Professor Iain McGregor

A16 - Badham Building
The University of Sydney


Website Contact Details
Psychopharmacology Laboratory
Curriculum vitae Curriculum vitae

Biographical details

I completed my undergraduate degree in Experimental Psychology at the University of Oxford and gained my PhD in Psychology at the University of Sydney. I am currently an NHMRC Principal Research Fellow, Professor of Psychopharmacology and Director of the Psychopharmacology laboratory.

Research interests

I have broad research interests in human and preclinical psychopharmacology. I am particularly interested in assessing the long term effects of recreational drugs and alcohol on behaviour and brain function. With our medicinal chemistry collaborators I am also interested in the development of new drugs for the treatment of anxiety disorders, autism and depression. An additional interests is in characterising the effects of novel emerging psychoactive substances drugs such as synthetic cannabinoids, mephedrone and MDPV. Finally, the lab also does work in the area of pheromones and the olfactory system. For more details on my current research see

http://sydney.edu.au/science/psychology/staff/iain/lab/

Teaching and supervision

I currently supervise 7 PhD students and am an associate supervisor of 5 more. I also supervise 2 honours students each year. These projects involve a diverse range of topics in human and basic psychopharmacology.

Current projects

1. Characteristing novel synthetic drugs: cannabinoids and cathinones.

2. Exercise and fasting related release of cannabinoids from fat tissue.

3. Oxytocin as a treatment for drug addiction.

4. Drug discovery: development of new drugs to ehnace social behaviour

5. Pheromones for repellling pest species.

6. Current utilisation patterns of psychotropic drugs in Australia

Awards and honours

NHMRC Achievement Award (2007)

Australian Research Council Professorial Fellowship 2009

European Behavioural Pharmacology Society best paper award (2013)

In the media

Stoners beware: exercising might lead to a positive drug test: Media release that received worldwide coverage (e.g. time.com, abc news) detailing our recent study of exercise effects in regular cannabis users.

The straight dope: Marijuana in NSW is among strongest in the world. Sydney Morning Herald article on our recent potency study of NSW cannabis.

High Alert for Synthetic Drugs. Iain McGregor comments on the emerging synthetic drugs in Australia.

Life Enhancing Drugs. Iain McGregor and the lab were featured on ABC Catalyst in a story about smart drugs.

TGA to decide on benzos rescheduling.Iain McGregor comments on the likely rescheduling of the benzodiazepine alprazolam.

Marketing Crazy.Iain McGregor comments on the explosive growth in antidepressant utilization in Australia.

An articleon the inherited risk of alcoholism and relapse featuringMichael Bowen.

Wikipedia articleon SDB-001, one of the synthetic cannabinoids currently being examined in the lab, with a mention of one of our recent publications.

Drug experts meet in Hobart.Iain McGregor provides the keynote address to the 2013 Comorbidity Symposium in Hobart.

Concerns over rising psychotropic drug use.A piece in Psychiatry Update on our work on trends in psychotropic drug use over the last decade.

Selected grants

2015

  • Novel therapeutics for the remediation of social deficits in psychiatric illness; McGregor I, Kassiou M, Hunt G, Cornish J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • An RCT of cannabinoid replacement therapy (Sativex®) for preventing relapse in treatment-resistant cannabis dependent patients; Lintzeris N, Allsop D, Copeland J, McGregor I, Dunlop A, Shanahan M, Bruno R; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A Mouse Biotelemetry System for Stroke, Epilepsy and Sleep Research; McGregor I, Collins M, Grunstein R, Kassiou M, Bowen M; DVC Research/Equipment Grant.

2014

  • γ-Hydroxybutyric acid (GHB) and α4-containing GABA-A receptors; Collins M, McGregor I, Hunt G, Absalom N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Randomised control trial of exercise for the management of cannabis withdrawal in adult humans; Lintzeris N, McGregor I, Rooney K, Allsop D, Arnold J; National Health and Medical Research Council (NHMRC)/Project Grants.

2013

  • Mouse behavioural phenotyping battery; Hunt N, Christie M, McGregor I, Kassiou M, Collins M, Stone J, Arnold J, Sawatari A, Mitrofanis J, Camp A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Health outcomes associated with long-term cannabis use; Johnston J, Lintzeris N, McGregor I; Health Administration Corporation/Drug and Alcohol Research Grant.
  • Brain oxytocin in basal and chronic stress-induced alcohol preference and relapse; McGregor I, Neumann I; Group of Eight/Germany Joint Research Co-operation Scheme.
  • Mephedrone (Meow, 4-Methylmethcathinone): examining the effects of a novel party drug on brain and behaviour; McGregor I, Hunt G, Winstock A, Cornish J, Callaghan P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Oxytocin receptor agonists for treatment of social anxiety; Kassiou M, McGregor I, Hunt G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A flexible high throughput analytical system for psychopharmacology and drug discovery; McGregor I, Simpson S, Shannon Weickert C, Kassiou M, Copeland J, Solowij N, Codd R, Arnold J, Karl T, Long L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2011

  • A double blind placebo randomised controlled trial of Sativex in the management of cannabis withdrawal; Copeland J, McGregor I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Preclinical validation of oxytocin as a novel treatment for alcohol dependence; McGregor I, Hunt G, Kassiou M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The characteristics of cannabis cautioning seizures in NSW, Australia; McGregor I; Department of Health and Ageing (Federal)/Targeted Prevention Programs.
  • Extrasynaptic GABA-A receptors as novel targets for gamma-Hydroxybutyric acid (GHB); Collins M, Wellendorph P, McGregor I, Hunt G, Brauner-Osborne H; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Purinergic P2X7 Receptor as a Target for Antidepressant Drug Discovery; Kassiou M, McGregor I, Bennett M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • A Trial of Oxytocin To Improve Behaviour and Cognition in Prader-Willi Syndrome; Einfeld S, McGregor I, Guastella A, Smith A; Foundation for Prader-Willi Research/Research Grant.
  • Randomised, double-blind, placebo controlled trial of lithium carbonate for the management of human cannabis withdrawal; Lintzeris N, McGregor I, Winstock A, Guastella A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Motion Menura multimodal mouse testing apparatus (MMTA): (Turnkey system comprising 6 testing chambers with associated control and tracking software).; Kemp A, Hermens D, McGregor I, Einfeld S, Kassiou M, Arnold J, Hunt G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Mechanisms of disease in Bacterial meningitis; Hunt N, Ball H, Jones C, McGregor I; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Multiphoton microscope for Cellular Imaging in Live Animals; Leamey C, Phillips W, Dampney R, Westbrook R, Morley J, Arabzadeh E, Dreher B, Solomon S, Protti D, McGregor I, King N, Hunt N, Keay K, Allen D, Koeppl C, Cullen K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Models of adolescent drug use and its consequences; McGregor I; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • The role of neuropeptides in the acute and long-term effects of MDMA, methamphetamine and GHB; McGregor I, Hunt G, Cornish J; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Shimadzu GCMS QP-2010 EI Plus; AOC- 20i/s Gas Chromatograph- Mass Spectrometer with GCMS Solutions Software V2.5; McGregor I; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • Learning about threats: the neural and behavioural response to predator-related cues in rodents; McGregor I; Australian Research Council (ARC)/Discovery Projects (DP).
  • Cannabis re-intoxication: the causes and consequences of THC release from fat stores into blood; McGregor I, Arnold J; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Ecstacy, methamphetamine and their combination: assessment of adverse effects; McGregor I, Hunt G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Flashback: the release of THC from fat stores as a result of food deprivation or stress; McGregor I, Arnold J; University of Sydney/Research & Development.
  • Age-dependent effects of cannabinoids on emotion, cognition and vulnerability to addiction; Mallet P, McGregor I, Mallet P; Australian Research Council (ARC)/Discovery Projects (DP).

2004

  • The interaction between alcohol consumption and craving for other drugs; McGregor I; Australian Brewers Foundation/Research Support.

2003

  • Defensive behaviours elicited by predator odours [Fellowship: APF]; McGregor I; Australian Research Council (ARC)/Discovery Projects (DP).

2002

  • DataSciences International Telemetry System; McGregor I, Hunt N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Shimadzu HPLC system with electrochemical detection; McGregor I; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.

2001

  • Factors affecting the reinstatement of alcohol seeking behaviour in rats; McGregor I; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • The neural, behavioural and cognitive effects of cannabinoids; McGregor I, Mallet P; Australian Research Council (ARC)/Large Research Grants (LRG).
  • The neurotoxic and behavioural effects of MDMA (Ecstasy); McGregor I, Hunt G; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • The neural, behavioural and cognitive effects of cannabinoids; McGregor I; Australian Research Council (ARC)/Large Research Grants (LRG).
  • Predatory odours and anxiety in rats; McGregor I; Australian Research Council (ARC)/Large Research Grants (LRG).
  • Defining and applying the relationship between the molecular structure of odorants and the properties of fragrances and deodorants; Bridger L, Fiora R, McGregor I; Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT).
  • Neural basis of addictive behaviour; Hunt G, McGregor I; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Barron, M., Werry, E., McGregor, I., Kassiou, M. (2014). P2X7 in Bipolar and Depressive Disorders. In Norbert Weiss, Alexandra Koschak (Eds.), Pathologies of Calcium Channels, (pp. 635-661). Berlin: Springer-Verlag.
  • Thompson, M., Callaghan, P., McGregor, I. (2010). The Pharmacology of MDMA (Ecstasy). In Degenhardt L. & Hall W. (Eds.), The Health and Psychological Effects of "Ecstasy" (MDMA) Use, (pp. 47-80). Randwick, NSW: National Drug and Alcohol Research Centre.

