student profile: Mr Jamie Batten


Thesis work

Thesis title: Combating the Burgeoning Incidence of Drug-Resistant TB

Supervisors: Peter RUTLEDGE , Matthew TODD

Thesis abstract:

In 2014, 1.5 million people lost their lives to Tuberculosis. One third of the world’s population is currently infected with Mycobacterium tuberculosis, the causative agent of the disease. Current treatment programs are incapable of addressing the emergence of drug-resistant bacteria and pipeline alternatives are similarly inadequate. The need for new drugs is urgent.

We have identified a new class of compounds with potent activity against drug-resistant Mycobacterium tuberculosis. These compounds, based on a bis-functionalised naphthalimide-azamacrocycle ligand and its metal complexes, inhibit intracellular bacterial growth and are nontoxic to human cells.

Given the imperative demand for novel TB drugs, optimisation of this promising lead is of paramount importance. Thus far, the effects of varying the metal centre, the pendant groups and the triazole linkers have been studied, but there remains much work to be done on these complexes.

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