Dr Aviva Levina

Senior Research Associate

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 7600
Fax 61 2 9351 3329

Current research students

Project title Research student
Molecular mechanisms for delivery of anti-metastatic and cytotoxic ruthenium anti-cancer drugs Anthony CHETCUTI
Development of Metal-Based Anti-Cancer Drugs and Nanovesicle CarrierSystems for Intratumoral Injection Andria YAOURTIS

Selected grants

2012

  • Chromium and vanadium complexes: biotransformations in biological fluids and cells (ANBF); Levina A, Lay P; Australian Synchrotron/International Access Program.

Selected publications

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Book Chapters

  • Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer. [More Information]
  • Levina, A., Mulyani, I., Lay, P. (2007). Redox chemistry and biological activities of chromium(III) complexes. In J. B. Vincent (Eds.), The Nutritional Biochemistry of Chromium(III), (pp. 225-256). Amsterdam, Netherlands: Elsevier. [More Information]
  • Lay, P., Levina, A. (2004). Chromium. In A. G. Webb (Eds.), Comprehensive Coordination Chemistry II : From Biology to Nanotechnology [Volume 4: Transition Metal Groups 3-6], (pp. 313-413). Amsterdam: Pergamon Elsevier.
  • Lay, P., Levina, A. (2004). Chromium. In E. C. Constable & J. R. Dilworth (Eds.), Comprehensive Coordination Chemistry II : From biology to nanotechnology. Volume 5: Transition Metal groups 7-8, (pp. 313-413). Amsterdam: Pergamon Elsevier. [More Information]
  • Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.