Journals

  • Einfeld, S., Smith, E., McGregor, I., Steinbeck, K., Taffe, J., Rice, L., Horstead, S., Rogers, N., Hodge, M., Guastella, A. (2014). A Double-Blind Randomized Controlled Trial of Oxytocin Nasal Spray in Prader Willi Syndrome. American Journal of Medical Genetics. Part A, 164(9), 2232-2239. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, Behavior, and Immunity, 35, 107-124. [More Information]
  • Hicks, C., Ramos, L., Reekie, T., Misagh, G., Narlawar, R., Kassiou, M., McGregor, I. (2014). Body temperature and cardiac changes induced by peripherally administered oxytocin, vaspressin and the non-peptide oxytocin receptor agonist WAY 267, 464: a biotelemetry study in rats. British Journal of Pharmacology, 171(11), 2868-2887. [More Information]
  • Allsop, D., Dunlop, A., Sadler, C., Rivas, G., McGregor, I., Copeland, J. (2014). Changes in cigarette and alcohol use during cannabis abstinence. Drug and Alcohol Dependence, 138, 54-60. [More Information]
  • Wong, A., Keats, K., Rooney, K., Hicks, C., Allsop, D., Arnold, J., McGregor, I. (2014). Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences. Psychopharmacology, 231(20), 3987-3996. [More Information]
  • Too, L., Mitchell, A., Yau, B., Ball, H., McGregor, I., Hunt, N. (2014). Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis. Behavioural Brain Research, 263, 176-189. [More Information]
  • Johnston, J., Lintzeris, N., Allsop, D., Suraev, A., Booth, J., Carson, D., Helliwell, D., Winstock, A., McGregor, I. (2014). Lithium carbonate in the management of cannabis withdrawal: a randomized placebo-controlled trial in an inpatient setting. Psychopharmacology, In Press. [More Information]
  • Johnston, J., Lintzeris, N., Allsop, D., Suraev, A., Booth, J., Carson, D., Helliwell, D., Winstock, A., McGregor, I. (2014). Lithium carbonate in the management of cannabis withdrawal: a randomized placebo-controlled trial in an inpatient setting. Psychopharmacology, 231(24), 4623-4636. [More Information]
  • Allsop, D., Copeland, J., Lintzeris, N., Dunlop, A., Montebello, M., Sadler, C., Rivas, G., Holland, R., Muhleisen, P., Norberg, M., Booth, J., McGregor, I. (2014). Nabiximols as an Agonist Replacement Therapy During Cannabis Withdrawal: A Randomized Clinical Trial. JAMA Psychiatry, 71(3), 281-291. [More Information]
  • Ahmed, S., Kashem, M., Sarker, R., Ahmed, E., Hargreaves, G., McGregor, I. (2014). Neuroadaptations in the striatal proteome of the rat following prolonged excessive sucrose intake. Neurochemical Research, 39(5), 815-824. [More Information]
  • Bowen, M., McGregor, I. (2014). Oxytocin and vasopressin modulate the social response to threat: a preclinical study. International Journal of Neuropsychopharmacology, 17, 1621-1633. [More Information]
  • Reekie, T., McGregor, I., Kassiou, M. (2014). Pyrazolo[1,4]diazepines as non-peptidic probes of the oxytocin and vasopressin receptors. Tetrahedron Letters, 55(33), 4568-4571. [More Information]
  • van Nieuwenhuijzen, P., McGregor, I., Chebib, M., Hunt, G. (2014). Regional Fos-expression induced by γ-hydroxybutyrate (GHB): comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Neuroscience, 277(C), 700-715. [More Information]
  • van Nieuwenhuijzen, P., McGregor, I., Chebib, M., Hunt, G. (2014). Regional Fos-expression induced by γ-hydroxybutyrate (GHB): Comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Neuroscience, 277, 700-715. [More Information]
  • Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information]
  • Too, L., McQuillan, J., Ball, H., Kanai, M., Nakamura, T., Funakoshi, H., McGregor, I., Hunt, N. (2014). The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behavioural Brain Research, 270, 179-195. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis. Brain, Behavior, and Immunity, 40, 252-268. [More Information]
  • Carson, D., Guastella, A., Taylor, E., McGregor, I. (2013). A brief history of oxytocin and its role in modulating psychostimulant effects. Journal of Psychopharmacology, 27(3), 231-247. [More Information]
  • Quintana, D., McGregor, I., Guastella, A., Malhi, G., Kemp, A. (2013). A Meta-Analysis on the Impact of Alcohol Dependence on Short-Term Resting-State Heart Rate Variability: Implications for Cardiovascular Risk. Alcoholism: Clinical and Experimental Research, 37(S1), E23-E29. [More Information]
  • Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., McGregor, I. (2013). Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the VI(A) Receptor. Neuropsychopharmacology, 38(11), 2249-2259. [More Information]
  • Swift, W., Wong, A., Li, K., Arnold, J., McGregor, I. (2013). Analysis of cannabis seizures in NSW, Australia: Cannabis potency and cannabinoid profile. PloS One, 8(7), 1-9. [More Information]
  • Bowen, M., Kevin, R., May, M., Staples, L., Hunt, G., McGregor, I. (2013). Defensive Aggregation (Huddling) in Rattus Norvegicus toward Predator Odor: Individual Differences, Social Buffering Effects and Neural Correlates. PloS One, 8(7), 1-15. [More Information]
  • Bosanquet, D., MacDougall, H., Rogers, S., Starmer, G., McKetin, R., Blaszczynski, A., McGregor, I. (2013). Driving on ice: Impaired driving skills in current methamphetamine users. Psychopharmacology, 225, 161-172. [More Information]
  • Wong, A., Montebello, M., Norberg, M., Rooney, K., Lintzeris, N., Bruno, R., Booth, J., Arnold, J., McGregor, I. (2013). Exercise increases plasma THC concentrations in regular cannabis users. Drug and Alcohol Dependence, 133(2), 763-767. [More Information]
  • Hunt, G., McGregor, I., Malhi, G. (2013). Give me a hi-5! An additional version of the h-index. Australian and New Zealand Journal of Psychiatry, 47(12), 1119-1123. [More Information]
  • Quintana, D., Guastella, A., McGregor, I., Hickie, I., Kemp, A. (2013). Heart rate variability predicts alcohol craving in alcohol dependent outpatients: Further evidence for HRV as a psychophysiological marker of self-regulation. Drug and Alcohol Dependence, 132(1-2), 395-398. [More Information]
  • Motbey, C., Clemens, K., Apetz, N., Winstock, A., Ramsey, J., Li, K., Wyatt, N., Callaghan, P., Bowen, M., Cornish, J., McGregor, I. (2013). High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine. Journal of Psychopharmacology, 27(9), 823-836. [More Information]
  • Karanges, E., Kashem, M., Sarker, R., Ahmed, E., Ahmed, S., van Nieuwenhuijzen, P., Kemp, A., McGregor, I. (2013). Hippocampal protein expression is differentially affected by chronic paroxetine treatment in adolescent and adult rats: a possible mechanism of "paradoxical" antidepressant responses in young persons. Frontiers in Pharmacology, 4, 1-13. [More Information]
  • Quintana, D., Guastella, A., McGregor, I., Hickie, I., Kemp, A. (2013). Moderate alcohol intake is related to increased heart rate variability in young adults: Implications for health and well-being. Psychophysiology, 50(12), 1202-1208. [More Information]
  • Spencer, J., Darbyshire, K., Boucher, A., Kashem, M., Long, L., McGregor, I., Karl, T., Arnold, J. (2013). Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice. Frontiers in Cellular Neuroscience, 7, 1-13. [More Information]
  • Banister, S., Wilkinson, S., Longworth, M., Stuart, J., Apetz, N., English, K., Brooker, L., Goebel, C., Hibbs, D., Glass, M., McGregor, I., Kassiou, M., et al (2013). The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse. ACS Chemical Neuroscience, 4(7), 1081-1092. [More Information]
  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2013). Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence. International Journal of Neuropsychopharmacology, 16(1), 163-175. [More Information]
  • Stephenson, C., Karanges, E., McGregor, I. (2013). Trends in the utilisation of psychotropic medications in Australia from 2000-2011. Australian and New Zealand Journal of Psychiatry, 47(1), 74-87. [More Information]
  • Bowen, M., Keats, K., Kendig, M., Cakic, V., Callaghan, P., McGregor, I. (2012). Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behavioural Processes, 90(3), 331-336. [More Information]
  • Ahmed, E., Ahmed, S., Ukai, W., Matsumoto, I., Kemp, A., McGregor, I., Kashem, M. (2012). Antipsychotic Induced Alteration of Growth and Proteome of Rat Neural Stem Cells. Neurochemical Research, 37, 1649-1659. [More Information]
  • McGregor, I., Bowen, M. (2012). Breaking the loop: Oxytocin as a potential treatment for drug addiction. Hormones and Behavior, 61(3), 331-339. [More Information]
  • Long, L., Chesworth, R., Huang, X., Wong, A., Spiro, A., McGregor, I., Arnold, J., Karl, T. (2012). Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice. PloS One, 7(4), 1-11. [More Information]
  • Kashem, M., Ahmed, S., Sarker, R., Ahmed, E., Hargreaves, G., McGregor, I. (2012). Long-term daily access to alcohol alters dopamine-related synthesis and signaling proteins in the rat striatum. Neurochemistry International, 61(8), 1280-1288. [More Information]
  • Motbey, C., Hunt, G., Bowen, M., Artiss, S., McGregor, I. (2012). Mephedrone (4-Methylmethcathinone, "Meow"): Acute Behavioural Effects and Distribution of Fos Expression in Adolescent Rats. Addiction Biology, 17(2), 409-422. [More Information]
  • Motbey, C., Karanges, E., Li, K., Wilkinson, S., Winstock, A., Ramsay, J., Hicks, C., Kendig, M., Wyatt, N., Callaghan, P., McGregor, I. (2012). Mephedrone in adolescent rats: Residual memory impairment and acute but not lasting 5-HT depletion. PloS One, 7(9), 1-10. [More Information]
  • Baracz, S., Rourke, P., Pardey, M., Hunt, G., McGregor, I., Cornish, J. (2012). Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference. Behavioural Brain Research, 228(1), 185-193. [More Information]
  • Carson, D., Bosanquet, D., Carter, S., Pournajafi-Nazarloo, H., Blaszczynski, A., McGregor, I. (2012). Preliminary Evidence for Lowered Basal Cortisol in a Naturalistic Sample of Methamphetamine Polydrug Users. Experimental and Clinical Psychopharmacology, 20(6), 497-503. [More Information]
  • Cornish, J., Hunt, G., Robins, L., McGregor, I. (2012). Regional c-Fos and FosB/δFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats. Neuroscience, 206, 100-114. [More Information]
  • May, M., Bowen, M., McGregor, I., Timberlake, W. (2012). Rubbings deposited by cats elicit defensive behavior in rats. Physiology and Behavior, 107(5), 711-718. [More Information]
  • Wong, A., Gunasekaran, N., Hancock, D., Denyer, G., Meng, L., Radford, J., McGregor, I., Arnold, J. (2012). The major plant-derived cannabinoid 9-tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Hormone And Metabolic Research, 44(2), 105-113. [More Information]
  • Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C., Kassiou, M., Hunt, G., McGregor, I. (2012). The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor-Binding Profile, Prosocial Effects and Distribution of c-Fos Expression in Adolescent Rats. Journal of Neuroendocrinology, 24(7), 1012-1029. [More Information]
  • Hunt, G., van Nieuwenhuijzen, P., Chan-Ling, T., McGregor, I. (2011). 'When an old rat smells a cat': a decline in defense-related, but not accessory olfactory, Fos expression in aged rats. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 32(4), 737-749. [More Information]
  • Bowen, M., Carson, D., Spiro, A., Arnold, J., McGregor, I. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PloS One, 6(11), 1 (e27237)-11. [More Information]
  • Karanges, E., McGregor, I. (2011). Antidepressants and adolescent brain development. Future Neurology, 6(6), 783-808. [More Information]
  • Hargreaves, G., Wang, E., Lawrence, A., McGregor, I. (2011). Beer promotes high levels of alcohol intake in adolescent and adult alcohol-preferring rats. Alcohol, 45(5), 485-498. [More Information]
  • Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L., Huang, X., Arnold, J., McGregor, I., et al (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443-457. [More Information]
  • Karanges, E., Li, K., Motbey, C., Callaghan, P., Katsifis, A., McGregor, I. (2011). Differential behavioural and neurochemical outcomes from chronic paroxetine treatment in adolescent and adult rats: a model of adverse antidepressant effects in human adolescents? International Journal of Neuropsychopharmacology, 14(4), 491-504. [More Information]
  • Ferguson (Sokolic), L., Long, L., Hunt, G., Arnold, J., McGregor, I. (2011). Disruptive effects of the prototypical cannabinoid Delta9-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. Behavioural Pharmacology, 22(3), 191-202. [More Information]
  • Hunt, G., McGregor, I., Cornish, J., Callaghan, P. (2011). MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635. Brain Research Bulletin, 86, 65-73. [More Information]
  • Kendig, M., Bowen, M., Kemp, A., McGregor, I. (2011). Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience. Behavioural Brain Research, 225(2), 405-414. [More Information]
  • Boucher, A., Arnold, J., Hunt, G., Spiro, A., Spencer, J., Brown, C., McGregor, I., Bennett, M., Kassiou, M. (2011). Resilience and Reduced C-FOS Expression in P2X7 Receptor Knockout Mice Exposed to Repeated Forced Swim Test. Neuroscience, 189, 170-177. [More Information]
  • Verty, A., Evetts, M., Crouch, G., McGregor, I., Stefanidis, A., Oldfield, B. (2011). The Cannabinoid Receptor Agonist THC Attenuates Weight Loss in a Rodent Model of Activity-Based Anorexia. Neuropsychopharmacology, 36, 1349-1358.
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2011). The schizophrenia-susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]
  • van Nieuwenhuijzen, P., Kashem, M., Matsumoto, I., Hunt, G., McGregor, I. (2010). A long hangover from party drugs: Residual proteomic changes in the hippocampus of rats 8 weeks after gamma-hydroxybutyrate (GHB),3,4-methylenedioxymethamphetamine (MDMA) or their combination. Neurochemistry International, 56(8), 871-877. [More Information]
  • Arnold, J., Dielenberg, R., McGregor, I. (2010). Cannabinoids increase conditioned ultrasonic vocalisations and cat odour avoidance in rats: Strain differences in drug-induced anxiety. Life Sciences, 87(17-18), 572-578. [More Information]
  • Carson, D., Cornish, J., Guastella, A., Hunt, G., McGregor, I. (2010). Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats. Neuropharmacology, 58(1), 38-43. [More Information]
  • van Nieuwenhuijzen, P., Long, L., Hunt, G., Arnold, J., McGregor, I. (2010). Residual social, memory and oxytocin-related changes in rats following repeated exposure to gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology, 212(4), 663-674. [More Information]
  • Carson, D., Hunt, G., Guastella, A., Barber, L., Cornish, J., Arnold, J., Boucher, A., McGregor, I. (2010). Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addiction Biology, 15(4), 448-463. [More Information]
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2010). The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]
  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2009). A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. International Journal of Neuropsychopharmacology, 13 (2010)(7), 861-876. [More Information]
  • Kashem, M., Sarker, R., Des Etages, H., Machaalani, R., King, N., McGregor, I., Matsumoto, I. (2009). Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry International, 55(7), 483-490. [More Information]
  • Kashem, M., Des Etages, H., Kopitar-Jerala, N., McGregor, I., Matsumoto, I. (2009). Differential protein expression in the corpus callosum (body) of human alcoholic brain. Journal of Neurochemistry, 110(2), 486-495. [More Information]
  • Kashem, M., Ummehany, R., Ukai, W., Hashimoto, E., Saito, T., McGregor, I., Matsumoto, I. (2009). Effects of typical (haloperidol) and atypical (risperidone) antipsychotic agents on protein expression in rat neural stem cells. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, 55(7), 558-565. [More Information]
  • Hargreaves, G., Monds, L., Gunasekaran, N., Dawson, B., McGregor, I. (2009). Intermittent access to beer promotes binge-like drinking in adolescent but not adult Wistar rats. Alcohol, 43, 305-314. [More Information]
  • Verty, A., Boon, W., Mallett, P., McGregor, I., Oldfield, B. (2009). Involvement of hypothalamic peptides in the anorectic action of the CB1 receptor antagonist rimonabant (SR 141716). European Journal of Neuroscience, 29(11), 2207-2216.
  • Staples, L., McGregor, I., Hunt, G. (2009). Long-lasting FosB/delta-FosB immunoreactivity in the rat brain after repeated cat odor exposure. Neuroscience Letters, 462(2), 157-161.
  • Thompson, M., Hunt, G., McGregor, I. (2009). Neural correlates of MDMA ("Ecstasy")-induced social interaction in rats. Social Neuroscience, 4(1), 60-72. [More Information]
  • Hargreaves, G., Quinn, H., Kashem, M., Matsumoto, I., McGregor, I. (2009). Proteomic Analysis Demonstrates Adolescent Vulnerability to Lasting Hippocampal Changes Following Chronic Alcohol Consumption. Alcoholism: Clinical and Experimental Research, 33(1), 86-94. [More Information]
  • Gunasekaran, N., Long, L., Dawson, B., Hansen, G., Richardson, D., Li, K., Arnold, J., McGregor, I. (2009). Reintoxication: the release of fat-stored delta-9-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure. British Journal of Pharmacology, 158(5), 1330-1337. [More Information]
  • van Nieuwenhuijzen, P., McGregor, I., Hunt, G. (2009). The distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen. Neuroscience, 158(2), 441-455. [More Information]
  • van Nieuwenhuijzen, P., Li, K., Hunt, G., McGregor, I. (2009). Weekly gamma-hydroxybutyrate exposure sensitizes locomotor hyperactivity to low-dose 3,4-methylenedioxymethamphetamine in rats. Neuropsychobiology, 60(3-4), 195-203. [More Information]
  • Rutten, K., Reneerkensa, O., Hamers, H., Sik, A., McGregor, I., Prickaerts, J., Blokland, A. (2008). Automated scoring of novel object recognition in rats. Journal of Neuroscience Methods, 171, 72-77. [More Information]
  • Staples, L., McGregor, I., Apfelbach, R., Hunt, G. (2008). Cat odor, but not trimethylthiazoline (fox odor), activates accessory olfactory and defense-related brain regions in rats. Neuroscience, 151, 937-947. [More Information]
  • McGregor, I., Callaghan, P., Hunt, G. (2008). From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? British Journal of Pharmacology, 154, 358-368. [More Information]
  • Cornish, J., Clemens, K., Thompson, M., Callaghan, P., Dawson, B., McGregor, I. (2008). High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats. Journal of Psychopharmacology, 22(1), 100-110.
  • Iwazaki, T., McGregor, I., Matsumoto, I. (2008). Protein expression profile in the amygdala of rats with methamphetamine-induced behavioral sensitization. Neuroscience Letters, 435(2), 113-119. [More Information]
  • Staples, L., Hunt, G., van Nieuwenhuijzen, P., McGregor, I. (2008). Rats discriminate individual cats by their odor: Possible involvement of the accessory olfactory system. Neuroscience and Biobehavioral Reviews, 32(7), 1209-1217. [More Information]
  • Thompson, M., Callaghan, P., Hunt, G., McGregor, I. (2008). Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(4), 1013-1021. [More Information]
  • Thompson, M., Callaghan, P., Hunt, G., Cornish, J., McGregor, I. (2007). A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience, 146(2), 509-514. [More Information]
  • Quinn, H., Matsumoto, I., Callaghan, P., Long, L., Arnold, J., Gunasekaran, N., Thompson, M., Dawson, B., Mallet, P., Kashem, M., Matsuda-Matsumoto, H., Iwazaki, T., McGregor, I. (2007). Adolescent rats find repeated delta-9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33 (epub ahead of print Jun 20), 1-14. [More Information]
  • Ferguson (Sokolic), L., Laing, D., McGregor, I. (2007). Asymmetric suppression of components in binary aldehyde mixtures: Behavioral studies in the laboratory rat. Chemical Senses, 32(2), 191-199.
  • Ferguson (Sokolic), L., McGregor, I. (2007). Benzodiazepines impair the acquisition and reversal of olfactory go/no-go discriminations in rats. Behavioral Neuroscience, 121(3), 527-534.
  • McGregor, I., Arnold, J. (2007). Cannabis reward: biased towards the fairer sex? British Journal of Pharmacology, 152(5), 562-564. [More Information]
  • Boucher, A., Hunt, G., Karl, T., Micheau, J., McGregor, I., Arnold, J. (2007). Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience, 149(4), 861-870. [More Information]
  • Hargreaves, G., Hunt, G., Cornish, J., McGregor, I. (2007). High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")-induced Fos expression in a region-specific manner. Neuroscience, 145(2), 764-774. [More Information]
  • Chan-Ling, T., Hughes, S., Baxter, L., Rosinova, E., McGregor, I., Morcos, Y., van Nieuwenhuijzen, P., Hu, P. (2007). Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: A model for CNS aging. Microcirculation, 14(1), 63-76. [More Information]
  • Clemens, K., McGregor, I., Hunt, G., Cornish, J. (2007). MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research. Drug and Alcohol Review, 26(1), 9-15. [More Information]
  • Iwazaki, T., McGregor, I., Matsumoto, I. (2007). Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitization. Proteomics, 7(7), 1131-1139. [More Information]
