Dr Hannah Nicholas

Senior Lecturer in Molecular Biology

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 2549
Fax +61 2 9351 4726

Biographical details

Dr Hannah Nicholas joined the School of Molecular Bioscience in 2005 as an Associate Lecturer after completing her DPhil in Genetics at the University of Oxford. In 2006 she was awarded a University of Sydney Postdoctoral Research Fellowship to develop a C. elegans research program, using the nematode as a model system for understanding the biology of multi-cellular organisms, including humans.

She is now a Senior Lecturer in the School, where she is continuing to expand and develop the nematode model system to study aspects of gene regulation in development and disease. Current projects focus on neuronal development and neuronal aging.

Dr Nicholas also currently co-ordinates the School's Honours program, ensuring a first class learning experience for our fourth year students. She is also the School's TSP and Summer Scholarship co-ordinator.

Research interests

Hannah Nicholas is a Senior Lecturer in Molecular Biology who uses the nematode C. elegans as a model organism in which to investigate mechanisms of gene regulation in development and disease, with a focus on the nervous system.

Her group is investigating aspects of neuronal development and also studying the process of neuronal aging. As humans (and worms) age, physical changes occur in the nervous system that are linked to a progressive impairment of cognitive function. We have discovered that a nematode protein called PTL-1 is required for maintaining the integrity of neurons during aging and is also required for normal lifespan. PTL-1 is homologous to a human protein called Tau, which is implicated in the pathogenesis of Alzheimer’s disease and other neurodegenerative diseases. We are now investigating the mechanism by which PTL-1 contributes to neuronal aging and longevity.

Although most of our work is done using the nematode as a model organism, the discoveries we make in the worm will also shed light on mechanisms that are similarly important for normal human development and for the prevention of disease.

Teaching and supervision

Hannah Nicholas is involved in teaching intermediate and senior units of study in Molecular Biology and Genetics and Biochemistry. Hannah also co-ordinates the School of Molecular Bioscience Honours program in Biochemistry and Microbiology as well as the Talented Student Programand Summer Scholarships.

Keywords

Nutrition and metabolism; Nervous system; Molecular biology; Genetics

Selected grants

2011

  • Identifying regulators of the DNA damage response and tumorigenesis using C. elegans; Nicholas H, Crossley M; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Package for biolistic delivery; Goetz J, Carter D, Ittner L, Nicholas H, Schonrock N, Ke Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Applied Biosystems 7500 Fast Real Time PCR system; Campbell I, Crossley P, Brand-Miller J, Caterson I, Hall R, Weiss A, Conigrave A, Mackay J, Matthews J, Sunde M, Gell D, Bell-Anderson K, Nicholas H, Crossett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The transcriptional co-repressor C-terminal Binding Protein (CtBP) in metabolic control; Nicholas H, Crossley P, Crossley M; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • The transcriptional co-repressor C-Terminal Binding Protein (CtBP) from C. elegans: A model for inve; Nicholas H; University of Sydney/Bridging Support.

2006

  • Caenorhabditis elegans as a model for investigating the regulation of gene expression; Nicholas H; University of Sydney/PDF.
  • Caenorhabditis elegans as a model for investigating the regulation of gene expression; Nicholas H; University of Sydney/PDF.
  • Caenorhabditis elegans as a model for investigating the regulation of gene expression; Nicholas H; University of Sydney/Early Career Researcher.

Selected publications

Download citations: PDF RTF Endnote

Book Chapters

  • Goetz, J., Ittner, L., Goetz, N., Lam, H., Nicholas, H. (2011). Invertebrate and Vertebrate Models of Tauopathies. In J. Avila, J. J. Lucas and F. Hernandez (Eds.), Animal Models for Neurodegenerative Disease, (pp. 69-85). Cambridge, UK: RSC Publishing.