Journals

  • Markham, J., Liang, J., Levina, A., Mak, R., Johannessen, B., Kappen, P., Glover, C., Lai, B., Vogt, S., Lay, P. (2017). (Pentamethylcyclopentadienato)rhodium complexes for delivery of the curcumin anticancer drug. European Journal of Inorganic Chemistry, 2017 (12), 1812-1823. [More Information]
  • Safitri, A., Levina, A., Lay, P. (2017). Biospeciation of Cr(III) nutritional supplements in biological fluids. Makara Journal of Science, 21(2), 83-90. [More Information]
  • Le, M., Rathje, O., Levina, A., Lay, P. (2017). High cytotoxicity of vanadium(IV) complexes with 1,10-phenanthroline and related ligands is due to decomposition in cell culture medium. Journal of Biological Inorganic Chemistry, 22(5), 663-672. [More Information]
  • Levina, A., Crans, D., Lay, P. (2017). Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities. Coordination Chemistry Reviews. [More Information]
  • Levina, A., Lay, P. (2017). Stabilities and biological activities of vanadium drugs: What is the nature of the active species? Chemistry: An Asian Journal, 12, 1692-1699. [More Information]
  • O'Riley, H., Levina, A., Aitken, J., Lay, P. (2017). Synthesis, reactivities and anti-cancer properties of ruthenium(II) complexes with a thiaether macrocyclic ligand. Inorganica Chimica Acta, 454, 128-138. [More Information]
  • Levina, A., Pham, T., Lay, P. (2016). Binding of chromium(III) to transferrin could be involved in detoxification of dietary chromium(III) rather than transport of an essential trace element. Angewandte Chemie: International Edition, 55(28), 8104-8107. [More Information]
  • Wu, L., Levina, A., Harris, H., Cai, Z., Lai, B., Vogt, S., James, D., Lay, P. (2016). Carcinogenic chromium(VI) compounds formed by intracellular oxidation of chromium(III) dietary supplements by adipocytes. Angewandte Chemie: International Edition, 55(5), 1742-1745. [More Information]
  • Gransbury, G., Kappen, P., Glover, C., Hughes, J., Levina, A., Lay, P., Musgrave, I., Harris, H. (2016). Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics, 8(8), 762-773. [More Information]
  • Soe, C., Telfer, T., Levina, A., Lay, P., Codd, R. (2016). Simultaneous biosynthesis of putrebactin, avaroferrin and bisucaberin by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V). Journal of Inorganic Biochemistry, 162, 207-215. [More Information]
  • Best, S., Levina, A., Glover, C., Johannessen, B., Kappen, P., Lay, P. (2016). XAS spectroelectrochemistry: reliable measurement of X-ray absorption spectra from redox manipulated solutions at room temperature. Journal of Synchrotron Radiation, 23(3), 743-750. [More Information]
  • Levina, A., McLeod, A., Pulte, A., Aitken, J., Lay, P. (2015). Biotransformations of antidiabetic vanadium prodrugs in mammalian cells and cell culture media: A XANES spectroscopic study. Inorganic Chemistry, 54(14), 6707-6718. [More Information]
  • Weeks, C., Levina, A., Fenton, R., Lay, P. (2015). EXAFS and EPR studies of the alkene oxidation catalyst species trans-[CrIII(bpb)(L)2]n+ and Crv oxidation products (bpb = N,N'-bis(2-pyridinecarboxamido)-1,2-benzene). Australian Journal of Chemistry, 68(4), 581-592. [More Information]
  • Levina, A., McLeod, A., Gasparini, S., Nguyen, A., De Silva, W., Aitken, J., Harris, H., Glover, C., Johannessen, B., Lay, P. (2015). Reactivity and speciation of anti-diabetic vanadium complexes in whole blood and its components: The important role of red blood cells. Inorganic Chemistry, 54(16), 7753-7766. [More Information]
  • Kremer, L., McLeod, A., Aitken, J., Levina, A., Lay, P. (2015). Vanadium(V) and -(IV) complexes of anionic polysaccharides: Controlled release pharmaceutical formulations and models of vanadium biotransformation products. Journal of Inorganic Biochemistry, 147, 227-234. [More Information]
  • Levina, A., Lay, P. (2014). Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry. Inorganic Chemistry Frontiers, 1(1), 44-48. [More Information]
  • Levina, A., McLeod, A., Kremer, L., Aitken, J., Glover, C., Johannessen, B., Lay, P. (2014). Reactivity-activity relationships of oral anti-diabetic vanadium complexes in gastrointestinal media: an X-ray absorption spectroscopic study. Metallomics, 6(10), 1880-1888. [More Information]
  • Pham, T., Aitken, J., Levina, A., Lay, P. (2014). Solid-state structural studies of chromium(III) nicotinato nutritional supplements. Inorganic Chemistry, 53(19), 10685-10694. [More Information]
  • Liang, J., Levina, A., Lay, P. (2014). Synthesis and in-vitro evaluation of anticancer RH(III) complexes. Asia-Pacific Journal of Clinical Oncology, 10(S7), 35-35.
  • Safitria, A., Levina, A., Lay, P. (2014). The role of transition metals in protein phosphorylation in human health and diseases. Asia-Pacific Journal of Clinical Oncology, 10(S7), 41-41.
