Professor David Thwaites

A28 - Physics Building
The University of Sydney

Telephone +61 2 9351 8731
Fax +61 2 9351 7726

Research interests

Radiation oncology physics, radiation dosimetry, radiation protection, imaging in oncology, image-guided radiotherapy. Director of the Institute of Medical Physics.

Selected grants

2014

  • Funding for Chair Medical Physics; Thwaites D; Health Administration Corporation/Chair Medical Physics.
  • Conjoint Research Medical Physics Post (Westmead Hospital and USyd Institute of Medical Physics) re-Data- Mining project; Thwaites D; Westmead Hospital/Research Support.
  • Rapid learning proof-of-concept for NSW radiotherapy: Linking and mining imaging and clinical data to support optimised decisions for NSW lung cancer patients; Thwaites D, Holloway L, Dekker A, Delaney G, Bailey M, Ghose A, Vinod S, Miller A, Hegi-Johnson F; NSW Ministry of Health, Office for Health and Medical Research/Bioinformatics Collaborative Grants Program.
  • Conjoint research medical physics post (Royal North Shore Hospital and USyd Institute of Medical Physics), re: advanced radiation oncology technology and techniques; Thwaites D; Royal North Shore Hospital/Research Support.
  • Institute of Medical Physics conjoint university-hospital medical physics research post - re: advanced radiation oncology technology and techniques; Thwaites D; Calvary Mater Hospital (CMN) - Newcastle/Research Support.
  • Do treatment delivery uncertainties limit the effectiveness of advanced technology radiotherapy treatments?; Thwaites D, Arumugam S, Vinod S, Lee M, Rozenfeld A, Metcalfe P; Cancer Council New South Wales/Research Project Grants.

2013

  • Chair of Medical Physics research program; Thwaites D; Health Administration Corporation/Research Support.
  • Conjoint research medical physics post (Orange CCC and USyd Institute of Medical Physics): Advanced radiation oncology technology and techniques; Thwaites D; Health Administration Corporation/Research Support.

2012

  • The National Medical Physics University Network; Thwaites D; Department of Health and Ageing (Federal)/Targeted Prevention Programs.
  • Radiation oncology medical physics conjoint academic posts; Thwaites D; Department of Health and Ageing (Federal)/Targeted Prevention Programs.
  • Conjoint research medical physics research post (Westmead and Nepean Hospitals) re: advanced radiation oncology technology and techniques; Thwaites D; Westmead Hospital/Research Support.
  • Medical Physics academic program Co-ordinators Group (MPCG); Thwaites D; Department of Health and Ageing (Federal)/Targeted Prevention Programs.
  • An adaptable and dedicated linear accelerator for medical radiation research; Keall P, Jackson M, Rozenfeld A, Barton M, Greer P, Vial J, Baldock C, Metcalfe P, Thwaites D, Kuncic Z, Holloway L, Bosi S, Eslick E, Downes S; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2010

  • Chair of medical physics research program; Thwaites D; Health Administration Corporation/Research Support.

