Professor Iain Campbell

Head of School and Chair, Molecular Biology

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 4676
Fax +61 2 9351 5858

Website Related website

Biographical details

Iain Campbell grew up in Dee Why on the northern beaches of Sydney, Australia and obtained his graduate (1979) and doctoral (1982) degrees in Science from the University of Sydney. After a short postdoctoral period in Britain and Sweden, Iain returned to the Royal Melbourne Hospital in 1982 and then moved to the Walter and Eliza Hall Institute in 1985. In 1989, he left Australia¿s shores to do a sabbatical at the Scripps Research Institute in San Diego, USA and that is where he remained for over 14 years as a US National Institutes of Health (NIH)-funded biomedical research scientist and a Professor in the Department of Neuropharmacology. In January of 2004, Iain returned to Australia to take on a new challenge as Chair of Molecular Biology within the School of Molecular Bioscience at the University of Sydney.

Research interests

The overall goal of our research is to understand the molecular and cellular basis of host defense and immunoinflammatory processes that contribute to disease in the central nervous system. During my time at Scripps our research was responsible for the development of a number of unique functional genomics approaches including the generation of novel transgenicmodeling strategies to express key proinflammatory and anti-microbial cytokine genes specifically in astrocytes in the CNS. The results of this research have considerably advanced knowledge of the causal role of cytokines and chemokines in inflammation and neurological disease and unraveled key mechanisms that control how these potent biological response modifiers communicate in the CNS to modulate cellular function and how this translates into altered behavior. Since relocating to Sydney and with the support of NIH and NHMRC funding the focus of our work has continued in this area.

Keywords

Virology; Multiple sclerosis; Inflammation; Autoimmunity; Infection and immunity

Honours project opportunities

  • Changes in gene expression in neurons and microglia in WNV encephalitis
  • Infiltrating leukocytes in WNV encephalitis - their role in mortality

International links

Germany

(Professors Rose-John and Scheller, University of Kiel) Research collaboration investigating IL-6 trans-signalling in central nervous system inflammation and injury

Spain

(Professors Castellano, Gonzalez and Hidalgo, Autonomous University of Barcelona) Research collaboration studying the mechanisms of IL-6-induced inflammation and injury in the central nervous system

Selected grants

2015

  • Regulation of pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) expression and release in astrocytes from GFAP-Interleukin-6 and GFAP-Interferon-alpha transgenic mice; Castorina A, Campbell I; DVC Research/International Research Collaboration Award (IRCA).

2014

  • A CyTOF for the NSW Advanced Cytometry Facility - clean multidimensional multiparametric flow cytometry using single cell mass spectrometry; King N, Campbell I, Fazekas B, Cordwell S, Rendina L, Gunning P, Crossley M, Davenport M, Hogg P, Pimanda J, Goldys E, Jin D, Molloy M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2013

  • The regulation and function of strawberry notch in neuroinflammation; Campbell I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Nanotemper: State-of-the-art instrumentation for the characterization of protein interactions; Payne R, Matthews J, Ataide S, Campbell I, Weiss A, Sunde M, Mackay J; Clive and Vera Ramaciotti Foundations/Awards for Biomedical Research: Major Equipment.

2012

  • Integrated Facility for Confocal Imaging and Single Molecule Fluorescence Analysis; Yerbury J, Olsson M, Sunde M, Campbell I, Truscott R; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2011

  • Role of IRF8 in central nervous system glial cell function; Campbell I; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Interleukin-6 /gp130 signaling and actions in the CNS; Campbell I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Next-generation high-speed flow cytometric cell sorter; Fazekas B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Interleukin-6 /gp130 signaling and actions in the CNS; Campbell I; DVC Research/Bridging Support Grant.
  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Applied Biosystems 7500 Fast Real Time PCR system; Campbell I, Crossley P, Brand-Miller J, Caterson I, Hall R, Weiss A, Conigrave A, Mackay J, Matthews J, Sunde M, Gell D, Bell-Anderson K, Nicholas H, Crossett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Mechanisms of central nervous system disease induced by dysrgulated inerferon signalling; Campbell I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Lipocalin 2 in host defence of the central nervous system; Campbell I, King N, Richardson D; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Immunopathological role of monocyte/macrophages in flavivirus encephalitis; King N, Campbell I; National Health and Medical Research Council (NHMRC)/Project Grants.

2006

  • Advanced Imaging Flow Cytometry Facility for NSW; King N, Campbell I, Cook D, Black J, Halliday G, McAvoy J, Gunning P, Pollard J, Murray M, Britton W, Dawes I, Khachigian L, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Signal transduction mechanisms in Interleukin-6-induced inflammation and injury in the central nervous system; Campbell I; NSW Ministry of Science and Medical Research/Spinal Cord Injury Research Grants Program.

2004

  • IFN-ALPHA and HIV GP120 IN Neuro AIDS Studies; Campbell I; NIH - Intstitute of Mental Health/Research Grant.
  • CNS Pathobiology of IFN-inducible non-ELR CXC Chemokines; Campbell I; NIH - Intstitute of Mental Health/Research Grant.
  • Interleukin 12 in inflammatory neurological diseases.; Campbell I; NIH - Intstitute of Mental Health/Research Grant.

Selected publications

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Book Chapters

  • Campbell, I., Owens, T. (2005). Animal models of neuroimmunologic disease. In J. Antel, G. Birnbaum, H-P. Hartung and A. Vincent (Eds.), Clinical Neuroimmunology, (pp. 129-146). United Kingdom: Oxford University Press.
  • Campbell, I., Asensio, V. (2002). Insights from transgenic and knockout mice [Chapter 38]. In R.M. Ransohoff, K. Suzuki, A.E.I. Proudfoot, W.F. Hickey, J.K. Harrison (Eds.), Universes in delicate balance: chemokines and the nervous system, (pp. 225-233). United States: Elsevier.
  • Asensio, V., Campbell, I. (2001). Chemokines and viral diseases of the central nervous system. In Michael J. Buchmeier and Iain L. Campbell (Eds.), Neurovirology: Viruses and the Brain, (pp. 127-173). United States: Academic Press Elsevier.
  • Campbell, I. (2001). Cytokine-mediated inflammation and signaling in the intact central nervous system. In B. Castellano Lopez and M. Nieto-Sampedro (Eds.), Glial Cell Function, (pp. 481-489). Amsterdam: Elsevier Science.

