Dr Jason Low

School of Life and Environmental Sciences

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 93513907

Website Mackay lab website

Biographical details

Dr Jason Low is a researcher in the field of gene regulation with a special interest in protein structure and function, proteomics and mass spectrometry.

Jason was under the tutelage of Prof. Marc Wilkins at the University of New South Wales and was awarded his PhD in 2012. During his time with Prof. Wilkins, he studied arginine methylation as a form of post-translational modification, using experimental approaches that included the use of cutting-edge whole proteome microarray technology. He moved to the University of Sydney in 2013 and is currently a post-doctoral research associate with Prof. Joel Mackay.

Research interests

Currently, Jason's work has been mainly focused on large multi-subunit transcriptional complexes. He has been implementing recently described mass spectrometry-based techniques to probe protein interactions and stoichiometry of the complexes with the ultimate goal of gaining a structural and mechanistic understanding of the complexes. He is also spearheading blue-sky projects to create human protein microarrays and to engineer targetable epigenetic modifiers using the CRISPR-Cas system.

Teaching and supervision

Jason helps co-supervise BSc Honours and PhD students, as well as visiting international research students in Prof. Joel Mackay’s laboratory.

Associations

Professional appointments: Secretary for the Sydney Protein Group; 2015 - Current.

Awards and honours

UNSW University Medal; 2007

UNSW Research Excellence Award; 2009 - 2012

Sydney Protein Group Thompson Prize (shortlisted); 2011

Best Oral Presentation Prize (APAF 2nd Proteomics and Beyond Symposium); 2014

Selected publications

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Journals

  • Low, J., Webb, S., Silva, A., Saathoff, H., Ryan, D., Torrado Del Rey, M., Brofelth, M., Parker, B., Shepherd, N., Mackay, J. (2016). CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex. The Journal of Biological Chemistry, 291(30), 15853-15866. [More Information]
  • Low, J., Im, H., Erce, M., Hart-Smith, G., Snyder, M., Wilkins, M. (2016). Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Proteomics, 16(3), 465-476. [More Information]
  • Schmidberger, J., Sharifi Tabar, M., Torrado Del Rey, M., Silva, A., Landsberg, M., Brillault, L., Alqarni, S., Zeng, Y., Parker, B., Low, J., Mackay, J. (2016). The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7. Protein Science, 25, 1472-1482. [More Information]
  • Silva, A., Ryan, D., Galanty, Y., Low, J., Vandevenne, M., Jackson, S., Mackay, J. (2016). The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose). The Journal of Biological Chemistry, 291(2), 924-938. [More Information]
  • Wai, D., Shihab, M., Low, J., Mackay, J. (2016). The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity. Nucleic Acids Research, 44(19), 9153-9165. [More Information]
  • Saathoff, H., Brofelth, M., Trinh, A., Parker, B., Ryan, D., Low, J., Webb, S., Silva, A., Mackay, J., Shepherd, N. (2015). A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells. Bioorganic and Medicinal Chemistry, 23(5), 960-965. [More Information]
  • Hart-Smith, G., Chia, S., Low, J., McKay, M., Molloy, M., Wilkins, M. (2014). Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-histone Protein Lysine Methyltransferase Activity. Journal of Proteome Research, 13(3), 1744-1756. [More Information]
  • Low, J., Hart-Smith, G., Erce, M., Wilkins, M. (2014). The Saccharomyces cerevisiae poly(A)-binding protein is subject to multiple post-translational modifications, including the methylation of glutamic acid. Biochemical and Biophysical Research Communications, 443(2), 543-548. [More Information]
  • Erce, M., Low, J., Hart-Smith, G., Wilkins, M. (2013). A conditional two-hybrid (C2H) system for the detection of protein-protein interactions that are mediated by post-translational modification. Proteomics, 13(7), 1059-1064. [More Information]
  • Low, J., Hart-Smith, G., Erce, M., Wilkins, M. (2013). Analysis of the methylarginine proteome of Saccharomyces cerevisiae. Journal of Proteome Research, 12(9), 3884-3899. [More Information]
  • Erce, M., Abeygunawardena, D., Low, J., Hart-Smith, G., Wilkins, M. (2013). Interactions affected by arginine methylation in the yeast protein-protein interaction network. Molecular and Cellular Proteomics, 12(11), 3184-3198. [More Information]
  • Hart-Smith, G., Low, J., Erce, M., Wilkins, M. (2012). Enhanced Methylarginine Characterization by Post-Translational Modification-Specific Targeted Data Acquisition and Electron-Transfer Dissociation Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 23(8), 1376-1389. [More Information]
  • Low, J., Wilkins, M. (2012). Protein arginine methylation in Saccharomyces cerevisiae. The FEBS Journal, 279(24), 4423-4443. [More Information]
  • Erce, M., Low, J., Wilkins, M. (2010). Analysis of the RNA degradosome complex in Vibrio angustum S14. The FEBS Journal, 277, 5161-5173. [More Information]
  • Erce, M., Low, J., March, P., Wilkins, M., Takayama, K. (2009). Identification and functional analysis of RNase E of Vibrio angustum S14 and two-hybrid analysis of its interaction partners. Biochimica et Biophysica Acta. Proteins and Proteomics, 1794, 1107-1114. [More Information]

