Dr Elizabeth New

BSc(Adv) MSc Sydney; PhD Dunelm
ARC DECRA Fellow

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 1993
Fax 61 2 9351 3329

Website New Research Group
Contact Details

Biographical details

  • BSc (Adv, Hons1 and Medal), University of Sydney, 2005
  • MSc, University of Sydney, 2007
  • PhD, Durham University, 2009
  • Association of Commonwealth Universities' Commonwealth Scholarship, 2006-2009
  • Postdoctoral Fellow, University of California at Berkeley, 2010-2011
  • Royal Commission for the Exhibition of 1851 Research Fellow, 2010-2011
  • RSC Dalton Young Researchers Award, 2011
  • ARC DECRA Fellow, 2012-2014

Research interests

  • Chemical biology
  • Bioinorganic chemistry
  • Molecular imaging
  • Redox sensing
  • Metal ion sensing

The main research focus of the group is the development of chemical tools to assist the study of biological systems, particularly redox regulation.

Many diseases are associated with perturbations in redox state, so developing ways to measure biological redox state will help us to better understand these diseases and suggest ways to cure or treat them. We are developing probes that allow the monitoring of cellular redox state by MRI or fluorescence microscopy.

For more information please visit: http://www.chem.usyd.edu.au/~enew/

Current projects

  • MRI probes for oxidative stress
  • Fluorescent sensors for redox state
  • Fluorescent sensors for metal ions in biology
  • Fluorescent sensing methods for platinum

Awards and honours

  • Dalton Young Researchers Award, Royal Society of Chemistry, 2011
  • The University Medal, University of Sydney, 2005

PhD and master's project opportunities

Selected grants

2015

  • The effect of Pt binding to CTR1 on Cu homeostasis and cell phenotype; New E, Hambley T; Australian Research Council (ARC)/Discovery Projects (DP).

2014

  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Novel hypoxia selective MRI contrast agents; Bonnitcha P, New E, Grieve S; Heart Research Australia/Research Support.

2013

  • The role of oxidative stress in obesity; New E; Clive and Vera Ramaciotti Foundations/Awards for Biomedical Research: Establishment Gifts.

2012

  • Development of sensors for biological redox state; New E; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA).

