student profile: Mr James O'brien-brown


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Thesis work

Thesis title: Novel P2X7 Receptor Ligands

Supervisors: Michael KASSIOU , Louis RENDINA

Selected publications

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Journals

  • O'Brien-Brown, J., Jackson, A., Reekie, T., Barron, M., Werry, E., Schiavini, P., McDonnell, M., Munoz, L., Wilkinson, S., Noll, B., Kassiou, M., et al (2017). Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists. European Journal of Medicinal Chemistry, 130, 433-439. [More Information]
  • Wong, E., Reekie, T., Werry, E., O'Brien-Brown, J., Bowyer, S., Kassiou, M. (2017). Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X7 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 27(11), 2439-2442. [More Information]
  • Manohar, M., Banister, S., Beinat, C., O'Brien-Brown, J., Kassiou, M. (2015). Recent advances in the development of sigma-1 receptor ligands. Australian Journal of Chemistry, 68, 600-609. [More Information]
  • Beinat, C., Reekie, T., Banister, S., O'Brien-Brown, J., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Kassiou, M., et al (2015). Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at alpha7 nAChRs through incorporation of known structural motifs. European Journal of Medicinal Chemistry, 95, 277-301. [More Information]

2017

  • O'Brien-Brown, J., Jackson, A., Reekie, T., Barron, M., Werry, E., Schiavini, P., McDonnell, M., Munoz, L., Wilkinson, S., Noll, B., Kassiou, M., et al (2017). Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists. European Journal of Medicinal Chemistry, 130, 433-439. [More Information]
  • Wong, E., Reekie, T., Werry, E., O'Brien-Brown, J., Bowyer, S., Kassiou, M. (2017). Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X7 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 27(11), 2439-2442. [More Information]

2015

  • Manohar, M., Banister, S., Beinat, C., O'Brien-Brown, J., Kassiou, M. (2015). Recent advances in the development of sigma-1 receptor ligands. Australian Journal of Chemistry, 68, 600-609. [More Information]
  • Beinat, C., Reekie, T., Banister, S., O'Brien-Brown, J., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Kassiou, M., et al (2015). Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at alpha7 nAChRs through incorporation of known structural motifs. European Journal of Medicinal Chemistry, 95, 277-301. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.