Journals

  • Li, W., Hofer, M., Jung, S., Lim, S., Campbell, I. (2014). IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus. Journal of Virology, 88(13), 7578-7588. [More Information]
  • Nocon, A., Ip, J., Terry, R., Lim, S., Getts, D., Muller, M., Hofer, M., King, N., Campbell, I. (2014). The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west nile virus encephalitis. Journal of Virology, 88(1), 679-689. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]
  • Campbell, I., Erta, M., Lim, S., Frausto, R., May, U., Rose-John, S., Scheller, J., Hidalgo, J. (2014). Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain. The Journal of Neuroscience, 34(7), 2503-2513. [More Information]
  • Zimmermann, J., Krauthausen, M., Hofer, M., Heneka, M., Campbell, I., Muller, M. (2013). CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia. PLoS One, 8(2), 1-13. [More Information]
  • Roberts, K., Zeineddine, R., Corcoran, L., Li, W., Campbell, I., Yerbury, J. (2013). Extracellular Aggregated Cu/Zn Superoxide Dismutase Activates Microglia to Give a Cytotoxic Phenotype. Glia, 61(3), 409-419. [More Information]
  • Giralt, M., Ramos, R., Quintana, A., Ferrer, B., Erta, M., Castro-Freire, M., Comes, G., Sanz, E., Unzeta, M., Pifarre, P., Campbell, I., et al (2013). Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6. Glia, 61(4), 587-600. [More Information]
  • Li, W., Hofer, M., Nocon, A., Manders, P., Campbell, I. (2013). Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. Virology, 439(2), 152-162. [More Information]
  • Hofer, M., Campbell, I. (2013). Type I interferon in neurological disease-The devil from within. Cytokine and Growth Factor Reviews, 24(3), 257-267. [More Information]
  • Minten, C., Terry, R., Deffrasnes, C., King, N., Campbell, I. (2012). IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS. PLoS One, 7(11), 1-11. [More Information]
  • Terry, R., Getts, D., Deffrasnes, C., Van Vreden, C., Campbell, I., King, N. (2012). Inflammatory monocytes and the pathogenesis of viral encephalitis. Journal of Neuroinflammation, 9, 1-10. [More Information]
  • Hofer, M., Li, W., Manders, P., Terry, R., Lim, S., King, N., Campbell, I. (2012). Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Journal of Virology, 86(12), 6932-6946. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Deffrasnes, C., Ashhurst, T., Radford, J., Hofer, M., Thomas, S., Campbell, I., King, N. (2012). Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages. Journal of Neuroinflammation, 9(1), 1-8. [More Information]
  • Ip, J., Nocon, A., Hofer, M., Lim, S., Müller, M., Campbell, I. (2011). Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Journal of Neuroinflammation, 8(124), 1-15. [More Information]
  • Krauthausen, M., Ellis, S., Zimmermann, J., Sarris, M., Wakefield, D., Heneka, M., Campbell, I., Müller, M. (2011). Opposing Roles for CXCR3 Signaling in Central Nervous System Versus Ocular Inflammation Mediated by the Astrocyte-Targeted Production of IL-12. The American Journal of Pathology: cellular and molecular biology of disease, 179(5), 2346-2359. [More Information]
  • Thompson, C., Hofer, M., Campbell, I., Holmes, A. (2010). Community Dynamics in the Mouse Gut Microbiota: A Possible Role for IRF9-Regulated Genes in Community Homeostasis. PLoS One, 5(4), e10335-1-e10335-9. [More Information]
  • Muller, M., Carter, S., Hofer, M., Campbell, I. (2010). Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum. Neuropathology and Applied Neurobiology, 36(5), 368-387. [More Information]
  • Ellis, S., Gysbers, V., Manders, P., Li, W., Hofer, M., Muller, M., Campbell, I. (2010). The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-{gamma} in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1. Journal of Immunology, 185(3), 1864-1877. [More Information]
  • Hofer, M., Li, W., Lim, S., Campbell, I. (2010). The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. The Journal of Neuroscience, 30(3), 1149-1157. [More Information]
  • Campbell, I., Hofer, M., Pagenstecher, A. (2010). Transgenic models for cytokine-induced neurological disease. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802 (10), 903-917. [More Information]
  • Quintana, A., Muller, M., Frausto, R., Ramos, R., Getts, D., Sanz, E., Hofer, M., Krathausen, M., King, N., Hildago, J., Campbell, I. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enchances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 183(3), 2079-2088. [More Information]
  • Feuer, R., Ruller, C., An, N., Tabor-Godwin, J., Rhoades, R., Maciejewski, S., Pagarigan, R., Cornell, C., Crocker, S., Kiosses, W., Campbell, I., et al (2009). Viral Persistence and Chronic Immunopathology in the Adult Central Nervous System following Coxsackievirus Infection during the Neonatal Period. Journal of Virology, 83(18), 9356-9369. [More Information]
  • Miu, J., Mitchell, A., Muller, M., Carter, S., Manders, P., McQuillan, J., Saunders, B., Ball, H., Lu, B., Campbell, I., Hunt, N. (2008). Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of Immunology, 180(2), 1217-1230. [More Information]
  • Quintana, A., Molinero, A., Borup, R., Nielsen, F., Campbell, I., Penkowa, M., Hidalgo, J. (2008). Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Developmental Neurobiology, 68(2), 195-208. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I., King, N. (2008). Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. The Journal of Experimental Medicine, 205(10), 2319-2337. [More Information]
  • Sanz, E., Hofer, M., Unzeta, M., Campbell, I. (2008). Minimal Role for STAT1 in Interleukin-6 Signaling and Actions in the Murine Brain. Glia, 56(2), 190-199. [More Information]
  • Wang, J., Campbell, I., Zhang, H. (2008). Systemic interferon-alpha regulates interferon-stimulated genes in the central nervous system. Molecular Psychiatry, 13(3), 293-301. [More Information]
  • Hofer, M., Carter, S., Muller, M., Campbell, I. (2008). Unaltered Neurological Disease and Mortality in CXCR3-Deficient Mice Infected Intracranially with Lymphocytic Choriomeningitis Virus-Armstrong. Viral Immunology, 21(4), 425-433. [More Information]
  • Muller, M., Carter, S., Hofer, M., Manders, P., Getts, D., Getts, M., Dreykluft, A., Lu, B., Gerard, C., King, N., Campbell, I. (2007). CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. Journal of Immunology, 179(5), 2774-2786. [More Information]
  • Quintana, A., Molinero, A., Florit, S., Manso, Y., Comes, G., Carrasco, J., Giralt, M., Borup, R., Nielsen, F., Campbell, I., et al (2007). Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior. Journal of Neuroscience Research, 85(12), 2668-2685. [More Information]
  • Millward, J., Caruso, M., Campbell, I., Gauldie, J., Owens, T. (2007). IFN-γ-Induced Chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system. Journal of Immunology, 178(12), 8175-8182. [More Information]
