2024

• Diaz Vegas, A., Don, A., Burchfield, J. (2024). Analysis and Quantification of the Mitochondrial–ER Lipidome. Bio-protocol, 14(13). [More Information]
• Diaz Vegas, A., Cooke, K., Cutler, H., Yau, B., Masson, S., Harney, D., Fuller, O., Potter, M., Madsen, S., Craw, N., Zhang, Y., Moreno, C., Kebede, M., Neely, G., Stoeckli, J., Burchfield, J., James, D. (2024). Deletion of miPEP in adipocytes protects against obesity and insulin resistance by boosting muscle metabolism. Molecular Metabolism, 86. [More Information]
• Cutler, H., Madsen, S., Masson, S., Cooke, K., Potter, M., Burchfield, J., Stoeckli, J., Nelson, M., Cooney, G., James, D. (2024). Dual Tracer Test to Measure Tissue-Specific Insulin Action in Individual Mice Identifies In Vivo Insulin Resistance Without Fasting Hyperinsulinemia. Diabetes, 73(3), 359-373. [More Information]
• Samer, C., McWilliam, H., McSharry, B., Burchfield, J., Stanton, R., Rossjohn, J., Villadangos, J., Abendroth, A., Slobedman, B. (2024). Impaired endocytosis and accumulation in early endosomal compartments defines herpes simplex virus–mediated disruption of the nonclassical MHC class I–related molecule MR1. Journal of Biological Chemistry, 300(10), 107748. [More Information]
• Samer, C., McWilliam, H., McSharry, B., Velusamy, T., Burchfield, J., Stanton, R., Tscharke, D., Rossjohn, J., Villadangos, J., Abendroth, A., Slobedman, B. (2024). Multi-targeted loss of the antigen presentation molecule MR1 during HSV-1 and HSV-2 infection. iScience, 27(2). [More Information]

2023

• Diaz Vegas, A., Norris, D., Jall-Rogg, S., Cooke, K., Conway, O., Shun-Shion, A., Duan, X., Potter, M., Van Gerwen, J., Baird, H., Humphrey, S., James, D., Burchfield, J., et al (2023). A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology. Life Science Alliance, 6(1), 1-19. [More Information]
• Madsen, S., Nelson, M., Deshpande, V., Humphrey, S., Cooke, K., Howell, A., Diaz Vegas, A., Burchfield, J., Stoeckli, J., James, D. (2023). Deep Proteome Profiling of White Adipose Tissue Reveals Marked Conservation and Distinct Features Between Different Anatomical Depots. Molecular and Cellular Proteomics, 22(3), 100508. [More Information]
• Diaz Vegas, A., Madsen, S., Cooke, K., Carroll, L., Khor, J., Turner, N., Lim, X., Astore, M., Morris, J., Don, A., James, D., Burchfield, J., et al (2023). Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle. eLife, 12. [More Information]
• Fazakerley, D., Van Gerwen, J., Cooke, K., Duan, X., Needham, E., Diaz-Vegas, A., Madsen, S., Norris, D., Shun-Shion, A., Krycer, J., Burchfield, J., Yang, P., James, D., Humphrey, S., et al (2023). Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nature Communications, 14(1), 1-20. [More Information]
• Fazakerley, D., Van Gerwen, J., Cooke, K., Duan, X., Needham, E., Díaz-Vegas, A., Madsen, S., Norris, D., Shun-Shion, A., Krycer, J., Burchfield, J., Yang, P., James, D., Humphrey, S., et al (2023). Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance. Nature Communications, 14(1), 923.
• Xiao, D., Lin, M., Liu, C., Geddes, T., Burchfield, J., Parker, B., Humphrey, S., Yang, P. (2023). SnapKin: a snapshot deep learning ensemble for kinase-substrate prediction from phosphoproteomics data. NAR Genomics and Bioinformatics, 5(4), Article number Iqad099-1-Article number Iqad099-12. [More Information]