Selected publications

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Journals

  • Yeow, J., Kaur, A., Anscomb, M., New, E. (2014). A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes. Chemical Communications, 50(60), 8181-8184. [More Information]
  • Eljack, N., Ma, H., Drucker, J., Shen, C., Hambley, T., New, E., Friedrich, T., Clarke, R. (2014). Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin. Metallomics, 6(11), 2126-2133. [More Information]
  • Shen, C., New, E. (2013). Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents. Current Opinion In Chemical Biology, 17(2), 158-166. [More Information]
  • New, E. (2013). Tools to study distinct metal pools in biology. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 42(9), 3210-3219. [More Information]
  • Que, E., New, E., Chang, C. (2012). A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chemical Science, 3(6), 1829-1834. [More Information]
  • Au-Yeung, H., New, E., Chang, C. (2012). A selective reaction-based fluorescent probe for detecting cobalt in living cells. Chemical Communications, 48(43), 5268-5270. [More Information]
  • Dias, D., Teixeira, J., Kuprov, I., New, E., Parker, D., Geraldes, C. (2011). Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by (1)H STD NMR techniques. Organic and Biomolecular Chemistry, 9(14), 5047-5050. [More Information]
  • Yadav, P., Beveridge, R., Blay, J., Boyd, A., Chojnacka, M., Decken, A., Deshpande, A., Gardiner, M., Hambley, T., Hughes, M., New, E., et al (2011). Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies. MedChemComm (Medicinal Chemistry Communications), 2(4), 274-277. [More Information]
  • Lippert, A., New, E., Chang, C. (2011). Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. Journal of the American Chemical Society, 133(26), 10078-10080. [More Information]
  • New, E., Congreve, A., Parker, D. (2010). Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes. Chemical Science, 1(1), 111-118. [More Information]
  • New, E., Parker, D., Smith, D., Walton, J. (2010). Development of responsive lanthanide probes for cellular applications. Current Opinion In Chemical Biology, 14(2), 238-246. [More Information]
  • Miller, E., Taulet, N., Onak, C., New, E., Lanselle, J., Smelick, G., Chang, C. (2010). Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator. Journal of the American Chemical Society, 132(48), 17071-17073. [More Information]
  • Montgomery, C., Murray, B., New, E., Pal, R., Parker, D. (2009). Cell-penetrating metal complex optical probes: Targeted and responsive systems based on lanthanide luminescence. Accounts Of Chemical Research, 42(7), 925-937. [More Information]
  • New, E., Parker, D., Peacock, R. (2009). Comparative study of the constitution and chiroptical properties of emissive terbium and europium complexes with a common tetraazatriphenylene sensitiser; the nature of the sensitiser determines quenching sensitivity and cellular uptake. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (4), 672-679. [More Information]
  • Montgomery, C., New, E., Palsson, L., Parker, D., Batsanov, A., Lamarque, L. (2009). Emissive and cell-permeable 3-pyridyl- and 3-pyrazolyl-4-azaxanthone lanthanide complexes and their behaviour in cellulo. Helvetica Chimica Acta, 92(11), 2186-2213. [More Information]
  • New, E., Roche, C., Madawala, R., Zhang, J., Hambley, T. (2009). Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells. Journal of Inorganic Biochemistry, 103(8), 1120-1125. [More Information]
  • New, E., Duan, R., Zhang, J., Hambley, T. (2009). Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (16), 3092-3101.
  • New, E., Parker, D. (2009). The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation. Organic and Biomolecular Chemistry, 7(5), 851-855. [More Information]
  • Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]
  • Murray, B., New, E., Pal, R., Parker, D. (2008). Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile. Organic and Biomolecular Chemistry, 6(12), 2085-2094. [More Information]
  • Montgomery, C., New, E., Parker, D., Peacock, R. (2008). Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence. Chemical Communications, 2008 (36), 4261-4263. [More Information]
  • Kielar, F., Law, G., New, E., Parker, D. (2008). The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use. Organic and Biomolecular Chemistry, 6(13), 2256-2258. [More Information]
  • Kielar, F., Congreve, A., Law, G., New, E., Parker, D., Wong, K., Castreno, P., de Mendoza, J. (2008). Two-photon microscopy study of the intracellular compartmentalisation of emissive terbium complexes and their oligo-arginine and oligo-guanidinium conjugates. Chemical Communications, 2008 (21), 2435-2437. [More Information]
  • Kielar, F., Montgomery, C., New, E., Parker, D., Poole, R., Richardson, S., Stenson, P. (2007). A mechanistic study of the dynamic quenching of the excited state of europium(III) and terbium(III) macrocyclic complexes by charge- or electron transfer. Organic and Biomolecular Chemistry, 5(18), 2975-2982. [More Information]
  • Poole, R., Montgomery, C., New, E., Congreve, A., Parker, D., Botta, M. (2007). Identification of emissive lanthanide complexes suitable for cellular imaging that resist quenching by endogoenous anti-oxidants. Organic and Biomolecular Chemistry, 5(13), 2055-2062. [More Information]

2014

  • Yeow, J., Kaur, A., Anscomb, M., New, E. (2014). A novel flavin derivative reveals the impact of glucose on oxidative stress in adipocytes. Chemical Communications, 50(60), 8181-8184. [More Information]
  • Eljack, N., Ma, H., Drucker, J., Shen, C., Hambley, T., New, E., Friedrich, T., Clarke, R. (2014). Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin. Metallomics, 6(11), 2126-2133. [More Information]

2013

  • Shen, C., New, E. (2013). Promising strategies for Gd-based responsive magnetic resonance imaging contrast agents. Current Opinion In Chemical Biology, 17(2), 158-166. [More Information]
  • New, E. (2013). Tools to study distinct metal pools in biology. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 42(9), 3210-3219. [More Information]

2012

  • Que, E., New, E., Chang, C. (2012). A cell-permeable gadolinium contrast agent for magnetic resonance imaging of copper in a Menkes disease model. Chemical Science, 3(6), 1829-1834. [More Information]
  • Au-Yeung, H., New, E., Chang, C. (2012). A selective reaction-based fluorescent probe for detecting cobalt in living cells. Chemical Communications, 48(43), 5268-5270. [More Information]

2011

  • Dias, D., Teixeira, J., Kuprov, I., New, E., Parker, D., Geraldes, C. (2011). Enantioselective binding of a lanthanide(III) complex to human serum albumin studied by (1)H STD NMR techniques. Organic and Biomolecular Chemistry, 9(14), 5047-5050. [More Information]
  • Yadav, P., Beveridge, R., Blay, J., Boyd, A., Chojnacka, M., Decken, A., Deshpande, A., Gardiner, M., Hambley, T., Hughes, M., New, E., et al (2011). Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies. MedChemComm (Medicinal Chemistry Communications), 2(4), 274-277. [More Information]
  • Lippert, A., New, E., Chang, C. (2011). Reaction-based fluorescent probes for selective imaging of hydrogen sulfide in living cells. Journal of the American Chemical Society, 133(26), 10078-10080. [More Information]