  • Levina, A., McLeod, A., Lay, P. (2014). Vanadium speciation by XANES spectroscopy: A three-dimensional approach. Chemistry: A European Journal, 20(38), 12056-12060. [More Information]
  • Levina, A., Aitken, J., Gwee, Y., Lim, Z., Liu, M., Singharay, A., Wong, P., Lay, P. (2013). Biotransformations of anticancer ruthenium(III) complexes: An X-ray absorption spectroscopic study. Chemistry: A European Journal, 19(11), 3609-3619. [More Information]
  • Bartholomaus, R., Irwin, J., Shi, L., Meejoo Smith, S., Levina, A., Lay, P. (2013). Isolation, Characterization, and Nuclease Activity of Biologically Relevant Chromium(V) Complexes with Monosaccharides and Model Diols. Likely Intermediates in Chromium-Induced Cancers. Inorganic Chemistry, 52(8), 4282-4292. [More Information]
  • Bartholomaus, R., Harms, K., Levina, A., Lay, P. (2012). Synthesis and characterization of a chromium(V) cis-1,2-cyclohexanediolato complex: A model of reactive intermediates in chromium-induced cancers. Inorganic Chemistry, 51(21), 11238-11240. [More Information]
  • George, G., Pickering, I., Pushie, M., Nienaber, K., Hackett, M., Ascone, I., Hedman, B., Hodgson, K., Aitken, J., Levina, A., Lay, P., et al (2012). X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples. Journal of Synchrotron Radiation, 19(6), 875-886. [More Information]
  • Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. The Analyst, 136(14), 2941-2952. [More Information]
  • Levina, A., Lay, P. (2011). Metal-based anti-diabetic drugs: Advances and challenges. Dalton Transactions, 40(44), 11675-11686. [More Information]
  • Aitken, J., Levina, A., Lay, P. (2011). Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-ray Absorption Spectroscopy. Current Topics in Medicinal Chemistry, 11(5), 553-571. [More Information]
  • Liu, M., Lim, Z., Gwee, Y., Levina, A., Lay, P. (2010). Characterization of a ruthenium(III)/NAMI-A adduct with bovine serum albumin that exhibits a high anti-metastatic activity. Angewandte Chemie: International Edition, 49(9), 1661-1664. [More Information]
  • Levina, A., Zhang, L., Lay, P. (2010). Formation and reactivity of chromium(V)-thiolato complexes: A model for the intracellular reactions of carcinogenic chromium(VI) with biological thiols. Journal of the American Chemical Society, 132(25), 8720-8731. [More Information]
  • Finney, L., Chishti, Y., Khare, T., Giometti, C., Levina, A., Lay, P., Vogt, S. (2010). Imaging metals in proteins by combining electrophoresis with rapid X-ray fluorescence mapping. ACS Chemical Biology, 5(6), 577-587. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Aitken, J., Carter, E., Eastgate, H., Hackett, M., Harris, H., Levina, A., Lee, Y., Chen, C., Lai, B., Vogt, S., Lay, P. (2009). Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems. Radiation Physics and Chemistry, 79(2), 176-184. [More Information]
  • Levina, A., Singharay, A., Lay, P. (2009). Recent developments in ruthenium anticancer drugs. Metallomics, 1(6), 458-470. [More Information]
  • Chatterjee, D., Singharay, A., Levina, A., Lay, P. (2008). A potential role for protein tyrosine phosphatase inhibition by a Ru(III)-edta complex (edta = ethylenediaminetetraacetate) in its biological activity. Chemical Communications, 2008 (25), 2864-2866. [More Information]
  • Levina, A., Lay, P. (2008). Chemical properties and toxicity of chromium(III) nutritional supplements. Chemical Research in Toxicology, 21(3), 563-571. [More Information]
  • Nguyen, A., Mulyani, I., Levina, A., Lay, P. (2008). Reactivity of chromium(III) nutritional supplements in biological media: An X-ray absorption spectroscopic study. Inorganic Chemistry, 47(10), 4299-4309. [More Information]
  • Thomas, S., Terentis, A., Cai, H., Takikawa, O., Levina, A., Lay, P., Freewan, M., Stocker, R. (2007). Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. Journal of Biological Chemistry, 282(33), 23778-23787. [More Information]
  • Levina, A., McLeod, A., Seuring, J., Lay, P. (2007). Reactivity of potential anti-diabetic molybdenum(VI) complexes in biological media: A XANES spectroscopic study. Journal of Inorganic Biochemistry, 101(11-12), 1586-1593. [More Information]
  • Levina, A., Harris, H., Lay, P. (2007). X-ray Absorption and EPR Spectroscopic Studies of the Biotransformations of Chromium(VI) in Mammalian Cells. Is Chromodulin an Artifact of Isolation Methods? Journal of the American Chemical Society, 129(5), 1065-1075. [More Information]
  • Levina, A., Harris, H., Lay, P. (2006). Binding of chromium(VI) to histones: implications for chromium(VI)-induced genotoxicity. Journal of Biological Inorganic Chemistry, 11(2), 225-234. [More Information]