  • Millward, J., Caruso, M., Campbell, I., Gauldie, J., Owens, T. (2007). IFN-γ-Induced Chemokines Synergize with Pertussis Toxin to Promote T Cell Entry to the Central Nervous System. Journal of Immunology, 178(12), 8175-8182.
  • Carter, S., Muller, M., Manders, P., Campbell, I. (2007). Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro. Glia, 55(16), 1728-1739. [More Information]
  • Getts, D., Matsumoto, I., Muller, M., Getts, M., Radford, J., Shrestha, B., Campbell, I., King, N. (2007). Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures. Journal of Neurochemistry, 103(3), 1019-1030. [More Information]
  • Sanz, E., Hofer, M., Unzeta, M., Campbell, I. (2007). STAT1 has a minimal role in interleukin-6 signalling and actions in the murine brain. Journal of Interferon and Cytokine Research, 27(8), 722-722. [More Information]
  • Crocker, S., Milner, R., Pham-Mitchell, N., Campbell, I. (2006). Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells. Journal of Neurochemistry, 98(3), 812-823.
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated regulation and widespread cellular expression of the interferon-stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Carr, D., Campbell, I. (2006). Herpes Simplex Virus Type 1 Induction of Chemokine Production Is Unrelated to Viral Load in the Cornea But Not in the Nervous System. Viral Immunology, 19(4), 741-746. [More Information]
  • Milner, R., Campbell, I. (2006). Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system. Molecular and Cellular Neuroscience, 33(4), 429-440. [More Information]
  • Crocker, S., Whitmire, J., Frausto, R., Chertboonmuang, P., Soloway, P., Whitton, J., Campbell, I. (2006). Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. The American Journal of Pathology: cellular and molecular biology of disease, 169(6), 2104-2116.
  • Zirger, J., Barcia, C., Liu, C., Puntel, M., Mitchell, N., Campbell, I., Castro, M., Lowenstein, P. (2006). Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 10(8) international units, but not lower doses, of adenoviral vectors into the brain. Journal of Virology, 80(11), 5655-5659.
  • Campbell, I. (2005). Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS. Brain Research Reviews, 48(2), 166-177. [More Information]
  • Ousman, S., Wang, J., Campbell, I. (2005). Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. Journal of Virology, 79(12), 7514-7527. [More Information]
  • Quintana, A., Giralt, M., Rojas, S., Penkowa, M., Campbell, I., Hidalgo, J., Molinero, A. (2005). Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. Journal of Neuroscience Research, 82(5), 701-716. [More Information]
  • Reiman, R., Torres, A., Martin, B., Ting, J., Campbell, I., Barnum, S. (2005). Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis. Neuroscience Letters, 390(3), 134-138. [More Information]
  • Wang, J., Campbell, I. (2005). Innate STAT1-Dependent Genomic Response of Neurons to the Antiviral Cytokine Alpha Interferon. Journal of Virology, 79(13), 8295-8302. [More Information]
  • Ousman, S., Campbell, I. (2005). Regulation of murine interferon regulatory factor (IRF) gene expression in the central nervous system determined by multiprobe RNase protection assay. Methods in molecular medicine, 116, 115-134. [More Information]
  • Carr, D., Tomanek, L., Silverman, R., Campbell, I., Williams, B. (2005). RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2. Journal of Virology, 79(14), 9341-9345. [More Information]
  • Balosso, S., Ravizza, T., Perego, C., Peschon, J., Campbell, I., Simoni, M., Vezzani, A. (2005). Tumor necrosis factor-α inhibits seizures in mice via p75 receptors. Annals of Neurology, 57(6), 804-812. [More Information]
  • Vlkolinsky, R., Siggins, G., Campbell, I., Krucker, T. (2004). Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices. Journal of Neuroimmunology, 150(1-2), 37-47. [More Information]
  • Sanchez-Burgos, G., Hernandez-Pando, R., Campbell, I., Ramos-Castaneda, J., Ramos, C. (2004). Cytokine production in brain of mice experimentally infected with dengue virus. NeuroReport, 15(1), 37-42.
  • Boos, L., Campbell, I., Ames, R., Wetsel, R., Barnum, S. (2004). Deletion Of The Complement Anaphylatoxin C3a Receptor Attenuates, Whereas Ectopic Expression Of C3a In The Brain Exacerbates, Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 173(7), 4708-4714.
  • Zirger, J., Barcia, C., Liu, C., Puntel, M., Sitia, G., Guidotti, L., Mitchell, N., Campbell, I., Castro, M., Lowenstein, P. (2004). Immune System Regulation Of Transgene Expression In The Brain 2: Differential Increase Of Mrnas Encoding For Interferon-Regulated, Chemokine, And T-Cell Genes During Either Innate Acute Or Chronic Systemic Adaptive Immune Responses To First Generation Ade. Molecular Therapy, 9(S1), S390-S391.
  • Wang, J., Lin, W., Popko, B., Campbell, I. (2004). Inducible production of interferon-γ in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway. Molecular and Cellular Neuroscience, 27(4), 489-496.
  • Lin, W., Kemper, A., McCarthy, K., Pytel, P., Wang, J., Campbell, I., Utset, M., Popko, B. (2004). Interferon-γ Induced Medulloblastoma in the Developing Cerebellum. The Journal of Neuroscience, 24(45), 10074-10083.
  • Sitia, G., Isogawa, M., Iannacone, M., Campbell, I., Chisari, F., Guidotti, L. (2004). MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. Journal of Clinical Investigation, 113(8), 1158-1167.
  • Sanchez-Alavez, M., Gombart, L., Huitron-Resendiz, S., Carr, J., Wills, D., Berg, G., Campbell, I., Gauvin, D., Henriksen, S., Criado, J. (2004). Physiological and behavioral effects of methamphetamine in a mouse model of endotoxemia: a preliminary study. Pharmacology, Biochemistry and Behavior, 77(2), 365-370.
  • Crocker, S., Pagenstecher, A., Campbell, I. (2004). Review: The TIMPS tango with MMPs and more in the CNS. Journal of Neuroscience Research, 75(1), 1-11. [More Information]
  • Penkowa, M., Camats, J., Hadberg, H., Quintana, A., Rojas, S., Giralt, M., Molinero, A., Campbell, I., Hidalgo, J. (2003). Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. Journal of Neuroscience Research, 73(4), 481-496. [More Information]
  • Wang, J., Pham-Mitchell, N., Schindler, C., Campbell, I. (2003). Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-γ in the brain. Journal of Clinical Investigation, 112(4), 535-543.
  • Penkowa, M., Camats, J., Giralt, M., Molinero, A., Hernandez, J., Carrasco, J., Campbell, I., Hidalgo, J. (2003). Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia, 42(3), 287-306. [More Information]
  • Molinero, A., Hernandez, J., Penkowa, M., Camats, J., Giralt, M., Lago, N., Carrasco, J., Campbell, I., Hidalgo, J. (2003). Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Journal of Neuropathology and Experimental Neurology, 62(3), 315-328.