Journals

  • Liang, V., Ullrich, M., Lam, H., Chew, Y., Banister, S., Song, X., Zaw, T., Kassiou, M., Goetz, J., Nicholas, H. (2014). Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cellular and Molecular Life Sciences, 71(17), 3339-3361. [More Information]
  • Ullrich, M., Liang, V., Chew, Y., Banister, S., Song, X., Zaw, T., Lam, H., Berber, S., Kassiou, M., Nicholas, H., Goetz, J. (2014). Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nature Protocols, 9(9), 2237-2255. [More Information]
  • Chew, Y., Fan, X., Goetz, J., Nicholas, H. (2014). Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Scientific Reports, 4, 1-9. [More Information]
  • Yucel, D., Hoe, M., Llamosas, E., Kant, S., Jamieson, C., Young, P., Crossley, M., Nicholas, H. (2014). SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans. Developmental Biology, 392(2), 266-282. [More Information]
  • Chew, Y., Fan, X., Gotz, J., Nicholas, H. (2013). Aging in the nervous system of Caenorhabditis elegans. Communicative and Integrative Biology, 6(5), 1-6. [More Information]
  • Berber, S., Llamosas, E., Thaivalappil, P., Boag, P., Crossley, M., Nicholas, H. (2013). Homeodomain Interacting Protein Kinase (HPK-1) is Required in the Soma for Robust Germline Proliferation in C. elegans. Developmental Dynamics, 242(11), 1250-1261. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Chew, Y., Fan, X., Gotz, J., Nicholas, H. (2013). PTL-1 regulates neuronal integrity and lifespan in C. elegans. Journal of Cell Science, 126(9), 2079-2091. [More Information]
  • Goetz, J., Xia, D., Leinenga, G., Chew, Y., Nicholas, H. (2013). What renders TAU toxic. Frontiers in Neurology, 4(72), 1-10. [More Information]
  • Nicholas, H., Hodgkin, J. (2009). The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum. Developmental Biology, 329, 16-24. [More Information]
  • Eaton, S., Funnell, A., Sue, N., Nicholas, H., Pearson, R., Crossley, P. (2008). A network of Kruppel-like Factors (Klfs): Klf8 is repressed by Klf3 and activated by Klf1 in vivo. Journal of Biological Chemistry, 283(40), 26937-26947. [More Information]
  • Nicholas, H., Lowry, J., Wu, T., Crossley, P. (2008). The Caenorhabditis elegans Protein CTBP-1 Defines a New Group of THAP Domain-Containing CtBP Corepressors. Journal of Molecular Biology, 375, 1-11. [More Information]
  • Liew, C., Crossley, P., Mackay, J., Nicholas, H. (2006). Solution Structure of the THAP Domain from Caenorhabditis elegans C-terminal Binding Protein (CtBP). Journal of Molecular Biology, 366(2), 382-390. [More Information]
  • Gravato-Nobre, M., Nicholas, H., Nijland, R., O'Rourke, D., Whittington, D., Yook, K., Hodgkin, J. (2005). Multiple genes affect sensitivity of Caenorhabditis elegans to the bacterial pathogen Microbacterium nematophilum. Genetics, 171(3), 1033-1045.
  • Nicholas, H., Hodgkin, J. (2004). Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Molecular Immunology, 41(5), 479-493.
  • Nicholas, H., Hodgkin, J. (2004). The ERK MAP kinase cascade mediates tail-swelling and a protective response to rectal infection in C. elegans. Current Biology, 14(14), 1256-1261. [More Information]
  • Turner, J., Nicholas, H., Bishop, D., Matthews, J., Crossley, P. (2003). The LIM protein FHL3 binds basic Kruppel-like factor/Kruppel-like factor 3 and its co-repressor C-teminal-binding protein 2. Journal of Biological Chemistry, 278(15), 12786-12795.
  • Nicholas, H., Hodgkin, J. (2002). Innate Immunity: The worm fights back. Current Biology, 12(21), R731-R732.

2014

  • Liang, V., Ullrich, M., Lam, H., Chew, Y., Banister, S., Song, X., Zaw, T., Kassiou, M., Goetz, J., Nicholas, H. (2014). Altered proteostasis in aging and heat shock response in C. elegans revealed by analysis of the global and de novo synthesized proteome. Cellular and Molecular Life Sciences, 71(17), 3339-3361. [More Information]
  • Ullrich, M., Liang, V., Chew, Y., Banister, S., Song, X., Zaw, T., Lam, H., Berber, S., Kassiou, M., Nicholas, H., Goetz, J. (2014). Bio-orthogonal labeling as a tool to visualize and identify newly synthesized proteins in Caenorhabditis elegans. Nature Protocols, 9(9), 2237-2255. [More Information]
  • Chew, Y., Fan, X., Goetz, J., Nicholas, H. (2014). Regulation of age-related structural integrity in neurons by protein with tau-like repeats (PTL-1) is cell autonomous. Scientific Reports, 4, 1-9. [More Information]
  • Yucel, D., Hoe, M., Llamosas, E., Kant, S., Jamieson, C., Young, P., Crossley, M., Nicholas, H. (2014). SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans. Developmental Biology, 392(2), 266-282. [More Information]