2022

• Duan, X., Norris, D., Humphrey, S., Yang, P., Cooke, K., Bultitude, W., Parker, B., Conway, O., Burchfield, J., Krycer, J., James, D., Fazakerley, D., et al (2022). Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate. Biochemical Journal, 479(11), 1237-1256. [More Information]

2021

• Burchfield, J., James, D. (2021). A co-receptor that represses beta-cell insulin action. Nature Metabolism, 3(2), 126-127. [More Information]
• Kearney, A., Norris, D., Ghomlaghi, M., Wong, M., Humphrey, S., Carroll, L., Yang, G., Cooke, K., Yang, P., Geddes, T., James, D., Burchfield, J., et al (2021). Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. eLife, 10, 1-32. [More Information]
• Norris, D., Yang, P., Shin, S., Kearney, A., Kim, H., Geddes, T., Senior, A., Fazakerley, D., Nguyen, L., James, D., Burchfield, J. (2021). Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression. iScience, 24(2), 102118. [More Information]

2020

• Zhang, Z., Li, W., Yang, G., Lu, X., Qi, X., Wang, S., Cao, C., Zhang, P., Ren, J., Zhao, J., Burchfield, J., James, D., et al (2020). CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discovery, 6(1), 1-17. [More Information]
• Krycer, J., Elkington, S., Diaz Vegas, A., Cooke, K., Burchfield, J., Fisher-Wellman, K., Cooney, G., Fazakerley, D., James, D. (2020). Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes. Journal of Biological Chemistry, 295(1), 99-110. [More Information]
• Aji, G., Huang, Y., Ng, M., Wang, W., Lan, T., Li, M., Li, Y., Chen, Q., Li, R., Yan, S., Tran, C., Burchfield, J., Couttas, T., Chen, J., Chung, L., Liu, D., Wadham, C., Hogg, P., Vadas, M., Gamble, J., Don, A., Qi, J., et al (2020). Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2. Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24434-24442. [More Information]

2019

• Geddes, T., Kim, T., Nan, L., Burchfield, J., Yang, J., Tao, D., Yang, P. (2019). Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis. BMC Bioinformatics, 20(Suppl 19), 1-11. [More Information]
• Su, Z., Burchfield, J., Yang, P., Humphrey, S., Yang, G., Francis, D., Yasmin, S., Shin, S., Norris, D., Kearney, A., Astore, M., Scavuzzo, J., Wang, Q., Parker, B., Neely, G., Vafaee, F., Chiu, J., Yeo, R., Hogg, P., Fazakerley, D., Kuyucak, S., James, D., et al (2019). Global redox proteome and phosphoproteome analysis reveals redox switch in Akt. Nature Communications, 10(1), 1-18. [More Information]
• Nelson, M., Parker, B., Burchfield, J., Hoffman, N., Needham, E., Cooke, K., Naim, T., Sylow, L., Ling, N., Francis, D., Norris, D., Chaudhuri, R., Stoeckli, J., James, D., et al (2019). Phosphoproteomics reveals conserved exercise-stimulated signaling and AMPK regulation of store-operated calcium entry. EMBO Journal, 38(24), 1-20. [More Information]
• Kearney, A., Cooke, K., Norris, D., Zadoorian, A., Krycer, J., Fazakerley, D., Burchfield, J., James, D. (2019). Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes. Journal of Biological Chemistry, 294(45), 16729-16739. [More Information]

2018

• Norris, D., Geddes, T., James, D., Fazakerley, D., Burchfield, J. (2018). Glucose transport: Methods for interrogating GLUT4 trafficking in adipocytes. Methods in Molecular Biology, 1713, 193-215. [More Information]
• Burchfield, J., Kebede, M., Meoli, C., Stoeckli, J., Whitworth, P., Wright, A., Hoffman, N., Minard, A., Ma, X., Krycer, J., Nelson, M., Yau, B., Cooke, K., Cooney, G., James, D., Fazakerley, D., et al (2018). High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice. Journal of Biological Chemistry, 293(15), 5731-5745. [More Information]
• Fazakerley, D., Chaudhuri, R., Yang, P., Maghazal, G., Cooke, K., Krycer, J., Humphrey, S., Parker, B., Fisher-Wellman, K., Meoli, C., Hoffman, N., Diskin, C., Burchfield, J., Yang, J., James, D., et al (2018). Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. eLife, 7(Article number e32111), 1-38. [More Information]
• Fazakerley, D., Minard, A., Krycer, J., Cooke, K., Stoeckli, J., Harney, D., Burchfield, J., Maghzal, G., Caldwell, S., Hartley, R., James, D., et al (2018). Mitochondrial oxidative stress causes insulin resistance without disrupting oxidative phosphorylation. Journal of Biological Chemistry, 293(19), 7315-7328. [More Information]