  • Samland, H., Huitron-Resendiz, S., Masliah, E., Criado, J., Henriksen, S., Campbell, I. (2003). Profound increase in the sensitivity to glutamatergic but not cholinergic agonist- induced seizures in transgenic mice with astrocyte production of IL-6. Journal of Neuroscience Research, 73, 176-187. [More Information]
  • Campbell, I. (2003). Review: Chemokines as plurifunctional mediators in the CNS: Implications for the pathogenesis of stroke. Ernst Schering Research Foundation Workshop, 45, 31-52.
  • Carrasco, J., Penkowa, M., Giralt, M., Camats, J., Molinero, A., Campbell, I., Palmiter, R., Hidalgo, J. (2003). Role of metallothionein-III following central nervous system damage. Neurobiology of Disease, 13, 22-36.
  • Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V., Campbell, I., DeArmond, S., Coon, B., Teng, C., et al (2003). T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies. Journal of Virology, 77(6), 3799-3808.
  • Milner, R., Campbell, I. (2003). The Extracellular Matrix and Cytokines Regulate Microglial Integrin Expression and Activation. Journal of Immunology, 170(7), 3850-3858.
  • Moore, T., Moore, J., Kaji, Y., Frizzell, N., Usui, T., Poulaki, V., Campbell, I., Stitt, A., Gardiner, T., Archer, D., et al (2003). The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis. Investigative Ophthalmology and Visual Science, 44(10), 4457-4464.
  • Kayali, A., Gunst, K., Campbell, I., Stotland, A., Kritzik, M., Liu, G., Flodstrom-Tulllberg, M., Zhang, Y., Sarvetnick, N. (2003). The stromal cell-derived factor-1#/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. The Journal of Cell Biology, 163(4), 859-869.
  • Freude, S., Hausmann, J., Hofer, M., Pham-Mitchell, N., Campbell, I., Staeheli, P., Pagenstecher, A. (2002). Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. Journal Of Clinical Virology, 76(23), 12223-122232.
  • Freude, S., Hausmann, J., Hofer, M., Pham-Mitchell, N., Campbell, I., Staeheli, P., Pagenstecher, A. (2002). Borna Disease Virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. Journal of Virology, 76(23), 12223-12232.
  • Strack, A., Asensio, V., Campbell, I., Schluter, D., Deckert, M. (2002). Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-γ. Acta Neuropathologica, 103, 458-468.
  • Milner, R., Campbell, I. (2002). Cytokines regulate microglial adhesion to laminin and astrocytes Extracellular Matrix via protein kinase C-dependent activation of the α6β1 integrin. The Journal of Neuroscience, 22(5), 1562-1572.
  • Milner, R., Campbell, I. (2002). Developmental regulation of β1 integrins during angiogenesis in the central nervous system. Molecular and Cellular Neuroscience, 20, 616-626.
  • Reiman, R., Gerard, C., Campbell, I., Barnum, S. (2002). Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis. European Journal of Immunology, 32, 1157-1163.
  • Boztug, K., Carson, M., Pham-Mitchell, N., Asensio, V., DeMartino, J., Campbell, I. (2002). Leukocyte infiltration but not neurodegeneration in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10. Journal of Immunology, 169, 1505-1515.
  • Giralt, M., Penkowa, M., Hernandez, J., Molinero, A., Carrasco, J., Lago, N., Camats, J., Campbell, I., Hidalgo, J. (2002). Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiology of Disease, 9, 319-338.
  • Vallieres, L., Campbell, I., Gage, F., Sawchenko, P. (2002). Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. The Journal of Neuroscience, 22(2), 486-492.
  • Maier, J., Kincaid, C., Pagenstecher, A., Campbell, I. (2002). Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis. The American Journal of Pathology: cellular and molecular biology of disease, 160(1), 271-288.
  • Strack, A., Schluter, D., Asensio, V., Campbell, I., Deckert, M. (2002). Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: Impact of host genetic factors. Glia, 40, 372-377.
  • Al-Khatib, K., Campbell, I., Carr, D. (2002). Resistance to ocular Herpes simplex virus type I infection in IL-12 transgenic mice. Journal of Neuroimmunology, 132, 41-48.
  • Campbell, I. (2002). Review: Cytokine mediated inflammation and other actions in the central nervous system. Ernst Schering Research Foundation Workshop, 39, 61-83.
  • Wang, J., Campbell, I. (2002). Review: Cytokine Signaling in the Brain: Putting a SOCS in It? Journal of Neuroscience Research, 67(4), 423-427.
  • Wang, J., Asensio, V., Campbell, I. (2002). Review: Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice. Current Topics in Microbiology and Immunology, 265, 23-48.
  • Milner, R., Campbell, I. (2002). Review: The Integrin Family of Cell Adhesion Molecules Has Multiple Functions Within The CNS. Journal of Neuroscience Research, 69(3), 286-291.
  • Wang, J., Schreiber, R., Campbell, I. (2002). STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-α in the central nervous system. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 99(25), 16209-16214.
  • Moore, J., McMullen, T., Campbell, I., Rohan, R., Kaji, Y., Afshari, N., Usui, T., Archer, D., Adamis, A. (2002). The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1RA gene therapy. Investigative Ophthalmology and Visual Science, 43(9), 2905-2915.
  • Carr, D., Ash, J., Al-Khatib, K., Campbell, I. (2002). Unforeseen consequences of IL-12 expression in the eye of GFAP-IL12 transgenic mice following Herpes Simplex virus type I infection. DNA and Cell Biology, 21(5-6), 467-473.
  • Murtaza, A., Nugent, C., Tailor, P., Asensio, V., Biggs, J., Campbell, I., Sherman, L. (2001). Altered functional and biochemical response by CD8(+) T cells that remain after tolerance. International Immunology, 13, 1085-1093.
  • Giralt, M., Carrasco, J., Penkowa, M., Angel Morcillo, M., Santamaria, J., Campbell, I., Hidalgo, J. (2001). Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain. Experimental Neurology, 168, 334-346.
  • Kakimi, K., lane, T., Wieland, S., Asensio, V., Campbell, I., Chisari, F., Guidotti, L. (2001). Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. The Journal of Experimental Medicine, 194, 1755-1766.
  • Pagenstecher, A., wussler, E., Opdenakker, G., Volk, B., Campbell, I. (2001). Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors. Journal of Neuropathology and Experimental Neurology, 60, 598-612.
  • Lassmann, S., Kincaid, C., Asensio, V., Campbell, I. (2001). Induction of type-I immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12. Journal of Immunology, 167, 5485-5493.
  • Asensio, V., Maier, J., Milner, R., Boztug, K., Kincaid, C., moulard, M., Phillipson, C., Lindsley, K., Krucker, T., Fox, H., Campbell, I. (2001). Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro. Journal of Virology, 75(15), 7067-7077.
  • Swartz, K., Liu, F., Sewell, D., schochet, T., Campbell, I., Sandor, D., Fabry, Z. (2001). Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Research, 896(1-2), 86-95.

