Dr James Burchfield

Group Leader - Molecular Imaging
Research Fellow
School of Life and Environmental Sciences

Member of the Charles Perkins Centre

D17 - Charles Perkins Centre
The University of Sydney

Selected grants

2017

  • GLUT4 trafficking and insulin resistance; Burchfield J, Fazakerley D; Diabetes Australia/Research Grant.

Selected publications

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Journals

  • Norris, D., Yang, P., Krycer, J., Fazakerley, D., James, D., Burchfield, J. (2017). An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Journal of Cell Science, 130, 2757-2766. [More Information]
  • Krycer, J., Fazakerley, D., Cater, R., Thomas, K., Naghiloo, S., Burchfield, J., Humphrey, S., Vandenberg, R., Ryan, R., James, D. (2017). The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. FEBS Letters, 591(2), 322-330. [More Information]
  • Wong, M., Krycer, J., Burchfield, J., James, D., Kuncic, Z. (2015). A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems. FEBS Open Bio, 5, 226-239. [More Information]
  • Hoffman, N., Parker, B., Chaudhuri, R., Fisher-Wellman, K., Kleinert, M., Humphrey, S., Yang, P., Holliday, M., Trefely, S., Fazakerley, D., Stoeckli, J., Burchfield, J., James, D., et al (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metabolism, 22(5), 922-935. [More Information]
  • Fazakerley, D., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J., Thomas, K., Krycer, J., Prior, M., Parker, B., Murrow, B., Stoeckli, J., Meoli, C., James, D., et al (2015). Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. The Journal of Biological Chemistry, 290(39), 23528-23542. [More Information]
  • Yang, P., Patrick, E., Tan, S., Fazakerley, D., Burchfield, J., Gribben, C., Prior, M., James, D., Yang, J. (2014). Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway. Bioinformatics, 30(6), 808-814. [More Information]
  • Li, J., Cantley, J., Burchfield, J., Meoli, C., Stockli, J., Whitworth, P., Pant, H., Chaudhuri, R., Groffen, A., Verhage, M., James, D. (2014). DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. Diabetologia, 57(10), 2173-2182. [More Information]
  • Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
  • Fletcher, R., Gribben, C., Ma, X., Burchfield, J., Thomas, K., Krycer, J., James, D., Fazakerley, D. (2014). The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action. PloS One, 9(4), 1-10. [More Information]
  • Burchfield, J., Lu, J., Fazakerley, D., Tan, S., Ng, Y., Mele, K., Buckley, M., Han, W., Hughes, W., James, D. (2013). Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response. Traffic, 14(3), 259-273. [More Information]
  • Tan, S., Ng, Y., Burchfield, J., Ramm, G., Lambright, D., Stockli, J., James, D. (2012). The RabGAP TBC1D4/AS160 contains an atypical PTB domain that interacts with plasma membrane phospholipids to facilitae GLUT4 trafficking in adipocytes. Molecular and Cellular Biology, 32(24), 4946-4959. [More Information]
  • Prior, M., Larance, M., Lawrence, R., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J., La-Borde, P., Buckley, M., James, D., et al (2011). Quantitative Proteomic Analysis of the Adipocyte Plasma Membrane. Journal of Proteome Research, 10(11), 4970-4982. [More Information]
  • Ng, Y., Ramm, G., Burchfield, J., Coster, A., Stockli, J., James, D. (2010). Cluster Analysis of Insulin Action in Adipocytes Reveals a Key Role for Akt at the Plasma Membrane. Journal of Biological Chemistry, 285(4), 2245-2257. [More Information]
  • Lopez, J., Burchfield, J., Blair, D., Mele, K., Ng, Y., Vallotton, P., James, D., Hughes, W. (2009). Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerisation. Molecular Biology of the Cell, 20(17), 3918-3929. [More Information]
  • Zhao, P., Yang, L., Lopez, J., Fan, J., Burchfield, J., Bai, L., Hong, W., Xu, T., James, D. (2009). Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. Journal of Cell Science, 122(19), 3472-3480. [More Information]