  • Milsmann, C., Levina, A., Harris, H., Foran, G., Turner, P., Lay, P. (2006). Charge distribution in chromium and vanadium catecholato complexes: X-ray absorption spectroscopic and computational studies. Inorganic Chemistry, 45(12), 4743-4754. [More Information]
  • Shi, L., Jing, H., Ren, G., Levina, A., Lay, P. (2006). Studies on the mechanism of Cr-induced DNA damage in glucose and its derivative. Weisheng Yanjiu, 35, 348-351.
  • Immoos, C., Sulc, F., Farmer, P., Czarnecki, K., Bocian, D., Levina, A., Aitken, J., Armstrong, R., Lay, P. (2005). Bonding in HNO-myoglobin as characterized by X-ray absorption and resonance Raman spectroscopies. Journal of the American Chemical Society, 127(3), 814-815. [More Information]
  • Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
  • Barnard, P., Levina, A., Lay, P. (2005). Chromium(V) peptide complexes: Synthesis and spectroscopic characterization. Inorganic Chemistry, 44(4), 1044-1053. [More Information]
  • Levina, A., Lay, P. (2005). Mechanistic studies of relevance to the biological activities of chromium. Coordination Chemistry Reviews, 249(3-4), 281-298. [More Information]
  • Signorella, S., Garcia, S., Rizzotto, M., Levina, A., Lay, P., Sala, L. (2005). The EPR pattern of Cr-V complexes of D-ribose derivatives. Polyhedron, 24(9), 1079-1085. [More Information]
  • Levina, A., Armstrong, R., Lay, P. (2005). Three-dimensional structure determination using multiple-scattering analysis of XAFS: applications to metalloproteins and coordination chemistry. Coordination Chemistry Reviews, 249(1-2), 141-160. [More Information]
  • Harris, H., Levina, A., Dillon, C., Mulyana, Y., Lai, B., Cai, Z., Lay, P. (2005). Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques. Journal of Biological Inorganic Chemistry, 10(2), 105-118. [More Information]
  • Mulyani, I., Levina, A., Lay, P. (2004). Biomimetic Oxidation Of Chromium(III): Does The Antidiabetic Activity Of Chromium(III) Involve Carcinogenic Chromium(VI)? Angewandte Chemie: International Edition, 43(34), 4504-4507. [More Information]
  • Levina, A., Lay, P. (2004). Solution Structures Of Chromium(Vi) Complexes With Glutathione And Model Thiols. Inorganic Chemistry, 43(1), 324-335. [More Information]
  • Weeks, C., Levina, A., Dillon, C., Turner, P., Fenton, R., Lay, P. (2004). Synthesis And Characterization Of A Chromium(V) Cis-Dioxo Bis(1,10-Phenanthroline) Complex And Crystal Molecular Structures Of Its Chromium(Iii) Precursor. Inorganic Chemistry, 43(24), 7844-7856. [More Information]
  • Levina, A., Foran, G., Pattison, D., Lay, P. (2004). X-Ray Absorption Spectroscopic And Electrochemical Studies Of Tris(Catecholato (2-))Chromate (V/I V/Iii) Complexes. Angewandte Chemie: International Edition, 43(4), 462-465. [More Information]
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055. [More Information]
  • Mulyani, I., Levina, A., Lay, P. (2003). Chromium(III) complexes used as nutritional supplements: structures and reactivities. Journal of Inorganic Biochemistry, 961, 196.
  • Levina, A., Zhang, L., Lay, P. (2003). Structure and reactivity of a chromium(V) glutathione complex. Inorganic Chemistry, 42(3), 767-784. [More Information]
  • Cawich, C., Ibrahim, A., Link, K., Bumgartner, A., Patro, M., Mahapatro, S., Lay, P., Levina, A., Eaton, S., Eaton, G. (2003). Synthesis of a pyridinium bis[citrato(2-)]oxochromate(V) complex and its ligand-exchange reactions. Inorganic Chemistry, 42(20), 6458-6468. [More Information]
  • Levina, A., Turner, P., Lay, P. (2003). X-ray absorption spectroscopic studies of chromium nitroso complexes. Crystal and molecular strucute of (Ph4P)3[Cr(NO)(NCS)5].2.4(Ch3)2CO. Inorganic Chemistry, 42(17), 5392-5398. [More Information]
  • Rizzotto, M., Levina, A., Santoro, M., García, S., Frascaroli, M., Signorella, S., Sala, L., Lay, P. (2002). Redox and ligand-exchange chemistry of chromium(VI/V)-methyl glycoside systems. Dalton Transactions, , 3206-3213.
  • Pattison, D., Levina, A., Lay, P., Davies, M. (2001). An investigation of the chromium oxidation state of a monoanionic chromium tris(catecholate) complex by X-ray absorption and EPR spectroscopies. Inorganic Chemistry, 40, 214-217.
  • Pattison, D., Levina, A., Lay, P., Davies, M., Dixon, N. (2001). Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: Relevance to chromium genotoxicity. Chemical Research in Toxicology, 14, 500-510. [More Information]
  • Levina, A., Lay, P., Dixon, N. (2001). Disproportionation of a model chromium(V) complex causes extensive chromium(III)-DNA binding in vitro. Chemical Research in Toxicology, 14, 946-950. [More Information]
  • Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582.
  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