  • Clemens, K., Cornish, J., Hunt, G., McGregor, I. (2007). Repeated weekly exposure to MDMA, methamphetamine or their combination: Long-term behavioural and neurochemical effects in rats. Drug and Alcohol Dependence, 86(2-3), 183-190.
  • Hargreaves, G., McGregor, I. (2007). Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcoholism: Clinical and Experimental Research, 31(11), 1900-1907.
  • Staples, L., McGregor, I. (2006). Defensive responses of Wistar and Sprague-Dawley rats to cat odour and TMT. Behavioural Brain Research, 172(2), 351-354. [More Information]
  • Siviy, S., Harrison, K., McGregor, I. (2006). Fear, risk assessment, and playfulness in the juvenile rat. Behavioral Neuroscience, 120(1), 49-59.
  • Clemens, K., Cornish, J., Hunt, G., McGregor, I. (2006). Intravenous methamphetamine self-administration in rats: Effects of intravenous or intraperitoneal MDMA co-administration. Pharmacology, Biochemistry and Behavior, 85, 454-463. [More Information]
  • Iwazaki, T., McGregor, I., Matsumoto, I. (2006). Protein expression profile in the striatum of acute methamphetamine-treated rats. Brain Research, 1097, 19-25. [More Information]
  • O'Shea, M., McGregor, I., Mallet, P. (2006). Repeated cannabinoid exposure during perinatal, adolescent, or early adult ages produces similar long-lasting deficits in object recognition and reduced social interaction in rats. Journal of Psychopharmacology, 20(5), 611-621.
  • Hargreaves, G., McGregor, I., Sachdev, P. (2005). Chronic repetitive transcranial magnetic stimulation is antidepressant but not anxiolytic in rat models of anxiety and depression. Psychiatry Research, 137(1-2), 113-121.
  • Young, J., McGregor, I., Mallet, P. (2005). Co-administration of THC and MDMA ('Ecstasy') synergistically disrupts memory in rats. Neuropsychopharmacology, 30(8), 1475-1482.
  • Cornish, J., Lontos, J., Clemens, K., McGregor, I. (2005). Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. Psychopharmacology, 180(1), 21-32. [More Information]
  • McGregor, I., Touyz, S., Marks, P., Vocks, S., Beumont, P. (2005). Defensive behavior. Neuroscience and Biobehavioral Reviews, 29(8), 1121-1122.
  • McGregor, I., Dam, K., Mallet, P., Gallate, J. (2005). Delta(9)-THC reinstates beer- and sucrose-seeking behaviour in abstinent rats: Comparison with midazolam, food deprivation and predator odour. Alcohol and Alcoholism, 40(1), 35-45.
  • Clemens, K., Cornish, J., Li, K., Hunt, G., McGregor, I. (2005). MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats. Neuropharmacology, 49(2), 195-207. [More Information]
  • McGregor, I., Clemens, K., Cornish, J., Thompson, M., He, S., Clarke, S., Kohn, M., Gordon, E. (2005). MDMA, methamphetamine and their combination: Comparison of long-term behavioural and neural effects in rats. Behavioural Pharmacology, 16, S11-S11.
  • Staples, L., Hunt, G., Cornish, J., McGregor, I. (2005). Neural activation during cat odor-induced conditioned fear and 'trial 2' fear in rats. Neuroscience and Biobehavioral Reviews, 29(8), 1265-1277. [More Information]
  • Verty, A., McGregor, I., Mallet, P. (2005). Paraventricular hypothalamic CB1 cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol. Neuropharmacology, 49(8), 1101-1109.
  • Singh, M., McGregor, I., Mallet, P. (2005). Perinatal exposure to Delta(9)-tetrahydrocannabinol alters heroin-induced place conditioning and Fos-immunoreactivity. Neuropsychopharmacology, 31(1), 1-12.
  • Singh, M., McGregor, I., Mallet, P. (2005). Repeated exposure to Delta(9)-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity. Neuropharmacology, 49(8), 1189-1200.
  • Morley, K., Arnold, J., McGregor, I. (2005). Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(5), 648-657. [More Information]
  • Apfelbach, R., Blanchard, C., Blanchard, R., Hayes, R., McGregor, I. (2005). The effects of predator odors in mammalian prey species: A review of field and laboratory studies. Neuroscience and Biobehavioral Reviews, 29(8), 1123-1144.
  • Fendt, M., Endres, T., Lowry, C., Apfelbach, R., McGregor, I. (2005). TMT-induced autonomic and behavioral changes and the neural basis of its processing. Neuroscience and Biobehavioral Reviews, 29(8), 1145-1156.
  • Morley, K., Li, K., Hunt, G., Mallet, P., McGregor, I. (2004). Cannabinoids Prevent The Acute Hyperthermia And Partially Protect Against The 5-Ht Depleting Effects Of Mdma ('Ecstasy') In Rats. Neuropharmacology, 46(7), 954-965.
  • Thompson, M., Li, K., Clemens, K., Gurtman, C., Hunt, G., Cornish, J., McGregor, I. (2004). Chronic Fluoxetine Treatment Partly Attenuates The Long-Term Anxiety And Depressive Symptoms Induced By Mdma ('Ecstasy') In Rats. Neuropsychopharmacology, 29(4), 694-704.
  • Gallate, J., McGregor, I., Mallet, P. (2004). Combined Low Dose Treatment With Opioid And Cannabinoid Receptor Antagonists Synergistically Reduces The Motivation To Consume Alcohol In Rats. Psychopharmacology, 173(1-2), 210-216. [More Information]
  • McGregor, I., Verty, A., Mallet, P. (2004). Consumption Of High Carbohydrate, High Fat, And Normal Chow Is Equally Suppressed By A Cannabinoid Receptor Antagonist In Non-Deprived Rats. Neuroscience Letters, 354(3), 217-220.
  • Ball, H., MacDougall, H., McGregor, I., Hunt, N. (2004). Cyclooxygenase-2 In The Pathogenesis Of Murine Cerebral Malaria. The Journal of Infectious Diseases, 189(4), 751-758.
  • Verty, A., McFarlane, J., McGregor, I., Mallet, P. (2004). Evidence For An Interaction Between Cb1 Cannabinoid And Melanocortin MCR-4 Receptors In Regulating Food Intake. Endocrinology, 145(7), 3224-3231.
  • Verty, A., McFarlane, J., McGregor, I., Mallet, P. (2004). Evidence For An Interaction Between Cb1 Cannabinoid And Oxytocin Receptors In Food And Water Intake. Neuropharmacology, 47(4), 593-603.
  • Clemens, K., van Nieuwenhuijzen, P., Li, K., Cornish, J., Hunt, G., McGregor, I. (2004). Mdma ('Ecstasy'), Methamphetamine And Their Combination: Long-Term Changes In Social Interaction And Neurochemistry In The Rat. Psychopharmacology, 173(38445), 318-325. [More Information]
  • McGregor, I., Hargreaves, G., Apfelbach, R., Hunt, G. (2004). Neural Correlates Of Cat Odor-Induced Anxiety In Rats: Region-Specific Effects Of The Benzodiazepine Midazolam. The Journal of Neuroscience, 24(17), 4134-4144.
  • Morley, K., Cornish, J., Li, K., McGregor, I. (2004). Preexposure To Mdma ("Ecstasy") Delays Acquisition But Facilitates Mdma-Induced Reinstatement Of Amphetamine Self-Administration Behavior In Rats. Pharmacology, Biochemistry and Behavior, 79(2), 331-342.
  • Li, K., Thompson, M., McGregor, I. (2004). Rapid Quantitation Of Fluoxetine And Norfluoxetine In Serum By Micro-Disc Solid-Phase Extraction With High-Performance Liquid Chromatography-Ultraviolet Absorbance Detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 804(2), 319-326. [More Information]
  • McGregor, I., Gallate, J. (2004). Rats On The Grog: Novel Pharmacotherapies For Alcohol Craving,. Addictive Behaviors, 29(7), 1341-1357. [More Information]
  • Verty, A., McGregor, I., Mallet, P. (2004). The Doparnine Receptor Antagonist Sch 23390 Attenuates Feeding Induced By Delta(9)-Tetrahydrocannobinol. Brain Research, 1020 (38384), 188-195. [More Information]
  • Cornish, J., Shahnawaz, Z., Thompson, M., Wong, S., Morley, K., Hunt, G., McGregor, I. (2003). Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats. European Journal of Pharmacology, 482(1-3), 339-341. [More Information]
  • McGregor, I., Clemens, K., Van Der Plasse, G., Li, K., Hunt, G., Chen, F., Lawrence, A. (2003). Increased Anxiety 3 Months after Brief Exposure to MDMA ('Ecstasy') in Rats: Association with Altered 5-HT Transporter and Receptor Density. Neuropsychopharmacology, 28, 1472-1484.
  • McGregor, I., Gurtman, C., Morley, K., Clemens, K., Li, K., Blokland, A., Cornish, J., Hunt, G. (2003). Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. Psychopharmacology, 168(4), 465-474. [More Information]
  • Norwood, C., Cornish, J., Mallet, P., McGregor, I. (2003). Pre-exposure to the cannabinoid receptor agonist CP 55,940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats. European Journal of Pharmacology, 465(1-2), 105-114.
  • Allen, K., McGregor, I., Hunt, G., Singh, M., Mallet, P. (2003). Regional differences in nalaxone modulation of Delta 9 - THC induced Fos expression in rat brain. Neuropharmacology, 44(2), 264-274.
  • Verty, A., Singh, M., McGregor, I., Mallet, P. (2003). The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine. Psychopharmacology, 168(3), 314-323. [More Information]
  • Gallate, J., Morley, K., Ambermoon, P., McGregor, I. (2003). The consequences of beer consumption in rats: acute anxiolytic and ataxic effects and withdrawal-induced anxiety. Psychopharmacology, 166(1), 51-60. [More Information]
  • Hunt, G., McGregor, I. (2002). Contrasting effects of dopamine antagonists and frequency reduction on Fos expression induced by lateral hypothalamic stimulation. Behavioural Brain Research, 132(2), 187-201.
  • Gurtman, C., Morley, K., Li, K., Hunt, G., McGregor, I. (2002). Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. European Journal of Pharmacology, 446(1-3), 89-96.
  • McGregor, I., Schrama, L., Ambermoon, P., Dielenberg, R. (2002). Not all 'predator odours' are equal: cat odur but not 2,4,5 trimrthylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats. Behavioural Brain Research, 130(1-2), 1-16.
  • Green, R., McGregor, I. (2002). On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA. Psychopharmacology, 162(4), 448-450.
  • Dielenberg, R., Hunt, G., McGregor, I. (2001). 'When a rat smells a cat': The distribution of fos immunoreactivity in rat brain following exposure to a predatory odor. Neuroscience, 104, 1085-1097.
  • Dielenberg, R., McGregor, I. (2001). Defensive behvior in rats towards predatory odors: a review. Neuroscience and Biobehavioral Reviews, 25, 597-609.
  • Arnold, J., Hunt, G., McGregor, I. (2001). Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rat. Life Sciences, 70, 97-108.
  • Morley, K., Gallate, J., Hunt, G., McGregor, I., Mallet, P. (2001). Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine ("Ecstasy"). European Journal of Pharmacology, 433(1), 91-99.
  • Dielenberg, R., McGregor, I., Carrive, P. (2001). The cardiovascular and behavioral response to cat odor in rats: unconditioned and conditioned effects. Brain Research, 897, 228-237.
  • Arnold, J., Topple, A., Hunt, G., McGregor, I., Mallet, P. (2001). The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain. Brain Research, 921, 240-255.