Conferences

  • Mele, K., Vallotton, P., Burchfield, J., James, D., Hughes, W. (2009). Towards fully automated identification of Vesicle-Membrane Fusion Events in TIRF Microscopy. [More Information]

2017

  • Norris, D., Yang, P., Krycer, J., Fazakerley, D., James, D., Burchfield, J. (2017). An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Journal of Cell Science, 130, 2757-2766. [More Information]
  • Krycer, J., Fazakerley, D., Cater, R., Thomas, K., Naghiloo, S., Burchfield, J., Humphrey, S., Vandenberg, R., Ryan, R., James, D. (2017). The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. FEBS Letters, 591(2), 322-330. [More Information]

2015

  • Wong, M., Krycer, J., Burchfield, J., James, D., Kuncic, Z. (2015). A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems. FEBS Open Bio, 5, 226-239. [More Information]
  • Hoffman, N., Parker, B., Chaudhuri, R., Fisher-Wellman, K., Kleinert, M., Humphrey, S., Yang, P., Holliday, M., Trefely, S., Fazakerley, D., Stoeckli, J., Burchfield, J., James, D., et al (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metabolism, 22(5), 922-935. [More Information]
  • Fazakerley, D., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J., Thomas, K., Krycer, J., Prior, M., Parker, B., Murrow, B., Stoeckli, J., Meoli, C., James, D., et al (2015). Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. The Journal of Biological Chemistry, 290(39), 23528-23542. [More Information]

2014

  • Yang, P., Patrick, E., Tan, S., Fazakerley, D., Burchfield, J., Gribben, C., Prior, M., James, D., Yang, J. (2014). Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway. Bioinformatics, 30(6), 808-814. [More Information]
  • Li, J., Cantley, J., Burchfield, J., Meoli, C., Stockli, J., Whitworth, P., Pant, H., Chaudhuri, R., Groffen, A., Verhage, M., James, D. (2014). DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. Diabetologia, 57(10), 2173-2182. [More Information]
  • Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
  • Fletcher, R., Gribben, C., Ma, X., Burchfield, J., Thomas, K., Krycer, J., James, D., Fazakerley, D. (2014). The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action. PloS One, 9(4), 1-10. [More Information]

2013

  • Burchfield, J., Lu, J., Fazakerley, D., Tan, S., Ng, Y., Mele, K., Buckley, M., Han, W., Hughes, W., James, D. (2013). Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response. Traffic, 14(3), 259-273. [More Information]

2012

  • Tan, S., Ng, Y., Burchfield, J., Ramm, G., Lambright, D., Stockli, J., James, D. (2012). The RabGAP TBC1D4/AS160 contains an atypical PTB domain that interacts with plasma membrane phospholipids to facilitae GLUT4 trafficking in adipocytes. Molecular and Cellular Biology, 32(24), 4946-4959. [More Information]

2011

  • Prior, M., Larance, M., Lawrence, R., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J., La-Borde, P., Buckley, M., James, D., et al (2011). Quantitative Proteomic Analysis of the Adipocyte Plasma Membrane. Journal of Proteome Research, 10(11), 4970-4982. [More Information]

2010

  • Ng, Y., Ramm, G., Burchfield, J., Coster, A., Stockli, J., James, D. (2010). Cluster Analysis of Insulin Action in Adipocytes Reveals a Key Role for Akt at the Plasma Membrane. Journal of Biological Chemistry, 285(4), 2245-2257. [More Information]

2009

  • Lopez, J., Burchfield, J., Blair, D., Mele, K., Ng, Y., Vallotton, P., James, D., Hughes, W. (2009). Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerisation. Molecular Biology of the Cell, 20(17), 3918-3929. [More Information]
  • Mele, K., Vallotton, P., Burchfield, J., James, D., Hughes, W. (2009). Towards fully automated identification of Vesicle-Membrane Fusion Events in TIRF Microscopy. [More Information]
  • Zhao, P., Yang, L., Lopez, J., Fan, J., Burchfield, J., Bai, L., Hong, W., Xu, T., James, D. (2009). Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. Journal of Cell Science, 122(19), 3472-3480. [More Information]

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