylation site in the calcium-sensing receptor causes autosomal dominant hypocalcemia. European Journal of Endocrinology, 164(3), 429-435. [More Information]
  • Broadhead, G., Mun, H., Avlani, V., Jourdon, O., Church, W., Christopoulos, A., Delbridge, L., Conigrave, A. (2011). Allosteric Modulation of the Calcium-sensing Receptor by y-Glutamyl Peptides Inhibition of PTH Secretion, Suppression of Intracellular cAMP Levels and A Common Mechanism of Action with L-Amino Acids. Journal of Biological Chemistry, 286(11), 8786-8797. [More Information]
  • Rybchyn, M., Slater, M., Conigrave, A., Mason, R. (2011). An Akt-dependent increase in canonical Wnt Signalling and a Decrease in Sclerostin Protein Levels Are Involved in Strontium Ranelate-induced Osteogenic Effects in Human Osteoblasts. Journal of Biological Chemistry, 286(27), 23771-23779. [More Information]
  • Tharmalingam, S., Daulat, A., Antflick, J., Ahmed, S., Nemeth, E., Angers, S., Conigrave, A., Hampson, D. (2011). Calcium-sensing Receptor Modulates Cell Adhesion and Migration via Integrins. Journal of Biological Chemistry, 286(47), 40922-40933. [More Information]
  • Magno, A., Ingley, E., Brown, S., Conigrave, A., Ratajczak, T., Ward, B. (2011). Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling. Biochemical and Biophysical Research Communications, 412(4), 584-589. [More Information]
  • Gosby, A., Conigrave, A., Lau, N., Iglesias, M., Hall, R., Jebb, S., Brand-Miller, J., Caterson, I., Raubenheimer, D., Simpson, S. (2011). Testing Protein Leverage in Lean Humans: A Randomised Controlled Experimental Study. PloS One, 6(10), e25929-(11pp). [More Information]

2010

  • Conigrave, A., Hampson, D. (2010). Broad-spectrum amino acid-sensing class C G-protein coupled receptors: Molecular mechanisms, physiological significance and options for drug development. Pharmacology and Therapeutics, 127(3), 252-260. [More Information]
  • Hannan, F., Nesbit, M., Turner, J., Stacey, J., Cianferotti, L., Christie, P., Conigrave, A., Whyte, M., Thakker, R. (2010). Comparison of human chromosome 19q13 and syntenic region on mouse chromosome 7 reveals absence, in man, of 11.6 Mb containing four mouse calcium-sensing receptor-related sequences: relevance to familial benign hypocalciuric hypercalcaemia type 3. European Journal of Human Genetics, 18(4), 442-447. [More Information]
  • Gosby, A., Soares-Wynter, S., Campbell, C., Badaloo, A., Antonelli, M., Hall, R., Martinez-Cordero, C., Jebb, S., Brand-Miller, J., Caterson, I., Conigrave, A., Simpson, S., et al (2010). Design and testing of foods differing in protein to energy ratios. Appetite, 55(2), 367-370. [More Information]
  • McCormick, W., Atkinson-Dell, R., Campion, K., Mun, H., Conigrave, A., Ward, D. (2010). Increased Receptor Stimulation Elicits Differential Calcium-sensing Receptor(T888) Dephosphorylation. Journal of Biological Chemistry, 285(19), 14170-14177. [More Information]
  • Khan, M., Conigrave, A. (2010). Mechanisms of multimodal sensing by extracellular Ca(2+)-sensing receptors: a domain-based survey of requirements for binding and signalling. British Journal of Pharmacology, 159(5), 1039-1050. [More Information]
  • Clissold, F., Tedder, B., Conigrave, A., Simpson, S. (2010). The gastrointestinal tract as a nutrient-balancing organ. Proceedings of the Royal Society B: Biological Sciences, 227(1688), 1751-1759. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]