2013

  • Chew, Y., Fan, X., Gotz, J., Nicholas, H. (2013). Aging in the nervous system of Caenorhabditis elegans. Communicative and Integrative Biology, 6(5), 1-6. [More Information]
  • Berber, S., Llamosas, E., Thaivalappil, P., Boag, P., Crossley, M., Nicholas, H. (2013). Homeodomain Interacting Protein Kinase (HPK-1) is Required in the Soma for Robust Germline Proliferation in C. elegans. Developmental Dynamics, 242(11), 1250-1261. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Chew, Y., Fan, X., Gotz, J., Nicholas, H. (2013). PTL-1 regulates neuronal integrity and lifespan in C. elegans. Journal of Cell Science, 126(9), 2079-2091. [More Information]
  • Goetz, J., Xia, D., Leinenga, G., Chew, Y., Nicholas, H. (2013). What renders TAU toxic. Frontiers in Neurology, 4(72), 1-10. [More Information]

2011

  • Goetz, J., Ittner, L., Goetz, N., Lam, H., Nicholas, H. (2011). Invertebrate and Vertebrate Models of Tauopathies. In J. Avila, J. J. Lucas and F. Hernandez (Eds.), Animal Models for Neurodegenerative Disease, (pp. 69-85). Cambridge, UK: RSC Publishing.

2009

  • Nicholas, H., Hodgkin, J. (2009). The C. elegans Hox gene egl-5 is required for correct development of the hermaphrodite hindgut and for the response to rectal infection by Microbacterium nematophilum. Developmental Biology, 329, 16-24. [More Information]

2008

  • Eaton, S., Funnell, A., Sue, N., Nicholas, H., Pearson, R., Crossley, P. (2008). A network of Kruppel-like Factors (Klfs): Klf8 is repressed by Klf3 and activated by Klf1 in vivo. Journal of Biological Chemistry, 283(40), 26937-26947. [More Information]
  • Nicholas, H., Lowry, J., Wu, T., Crossley, P. (2008). The Caenorhabditis elegans Protein CTBP-1 Defines a New Group of THAP Domain-Containing CtBP Corepressors. Journal of Molecular Biology, 375, 1-11. [More Information]

2006

  • Liew, C., Crossley, P., Mackay, J., Nicholas, H. (2006). Solution Structure of the THAP Domain from Caenorhabditis elegans C-terminal Binding Protein (CtBP). Journal of Molecular Biology, 366(2), 382-390. [More Information]

2005

  • Gravato-Nobre, M., Nicholas, H., Nijland, R., O'Rourke, D., Whittington, D., Yook, K., Hodgkin, J. (2005). Multiple genes affect sensitivity of Caenorhabditis elegans to the bacterial pathogen Microbacterium nematophilum. Genetics, 171(3), 1033-1045.

2004

  • Nicholas, H., Hodgkin, J. (2004). Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Molecular Immunology, 41(5), 479-493.
  • Nicholas, H., Hodgkin, J. (2004). The ERK MAP kinase cascade mediates tail-swelling and a protective response to rectal infection in C. elegans. Current Biology, 14(14), 1256-1261. [More Information]

2003

  • Turner, J., Nicholas, H., Bishop, D., Matthews, J., Crossley, P. (2003). The LIM protein FHL3 binds basic Kruppel-like factor/Kruppel-like factor 3 and its co-repressor C-teminal-binding protein 2. Journal of Biological Chemistry, 278(15), 12786-12795.

2002

  • Nicholas, H., Hodgkin, J. (2002). Innate Immunity: The worm fights back. Current Biology, 12(21), R731-R732.

To update your profile click here. For support on your academic profile contact .