Conferences

  • Safitri, A., Levina, A., Lee, J., Carter, E., Lay, P. (2017). Biospectroscopy for studying the influences of anti-diabetic metals (V, Cr, Mo, and W) to the insulin signaling pathway. International Conference on Chemistry, Chemical Process and Engineering (IC3PE 2017), Melville, NY, USA: AIP Publishing. [More Information]
  • Levina, A., Aitken, J., Harris, H., McLeod, A., Lim, Z., Singharay, A., Pham, T., Safitri, A., Wu, L., Lay, P. (2009). Applications of X-ray absorption spectroscopy to the studies of metabolism of biologically active metal complexes. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Tarr, S., Carter, E., Whan, R., Levina, A., Tobin, M., Lay, P. (2009). Mapping and fluorescent imaging: Investigating the effects of fluorophores on intracellular biochemistry. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.
  • Carter, E., Rich, A., Wu, L., Tam, K., Lay, P., Harris, H., Levina, A., Mulyana, Y., Stamfl, A., Chen, C., et al (2005). SR-FTIR Spectroscopy of Biological Samples at Beamline 14A NSRRC. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.

2017

  • Markham, J., Liang, J., Levina, A., Mak, R., Johannessen, B., Kappen, P., Glover, C., Lai, B., Vogt, S., Lay, P. (2017). (Pentamethylcyclopentadienato)rhodium complexes for delivery of the curcumin anticancer drug. European Journal of Inorganic Chemistry, 2017 (12), 1812-1823. [More Information]
  • Safitri, A., Levina, A., Lay, P. (2017). Biospeciation of Cr(III) nutritional supplements in biological fluids. Makara Journal of Science, 21(2), 83-90. [More Information]
  • Safitri, A., Levina, A., Lee, J., Carter, E., Lay, P. (2017). Biospectroscopy for studying the influences of anti-diabetic metals (V, Cr, Mo, and W) to the insulin signaling pathway. International Conference on Chemistry, Chemical Process and Engineering (IC3PE 2017), Melville, NY, USA: AIP Publishing. [More Information]
  • Le, M., Rathje, O., Levina, A., Lay, P. (2017). High cytotoxicity of vanadium(IV) complexes with 1,10-phenanthroline and related ligands is due to decomposition in cell culture medium. Journal of Biological Inorganic Chemistry, 22(5), 663-672. [More Information]
  • Levina, A., Crans, D., Lay, P. (2017). Speciation of metal drugs, supplements and toxins in media and bodily fluids controls in vitro activities. Coordination Chemistry Reviews. [More Information]
  • Levina, A., Lay, P. (2017). Stabilities and biological activities of vanadium drugs: What is the nature of the active species? Chemistry: An Asian Journal, 12, 1692-1699. [More Information]
  • O'Riley, H., Levina, A., Aitken, J., Lay, P. (2017). Synthesis, reactivities and anti-cancer properties of ruthenium(II) complexes with a thiaether macrocyclic ligand. Inorganica Chimica Acta, 454, 128-138. [More Information]

2016

  • Levina, A., Pham, T., Lay, P. (2016). Binding of chromium(III) to transferrin could be involved in detoxification of dietary chromium(III) rather than transport of an essential trace element. Angewandte Chemie: International Edition, 55(28), 8104-8107. [More Information]
  • Wu, L., Levina, A., Harris, H., Cai, Z., Lai, B., Vogt, S., James, D., Lay, P. (2016). Carcinogenic chromium(VI) compounds formed by intracellular oxidation of chromium(III) dietary supplements by adipocytes. Angewandte Chemie: International Edition, 55(5), 1742-1745. [More Information]
  • Gransbury, G., Kappen, P., Glover, C., Hughes, J., Levina, A., Lay, P., Musgrave, I., Harris, H. (2016). Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics, 8(8), 762-773. [More Information]
  • Soe, C., Telfer, T., Levina, A., Lay, P., Codd, R. (2016). Simultaneous biosynthesis of putrebactin, avaroferrin and bisucaberin by Shewanella putrefaciens and characterisation of complexes with iron(III), molybdenum(VI) or chromium(V). Journal of Inorganic Biochemistry, 162, 207-215. [More Information]
  • Best, S., Levina, A., Glover, C., Johannessen, B., Kappen, P., Lay, P. (2016). XAS spectroelectrochemistry: reliable measurement of X-ray absorption spectra from redox manipulated solutions at room temperature. Journal of Synchrotron Radiation, 23(3), 743-750. [More Information]

2015

  • Levina, A., McLeod, A., Pulte, A., Aitken, J., Lay, P. (2015). Biotransformations of antidiabetic vanadium prodrugs in mammalian cells and cell culture media: A XANES spectroscopic study. Inorganic Chemistry, 54(14), 6707-6718. [More Information]
  • Weeks, C., Levina, A., Fenton, R., Lay, P. (2015). EXAFS and EPR studies of the alkene oxidation catalyst species trans-[CrIII(bpb)(L)2]n+ and Crv oxidation products (bpb = N,N'-bis(2-pyridinecarboxamido)-1,2-benzene). Australian Journal of Chemistry, 68(4), 581-592. [More Information]
  • Levina, A., McLeod, A., Gasparini, S., Nguyen, A., De Silva, W., Aitken, J., Harris, H., Glover, C., Johannessen, B., Lay, P. (2015). Reactivity and speciation of anti-diabetic vanadium complexes in whole blood and its components: The important role of red blood cells. Inorganic Chemistry, 54(16), 7753-7766. [More Information]
  • Kremer, L., McLeod, A., Aitken, J., Levina, A., Lay, P. (2015). Vanadium(V) and -(IV) complexes of anionic polysaccharides: Controlled release pharmaceutical formulations and models of vanadium biotransformation products. Journal of Inorganic Biochemistry, 147, 227-234. [More Information]