Edited Journals

  • Buchmeier, M., Campbell, I. (2001). Advances in Virus Research Vol 56. Advances in Virus Research, 56.

Conferences

  • Hofer, M., Mueller, M., O'Sullivan, C., Manders, P., Campbell, I. (2007). Lethal lymphocytic choriomeningitis virus (LCMV) infection in STAT1 KO mice is associated with dysregulated PD-1/B7-H1 and a phenotypic switch in the T-cell response. International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (ISICR 2007), United Kingdom: Mary Ann Liebert Inc. Publishers.

Reference Works

  • Campbell, I. (2003). The chemokines. In Michael Aminoff, Robert Daroff (Eds.), Encyclopedia of the Neurological Sciences. (pp. 686-691). Netherlands: Elsevier Science.

2014

  • Li, W., Hofer, M., Jung, S., Lim, S., Campbell, I. (2014). IRF7-Dependent Type I Interferon Production Induces Lethal Immune-Mediated Disease in STAT1 Knockout Mice Infected with Lymphocytic Choriomeningitis Virus. Journal of Virology, 88(13), 7578-7588. [More Information]
  • Nocon, A., Ip, J., Terry, R., Lim, S., Getts, D., Muller, M., Hofer, M., King, N., Campbell, I. (2014). The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with west nile virus encephalitis. Journal of Virology, 88(1), 679-689. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]
  • Campbell, I., Erta, M., Lim, S., Frausto, R., May, U., Rose-John, S., Scheller, J., Hidalgo, J. (2014). Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain. The Journal of Neuroscience, 34(7), 2503-2513. [More Information]

2013

  • Zimmermann, J., Krauthausen, M., Hofer, M., Heneka, M., Campbell, I., Muller, M. (2013). CNS-Targeted Production of IL-17A Induces Glial Activation, Microvascular Pathology and Enhances the Neuroinflammatory Response to Systemic Endotoxemia. PLoS One, 8(2), 1-13. [More Information]
  • Roberts, K., Zeineddine, R., Corcoran, L., Li, W., Campbell, I., Yerbury, J. (2013). Extracellular Aggregated Cu/Zn Superoxide Dismutase Activates Microglia to Give a Cytotoxic Phenotype. Glia, 61(3), 409-419. [More Information]
  • Giralt, M., Ramos, R., Quintana, A., Ferrer, B., Erta, M., Castro-Freire, M., Comes, G., Sanz, E., Unzeta, M., Pifarre, P., Campbell, I., et al (2013). Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6. Glia, 61(4), 587-600. [More Information]
  • Li, W., Hofer, M., Nocon, A., Manders, P., Campbell, I. (2013). Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. Virology, 439(2), 152-162. [More Information]
  • Hofer, M., Campbell, I. (2013). Type I interferon in neurological disease-The devil from within. Cytokine and Growth Factor Reviews, 24(3), 257-267. [More Information]

2012

  • Minten, C., Terry, R., Deffrasnes, C., King, N., Campbell, I. (2012). IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS. PLoS One, 7(11), 1-11. [More Information]
  • Terry, R., Getts, D., Deffrasnes, C., Van Vreden, C., Campbell, I., King, N. (2012). Inflammatory monocytes and the pathogenesis of viral encephalitis. Journal of Neuroinflammation, 9, 1-10. [More Information]
  • Hofer, M., Li, W., Manders, P., Terry, R., Lim, S., King, N., Campbell, I. (2012). Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Journal of Virology, 86(12), 6932-6946. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Deffrasnes, C., Ashhurst, T., Radford, J., Hofer, M., Thomas, S., Campbell, I., King, N. (2012). Targeted blockade in lethal West Nile virus encephalitis indicates a crucial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages. Journal of Neuroinflammation, 9(1), 1-8. [More Information]

2011

  • Ip, J., Nocon, A., Hofer, M., Lim, S., Müller, M., Campbell, I. (2011). Lipocalin 2 in the central nervous system host response to systemic lipopolysaccharide administration. Journal of Neuroinflammation, 8(124), 1-15. [More Information]
  • Krauthausen, M., Ellis, S., Zimmermann, J., Sarris, M., Wakefield, D., Heneka, M., Campbell, I., Müller, M. (2011). Opposing Roles for CXCR3 Signaling in Central Nervous System Versus Ocular Inflammation Mediated by the Astrocyte-Targeted Production of IL-12. The American Journal of Pathology: cellular and molecular biology of disease, 179(5), 2346-2359. [More Information]

2010

  • Thompson, C., Hofer, M., Campbell, I., Holmes, A. (2010). Community Dynamics in the Mouse Gut Microbiota: A Possible Role for IRF9-Regulated Genes in Community Homeostasis. PLoS One, 5(4), e10335-1-e10335-9. [More Information]
  • Muller, M., Carter, S., Hofer, M., Campbell, I. (2010). Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity - a tale of conflict and conundrum. Neuropathology and Applied Neurobiology, 36(5), 368-387. [More Information]
  • Ellis, S., Gysbers, V., Manders, P., Li, W., Hofer, M., Muller, M., Campbell, I. (2010). The Cell-Specific Induction of CXC Chemokine Ligand 9 Mediated by IFN-{gamma} in Microglia of the Central Nervous System Is Determined by the Myeloid Transcription Factor PU.1. Journal of Immunology, 185(3), 1864-1877. [More Information]
  • Hofer, M., Li, W., Lim, S., Campbell, I. (2010). The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. The Journal of Neuroscience, 30(3), 1149-1157. [More Information]
  • Campbell, I., Hofer, M., Pagenstecher, A. (2010). Transgenic models for cytokine-induced neurological disease. Biochimica et Biophysica Acta-Molecular Basis of Disease, 1802 (10), 903-917. [More Information]

2009

  • Quintana, A., Muller, M., Frausto, R., Ramos, R., Getts, D., Sanz, E., Hofer, M., Krathausen, M., King, N., Hildago, J., Campbell, I. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enchances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 183(3), 2079-2088. [More Information]
  • Feuer, R., Ruller, C., An, N., Tabor-Godwin, J., Rhoades, R., Maciejewski, S., Pagarigan, R., Cornell, C., Crocker, S., Kiosses, W., Campbell, I., et al (2009). Viral Persistence and Chronic Immunopathology in the Adult Central Nervous System following Coxsackievirus Infection during the Neonatal Period. Journal of Virology, 83(18), 9356-9369. [More Information]

2008

  • Miu, J., Mitchell, A., Muller, M., Carter, S., Manders, P., McQuillan, J., Saunders, B., Ball, H., Lu, B., Campbell, I., Hunt, N. (2008). Chemokine gene expression during fatal murine cerebral malaria and protection due to CXCR3 deficiency. Journal of Immunology, 180(2), 1217-1230. [More Information]
  • Quintana, A., Molinero, A., Borup, R., Nielsen, F., Campbell, I., Penkowa, M., Hidalgo, J. (2008). Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome. Developmental Neurobiology, 68(2), 195-208. [More Information]
  • Getts, D., Terry, R., Getts, M., Muller, M., Rana, S., Shrestha, B., Radford, J., Van Rooijen, N., Campbell, I., King, N. (2008). Ly6c+ "inflammatory monocytes" are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis. The Journal of Experimental Medicine, 205(10), 2319-2337. [More Information]
  • Sanz, E., Hofer, M., Unzeta, M., Campbell, I. (2008). Minimal Role for STAT1 in Interleukin-6 Signaling and Actions in the Murine Brain. Glia, 56(2), 190-199. [More Information]
  • Wang, J., Campbell, I., Zhang, H. (2008). Systemic interferon-alpha regulates interferon-stimulated genes in the central nervous system. Molecular Psychiatry, 13(3), 293-301. [More Information]
  • Hofer, M., Carter, S., Muller, M., Campbell, I. (2008). Unaltered Neurological Disease and Mortality in CXCR3-Deficient Mice Infected Intracranially with Lymphocytic Choriomeningitis Virus-Armstrong. Viral Immunology, 21(4), 425-433. [More Information]