2017

• Norris, D., Yang, P., Krycer, J., Fazakerley, D., James, D., Burchfield, J. (2017). An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction. Journal of Cell Science, 130, 2757-2766. [More Information]
• Parker, B., Burchfield, J., Clayton, D., Geddes, T., Payne, R., Kiens, B., Wojtaszewski, J., Richter, E., James, D. (2017). Multiplexed temporal quantification of the exercise-regulated plasma peptidome. Molecular and Cellular Proteomics, 16(12), 2055-2068. [More Information]
• Krycer, J., Fazakerley, D., Cater, R., Cooke, K., Naghiloo, S., Burchfield, J., Humphrey, S., Vandenberg, R., Ryan, R., James, D. (2017). The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. FEBS Letters, 591(2), 322-330. [More Information]

2015

• Wong, M., Krycer, J., Burchfield, J., James, D., Kuncic, Z. (2015). A generalised enzyme kinetic model for predicting the behaviour of complex biochemical systems. FEBS Open Bio, 5, 226-239. [More Information]
• Hoffman, N., Parker, B., Chaudhuri, R., Fisher-Wellman, K., Kleinert, M., Humphrey, S., Yang, P., Holliday, M., Trefely, S., Fazakerley, D., Stoeckli, J., Burchfield, J., James, D., et al (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates. Cell Metabolism, 22(5), 922-935. [More Information]
• Fazakerley, D., Naghiloo, S., Chaudhuri, R., Koumanov, F., Burchfield, J., Cooke, K., Krycer, J., Prior, M., Parker, B., Murrow, B., Stoeckli, J., Meoli, C., James, D., et al (2015). Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumour Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes. Journal of Biological Chemistry, 290(39), 23528-23542. [More Information]

2014

• Yang, P., Patrick, E., Tan, S., Fazakerley, D., Burchfield, J., Gribben, C., Prior, M., James, D., Yang, J. (2014). Direction pathway analysis of large-scale proteomics data reveals novel features of the insulin action pathway. Bioinformatics, 30(6), 808-814. [More Information]
• Li, J., Cantley, J., Burchfield, J., Meoli, C., Stockli, J., Whitworth, P., Pant, H., Chaudhuri, R., Groffen, A., Verhage, M., James, D. (2014). DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake. Diabetologia, 57(10), 2173-2182. [More Information]
• Wu, L., Meoli, C., Mangiafico, S., Fazakerley, D., Cogger, V., Mohamad, M., Pant, H., Kang, M., Powter, E., Burchfield, J., Gamble, J., Le Couteur, D., James, D., et al (2014). Systemic VEGF-A Neutralization Ameliorates Diet-Induced Metabolic Dysfunction. Diabetes, 63(8), 2656-2667. [More Information]
• Fletcher, R., Gribben, C., Ma, X., Burchfield, J., Thomas, K., Krycer, J., James, D., Fazakerley, D. (2014). The Role of the Niemann-Pick Disease, Type C1 Protein in Adipocyte Insulin Action. PloS One, 9(4), 1-10. [More Information]

2013

• Iismaa, S., Aplin, M., Holman, S., Yiu, T., Jackson, K., Burchfield, J., Mitchell, C., O'Reilly, L., Davenport, A., Cantley, J., et al (2013). Glucose Homeostasis in Mice Is Transglutaminase 2 Independent. PloS One, 8(5). [More Information]
• Burchfield, J., Lu, J., Fazakerley, D., Tan, S., Ng, Y., Mele, K., Buckley, M., Han, W., Hughes, W., James, D. (2013). Novel systems for dynamically assessing insulin action in live cells reveals heterogeneity in the insulin response. Traffic, 14(3), 259-273. [More Information]