2014

  • Levina, A., Lay, P. (2014). Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry. Inorganic Chemistry Frontiers, 1(1), 44-48. [More Information]
  • Levina, A., McLeod, A., Kremer, L., Aitken, J., Glover, C., Johannessen, B., Lay, P. (2014). Reactivity-activity relationships of oral anti-diabetic vanadium complexes in gastrointestinal media: an X-ray absorption spectroscopic study. Metallomics, 6(10), 1880-1888. [More Information]
  • Pham, T., Aitken, J., Levina, A., Lay, P. (2014). Solid-state structural studies of chromium(III) nicotinato nutritional supplements. Inorganic Chemistry, 53(19), 10685-10694. [More Information]
  • Liang, J., Levina, A., Lay, P. (2014). Synthesis and in-vitro evaluation of anticancer RH(III) complexes. Asia-Pacific Journal of Clinical Oncology, 10(S7), 35-35.
  • Safitria, A., Levina, A., Lay, P. (2014). The role of transition metals in protein phosphorylation in human health and diseases. Asia-Pacific Journal of Clinical Oncology, 10(S7), 41-41.
  • Levina, A., McLeod, A., Lay, P. (2014). Vanadium speciation by XANES spectroscopy: A three-dimensional approach. Chemistry: A European Journal, 20(38), 12056-12060. [More Information]

2013

  • Levina, A., Aitken, J., Gwee, Y., Lim, Z., Liu, M., Singharay, A., Wong, P., Lay, P. (2013). Biotransformations of anticancer ruthenium(III) complexes: An X-ray absorption spectroscopic study. Chemistry: A European Journal, 19(11), 3609-3619. [More Information]
  • Bartholomaus, R., Irwin, J., Shi, L., Meejoo Smith, S., Levina, A., Lay, P. (2013). Isolation, Characterization, and Nuclease Activity of Biologically Relevant Chromium(V) Complexes with Monosaccharides and Model Diols. Likely Intermediates in Chromium-Induced Cancers. Inorganic Chemistry, 52(8), 4282-4292. [More Information]

2012

  • Bartholomaus, R., Harms, K., Levina, A., Lay, P. (2012). Synthesis and characterization of a chromium(V) cis-1,2-cyclohexanediolato complex: A model of reactive intermediates in chromium-induced cancers. Inorganic Chemistry, 51(21), 11238-11240. [More Information]
  • George, G., Pickering, I., Pushie, M., Nienaber, K., Hackett, M., Ascone, I., Hedman, B., Hodgson, K., Aitken, J., Levina, A., Lay, P., et al (2012). X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples. Journal of Synchrotron Radiation, 19(6), 875-886. [More Information]

2011

  • Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. The Analyst, 136(14), 2941-2952. [More Information]
  • Levina, A., Lay, P. (2011). Metal-based anti-diabetic drugs: Advances and challenges. Dalton Transactions, 40(44), 11675-11686. [More Information]
  • Aitken, J., Levina, A., Lay, P. (2011). Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-ray Absorption Spectroscopy. Current Topics in Medicinal Chemistry, 11(5), 553-571. [More Information]

2010

  • Liu, M., Lim, Z., Gwee, Y., Levina, A., Lay, P. (2010). Characterization of a ruthenium(III)/NAMI-A adduct with bovine serum albumin that exhibits a high anti-metastatic activity. Angewandte Chemie: International Edition, 49(9), 1661-1664. [More Information]
  • Levina, A., Zhang, L., Lay, P. (2010). Formation and reactivity of chromium(V)-thiolato complexes: A model for the intracellular reactions of carcinogenic chromium(VI) with biological thiols. Journal of the American Chemical Society, 132(25), 8720-8731. [More Information]
  • Finney, L., Chishti, Y., Khare, T., Giometti, C., Levina, A., Lay, P., Vogt, S. (2010). Imaging metals in proteins by combining electrophoresis with rapid X-ray fluorescence mapping. ACS Chemical Biology, 5(6), 577-587. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]