2007

  • Muller, M., Carter, S., Hofer, M., Manders, P., Getts, D., Getts, M., Dreykluft, A., Lu, B., Gerard, C., King, N., Campbell, I. (2007). CXCR3 Signaling Reduces the Severity of Experimental Autoimmune Encephalomyelitis by Controlling the Parenchymal Distribution of Effector and Regulatory T Cells in the Central Nervous System. Journal of Immunology, 179(5), 2774-2786. [More Information]
  • Quintana, A., Molinero, A., Florit, S., Manso, Y., Comes, G., Carrasco, J., Giralt, M., Borup, R., Nielsen, F., Campbell, I., et al (2007). Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior. Journal of Neuroscience Research, 85(12), 2668-2685. [More Information]
  • Millward, J., Caruso, M., Campbell, I., Gauldie, J., Owens, T. (2007). IFN-γ-Induced Chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system. Journal of Immunology, 178(12), 8175-8182. [More Information]
  • Millward, J., Caruso, M., Campbell, I., Gauldie, J., Owens, T. (2007). IFN-γ-Induced Chemokines Synergize with Pertussis Toxin to Promote T Cell Entry to the Central Nervous System. Journal of Immunology, 178(12), 8175-8182.
  • Carter, S., Muller, M., Manders, P., Campbell, I. (2007). Induction of the genes for Cxcl9 and Cxcl10 is dependent on IFN-gamma but shows differential cellular expression in experimental autoimmune encephalomyelitis and by astrocytes and microglia in vitro. Glia, 55(16), 1728-1739. [More Information]
  • Hofer, M., Mueller, M., O'Sullivan, C., Manders, P., Campbell, I. (2007). Lethal lymphocytic choriomeningitis virus (LCMV) infection in STAT1 KO mice is associated with dysregulated PD-1/B7-H1 and a phenotypic switch in the T-cell response. International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (ISICR 2007), United Kingdom: Mary Ann Liebert Inc. Publishers.
  • Getts, D., Matsumoto, I., Muller, M., Getts, M., Radford, J., Shrestha, B., Campbell, I., King, N. (2007). Role of IFN-gamma in an experimental murine model of West Nile virus-induced seizures. Journal of Neurochemistry, 103(3), 1019-1030. [More Information]
  • Sanz, E., Hofer, M., Unzeta, M., Campbell, I. (2007). STAT1 has a minimal role in interleukin-6 signalling and actions in the murine brain. Journal of Interferon and Cytokine Research, 27(8), 722-722. [More Information]

2006

  • Crocker, S., Milner, R., Pham-Mitchell, N., Campbell, I. (2006). Cell and agonist-specific regulation of genes for matrix metalloproteinases and their tissue inhibitors by primary glial cells. Journal of Neurochemistry, 98(3), 812-823.
  • Wacher, C., Muller, M., Hofer, M., Getts, D., Zabaras, R., Ousman, S., Terenzi, F., Sen, G., King, N., Campbell, I. (2006). Coordinated regulation and widespread cellular expression of the interferon-stimulated genes (ISG)-49, ISG-54 and ISG-56 in the central nervous system following infection with distinct viruses. Journal of Virology, 81(2), 860-871. [More Information]
  • Carr, D., Campbell, I. (2006). Herpes Simplex Virus Type 1 Induction of Chemokine Production Is Unrelated to Viral Load in the Cornea But Not in the Nervous System. Viral Immunology, 19(4), 741-746. [More Information]
  • Milner, R., Campbell, I. (2006). Increased expression of the beta4 and alpha5 integrin subunits in cerebral blood vessels of transgenic mice chronically producing the pro-inflammatory cytokines IL-6 or IFN-alpha in the central nervous system. Molecular and Cellular Neuroscience, 33(4), 429-440. [More Information]
  • Crocker, S., Whitmire, J., Frausto, R., Chertboonmuang, P., Soloway, P., Whitton, J., Campbell, I. (2006). Persistent macrophage/microglial activation and myelin disruption after experimental autoimmune encephalomyelitis in tissue inhibitor of metalloproteinase-1-deficient mice. The American Journal of Pathology: cellular and molecular biology of disease, 169(6), 2104-2116.
  • Zirger, J., Barcia, C., Liu, C., Puntel, M., Mitchell, N., Campbell, I., Castro, M., Lowenstein, P. (2006). Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 10(8) international units, but not lower doses, of adenoviral vectors into the brain. Journal of Virology, 80(11), 5655-5659.

2005

  • Campbell, I., Owens, T. (2005). Animal models of neuroimmunologic disease. In J. Antel, G. Birnbaum, H-P. Hartung and A. Vincent (Eds.), Clinical Neuroimmunology, (pp. 129-146). United Kingdom: Oxford University Press.
  • Campbell, I. (2005). Cytokine-mediated inflammation, tumorigenesis, and disease-associated JAK/STAT/SOCS signaling circuits in the CNS. Brain Research Reviews, 48(2), 166-177. [More Information]
  • Ousman, S., Wang, J., Campbell, I. (2005). Differential regulation of interferon regulatory factor (IRF)-7 and IRF-9 gene expression in the central nervous system during viral infection. Journal of Virology, 79(12), 7514-7527. [More Information]
  • Quintana, A., Giralt, M., Rojas, S., Penkowa, M., Campbell, I., Hidalgo, J., Molinero, A. (2005). Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. Journal of Neuroscience Research, 82(5), 701-716. [More Information]
  • Reiman, R., Torres, A., Martin, B., Ting, J., Campbell, I., Barnum, S. (2005). Expression of C5a in the brain does not exacerbate experimental autoimmune encephalomyelitis. Neuroscience Letters, 390(3), 134-138. [More Information]
  • Wang, J., Campbell, I. (2005). Innate STAT1-Dependent Genomic Response of Neurons to the Antiviral Cytokine Alpha Interferon. Journal of Virology, 79(13), 8295-8302. [More Information]
  • Ousman, S., Campbell, I. (2005). Regulation of murine interferon regulatory factor (IRF) gene expression in the central nervous system determined by multiprobe RNase protection assay. Methods in molecular medicine, 116, 115-134. [More Information]
  • Carr, D., Tomanek, L., Silverman, R., Campbell, I., Williams, B. (2005). RNA-dependent protein kinase is required for alpha-1 interferon transgene-induced resistance to genital herpes simplex virus type 2. Journal of Virology, 79(14), 9341-9345. [More Information]
  • Balosso, S., Ravizza, T., Perego, C., Peschon, J., Campbell, I., Simoni, M., Vezzani, A. (2005). Tumor necrosis factor-α inhibits seizures in mice via p75 receptors. Annals of Neurology, 57(6), 804-812. [More Information]

