student profile: Mr James Walshe


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Thesis work

Thesis title: Characterising Protein Nucleic Acid Interactions

Supervisors: Joel MACKAY , Sandro ATAIDE

Thesis abstract:

Interactions between nucleic acids (DNA or RNA) and proteins are well known regulators of essential cellular functions. DNA-protein complexes are involved in regulation of chromosomal maintenance, replication, transcriptional regulation and DNA repair. Initially, RNA-protein interactions were directly involved in transcription, translation, RNA metabolism and telomere maintenance among others. However, the RNA component of ribonucleoprotein (RNP) complexes has been found to play a major role in its function as well as participating solely in catalysis (e.g. spliceosome, ribosome, signal recognition particle, riboswitches). During my PhD, I will investigate the protein nucleic acid (RNA and DNA) interactions of a variety of different proteins from humans to prokaryotes. �br /�

Selected grants

2017

  • Sydney CAP; Jormakka M, Walshe J; Australian Synchrotron/Research Support.

Selected publications

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Journals

  • Lister, N., Shevchenko, G., Walshe, J., Groen, J., Johnsson, P., Vidarsdottire, L., Grander, D., Ataide, S., Morris, K. (2017). The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(37), 9942-9947. [More Information]
  • Flores, J., Walshe, J., Ataide, S. (2014). RNA and RNA-Protein Complex Crystallography and its Challenges. Australian Journal of Chemistry, 67(12), 1741-1750. [More Information]

2017

  • Lister, N., Shevchenko, G., Walshe, J., Groen, J., Johnsson, P., Vidarsdottire, L., Grander, D., Ataide, S., Morris, K. (2017). The molecular dynamics of long noncoding RNA control of transcription in PTEN and its pseudogene. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114(37), 9942-9947. [More Information]

2014

  • Flores, J., Walshe, J., Ataide, S. (2014). RNA and RNA-Protein Complex Crystallography and its Challenges. Australian Journal of Chemistry, 67(12), 1741-1750. [More Information]

Note: This profile is for a student at the University of Sydney. Views presented here are not necessarily those of the University.