2012

• Tan, S., Ng, Y., Burchfield, J., Ramm, G., Lambright, D., Stockli, J., James, D. (2012). The RabGAP TBC1D4/AS160 contains an atypical PTB domain that interacts with plasma membrane phospholipids to facilitae GLUT4 trafficking in adipocytes. Molecular and Cellular Biology, 32(24), 4946-4959. [More Information]

2011

• Prior, M., Larance, M., Lawrence, R., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J., La-Borde, P., Buckley, M., James, D., et al (2011). Quantitative Proteomic Analysis of the Adipocyte Plasma Membrane. Journal of Proteome Research, 10(11), 4970-4982. [More Information]

2010

• Ng, Y., Ramm, G., Burchfield, J., Coster, A., Stockli, J., James, D. (2010). Cluster Analysis of Insulin Action in Adipocytes Reveals a Key Role for Akt at the Plasma Membrane. Journal of Biological Chemistry, 285(4), 2245-2257. [More Information]

2009

• Cantley, J., Burchfield, J., Pearson, G., Schmitz-Peiffer, C., Leitges, M., Biden, T. (2009). Deletion of PKCε selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse β-cells. Diabetes, 58(8), 1826-1834. [More Information]
• Frangioudakis, G., Burchfield, J., Narasimhan, S., Cooney, G., Leitges, M., Biden, T., Schmitz-Peiffer, C. (2009). Diverse roles for protein kinase C δ and protein kinase C ε in the generation of high-fat-diet-induced glucose intolerance in mice: Regulation of lipogenesis by protein kinase C δ. Diabetologia, 52(12), 2616-2620. [More Information]
• Lopez, J., Burchfield, J., Blair, D., Mele, K., Ng, Y., Vallotton, P., James, D., Hughes, W. (2009). Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerisation. Molecular Biology of the Cell, 20(17), 3918-3929. [More Information]
• Mele, K., Vallotton, P., Burchfield, J., James, D., Hughes, W. (2009). Towards fully automated identification of Vesicle-Membrane Fusion Events in TIRF Microscopy. [More Information]
• Zhao, P., Yang, L., Lopez, J., Fan, J., Burchfield, J., Bai, L., Hong, W., Xu, T., James, D. (2009). Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes. Journal of Cell Science, 122(19), 3472-3480. [More Information]

2008

• Biden, T., Schmitz-Peiffer, C., Burchfield, J., Gurisik, E., Cantley, J., Mitchell, C., Carpenter, L. (2008). The diverse roles of protein kinase C in pancreatic β-cell function. Biochemical Society Transactions, 36(5), 916-919. [More Information]

2007

• Cazzolli, R., Mitchell, T., Burchfield, J., Pedersen, D., Turner, N., Biden, T., Schmitz-Peiffer, C. (2007). Dilinoleoyl-phosphatidic acid mediates reduced IRS-1 tyrosine phosphorylation in rat skeletal muscle cells and mouse muscle. Diabetologia, 50(8), 1732-1742. [More Information]
• Schmitz-Peiffer, C., Laybutt, D., Burchfield, J., Gurisik, E., Narasimhan, S., Mitchell, C., Pedersen, D., Braun, U., Cooney, G., Leitges, M., et al (2007). Inhibition of PKCε Improves Glucose-Stimulated Insulin Secretion and Reduces Insulin Clearance. Cell Metabolism, 6(4), 320-328. [More Information]

2004

• Burchfield, J., Lennard, A., Narasimhan, S., Hughes, W., Wasinger, V., Corthals, G., Okuda, T., Kondoh, H., Biden, T., Schmitz-Peiffer, C. (2004). Akt mediates insulin-stimulated phosphorylation of Ndrg2: Evidence for cross-talk with protein kinase C θ. Journal of Biological Chemistry, 279(18), 18623-18632. [More Information]