2004

  • Vlkolinsky, R., Siggins, G., Campbell, I., Krucker, T. (2004). Acute exposure to CXC chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices. Journal of Neuroimmunology, 150(1-2), 37-47. [More Information]
  • Sanchez-Burgos, G., Hernandez-Pando, R., Campbell, I., Ramos-Castaneda, J., Ramos, C. (2004). Cytokine production in brain of mice experimentally infected with dengue virus. NeuroReport, 15(1), 37-42.
  • Boos, L., Campbell, I., Ames, R., Wetsel, R., Barnum, S. (2004). Deletion Of The Complement Anaphylatoxin C3a Receptor Attenuates, Whereas Ectopic Expression Of C3a In The Brain Exacerbates, Experimental Autoimmune Encephalomyelitis. Journal of Immunology, 173(7), 4708-4714.
  • Zirger, J., Barcia, C., Liu, C., Puntel, M., Sitia, G., Guidotti, L., Mitchell, N., Campbell, I., Castro, M., Lowenstein, P. (2004). Immune System Regulation Of Transgene Expression In The Brain 2: Differential Increase Of Mrnas Encoding For Interferon-Regulated, Chemokine, And T-Cell Genes During Either Innate Acute Or Chronic Systemic Adaptive Immune Responses To First Generation Ade. Molecular Therapy, 9(S1), S390-S391.
  • Wang, J., Lin, W., Popko, B., Campbell, I. (2004). Inducible production of interferon-γ in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway. Molecular and Cellular Neuroscience, 27(4), 489-496.
  • Lin, W., Kemper, A., McCarthy, K., Pytel, P., Wang, J., Campbell, I., Utset, M., Popko, B. (2004). Interferon-γ Induced Medulloblastoma in the Developing Cerebellum. The Journal of Neuroscience, 24(45), 10074-10083.
  • Sitia, G., Isogawa, M., Iannacone, M., Campbell, I., Chisari, F., Guidotti, L. (2004). MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. Journal of Clinical Investigation, 113(8), 1158-1167.
  • Sanchez-Alavez, M., Gombart, L., Huitron-Resendiz, S., Carr, J., Wills, D., Berg, G., Campbell, I., Gauvin, D., Henriksen, S., Criado, J. (2004). Physiological and behavioral effects of methamphetamine in a mouse model of endotoxemia: a preliminary study. Pharmacology, Biochemistry and Behavior, 77(2), 365-370.
  • Crocker, S., Pagenstecher, A., Campbell, I. (2004). Review: The TIMPS tango with MMPs and more in the CNS. Journal of Neuroscience Research, 75(1), 1-11. [More Information]

2003

  • Penkowa, M., Camats, J., Hadberg, H., Quintana, A., Rojas, S., Giralt, M., Molinero, A., Campbell, I., Hidalgo, J. (2003). Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. Journal of Neuroscience Research, 73(4), 481-496. [More Information]
  • Wang, J., Pham-Mitchell, N., Schindler, C., Campbell, I. (2003). Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-γ in the brain. Journal of Clinical Investigation, 112(4), 535-543.
  • Penkowa, M., Camats, J., Giralt, M., Molinero, A., Hernandez, J., Carrasco, J., Campbell, I., Hidalgo, J. (2003). Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia, 42(3), 287-306. [More Information]
  • Molinero, A., Hernandez, J., Penkowa, M., Camats, J., Giralt, M., Lago, N., Carrasco, J., Campbell, I., Hidalgo, J. (2003). Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Journal of Neuropathology and Experimental Neurology, 62(3), 315-328.
  • Samland, H., Huitron-Resendiz, S., Masliah, E., Criado, J., Henriksen, S., Campbell, I. (2003). Profound increase in the sensitivity to glutamatergic but not cholinergic agonist- induced seizures in transgenic mice with astrocyte production of IL-6. Journal of Neuroscience Research, 73, 176-187. [More Information]
  • Campbell, I. (2003). Review: Chemokines as plurifunctional mediators in the CNS: Implications for the pathogenesis of stroke. Ernst Schering Research Foundation Workshop, 45, 31-52.
  • Carrasco, J., Penkowa, M., Giralt, M., Camats, J., Molinero, A., Campbell, I., Palmiter, R., Hidalgo, J. (2003). Role of metallothionein-III following central nervous system damage. Neurobiology of Disease, 13, 22-36.
  • Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V., Campbell, I., DeArmond, S., Coon, B., Teng, C., et al (2003). T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies. Journal of Virology, 77(6), 3799-3808.
  • Campbell, I. (2003). The chemokines. In Michael Aminoff, Robert Daroff (Eds.), Encyclopedia of the Neurological Sciences. (pp. 686-691). Netherlands: Elsevier Science.
  • Milner, R., Campbell, I. (2003). The Extracellular Matrix and Cytokines Regulate Microglial Integrin Expression and Activation. Journal of Immunology, 170(7), 3850-3858.
  • Moore, T., Moore, J., Kaji, Y., Frizzell, N., Usui, T., Poulaki, V., Campbell, I., Stitt, A., Gardiner, T., Archer, D., et al (2003). The Role of Advanced Glycation End Products in Retinal Microvascular Leukostasis. Investigative Ophthalmology and Visual Science, 44(10), 4457-4464.
  • Kayali, A., Gunst, K., Campbell, I., Stotland, A., Kritzik, M., Liu, G., Flodstrom-Tulllberg, M., Zhang, Y., Sarvetnick, N. (2003). The stromal cell-derived factor-1#/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. The Journal of Cell Biology, 163(4), 859-869.