2010

  • New, E., Congreve, A., Parker, D. (2010). Definition of the uptake mechanism and sub-cellular localisation profile of emissive lanthanide complexes as cellular optical probes. Chemical Science, 1(1), 111-118. [More Information]
  • New, E., Parker, D., Smith, D., Walton, J. (2010). Development of responsive lanthanide probes for cellular applications. Current Opinion In Chemical Biology, 14(2), 238-246. [More Information]
  • Miller, E., Taulet, N., Onak, C., New, E., Lanselle, J., Smelick, G., Chang, C. (2010). Light-activated regulation of cofilin dynamics using a photocaged hydrogen peroxide generator. Journal of the American Chemical Society, 132(48), 17071-17073. [More Information]

2009

  • Montgomery, C., Murray, B., New, E., Pal, R., Parker, D. (2009). Cell-penetrating metal complex optical probes: Targeted and responsive systems based on lanthanide luminescence. Accounts Of Chemical Research, 42(7), 925-937. [More Information]
  • New, E., Parker, D., Peacock, R. (2009). Comparative study of the constitution and chiroptical properties of emissive terbium and europium complexes with a common tetraazatriphenylene sensitiser; the nature of the sensitiser determines quenching sensitivity and cellular uptake. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (4), 672-679. [More Information]
  • Montgomery, C., New, E., Palsson, L., Parker, D., Batsanov, A., Lamarque, L. (2009). Emissive and cell-permeable 3-pyridyl- and 3-pyrazolyl-4-azaxanthone lanthanide complexes and their behaviour in cellulo. Helvetica Chimica Acta, 92(11), 2186-2213. [More Information]
  • New, E., Roche, C., Madawala, R., Zhang, J., Hambley, T. (2009). Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells. Journal of Inorganic Biochemistry, 103(8), 1120-1125. [More Information]
  • New, E., Duan, R., Zhang, J., Hambley, T. (2009). Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (16), 3092-3101.
  • New, E., Parker, D. (2009). The mechanism of cell uptake for luminescent lanthanide optical probes: the role of macropinocytosis and the effect of enhanced membrane permeability on compartmentalisation. Organic and Biomolecular Chemistry, 7(5), 851-855. [More Information]

2008

  • Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]
  • Murray, B., New, E., Pal, R., Parker, D. (2008). Critical evaluation of five emissive europium(III) complexes as optical probes: correlation of cytotoxicity, anion and protein affinity with complex structure, stability and intracellular localisation profile. Organic and Biomolecular Chemistry, 6(12), 2085-2094. [More Information]
  • Montgomery, C., New, E., Parker, D., Peacock, R. (2008). Enantioselective regulation of a metal complex in reversible binding to serum albumin: dynamic helicity inversion signalled by circularly polarised luminescence. Chemical Communications, 2008 (36), 4261-4263. [More Information]
  • Kielar, F., Law, G., New, E., Parker, D. (2008). The nature of the sensitiser substituent determines quenching sensitivity and protein affinity and influences the design of emissive lanthanide complexes as optical probes for intracellular use. Organic and Biomolecular Chemistry, 6(13), 2256-2258. [More Information]
  • Kielar, F., Congreve, A., Law, G., New, E., Parker, D., Wong, K., Castreno, P., de Mendoza, J. (2008). Two-photon microscopy study of the intracellular compartmentalisation of emissive terbium complexes and their oligo-arginine and oligo-guanidinium conjugates. Chemical Communications, 2008 (21), 2435-2437. [More Information]

2007

  • Kielar, F., Montgomery, C., New, E., Parker, D., Poole, R., Richardson, S., Stenson, P. (2007). A mechanistic study of the dynamic quenching of the excited state of europium(III) and terbium(III) macrocyclic complexes by charge- or electron transfer. Organic and Biomolecular Chemistry, 5(18), 2975-2982. [More Information]
  • Poole, R., Montgomery, C., New, E., Congreve, A., Parker, D., Botta, M. (2007). Identification of emissive lanthanide complexes suitable for cellular imaging that resist quenching by endogoenous anti-oxidants. Organic and Biomolecular Chemistry, 5(13), 2055-2062. [More Information]

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