Conferences

  • Creelman, A., Thominiaux, C., Chauveau, F., Fulton, R., Kuhnast, B., Henderson, D., Boutin, H., Selleri, S., McGregor, I., Hantraye, P., Kassiou, M., et al (2007). Synthesis and evaluation of the translocator protein (18kDa) (TSPO) ligand (11C)DPA0715 in rat and non-human primate. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.

2014

  • Einfeld, S., Smith, E., McGregor, I., Steinbeck, K., Taffe, J., Rice, L., Horstead, S., Rogers, N., Hodge, M., Guastella, A. (2014). A Double-Blind Randomized Controlled Trial of Oxytocin Nasal Spray in Prader Willi Syndrome. American Journal of Medical Genetics. Part A, 164(9), 2232-2239. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis. Brain, Behavior, and Immunity, 35, 107-124. [More Information]
  • Hicks, C., Ramos, L., Reekie, T., Misagh, G., Narlawar, R., Kassiou, M., McGregor, I. (2014). Body temperature and cardiac changes induced by peripherally administered oxytocin, vaspressin and the non-peptide oxytocin receptor agonist WAY 267, 464: a biotelemetry study in rats. British Journal of Pharmacology, 171(11), 2868-2887. [More Information]
  • Allsop, D., Dunlop, A., Sadler, C., Rivas, G., McGregor, I., Copeland, J. (2014). Changes in cigarette and alcohol use during cannabis abstinence. Drug and Alcohol Dependence, 138, 54-60. [More Information]
  • Wong, A., Keats, K., Rooney, K., Hicks, C., Allsop, D., Arnold, J., McGregor, I. (2014). Fasting and exercise increase plasma cannabinoid levels in THC pre-treated rats: an examination of behavioural consequences. Psychopharmacology, 231(20), 3987-3996. [More Information]
  • Too, L., Mitchell, A., Yau, B., Ball, H., McGregor, I., Hunt, N. (2014). Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis. Behavioural Brain Research, 263, 176-189. [More Information]
  • Johnston, J., Lintzeris, N., Allsop, D., Suraev, A., Booth, J., Carson, D., Helliwell, D., Winstock, A., McGregor, I. (2014). Lithium carbonate in the management of cannabis withdrawal: a randomized placebo-controlled trial in an inpatient setting. Psychopharmacology, In Press. [More Information]
  • Johnston, J., Lintzeris, N., Allsop, D., Suraev, A., Booth, J., Carson, D., Helliwell, D., Winstock, A., McGregor, I. (2014). Lithium carbonate in the management of cannabis withdrawal: a randomized placebo-controlled trial in an inpatient setting. Psychopharmacology, 231(24), 4623-4636. [More Information]
  • Allsop, D., Copeland, J., Lintzeris, N., Dunlop, A., Montebello, M., Sadler, C., Rivas, G., Holland, R., Muhleisen, P., Norberg, M., Booth, J., McGregor, I. (2014). Nabiximols as an Agonist Replacement Therapy During Cannabis Withdrawal: A Randomized Clinical Trial. JAMA Psychiatry, 71(3), 281-291. [More Information]
  • Ahmed, S., Kashem, M., Sarker, R., Ahmed, E., Hargreaves, G., McGregor, I. (2014). Neuroadaptations in the striatal proteome of the rat following prolonged excessive sucrose intake. Neurochemical Research, 39(5), 815-824. [More Information]
  • Bowen, M., McGregor, I. (2014). Oxytocin and vasopressin modulate the social response to threat: a preclinical study. International Journal of Neuropsychopharmacology, 17, 1621-1633. [More Information]
  • Barron, M., Werry, E., McGregor, I., Kassiou, M. (2014). P2X7 in Bipolar and Depressive Disorders. In Norbert Weiss, Alexandra Koschak (Eds.), Pathologies of Calcium Channels, (pp. 635-661). Berlin: Springer-Verlag.
  • Reekie, T., McGregor, I., Kassiou, M. (2014). Pyrazolo[1,4]diazepines as non-peptidic probes of the oxytocin and vasopressin receptors. Tetrahedron Letters, 55(33), 4568-4571. [More Information]
  • van Nieuwenhuijzen, P., McGregor, I., Chebib, M., Hunt, G. (2014). Regional Fos-expression induced by γ-hydroxybutyrate (GHB): comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Neuroscience, 277(C), 700-715. [More Information]
  • van Nieuwenhuijzen, P., McGregor, I., Chebib, M., Hunt, G. (2014). Regional Fos-expression induced by γ-hydroxybutyrate (GHB): Comparison with γ-butyrolactone (GBL) and effects of co-administration of the GABAB antagonist SCH 50911 and putative GHB antagonist NCS-382. Neuroscience, 277, 700-715. [More Information]
  • Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information]
  • Too, L., McQuillan, J., Ball, H., Kanai, M., Nakamura, T., Funakoshi, H., McGregor, I., Hunt, N. (2014). The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis. Behavioural Brain Research, 270, 179-195. [More Information]
  • Too, L., Ball, H., McGregor, I., Hunt, N. (2014). The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis. Brain, Behavior, and Immunity, 40, 252-268. [More Information]

2013

  • Carson, D., Guastella, A., Taylor, E., McGregor, I. (2013). A brief history of oxytocin and its role in modulating psychostimulant effects. Journal of Psychopharmacology, 27(3), 231-247. [More Information]
  • Quintana, D., McGregor, I., Guastella, A., Malhi, G., Kemp, A. (2013). A Meta-Analysis on the Impact of Alcohol Dependence on Short-Term Resting-State Heart Rate Variability: Implications for Cardiovascular Risk. Alcoholism: Clinical and Experimental Research, 37(S1), E23-E29. [More Information]
  • Ramos, L., Hicks, C., Kevin, R., Caminer, A., Narlawar, R., Kassiou, M., McGregor, I. (2013). Acute Prosocial Effects of Oxytocin and Vasopressin When Given Alone or in Combination with 3,4-Methylenedioxymethamphetamine in Rats: Involvement of the VI(A) Receptor. Neuropsychopharmacology, 38(11), 2249-2259. [More Information]
  • Swift, W., Wong, A., Li, K., Arnold, J., McGregor, I. (2013). Analysis of cannabis seizures in NSW, Australia: Cannabis potency and cannabinoid profile. PloS One, 8(7), 1-9. [More Information]
  • Bowen, M., Kevin, R., May, M., Staples, L., Hunt, G., McGregor, I. (2013). Defensive Aggregation (Huddling) in Rattus Norvegicus toward Predator Odor: Individual Differences, Social Buffering Effects and Neural Correlates. PloS One, 8(7), 1-15. [More Information]
  • Bosanquet, D., MacDougall, H., Rogers, S., Starmer, G., McKetin, R., Blaszczynski, A., McGregor, I. (2013). Driving on ice: Impaired driving skills in current methamphetamine users. Psychopharmacology, 225, 161-172. [More Information]
  • Wong, A., Montebello, M., Norberg, M., Rooney, K., Lintzeris, N., Bruno, R., Booth, J., Arnold, J., McGregor, I. (2013). Exercise increases plasma THC concentrations in regular cannabis users. Drug and Alcohol Dependence, 133(2), 763-767. [More Information]
  • Hunt, G., McGregor, I., Malhi, G. (2013). Give me a hi-5! An additional version of the h-index. Australian and New Zealand Journal of Psychiatry, 47(12), 1119-1123. [More Information]
  • Quintana, D., Guastella, A., McGregor, I., Hickie, I., Kemp, A. (2013). Heart rate variability predicts alcohol craving in alcohol dependent outpatients: Further evidence for HRV as a psychophysiological marker of self-regulation. Drug and Alcohol Dependence, 132(1-2), 395-398. [More Information]
  • Motbey, C., Clemens, K., Apetz, N., Winstock, A., Ramsey, J., Li, K., Wyatt, N., Callaghan, P., Bowen, M., Cornish, J., McGregor, I. (2013). High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine. Journal of Psychopharmacology, 27(9), 823-836. [More Information]
  • Karanges, E., Kashem, M., Sarker, R., Ahmed, E., Ahmed, S., van Nieuwenhuijzen, P., Kemp, A., McGregor, I. (2013). Hippocampal protein expression is differentially affected by chronic paroxetine treatment in adolescent and adult rats: a possible mechanism of "paradoxical" antidepressant responses in young persons. Frontiers in Pharmacology, 4, 1-13. [More Information]
  • Quintana, D., Guastella, A., McGregor, I., Hickie, I., Kemp, A. (2013). Moderate alcohol intake is related to increased heart rate variability in young adults: Implications for health and well-being. Psychophysiology, 50(12), 1202-1208. [More Information]
  • Spencer, J., Darbyshire, K., Boucher, A., Kashem, M., Long, L., McGregor, I., Karl, T., Arnold, J. (2013). Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: a hippocampal proteomic study in mice. Frontiers in Cellular Neuroscience, 7, 1-13. [More Information]
  • Banister, S., Wilkinson, S., Longworth, M., Stuart, J., Apetz, N., English, K., Brooker, L., Goebel, C., Hibbs, D., Glass, M., McGregor, I., Kassiou, M., et al (2013). The Synthesis and Pharmacological Evaluation of Adamantane-Derived Indoles: Cannabimimetic Drugs of Abuse. ACS Chemical Neuroscience, 4(7), 1081-1092. [More Information]
  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2013). Transmembrane domain Nrg1 mutant mice show altered susceptibility to the neurobehavioural actions of repeated THC exposure in adolescence. International Journal of Neuropsychopharmacology, 16(1), 163-175. [More Information]
  • Stephenson, C., Karanges, E., McGregor, I. (2013). Trends in the utilisation of psychotropic medications in Australia from 2000-2011. Australian and New Zealand Journal of Psychiatry, 47(1), 74-87. [More Information]