2009

  • Mun, H., Brennan, S., Delbridge, L., Wilkinson, M., Brown, E., Conigrave, A. (2009). Adenomatous human parathyroid cells exhibit impaired sensitivity to L-amino acids. Journal of Clinical Endocrinology and Metabolism, 94(9), 3567-3574. [More Information]
  • Szekely, D., Brennan, S., Mun, H., Conigrave, A., Kuchel, P. (2009). Effectors of the frequency of calcium oscillations in HEK-293 cells: wavelet analysis and a computer model. European Biophysics Journal, 39(1), 149-165. [More Information]
  • Speranza, T., Rybchyn, M., Green, W., Atwa, S., Conigrave, A., Mason, R. (2009). Osteoblasts play key roles in the mechanisms of action of strontium ranelate. British Journal of Pharmacology, 157, 1291-1300. [More Information]
  • Brennan, S., Conigrave, A. (2009). Regulation of cellular signal transduction pathways by the extracellular calcium-sensing receptor. Current Pharmaceutical Biotechnology, 10(3), 270-281. [More Information]

2008

  • Conigrave, A., Brown, E., Rizzoli, A. (2008). Dietary Protein and Bone Health: Roles of Amino Acid-Sensing Receptors in the Control of Calcium Metabolism and Bone Homeostasis. Annual Review of Nutrition, 28, 131-155. [More Information]
  • Lu, M., Forsberg, L., Hoog, A., Juhlin, C., Vukojevic, V., Larsson, C., Conigrave, A., Delbridge, L., Gill, A., Bark, C., et al (2008). Heterogeneous expression of SNARE proteins SNAP-23, SNAP-25, Syntaxin1 and VAMP in human parathyroid tissue. Molecular And Cellular Endocrinology, 287(1-2), 72-80. [More Information]
  • Au, A., McDonald, K., Gill, A., Sywak, M., Diamond, T., Conigrave, A., Clifton-Bligh, R. (2008). PTH Mutation with Primary Hyperparathyroidism and Undetectable Intact PTH. New England Journal of Medicine, 359(11), 1184-1186. [More Information]

2007

  • Lee, H., Mun, H., Lewis, N., Crouch, M., Culverston, E., Mason, R., Conigrave, A. (2007). Allosteric activation of the extracellular Ca2+- sensing receptor by L-amino acids enhances ERK1/2 phosphorylation. Biochemical Journal, 404(1), 141-149. [More Information]
  • Conigrave, A., Mun, H., Lok, H. (2007). Aromatic L-amino Acids activate the calcium-sensing receptor. The Journal of Nutrition, 137(Supplement), 1524S-1527S. [More Information]
  • Conigrave, A., Lok, H., Mun, H. (2007). Effects of specific amino acids on the calcium sensor. 6th Symposium on Nutritional Aspects of Osteoporosis 2006, United States: Elsevier.
  • Conigrave, A., Mun, H., Brennan, S. (2007). Physiological significance of L-amino acid sensing by extracellular Ca(2+)-sensing receptors. Biochemical Society Transactions, 35(5), 1195-1198. [More Information]
  • Speranza, T., Rybchyn, M., Halbout, P., Conigrave, A., Mason, R. (2007). Strontium ranelate effects in human osteoblasts support its uncoupling effect on bone formation and bone resorption. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.
  • Mason, R., Conigrave, A., Rybchyn, M., Brennen, T. (2007). Strontium ranelate effects on bone formation and bone resorption: an in vitro in human osteoblasts. Seventh European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, Washington, DC: Springer UK.

2006

  • Conigrave, A., Hampson, D. (2006). Broad-spectrum L-amino acid sensing by class 3 G-protein-coupled receptors. Trends in Endocrinology and Metabolism, 17(10), 398-407. [More Information]
  • Conigrave, A., Brown, E. (2006). Taste Receptors in the Gastrointestinal Tract II. L-Amino acid sensing by calcium-sensing receptors: implications for GI physiology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 291(5), G753-G761. [More Information]