2009

  • Levina, A., Aitken, J., Harris, H., McLeod, A., Lim, Z., Singharay, A., Pham, T., Safitri, A., Wu, L., Lay, P. (2009). Applications of X-ray absorption spectroscopy to the studies of metabolism of biologically active metal complexes. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Aitken, J., Carter, E., Eastgate, H., Hackett, M., Harris, H., Levina, A., Lee, Y., Chen, C., Lai, B., Vogt, S., Lay, P. (2009). Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems. Radiation Physics and Chemistry, 79(2), 176-184. [More Information]
  • Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer. [More Information]
  • Tarr, S., Carter, E., Whan, R., Levina, A., Tobin, M., Lay, P. (2009). Mapping and fluorescent imaging: Investigating the effects of fluorophores on intracellular biochemistry. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
  • Levina, A., Singharay, A., Lay, P. (2009). Recent developments in ruthenium anticancer drugs. Metallomics, 1(6), 458-470. [More Information]
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.

2008

  • Chatterjee, D., Singharay, A., Levina, A., Lay, P. (2008). A potential role for protein tyrosine phosphatase inhibition by a Ru(III)-edta complex (edta = ethylenediaminetetraacetate) in its biological activity. Chemical Communications, 2008 (25), 2864-2866. [More Information]
  • Levina, A., Lay, P. (2008). Chemical properties and toxicity of chromium(III) nutritional supplements. Chemical Research in Toxicology, 21(3), 563-571. [More Information]
  • Nguyen, A., Mulyani, I., Levina, A., Lay, P. (2008). Reactivity of chromium(III) nutritional supplements in biological media: An X-ray absorption spectroscopic study. Inorganic Chemistry, 47(10), 4299-4309. [More Information]

2007

  • Thomas, S., Terentis, A., Cai, H., Takikawa, O., Levina, A., Lay, P., Freewan, M., Stocker, R. (2007). Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. Journal of Biological Chemistry, 282(33), 23778-23787. [More Information]
  • Levina, A., McLeod, A., Seuring, J., Lay, P. (2007). Reactivity of potential anti-diabetic molybdenum(VI) complexes in biological media: A XANES spectroscopic study. Journal of Inorganic Biochemistry, 101(11-12), 1586-1593. [More Information]
  • Levina, A., Mulyani, I., Lay, P. (2007). Redox chemistry and biological activities of chromium(III) complexes. In J. B. Vincent (Eds.), The Nutritional Biochemistry of Chromium(III), (pp. 225-256). Amsterdam, Netherlands: Elsevier. [More Information]
  • Levina, A., Harris, H., Lay, P. (2007). X-ray Absorption and EPR Spectroscopic Studies of the Biotransformations of Chromium(VI) in Mammalian Cells. Is Chromodulin an Artifact of Isolation Methods? Journal of the American Chemical Society, 129(5), 1065-1075. [More Information]

2006

  • Levina, A., Harris, H., Lay, P. (2006). Binding of chromium(VI) to histones: implications for chromium(VI)-induced genotoxicity. Journal of Biological Inorganic Chemistry, 11(2), 225-234. [More Information]
  • Milsmann, C., Levina, A., Harris, H., Foran, G., Turner, P., Lay, P. (2006). Charge distribution in chromium and vanadium catecholato complexes: X-ray absorption spectroscopic and computational studies. Inorganic Chemistry, 45(12), 4743-4754. [More Information]
  • Shi, L., Jing, H., Ren, G., Levina, A., Lay, P. (2006). Studies on the mechanism of Cr-induced DNA damage in glucose and its derivative. Weisheng Yanjiu, 35, 348-351.

2005

  • Immoos, C., Sulc, F., Farmer, P., Czarnecki, K., Bocian, D., Levina, A., Aitken, J., Armstrong, R., Lay, P. (2005). Bonding in HNO-myoglobin as characterized by X-ray absorption and resonance Raman spectroscopies. Journal of the American Chemical Society, 127(3), 814-815. [More Information]
  • Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
  • Barnard, P., Levina, A., Lay, P. (2005). Chromium(V) peptide complexes: Synthesis and spectroscopic characterization. Inorganic Chemistry, 44(4), 1044-1053. [More Information]
  • Levina, A., Lay, P. (2005). Mechanistic studies of relevance to the biological activities of chromium. Coordination Chemistry Reviews, 249(3-4), 281-298. [More Information]
  • Carter, E., Rich, A., Wu, L., Tam, K., Lay, P., Harris, H., Levina, A., Mulyana, Y., Stamfl, A., Chen, C., et al (2005). SR-FTIR Spectroscopy of Biological Samples at Beamline 14A NSRRC. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Signorella, S., Garcia, S., Rizzotto, M., Levina, A., Lay, P., Sala, L. (2005). The EPR pattern of Cr-V complexes of D-ribose derivatives. Polyhedron, 24(9), 1079-1085. [More Information]
  • Levina, A., Armstrong, R., Lay, P. (2005). Three-dimensional structure determination using multiple-scattering analysis of XAFS: applications to metalloproteins and coordination chemistry. Coordination Chemistry Reviews, 249(1-2), 141-160. [More Information]
  • Harris, H., Levina, A., Dillon, C., Mulyana, Y., Lai, B., Cai, Z., Lay, P. (2005). Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques. Journal of Biological Inorganic Chemistry, 10(2), 105-118. [More Information]