2012

  • Bowen, M., Keats, K., Kendig, M., Cakic, V., Callaghan, P., McGregor, I. (2012). Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behavioural Processes, 90(3), 331-336. [More Information]
  • Ahmed, E., Ahmed, S., Ukai, W., Matsumoto, I., Kemp, A., McGregor, I., Kashem, M. (2012). Antipsychotic Induced Alteration of Growth and Proteome of Rat Neural Stem Cells. Neurochemical Research, 37, 1649-1659. [More Information]
  • McGregor, I., Bowen, M. (2012). Breaking the loop: Oxytocin as a potential treatment for drug addiction. Hormones and Behavior, 61(3), 331-339. [More Information]
  • Long, L., Chesworth, R., Huang, X., Wong, A., Spiro, A., McGregor, I., Arnold, J., Karl, T. (2012). Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice. PloS One, 7(4), 1-11. [More Information]
  • Kashem, M., Ahmed, S., Sarker, R., Ahmed, E., Hargreaves, G., McGregor, I. (2012). Long-term daily access to alcohol alters dopamine-related synthesis and signaling proteins in the rat striatum. Neurochemistry International, 61(8), 1280-1288. [More Information]
  • Motbey, C., Hunt, G., Bowen, M., Artiss, S., McGregor, I. (2012). Mephedrone (4-Methylmethcathinone, "Meow"): Acute Behavioural Effects and Distribution of Fos Expression in Adolescent Rats. Addiction Biology, 17(2), 409-422. [More Information]
  • Motbey, C., Karanges, E., Li, K., Wilkinson, S., Winstock, A., Ramsay, J., Hicks, C., Kendig, M., Wyatt, N., Callaghan, P., McGregor, I. (2012). Mephedrone in adolescent rats: Residual memory impairment and acute but not lasting 5-HT depletion. PloS One, 7(9), 1-10. [More Information]
  • Baracz, S., Rourke, P., Pardey, M., Hunt, G., McGregor, I., Cornish, J. (2012). Oxytocin directly administered into the nucleus accumbens core or subthalamic nucleus attenuates methamphetamine-induced conditioned place preference. Behavioural Brain Research, 228(1), 185-193. [More Information]
  • Carson, D., Bosanquet, D., Carter, S., Pournajafi-Nazarloo, H., Blaszczynski, A., McGregor, I. (2012). Preliminary Evidence for Lowered Basal Cortisol in a Naturalistic Sample of Methamphetamine Polydrug Users. Experimental and Clinical Psychopharmacology, 20(6), 497-503. [More Information]
  • Cornish, J., Hunt, G., Robins, L., McGregor, I. (2012). Regional c-Fos and FosB/δFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats. Neuroscience, 206, 100-114. [More Information]
  • May, M., Bowen, M., McGregor, I., Timberlake, W. (2012). Rubbings deposited by cats elicit defensive behavior in rats. Physiology and Behavior, 107(5), 711-718. [More Information]
  • Wong, A., Gunasekaran, N., Hancock, D., Denyer, G., Meng, L., Radford, J., McGregor, I., Arnold, J. (2012). The major plant-derived cannabinoid 9-tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Hormone And Metabolic Research, 44(2), 105-113. [More Information]
  • Hicks, C., Jorgensen, W., Brown, C., Fardell, J., Koehbach, J., Gruber, C., Kassiou, M., Hunt, G., McGregor, I. (2012). The Nonpeptide Oxytocin Receptor Agonist WAY 267,464: Receptor-Binding Profile, Prosocial Effects and Distribution of c-Fos Expression in Adolescent Rats. Journal of Neuroendocrinology, 24(7), 1012-1029. [More Information]

2011

  • Hunt, G., van Nieuwenhuijzen, P., Chan-Ling, T., McGregor, I. (2011). 'When an old rat smells a cat': a decline in defense-related, but not accessory olfactory, Fos expression in aged rats. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 32(4), 737-749. [More Information]
  • Bowen, M., Carson, D., Spiro, A., Arnold, J., McGregor, I. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PloS One, 6(11), 1 (e27237)-11. [More Information]
  • Karanges, E., McGregor, I. (2011). Antidepressants and adolescent brain development. Future Neurology, 6(6), 783-808. [More Information]
  • Hargreaves, G., Wang, E., Lawrence, A., McGregor, I. (2011). Beer promotes high levels of alcohol intake in adolescent and adult alcohol-preferring rats. Alcohol, 45(5), 485-498. [More Information]
  • Klein, C., Karanges, E., Spiro, A., Wong, A., Spencer, J., Huynh, T., Gunasekaran, N., Karl, T., Long, L., Huang, X., Arnold, J., McGregor, I., et al (2011). Cannabidiol potentiates Δ9-tetrahydrocannabinol (THC) behavioural effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats. Psychopharmacology, 218(2), 443-457. [More Information]
  • Karanges, E., Li, K., Motbey, C., Callaghan, P., Katsifis, A., McGregor, I. (2011). Differential behavioural and neurochemical outcomes from chronic paroxetine treatment in adolescent and adult rats: a model of adverse antidepressant effects in human adolescents? International Journal of Neuropsychopharmacology, 14(4), 491-504. [More Information]
  • Ferguson (Sokolic), L., Long, L., Hunt, G., Arnold, J., McGregor, I. (2011). Disruptive effects of the prototypical cannabinoid Delta9-tetrahydrocannabinol and the fatty acid amide inhibitor URB-597 on go/no-go auditory discrimination performance and olfactory reversal learning in rats. Behavioural Pharmacology, 22(3), 191-202. [More Information]
  • Hunt, G., McGregor, I., Cornish, J., Callaghan, P. (2011). MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635. Brain Research Bulletin, 86, 65-73. [More Information]
  • Kendig, M., Bowen, M., Kemp, A., McGregor, I. (2011). Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience. Behavioural Brain Research, 225(2), 405-414. [More Information]
  • Boucher, A., Arnold, J., Hunt, G., Spiro, A., Spencer, J., Brown, C., McGregor, I., Bennett, M., Kassiou, M. (2011). Resilience and Reduced C-FOS Expression in P2X7 Receptor Knockout Mice Exposed to Repeated Forced Swim Test. Neuroscience, 189, 170-177. [More Information]
  • Verty, A., Evetts, M., Crouch, G., McGregor, I., Stefanidis, A., Oldfield, B. (2011). The Cannabinoid Receptor Agonist THC Attenuates Weight Loss in a Rodent Model of Activity-Based Anorexia. Neuropsychopharmacology, 36, 1349-1358.
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2011). The schizophrenia-susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]

2010

  • van Nieuwenhuijzen, P., Kashem, M., Matsumoto, I., Hunt, G., McGregor, I. (2010). A long hangover from party drugs: Residual proteomic changes in the hippocampus of rats 8 weeks after gamma-hydroxybutyrate (GHB),3,4-methylenedioxymethamphetamine (MDMA) or their combination. Neurochemistry International, 56(8), 871-877. [More Information]
  • Arnold, J., Dielenberg, R., McGregor, I. (2010). Cannabinoids increase conditioned ultrasonic vocalisations and cat odour avoidance in rats: Strain differences in drug-induced anxiety. Life Sciences, 87(17-18), 572-578. [More Information]
  • Carson, D., Cornish, J., Guastella, A., Hunt, G., McGregor, I. (2010). Oxytocin decreases methamphetamine self-administration, methamphetamine hyperactivity, and relapse to methamphetamine-seeking behaviour in rats. Neuropharmacology, 58(1), 38-43. [More Information]
  • van Nieuwenhuijzen, P., Long, L., Hunt, G., Arnold, J., McGregor, I. (2010). Residual social, memory and oxytocin-related changes in rats following repeated exposure to gamma-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination. Psychopharmacology, 212(4), 663-674. [More Information]
  • Carson, D., Hunt, G., Guastella, A., Barber, L., Cornish, J., Arnold, J., Boucher, A., McGregor, I. (2010). Systemically administered oxytocin decreases methamphetamine activation of the subthalamic nucleus and accumbens core and stimulates oxytocinergic neurons in the hypothalamus. Addiction Biology, 15(4), 448-463. [More Information]
  • Thompson, M., Callaghan, P., McGregor, I. (2010). The Pharmacology of MDMA (Ecstasy). In Degenhardt L. & Hall W. (Eds.), The Health and Psychological Effects of "Ecstasy" (MDMA) Use, (pp. 47-80). Randwick, NSW: National Drug and Alcohol Research Centre.
  • Boucher, A., Hunt, G., Micheau, J., Huang, X., McGregor, I., Karl, T., Arnold, J. (2010). The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids. International Journal of Neuropsychopharmacology, 14(5), 631-643. [More Information]