Selected publications

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Journals

  • Charles, P., Cranmer-Sargison, G., Thwaites, D., Crowe, S., Kairn, T., Knight, R., Kenny, J., Langton, C., Trapp, J. (2014). A practical and theoretical definition of very small field size for radiotherapy output factor measurements. Medical Physics, 41(4), 1-8. [More Information]
  • Johnson, D., Weston, S., Cosgrove, V., Thwaites, D. (2014). A simple model for predicting the signal for a head-mounted transmission chamber system, allowing IMRT in-vivo dosimetry without pretreatment linac time. Journal of Applied Clinical Medical Physics, 15(4), 270-279-270-279. [More Information]
  • Hill, R., Healy, B., Holloway, L., Kuncic, Z., Thwaites, D., Baldock, C. (2014). Advances in kilovoltage x-ray beam dosimetry. Physics in Medicine and Biology, 59(6), R183-R231-R183-R231. [More Information]
  • Barber, J., Sykes, J., Holloway, L., Thwaites, D. (2014). Automatic image registration performance for two different CBCT systems; Variation with imaging dose. Journal of Physics: Conference Series, 489(1), 012070- 1-012070- 4. [More Information]
  • Paynter, D., Weston, S., Cosgrove, V., Evans, J., Thwaites, D. (2014). Beam characteristics of energy-matched flattening filter free beams. Medical Physics, 41(5), Article number 052103. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Thwaites, D., Henry, A. (2014). Dosimetry modeling for focal high-dose-rate prostate brachytherapy. Brachytherapy. [More Information]
  • Bawazeer, O., Gray, A., Arumugam, S., Vial, P., Thwaites, D., Descallar, J., Holloway, L. (2014). Evaluation of the ability of a 2D ionisation chamber array and an EPID to detect systematic delivery errors in IMRT plans. Journal of Physics: Conference Series, 489(1), 012071- 1-012071- 5. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Henry, A., Thwaites, D. (2014). Investigation of interseed attenuation and tissue composition effects in 125I seed implant prostate brachytherapy. Brachytherapy. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Wilson, D., Buckley, D., Thwaites, D., Carey, B., Henry, A. (2014). Multi-parametric MRI-guided focal tumor boost using HDR prostate brachytherapy: A feasibility study. Brachytherapy, 13(2), 137-145-137-145. [More Information]
  • Cho, G., Ebert, M., Holloway, L., Kuncic, Z., Baldock, C., Thwaites, D. (2014). Radiation treatment dose optimisation using Poisson tumour control probability parameters. Journal of Physics: Conference Series, 489(1), Article number 012047. [More Information]
  • Cranmer-Sargison, G., Charles, P., Trapp, J., Thwaites, D. (2013). A methodological approach to reporting corrected small field relative outputs. Radiotherapy and Oncology, 109(3), 350-355. [More Information]
  • Thwaites, D. (2013). Accuracy required and achievable in radiotherapy dosimetry: Have modern technology and techniques changed our views? Journal of Physics: Conference Series (Online), 444(1), 1-17. [More Information]
  • Sykes, J., Lindsay, R., Iball, G., Thwaites, D. (2013). Dosimetry of CBCT: Methods, doses and clinical consequences. Journal of Physics: Conference Series (Online), 444(1), 1-13. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Henry, A., Thwaites, D. (2013). Monte Carlo investigation of I-125 interseed attenuation for standard and thinner seeds in prostate brachytherapy with phantom validation using a MOSFET. Medical Physics, 40(3), 1-10. [More Information]
  • Thwaites, D., Baldock, C. (2013). Preface of the proceedings to the 7th International Conference on 3D Radiation Dosimetry (IC3DDose). Journal of Physics: Conference Series, 444(1), 1-2; 3. [More Information]
  • Cranmer-Sargison, G., Liu, P., Weston, S., Suchowerska, N., Thwaites, D. (2013). Small field dosimetric characterization of a new 160-leaf MLC. Physics in Medicine and Biology, 58(20), 7343-7354. [More Information]
  • Muren, L., Thwaites, D. (2013). The on-going quest for treatment precision and conformality in radiotherapy. Radiotherapy and Oncology, 109(3), 337-341. [More Information]
  • Yartsev, S., Muren, L., Thwaites, D. (2013). Treatment planning studies in radiotherapy. Radiotherapy and Oncology, 109(3), 342-343. [More Information]
  • Dean, C., Sykes, J., Cooper, R., Hatfield, P., Carey, B., Swift, S., Bacon, S., Thwaites, D., Sebag-Montefiore, D., Morgan, A. (2012). An evaluation of four CT-MRI co-registration techniques for radiotherapy treatment planning of prone rectal cancer patients. British Journal of Radiology, 85(1009), 61-68. [More Information]
  • Cranmer-Sargison, G., Weston, S., Evans, J., Sidhu, N., Thwaites, D. (2012). Monte Carlo modelling of diode detectors for small field MV photon dosimetry: detector model simplification and the sensitivity of correction factors to source parameterization. Physics in Medicine and Biology, 57(16), 5141-5153. [More Information]
  • Cranmer-Sargison, G., Weston, S., Sidhu, N., Thwaites, D. (2011). Experimental small field 6 MV output ratio analysis for various diode detector and accelerator combinations. Radiotherapy and Oncology, 100(3), 429-435. [More Information]
  • Cranmer-Sargison, G., Weston, S., Evans, J., Sidhu, N., Thwaites, D. (2011). Implementing a newly proposed Monte Carlo based small field dosimetry formalism for a comprehensive set of diode detectors. Medical Physics, 38(12), 6592-6602. [More Information]
  • Thwaites, D., Malicki, J. (2011). Physics and technology in ESTRO and in Radiotherapy and Oncology: Past, present and into the 4th dimension. Radiotherapy and Oncology, 100(3), 327-332. [More Information]
  • Speight, R., Sykes, J., Lindsay, R., Franks, K., Thwaites, D. (2011). The evaluation of a deformable image registration segmentation technique for semi-automating internal target volume (ITV) production from 4DCT images of lung stereotactic body radiotherapy (SBRT) patients. Radiotherapy and Oncology, 98(2), 277-283. [More Information]