2002

  • Freude, S., Hausmann, J., Hofer, M., Pham-Mitchell, N., Campbell, I., Staeheli, P., Pagenstecher, A. (2002). Borna disease virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. Journal Of Clinical Virology, 76(23), 12223-122232.
  • Freude, S., Hausmann, J., Hofer, M., Pham-Mitchell, N., Campbell, I., Staeheli, P., Pagenstecher, A. (2002). Borna Disease Virus accelerates inflammation and disease associated with transgenic expression of interleukin-12 in the central nervous system. Journal of Virology, 76(23), 12223-12232.
  • Strack, A., Asensio, V., Campbell, I., Schluter, D., Deckert, M. (2002). Chemokines are differentially expressed by astrocytes, microglia and inflammatory leukocytes in Toxoplasma encephalitis and critically regulated by interferon-γ. Acta Neuropathologica, 103, 458-468.
  • Milner, R., Campbell, I. (2002). Cytokines regulate microglial adhesion to laminin and astrocytes Extracellular Matrix via protein kinase C-dependent activation of the α6β1 integrin. The Journal of Neuroscience, 22(5), 1562-1572.
  • Milner, R., Campbell, I. (2002). Developmental regulation of β1 integrins during angiogenesis in the central nervous system. Molecular and Cellular Neuroscience, 20, 616-626.
  • Reiman, R., Gerard, C., Campbell, I., Barnum, S. (2002). Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis. European Journal of Immunology, 32, 1157-1163.
  • Campbell, I., Asensio, V. (2002). Insights from transgenic and knockout mice [Chapter 38]. In R.M. Ransohoff, K. Suzuki, A.E.I. Proudfoot, W.F. Hickey, J.K. Harrison (Eds.), Universes in delicate balance: chemokines and the nervous system, (pp. 225-233). United States: Elsevier.
  • Boztug, K., Carson, M., Pham-Mitchell, N., Asensio, V., DeMartino, J., Campbell, I. (2002). Leukocyte infiltration but not neurodegeneration in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10. Journal of Immunology, 169, 1505-1515.
  • Giralt, M., Penkowa, M., Hernandez, J., Molinero, A., Carrasco, J., Lago, N., Camats, J., Campbell, I., Hidalgo, J. (2002). Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6. Neurobiology of Disease, 9, 319-338.
  • Vallieres, L., Campbell, I., Gage, F., Sawchenko, P. (2002). Reduced hippocampal neurogenesis in adult transgenic mice with chronic astrocytic production of interleukin-6. The Journal of Neuroscience, 22(2), 486-492.
  • Maier, J., Kincaid, C., Pagenstecher, A., Campbell, I. (2002). Regulation of Signal Transducer and Activator of Transcription and Suppressor of Cytokine-Signaling Gene Expression in the Brain of Mice with Astrocyte-Targeted Production of Interleukin-12 or Experimental Autoimmune Encephalomyelitis. The American Journal of Pathology: cellular and molecular biology of disease, 160(1), 271-288.
  • Strack, A., Schluter, D., Asensio, V., Campbell, I., Deckert, M. (2002). Regulation of the kinetics of intracerebral chemokine gene expression in murine Toxoplasma encephalitis: Impact of host genetic factors. Glia, 40, 372-377.
  • Al-Khatib, K., Campbell, I., Carr, D. (2002). Resistance to ocular Herpes simplex virus type I infection in IL-12 transgenic mice. Journal of Neuroimmunology, 132, 41-48.
  • Campbell, I. (2002). Review: Cytokine mediated inflammation and other actions in the central nervous system. Ernst Schering Research Foundation Workshop, 39, 61-83.
  • Wang, J., Campbell, I. (2002). Review: Cytokine Signaling in the Brain: Putting a SOCS in It? Journal of Neuroscience Research, 67(4), 423-427.
  • Wang, J., Asensio, V., Campbell, I. (2002). Review: Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice. Current Topics in Microbiology and Immunology, 265, 23-48.
  • Milner, R., Campbell, I. (2002). Review: The Integrin Family of Cell Adhesion Molecules Has Multiple Functions Within The CNS. Journal of Neuroscience Research, 69(3), 286-291.
  • Wang, J., Schreiber, R., Campbell, I. (2002). STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-α in the central nervous system. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, 99(25), 16209-16214.
  • Moore, J., McMullen, T., Campbell, I., Rohan, R., Kaji, Y., Afshari, N., Usui, T., Archer, D., Adamis, A. (2002). The inflammatory milieu associated with conjunctivalized cornea and its alteration with IL-1RA gene therapy. Investigative Ophthalmology and Visual Science, 43(9), 2905-2915.
  • Carr, D., Ash, J., Al-Khatib, K., Campbell, I. (2002). Unforeseen consequences of IL-12 expression in the eye of GFAP-IL12 transgenic mice following Herpes Simplex virus type I infection. DNA and Cell Biology, 21(5-6), 467-473.

2001

  • Buchmeier, M., Campbell, I. (2001). Advances in Virus Research Vol 56. Advances in Virus Research, 56.
  • Murtaza, A., Nugent, C., Tailor, P., Asensio, V., Biggs, J., Campbell, I., Sherman, L. (2001). Altered functional and biochemical response by CD8(+) T cells that remain after tolerance. International Immunology, 13, 1085-1093.
  • Giralt, M., Carrasco, J., Penkowa, M., Angel Morcillo, M., Santamaria, J., Campbell, I., Hidalgo, J. (2001). Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain. Experimental Neurology, 168, 334-346.
  • Kakimi, K., lane, T., Wieland, S., Asensio, V., Campbell, I., Chisari, F., Guidotti, L. (2001). Blocking chemokine responsive to gamma-2/interferon (IFN)-gamma inducible protein and monokine induced by IFN-gamma activity in vivo reduces the pathogenetic but not the antiviral potential of hepatitis B virus-specific cytotoxic T lymphocytes. The Journal of Experimental Medicine, 194, 1755-1766.
  • Asensio, V., Campbell, I. (2001). Chemokines and viral diseases of the central nervous system. In Michael J. Buchmeier and Iain L. Campbell (Eds.), Neurovirology: Viruses and the Brain, (pp. 127-173). United States: Academic Press Elsevier.
  • Campbell, I. (2001). Cytokine-mediated inflammation and signaling in the intact central nervous system. In B. Castellano Lopez and M. Nieto-Sampedro (Eds.), Glial Cell Function, (pp. 481-489). Amsterdam: Elsevier Science.
  • Pagenstecher, A., wussler, E., Opdenakker, G., Volk, B., Campbell, I. (2001). Distinct expression patterns and levels of enzymatic activity of matrix metalloproteinases and their inhibitors in primary brain tumors. Journal of Neuropathology and Experimental Neurology, 60, 598-612.
  • Lassmann, S., Kincaid, C., Asensio, V., Campbell, I. (2001). Induction of type-I immune pathology in the brain following immunization without central nervous system autoantigen in transgenic mice with astrocyte-targeted expression of IL-12. Journal of Immunology, 167, 5485-5493.
  • Asensio, V., Maier, J., Milner, R., Boztug, K., Kincaid, C., moulard, M., Phillipson, C., Lindsley, K., Krucker, T., Fox, H., Campbell, I. (2001). Interferon-independent, human immunodeficiency virus type 1 gp120-mediated induction of CXCL10/IP-10 gene expression by astrocytes in vivo and in vitro. Journal of Virology, 75(15), 7067-7077.
  • Swartz, K., Liu, F., Sewell, D., schochet, T., Campbell, I., Sandor, D., Fabry, Z. (2001). Interleukin-6 promotes post-traumatic healing in the central nervous system. Brain Research, 896(1-2), 86-95.

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