2009

  • Long, L., Chesworth, R., Huang, X., McGregor, I., Arnold, J., Karl, T. (2009). A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice. International Journal of Neuropsychopharmacology, 13 (2010)(7), 861-876. [More Information]
  • Kashem, M., Sarker, R., Des Etages, H., Machaalani, R., King, N., McGregor, I., Matsumoto, I. (2009). Comparative proteomics in the corpus callosal sub-regions of postmortem human brain. Neurochemistry International, 55(7), 483-490. [More Information]
  • Kashem, M., Des Etages, H., Kopitar-Jerala, N., McGregor, I., Matsumoto, I. (2009). Differential protein expression in the corpus callosum (body) of human alcoholic brain. Journal of Neurochemistry, 110(2), 486-495. [More Information]
  • Kashem, M., Ummehany, R., Ukai, W., Hashimoto, E., Saito, T., McGregor, I., Matsumoto, I. (2009). Effects of typical (haloperidol) and atypical (risperidone) antipsychotic agents on protein expression in rat neural stem cells. Neurochemistry International: the journal for the publication of cellular and molecular aspects of neurochemistry, 55(7), 558-565. [More Information]
  • Hargreaves, G., Monds, L., Gunasekaran, N., Dawson, B., McGregor, I. (2009). Intermittent access to beer promotes binge-like drinking in adolescent but not adult Wistar rats. Alcohol, 43, 305-314. [More Information]
  • Verty, A., Boon, W., Mallett, P., McGregor, I., Oldfield, B. (2009). Involvement of hypothalamic peptides in the anorectic action of the CB1 receptor antagonist rimonabant (SR 141716). European Journal of Neuroscience, 29(11), 2207-2216.
  • Staples, L., McGregor, I., Hunt, G. (2009). Long-lasting FosB/delta-FosB immunoreactivity in the rat brain after repeated cat odor exposure. Neuroscience Letters, 462(2), 157-161.
  • Thompson, M., Hunt, G., McGregor, I. (2009). Neural correlates of MDMA ("Ecstasy")-induced social interaction in rats. Social Neuroscience, 4(1), 60-72. [More Information]
  • Hargreaves, G., Quinn, H., Kashem, M., Matsumoto, I., McGregor, I. (2009). Proteomic Analysis Demonstrates Adolescent Vulnerability to Lasting Hippocampal Changes Following Chronic Alcohol Consumption. Alcoholism: Clinical and Experimental Research, 33(1), 86-94. [More Information]
  • Gunasekaran, N., Long, L., Dawson, B., Hansen, G., Richardson, D., Li, K., Arnold, J., McGregor, I. (2009). Reintoxication: the release of fat-stored delta-9-tetrahydrocannabinol (THC) into blood is enhanced by food deprivation or ACTH exposure. British Journal of Pharmacology, 158(5), 1330-1337. [More Information]
  • van Nieuwenhuijzen, P., McGregor, I., Hunt, G. (2009). The distribution of gamma-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen. Neuroscience, 158(2), 441-455. [More Information]
  • van Nieuwenhuijzen, P., Li, K., Hunt, G., McGregor, I. (2009). Weekly gamma-hydroxybutyrate exposure sensitizes locomotor hyperactivity to low-dose 3,4-methylenedioxymethamphetamine in rats. Neuropsychobiology, 60(3-4), 195-203. [More Information]

2008

  • Rutten, K., Reneerkensa, O., Hamers, H., Sik, A., McGregor, I., Prickaerts, J., Blokland, A. (2008). Automated scoring of novel object recognition in rats. Journal of Neuroscience Methods, 171, 72-77. [More Information]
  • Staples, L., McGregor, I., Apfelbach, R., Hunt, G. (2008). Cat odor, but not trimethylthiazoline (fox odor), activates accessory olfactory and defense-related brain regions in rats. Neuroscience, 151, 937-947. [More Information]
  • McGregor, I., Callaghan, P., Hunt, G. (2008). From ultrasocial to antisocial: a role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? British Journal of Pharmacology, 154, 358-368. [More Information]
  • Cornish, J., Clemens, K., Thompson, M., Callaghan, P., Dawson, B., McGregor, I. (2008). High ambient temperature increases intravenous methamphetamine self-administration on fixed and progressive ratio schedules in rats. Journal of Psychopharmacology, 22(1), 100-110.
  • Iwazaki, T., McGregor, I., Matsumoto, I. (2008). Protein expression profile in the amygdala of rats with methamphetamine-induced behavioral sensitization. Neuroscience Letters, 435(2), 113-119. [More Information]
  • Staples, L., Hunt, G., van Nieuwenhuijzen, P., McGregor, I. (2008). Rats discriminate individual cats by their odor: Possible involvement of the accessory olfactory system. Neuroscience and Biobehavioral Reviews, 32(7), 1209-1217. [More Information]
  • Thompson, M., Callaghan, P., Hunt, G., McGregor, I. (2008). Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 32(4), 1013-1021. [More Information]

2007

  • Thompson, M., Callaghan, P., Hunt, G., Cornish, J., McGregor, I. (2007). A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience, 146(2), 509-514. [More Information]
  • Quinn, H., Matsumoto, I., Callaghan, P., Long, L., Arnold, J., Gunasekaran, N., Thompson, M., Dawson, B., Mallet, P., Kashem, M., Matsuda-Matsumoto, H., Iwazaki, T., McGregor, I. (2007). Adolescent rats find repeated delta-9-THC less aversive than adult rats but display greater residual cognitive deficits and changes in hippocampal protein expression following exposure. Neuropsychopharmacology, 33 (epub ahead of print Jun 20), 1-14. [More Information]
  • Ferguson (Sokolic), L., Laing, D., McGregor, I. (2007). Asymmetric suppression of components in binary aldehyde mixtures: Behavioral studies in the laboratory rat. Chemical Senses, 32(2), 191-199.
  • Ferguson (Sokolic), L., McGregor, I. (2007). Benzodiazepines impair the acquisition and reversal of olfactory go/no-go discriminations in rats. Behavioral Neuroscience, 121(3), 527-534.
  • McGregor, I., Arnold, J. (2007). Cannabis reward: biased towards the fairer sex? British Journal of Pharmacology, 152(5), 562-564. [More Information]
  • Boucher, A., Hunt, G., Karl, T., Micheau, J., McGregor, I., Arnold, J. (2007). Heterozygous neuregulin 1 mice display greater baseline and Delta(9)-tetrahydrocannabinol-induced c-Fos expression. Neuroscience, 149(4), 861-870. [More Information]
  • Hargreaves, G., Hunt, G., Cornish, J., McGregor, I. (2007). High ambient temperature increases 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy")-induced Fos expression in a region-specific manner. Neuroscience, 145(2), 764-774. [More Information]
  • Chan-Ling, T., Hughes, S., Baxter, L., Rosinova, E., McGregor, I., Morcos, Y., van Nieuwenhuijzen, P., Hu, P. (2007). Inflammation and breakdown of the blood-retinal barrier during "physiological aging" in the rat retina: A model for CNS aging. Microcirculation, 14(1), 63-76. [More Information]
  • Clemens, K., McGregor, I., Hunt, G., Cornish, J. (2007). MDMA, methamphetamine and their combination: possible lessons for party drug users from recent preclinical research. Drug and Alcohol Review, 26(1), 9-15. [More Information]
  • Iwazaki, T., McGregor, I., Matsumoto, I. (2007). Protein expression profile in the striatum of rats with methamphetamine-induced behavioral sensitization. Proteomics, 7(7), 1131-1139. [More Information]
  • Clemens, K., Cornish, J., Hunt, G., McGregor, I. (2007). Repeated weekly exposure to MDMA, methamphetamine or their combination: Long-term behavioural and neurochemical effects in rats. Drug and Alcohol Dependence, 86(2-3), 183-190.
  • Creelman, A., Thominiaux, C., Chauveau, F., Fulton, R., Kuhnast, B., Henderson, D., Boutin, H., Selleri, S., McGregor, I., Hantraye, P., Kassiou, M., et al (2007). Synthesis and evaluation of the translocator protein (18kDa) (TSPO) ligand (11C)DPA0715 in rat and non-human primate. 17th International Symposium on Radiopharmaceutical Sciences. John Wiley & Sons.
  • Hargreaves, G., McGregor, I. (2007). Topiramate moderately reduces the motivation to consume alcohol and has a marked antidepressant effect in rats. Alcoholism: Clinical and Experimental Research, 31(11), 1900-1907.

2006

  • Staples, L., McGregor, I. (2006). Defensive responses of Wistar and Sprague-Dawley rats to cat odour and TMT. Behavioural Brain Research, 172(2), 351-354. [More Information]
  • Siviy, S., Harrison, K., McGregor, I. (2006). Fear, risk assessment, and playfulness in the juvenile rat. Behavioral Neuroscience, 120(1), 49-59.
  • Clemens, K., Cornish, J., Hunt, G., McGregor, I. (2006). Intravenous methamphetamine self-administration in rats: Effects of intravenous or intraperitoneal MDMA co-administration. Pharmacology, Biochemistry and Behavior, 85, 454-463. [More Information]
  • Iwazaki, T., McGregor, I., Matsumoto, I. (2006). Protein expression profile in the striatum of acute methamphetamine-treated rats. Brain Research, 1097, 19-25. [More Information]
  • O'Shea, M., McGregor, I., Mallet, P. (2006). Repeated cannabinoid exposure during perinatal, adolescent, or early adult ages produces similar long-lasting deficits in object recognition and reduced social interaction in rats. Journal of Psychopharmacology, 20(5), 611-621.