Conferences

  • Izewska, J., Bera, P., Azangwe, G., Thwaites, D., George, D., Followill, D. (2011). IAEA Support to National TLD Audit Networks for Raidotherapy Dosimetry. International Symposium on Standards, Applications and Quality Assurance in Medical Radiation Dosimetry (IDOS 2010), Vienna, Austria: International Atomic Energy Agency (IAEA).

2014

  • Charles, P., Cranmer-Sargison, G., Thwaites, D., Crowe, S., Kairn, T., Knight, R., Kenny, J., Langton, C., Trapp, J. (2014). A practical and theoretical definition of very small field size for radiotherapy output factor measurements. Medical Physics, 41(4), 1-8. [More Information]
  • Johnson, D., Weston, S., Cosgrove, V., Thwaites, D. (2014). A simple model for predicting the signal for a head-mounted transmission chamber system, allowing IMRT in-vivo dosimetry without pretreatment linac time. Journal of Applied Clinical Medical Physics, 15(4), 270-279-270-279. [More Information]
  • Hill, R., Healy, B., Holloway, L., Kuncic, Z., Thwaites, D., Baldock, C. (2014). Advances in kilovoltage x-ray beam dosimetry. Physics in Medicine and Biology, 59(6), R183-R231-R183-R231. [More Information]
  • Barber, J., Sykes, J., Holloway, L., Thwaites, D. (2014). Automatic image registration performance for two different CBCT systems; Variation with imaging dose. Journal of Physics: Conference Series, 489(1), 012070- 1-012070- 4. [More Information]
  • Paynter, D., Weston, S., Cosgrove, V., Evans, J., Thwaites, D. (2014). Beam characteristics of energy-matched flattening filter free beams. Medical Physics, 41(5), Article number 052103. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Thwaites, D., Henry, A. (2014). Dosimetry modeling for focal high-dose-rate prostate brachytherapy. Brachytherapy. [More Information]
  • Bawazeer, O., Gray, A., Arumugam, S., Vial, P., Thwaites, D., Descallar, J., Holloway, L. (2014). Evaluation of the ability of a 2D ionisation chamber array and an EPID to detect systematic delivery errors in IMRT plans. Journal of Physics: Conference Series, 489(1), 012071- 1-012071- 5. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Henry, A., Thwaites, D. (2014). Investigation of interseed attenuation and tissue composition effects in 125I seed implant prostate brachytherapy. Brachytherapy. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Wilson, D., Buckley, D., Thwaites, D., Carey, B., Henry, A. (2014). Multi-parametric MRI-guided focal tumor boost using HDR prostate brachytherapy: A feasibility study. Brachytherapy, 13(2), 137-145-137-145. [More Information]
  • Cho, G., Ebert, M., Holloway, L., Kuncic, Z., Baldock, C., Thwaites, D. (2014). Radiation treatment dose optimisation using Poisson tumour control probability parameters. Journal of Physics: Conference Series, 489(1), Article number 012047. [More Information]