2004

  • Mulyani, I., Levina, A., Lay, P. (2004). Biomimetic Oxidation Of Chromium(III): Does The Antidiabetic Activity Of Chromium(III) Involve Carcinogenic Chromium(VI)? Angewandte Chemie: International Edition, 43(34), 4504-4507. [More Information]
  • Lay, P., Levina, A. (2004). Chromium. In A. G. Webb (Eds.), Comprehensive Coordination Chemistry II : From Biology to Nanotechnology [Volume 4: Transition Metal Groups 3-6], (pp. 313-413). Amsterdam: Pergamon Elsevier.
  • Lay, P., Levina, A. (2004). Chromium. In E. C. Constable & J. R. Dilworth (Eds.), Comprehensive Coordination Chemistry II : From biology to nanotechnology. Volume 5: Transition Metal groups 7-8, (pp. 313-413). Amsterdam: Pergamon Elsevier. [More Information]
  • Levina, A., Lay, P. (2004). Solution Structures Of Chromium(Vi) Complexes With Glutathione And Model Thiols. Inorganic Chemistry, 43(1), 324-335. [More Information]
  • Weeks, C., Levina, A., Dillon, C., Turner, P., Fenton, R., Lay, P. (2004). Synthesis And Characterization Of A Chromium(V) Cis-Dioxo Bis(1,10-Phenanthroline) Complex And Crystal Molecular Structures Of Its Chromium(Iii) Precursor. Inorganic Chemistry, 43(24), 7844-7856. [More Information]
  • Levina, A., Foran, G., Pattison, D., Lay, P. (2004). X-Ray Absorption Spectroscopic And Electrochemical Studies Of Tris(Catecholato (2-))Chromate (V/I V/Iii) Complexes. Angewandte Chemie: International Edition, 43(4), 462-465. [More Information]
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055. [More Information]

2003

  • Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.
  • Mulyani, I., Levina, A., Lay, P. (2003). Chromium(III) complexes used as nutritional supplements: structures and reactivities. Journal of Inorganic Biochemistry, 961, 196.
  • Levina, A., Zhang, L., Lay, P. (2003). Structure and reactivity of a chromium(V) glutathione complex. Inorganic Chemistry, 42(3), 767-784. [More Information]
  • Cawich, C., Ibrahim, A., Link, K., Bumgartner, A., Patro, M., Mahapatro, S., Lay, P., Levina, A., Eaton, S., Eaton, G. (2003). Synthesis of a pyridinium bis[citrato(2-)]oxochromate(V) complex and its ligand-exchange reactions. Inorganic Chemistry, 42(20), 6458-6468. [More Information]
  • Levina, A., Turner, P., Lay, P. (2003). X-ray absorption spectroscopic studies of chromium nitroso complexes. Crystal and molecular strucute of (Ph4P)3[Cr(NO)(NCS)5].2.4(Ch3)2CO. Inorganic Chemistry, 42(17), 5392-5398. [More Information]

2002

  • Rizzotto, M., Levina, A., Santoro, M., García, S., Frascaroli, M., Signorella, S., Sala, L., Lay, P. (2002). Redox and ligand-exchange chemistry of chromium(VI/V)-methyl glycoside systems. Dalton Transactions, , 3206-3213.

2001

  • Pattison, D., Levina, A., Lay, P., Davies, M. (2001). An investigation of the chromium oxidation state of a monoanionic chromium tris(catecholate) complex by X-ray absorption and EPR spectroscopies. Inorganic Chemistry, 40, 214-217.
  • Pattison, D., Levina, A., Lay, P., Davies, M., Dixon, N. (2001). Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: Relevance to chromium genotoxicity. Chemical Research in Toxicology, 14, 500-510. [More Information]
  • Levina, A., Lay, P., Dixon, N. (2001). Disproportionation of a model chromium(V) complex causes extensive chromium(III)-DNA binding in vitro. Chemical Research in Toxicology, 14, 946-950. [More Information]
  • Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582.

2000

  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

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