2005

  • Hargreaves, G., McGregor, I., Sachdev, P. (2005). Chronic repetitive transcranial magnetic stimulation is antidepressant but not anxiolytic in rat models of anxiety and depression. Psychiatry Research, 137(1-2), 113-121.
  • Young, J., McGregor, I., Mallet, P. (2005). Co-administration of THC and MDMA ('Ecstasy') synergistically disrupts memory in rats. Neuropsychopharmacology, 30(8), 1475-1482.
  • Cornish, J., Lontos, J., Clemens, K., McGregor, I. (2005). Cocaine and heroin ('speedball') self-administration: the involvement of nucleus accumbens dopamine and mu-opiate, but not delta-opiate receptors. Psychopharmacology, 180(1), 21-32. [More Information]
  • McGregor, I., Touyz, S., Marks, P., Vocks, S., Beumont, P. (2005). Defensive behavior. Neuroscience and Biobehavioral Reviews, 29(8), 1121-1122.
  • McGregor, I., Dam, K., Mallet, P., Gallate, J. (2005). Delta(9)-THC reinstates beer- and sucrose-seeking behaviour in abstinent rats: Comparison with midazolam, food deprivation and predator odour. Alcohol and Alcoholism, 40(1), 35-45.
  • Clemens, K., Cornish, J., Li, K., Hunt, G., McGregor, I. (2005). MDMA ('Ecstasy') and methamphetamine combined: order of administration influences hyperthermic and long-term adverse effects in female rats. Neuropharmacology, 49(2), 195-207. [More Information]
  • McGregor, I., Clemens, K., Cornish, J., Thompson, M., He, S., Clarke, S., Kohn, M., Gordon, E. (2005). MDMA, methamphetamine and their combination: Comparison of long-term behavioural and neural effects in rats. Behavioural Pharmacology, 16, S11-S11.
  • Staples, L., Hunt, G., Cornish, J., McGregor, I. (2005). Neural activation during cat odor-induced conditioned fear and 'trial 2' fear in rats. Neuroscience and Biobehavioral Reviews, 29(8), 1265-1277. [More Information]
  • Verty, A., McGregor, I., Mallet, P. (2005). Paraventricular hypothalamic CB1 cannabinoid receptors are involved in the feeding stimulatory effects of Delta(9)-tetrahydrocannabinol. Neuropharmacology, 49(8), 1101-1109.
  • Singh, M., McGregor, I., Mallet, P. (2005). Perinatal exposure to Delta(9)-tetrahydrocannabinol alters heroin-induced place conditioning and Fos-immunoreactivity. Neuropsychopharmacology, 31(1), 1-12.
  • Singh, M., McGregor, I., Mallet, P. (2005). Repeated exposure to Delta(9)-tetrahydrocannabinol alters heroin-induced locomotor sensitisation and Fos-immunoreactivity. Neuropharmacology, 49(8), 1189-1200.
  • Morley, K., Arnold, J., McGregor, I. (2005). Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 29(5), 648-657. [More Information]
  • Apfelbach, R., Blanchard, C., Blanchard, R., Hayes, R., McGregor, I. (2005). The effects of predator odors in mammalian prey species: A review of field and laboratory studies. Neuroscience and Biobehavioral Reviews, 29(8), 1123-1144.
  • Fendt, M., Endres, T., Lowry, C., Apfelbach, R., McGregor, I. (2005). TMT-induced autonomic and behavioral changes and the neural basis of its processing. Neuroscience and Biobehavioral Reviews, 29(8), 1145-1156.

2004

  • Morley, K., Li, K., Hunt, G., Mallet, P., McGregor, I. (2004). Cannabinoids Prevent The Acute Hyperthermia And Partially Protect Against The 5-Ht Depleting Effects Of Mdma ('Ecstasy') In Rats. Neuropharmacology, 46(7), 954-965.
  • Thompson, M., Li, K., Clemens, K., Gurtman, C., Hunt, G., Cornish, J., McGregor, I. (2004). Chronic Fluoxetine Treatment Partly Attenuates The Long-Term Anxiety And Depressive Symptoms Induced By Mdma ('Ecstasy') In Rats. Neuropsychopharmacology, 29(4), 694-704.
  • Gallate, J., McGregor, I., Mallet, P. (2004). Combined Low Dose Treatment With Opioid And Cannabinoid Receptor Antagonists Synergistically Reduces The Motivation To Consume Alcohol In Rats. Psychopharmacology, 173(1-2), 210-216. [More Information]
  • McGregor, I., Verty, A., Mallet, P. (2004). Consumption Of High Carbohydrate, High Fat, And Normal Chow Is Equally Suppressed By A Cannabinoid Receptor Antagonist In Non-Deprived Rats. Neuroscience Letters, 354(3), 217-220.
  • Ball, H., MacDougall, H., McGregor, I., Hunt, N. (2004). Cyclooxygenase-2 In The Pathogenesis Of Murine Cerebral Malaria. The Journal of Infectious Diseases, 189(4), 751-758.
  • Verty, A., McFarlane, J., McGregor, I., Mallet, P. (2004). Evidence For An Interaction Between Cb1 Cannabinoid And Melanocortin MCR-4 Receptors In Regulating Food Intake. Endocrinology, 145(7), 3224-3231.
  • Verty, A., McFarlane, J., McGregor, I., Mallet, P. (2004). Evidence For An Interaction Between Cb1 Cannabinoid And Oxytocin Receptors In Food And Water Intake. Neuropharmacology, 47(4), 593-603.
  • Clemens, K., van Nieuwenhuijzen, P., Li, K., Cornish, J., Hunt, G., McGregor, I. (2004). Mdma ('Ecstasy'), Methamphetamine And Their Combination: Long-Term Changes In Social Interaction And Neurochemistry In The Rat. Psychopharmacology, 173(38445), 318-325. [More Information]
  • McGregor, I., Hargreaves, G., Apfelbach, R., Hunt, G. (2004). Neural Correlates Of Cat Odor-Induced Anxiety In Rats: Region-Specific Effects Of The Benzodiazepine Midazolam. The Journal of Neuroscience, 24(17), 4134-4144.
  • Morley, K., Cornish, J., Li, K., McGregor, I. (2004). Preexposure To Mdma ("Ecstasy") Delays Acquisition But Facilitates Mdma-Induced Reinstatement Of Amphetamine Self-Administration Behavior In Rats. Pharmacology, Biochemistry and Behavior, 79(2), 331-342.
  • Li, K., Thompson, M., McGregor, I. (2004). Rapid Quantitation Of Fluoxetine And Norfluoxetine In Serum By Micro-Disc Solid-Phase Extraction With High-Performance Liquid Chromatography-Ultraviolet Absorbance Detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 804(2), 319-326. [More Information]
  • McGregor, I., Gallate, J. (2004). Rats On The Grog: Novel Pharmacotherapies For Alcohol Craving,. Addictive Behaviors, 29(7), 1341-1357. [More Information]
  • Verty, A., McGregor, I., Mallet, P. (2004). The Doparnine Receptor Antagonist Sch 23390 Attenuates Feeding Induced By Delta(9)-Tetrahydrocannobinol. Brain Research, 1020 (38384), 188-195. [More Information]

2003

  • Cornish, J., Shahnawaz, Z., Thompson, M., Wong, S., Morley, K., Hunt, G., McGregor, I. (2003). Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats. European Journal of Pharmacology, 482(1-3), 339-341. [More Information]
  • McGregor, I., Clemens, K., Van Der Plasse, G., Li, K., Hunt, G., Chen, F., Lawrence, A. (2003). Increased Anxiety 3 Months after Brief Exposure to MDMA ('Ecstasy') in Rats: Association with Altered 5-HT Transporter and Receptor Density. Neuropsychopharmacology, 28, 1472-1484.
  • McGregor, I., Gurtman, C., Morley, K., Clemens, K., Li, K., Blokland, A., Cornish, J., Hunt, G. (2003). Increased anxiety and "depressive" symptoms months after MDMA ("ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes. Psychopharmacology, 168(4), 465-474. [More Information]
  • Norwood, C., Cornish, J., Mallet, P., McGregor, I. (2003). Pre-exposure to the cannabinoid receptor agonist CP 55,940 enhances morphine behavioral sensitization and alters morphine self-administration in Lewis rats. European Journal of Pharmacology, 465(1-2), 105-114.
  • Allen, K., McGregor, I., Hunt, G., Singh, M., Mallet, P. (2003). Regional differences in nalaxone modulation of Delta 9 - THC induced Fos expression in rat brain. Neuropharmacology, 44(2), 264-274.
  • Verty, A., Singh, M., McGregor, I., Mallet, P. (2003). The cannabinoid receptor antagonist SR 141716 attenuates overfeeding induced by systemic or intracranial morphine. Psychopharmacology, 168(3), 314-323. [More Information]
  • Gallate, J., Morley, K., Ambermoon, P., McGregor, I. (2003). The consequences of beer consumption in rats: acute anxiolytic and ataxic effects and withdrawal-induced anxiety. Psychopharmacology, 166(1), 51-60. [More Information]

2002

  • Hunt, G., McGregor, I. (2002). Contrasting effects of dopamine antagonists and frequency reduction on Fos expression induced by lateral hypothalamic stimulation. Behavioural Brain Research, 132(2), 187-201.
  • Gurtman, C., Morley, K., Li, K., Hunt, G., McGregor, I. (2002). Increased anxiety in rats after 3,4-methylenedioxymethamphetamine: association with serotonin depletion. European Journal of Pharmacology, 446(1-3), 89-96.
  • McGregor, I., Schrama, L., Ambermoon, P., Dielenberg, R. (2002). Not all 'predator odours' are equal: cat odur but not 2,4,5 trimrthylthiazoline (TMT; fox odour) elicits specific defensive behaviours in rats. Behavioural Brain Research, 130(1-2), 1-16.
  • Green, R., McGregor, I. (2002). On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA. Psychopharmacology, 162(4), 448-450.

2001

  • Dielenberg, R., Hunt, G., McGregor, I. (2001). 'When a rat smells a cat': The distribution of fos immunoreactivity in rat brain following exposure to a predatory odor. Neuroscience, 104, 1085-1097.
  • Dielenberg, R., McGregor, I. (2001). Defensive behvior in rats towards predatory odors: a review. Neuroscience and Biobehavioral Reviews, 25, 597-609.
  • Arnold, J., Hunt, G., McGregor, I. (2001). Effects of the cannabinoid receptor agonist CP 55,940 and the cannabinoid receptor antagonist SR 141716 on intracranial self-stimulation in Lewis rat. Life Sciences, 70, 97-108.
  • Morley, K., Gallate, J., Hunt, G., McGregor, I., Mallet, P. (2001). Increased anxiety and impaired memory in rats 3 months after administration of 3,4-methylenedioxymethamphetamine ("Ecstasy"). European Journal of Pharmacology, 433(1), 91-99.
  • Dielenberg, R., McGregor, I., Carrive, P. (2001). The cardiovascular and behavioral response to cat odor in rats: unconditioned and conditioned effects. Brain Research, 897, 228-237.
  • Arnold, J., Topple, A., Hunt, G., McGregor, I., Mallet, P. (2001). The distribution of cannabinoid-induced Fos expression in rat brain: differences between the Lewis and Wistar strain. Brain Research, 921, 240-255.

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