2013

  • Cranmer-Sargison, G., Charles, P., Trapp, J., Thwaites, D. (2013). A methodological approach to reporting corrected small field relative outputs. Radiotherapy and Oncology, 109(3), 350-355. [More Information]
  • Thwaites, D. (2013). Accuracy required and achievable in radiotherapy dosimetry: Have modern technology and techniques changed our views? Journal of Physics: Conference Series (Online), 444(1), 1-17. [More Information]
  • Sykes, J., Lindsay, R., Iball, G., Thwaites, D. (2013). Dosimetry of CBCT: Methods, doses and clinical consequences. Journal of Physics: Conference Series (Online), 444(1), 1-13. [More Information]
  • Mason, J., Al-Qaisieh, B., Bownes, P., Henry, A., Thwaites, D. (2013). Monte Carlo investigation of I-125 interseed attenuation for standard and thinner seeds in prostate brachytherapy with phantom validation using a MOSFET. Medical Physics, 40(3), 1-10. [More Information]
  • Thwaites, D., Baldock, C. (2013). Preface of the proceedings to the 7th International Conference on 3D Radiation Dosimetry (IC3DDose). Journal of Physics: Conference Series, 444(1), 1-2; 3. [More Information]
  • Cranmer-Sargison, G., Liu, P., Weston, S., Suchowerska, N., Thwaites, D. (2013). Small field dosimetric characterization of a new 160-leaf MLC. Physics in Medicine and Biology, 58(20), 7343-7354. [More Information]
  • Muren, L., Thwaites, D. (2013). The on-going quest for treatment precision and conformality in radiotherapy. Radiotherapy and Oncology, 109(3), 337-341. [More Information]
  • Yartsev, S., Muren, L., Thwaites, D. (2013). Treatment planning studies in radiotherapy. Radiotherapy and Oncology, 109(3), 342-343. [More Information]

2012

  • Dean, C., Sykes, J., Cooper, R., Hatfield, P., Carey, B., Swift, S., Bacon, S., Thwaites, D., Sebag-Montefiore, D., Morgan, A. (2012). An evaluation of four CT-MRI co-registration techniques for radiotherapy treatment planning of prone rectal cancer patients. British Journal of Radiology, 85(1009), 61-68. [More Information]
  • Cranmer-Sargison, G., Weston, S., Evans, J., Sidhu, N., Thwaites, D. (2012). Monte Carlo modelling of diode detectors for small field MV photon dosimetry: detector model simplification and the sensitivity of correction factors to source parameterization. Physics in Medicine and Biology, 57(16), 5141-5153. [More Information]

2011

  • Cranmer-Sargison, G., Weston, S., Sidhu, N., Thwaites, D. (2011). Experimental small field 6 MV output ratio analysis for various diode detector and accelerator combinations. Radiotherapy and Oncology, 100(3), 429-435. [More Information]
  • Izewska, J., Bera, P., Azangwe, G., Thwaites, D., George, D., Followill, D. (2011). IAEA Support to National TLD Audit Networks for Raidotherapy Dosimetry. International Symposium on Standards, Applications and Quality Assurance in Medical Radiation Dosimetry (IDOS 2010), Vienna, Austria: International Atomic Energy Agency (IAEA).
  • Cranmer-Sargison, G., Weston, S., Evans, J., Sidhu, N., Thwaites, D. (2011). Implementing a newly proposed Monte Carlo based small field dosimetry formalism for a comprehensive set of diode detectors. Medical Physics, 38(12), 6592-6602. [More Information]
  • Thwaites, D., Malicki, J. (2011). Physics and technology in ESTRO and in Radiotherapy and Oncology: Past, present and into the 4th dimension. Radiotherapy and Oncology, 100(3), 327-332. [More Information]
  • Speight, R., Sykes, J., Lindsay, R., Franks, K., Thwaites, D. (2011). The evaluation of a deformable image registration segmentation technique for semi-automating internal target volume (ITV) production from 4DCT images of lung stereotactic body radiotherapy (SBRT) patients. Radiotherapy and Oncology, 98(2), 277-283. [More Information]

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