student profile: Mr James Walshe


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Thesis work

Thesis title: Characterising Protein Nucleic Acid Interactions

Supervisors: Sandro ATAIDE , Joel MACKAY

Thesis abstract:

Interactions between nucleic acids (DNA or RNA) and proteins are well known regulators of essential cellular functions. DNA-protein complexes are involved in regulation of chromosomal maintenance, replication, transcriptional regulation and DNA repair. Initially, RNA-protein interactions were directly involved in transcription, translation, RNA metabolism and telomere maintenance among others. However, the RNA component of ribonucleoprotein (RNP) complexes has been found to play a major role in its function as well as participating solely in catalysis (e.g. spliceosome, ribosome, signal recognition particle, riboswitches). During my PhD, I will investigate the protein nucleic acid (RNA and DNA) interactions of a variety of different proteins from humans to prokaryotes. �br /�

Selected grants

2017

  • Sydney CAP; Jormakka M, Walshe J; Australian Synchrotron/Research Support.

Selected publications

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Journals

  • Flores, J., Walshe, J., Ataide, S. (2014). RNA and RNA-Protein Complex Crystallography and its Challenges. Australian Journal of Chemistry, 67(12), 1741-1750. [More Information]

2014

  • Flores, J., Walshe, J., Ataide, S. (2014). RNA and RNA-Protein Complex Crystallography and its Challenges. Australian Journal of Chemistry, 67(12), 1741-1750. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.