2005

  • Mun, H., Culverston, E., Franks, A., Collyer, C., Clifton-Bligh, R., Conigrave, A. (2005). A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing. Journal of Biological Chemistry, 280(32), 29067-29072. [More Information]
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2005). Is strontium anabolic?: Mechanisms of action in human osteoblasts. 15th Annual Scientific Meeting of the Australian and New Zealand Bone and Mineral Society 2005.
  • Mun, H., Conigrave, A., Wilkinson, M., Delbridge, L. (2005). Surgery for hyperparathyroidism: does morphology or function matter most? Surgery, 138(6), 1111-1120. [More Information]

2004

  • Conigrave, A., Lok, H. (2004). Activation Of Renal Calcium And Water Excretion By Novel Physiological And Pharmacological Activators Of The Calcium-Sensing Receptor. Clinical and Experimental Pharmacology and Physiology, 31(5), 368-371.
  • Shemon, A., Sluyter, R., Conigrave, A., Wiley, J. (2004). Chelerythrine And Other Benzophenanthridine Alkaloids Block The Human P2X(7) Receptor. British Journal of Pharmacology, 142(6), 1015-1019.
  • Speranza, T., Muir, M., Conigrave, A., Mason, R. (2004). Functional responses of bone cells to stimulation by strontium. Australian and New Zealand Bone and Mineral Society, 14th Annual Scientific Meeting.
  • Conigrave, A., Mun, H., Delbridge, L., Quinn, S., Wilkinson, M., Brown, E. (2004). L-Amino Acids Regulate Parathyroid Hormone Secretion. Journal of Biological Chemistry, 279(37), 38151-38159.
  • Mun, H., Franks, A., Culverston, E., Krapcho, K., Nemeth, E., Conigrave, A. (2004). The Venus Fly Trap Domain Of The Extracellular Ca2+-Sensing Receptor Is Required For L-Amino Acid Sensing. Journal of Biological Chemistry, 279(50), 51739-51744.

2003

  • Conigrave, A., Franks, A. (2003). Allosteric activation of plasma membrane receptors - physiological implications and structural origins. Progress in Biophysics and Molecular Biology, 81, 219-240.
  • Quinn, S., Conigrave, A. (2003). Alternative agonists and modulators: evidence that the calcium-sensing receptor is a multi-modal sensor. In Chattopadhyay, Naibedya; Brown, Edward M (Eds.), Calcium-sensing Receptor, (pp. 203-226). Germany: Springer.
  • Tan, Y., Cardinal, J., Franks, A., Mun, H., Lewis, N., Harris, L., Prins, J., Conigrave, A. (2003). Autosomal dominant hypocalcemia: a novel activating mutation (E604K) in the cysteine-rich domain of the calcium-sensing receptor. Journal of Clinical Endocrinology and Metabolism, 88(2), 605-610.
  • Rae, C., Hare, N., Bubb, W., McEwan, S., Broer, A., McQuillan, J., Balcar, V., Conigrave, A., Broer, S. (2003). Inhibition of glutamine transport depletes glutamate and GABA neurotransmitter pools: further evidence for metabolic compartmentation. Journal of Neurochemistry, 85(2), 503-514.

2002

  • Conigrave, A., Franks, A., Brown, E., Quinn, S. (2002). L-Amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism? European Journal of Clinical Nutrition, 56(11), 1072-1080.
  • Bradbury, R., Cropley, J., Kifor, O., Lovicu, F., De Iongh, R., Kable, E., Brown, E., Seely, E., Peat, B., Conigrave, A. (2002). Localization of the extracellular Ca2+ -sensing receptor in the human placenta. Placenta, 23(2-3), 192-200.
  • Zhang, Z., Qiu, W., Quinn, S., Conigrave, A., Brown, E., Bai, M. (2002). Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of the receptor function. Journal of Biological Chemistry, 277(37), 33727-33735.

2001

  • Conigrave, A. (2001). Molecular mechanisms of receptor dysfunction: implications for endocrine disorders. Current Opinion in Endocrinology, Diabetes and Obesity, 8(1), 41-46.
  • Conigrave, A., Gu, B., Zhang, W., Wiley, J., Fernando, K., Tasevski, V., Luttrell, B. (2001). P2Y11 receptor expression by human lymphocytes: evidence for two cAMP-linked purinoceptors. European Journal of Pharmacology, 426, 157-163.

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