2016

  • Low, J., Webb, S., Silva, A., Saathoff, H., Ryan, D., Torrado Del Rey, M., Brofelth, M., Parker, B., Shepherd, N., Mackay, J. (2016). CHD4 Is a Peripheral Component of the Nucleosome Remodeling and Deacetylase Complex. The Journal of Biological Chemistry, 291(30), 15853-15866. [More Information]
  • Low, J., Im, H., Erce, M., Hart-Smith, G., Snyder, M., Wilkins, M. (2016). Protein substrates of the arginine methyltransferase Hmt1 identified by proteome arrays. Proteomics, 16(3), 465-476. [More Information]
  • Schmidberger, J., Sharifi Tabar, M., Torrado Del Rey, M., Silva, A., Landsberg, M., Brillault, L., Alqarni, S., Zeng, Y., Parker, B., Low, J., Mackay, J. (2016). The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7. Protein Science, 25, 1472-1482. [More Information]
  • Silva, A., Ryan, D., Galanty, Y., Low, J., Vandevenne, M., Jackson, S., Mackay, J. (2016). The N-terminal Region of Chromodomain Helicase DNA-binding Protein 4 (CHD4) Is Essential for Activity and Contains a High Mobility Group (HMG) Box-like-domain That Can Bind Poly(ADP-ribose). The Journal of Biological Chemistry, 291(2), 924-938. [More Information]
  • Wai, D., Shihab, M., Low, J., Mackay, J. (2016). The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity. Nucleic Acids Research, 44(19), 9153-9165. [More Information]

2015

  • Saathoff, H., Brofelth, M., Trinh, A., Parker, B., Ryan, D., Low, J., Webb, S., Silva, A., Mackay, J., Shepherd, N. (2015). A peptide affinity reagent for isolating an intact and catalytically active multi-protein complex from mammalian cells. Bioorganic and Medicinal Chemistry, 23(5), 960-965. [More Information]

2014

  • Hart-Smith, G., Chia, S., Low, J., McKay, M., Molloy, M., Wilkins, M. (2014). Stoichiometry of Saccharomyces cerevisiae Lysine Methylation: Insights into Non-histone Protein Lysine Methyltransferase Activity. Journal of Proteome Research, 13(3), 1744-1756. [More Information]
  • Low, J., Hart-Smith, G., Erce, M., Wilkins, M. (2014). The Saccharomyces cerevisiae poly(A)-binding protein is subject to multiple post-translational modifications, including the methylation of glutamic acid. Biochemical and Biophysical Research Communications, 443(2), 543-548. [More Information]

2013

  • Erce, M., Low, J., Hart-Smith, G., Wilkins, M. (2013). A conditional two-hybrid (C2H) system for the detection of protein-protein interactions that are mediated by post-translational modification. Proteomics, 13(7), 1059-1064. [More Information]
  • Low, J., Hart-Smith, G., Erce, M., Wilkins, M. (2013). Analysis of the methylarginine proteome of Saccharomyces cerevisiae. Journal of Proteome Research, 12(9), 3884-3899. [More Information]
  • Erce, M., Abeygunawardena, D., Low, J., Hart-Smith, G., Wilkins, M. (2013). Interactions affected by arginine methylation in the yeast protein-protein interaction network. Molecular and Cellular Proteomics, 12(11), 3184-3198. [More Information]

2012

  • Hart-Smith, G., Low, J., Erce, M., Wilkins, M. (2012). Enhanced Methylarginine Characterization by Post-Translational Modification-Specific Targeted Data Acquisition and Electron-Transfer Dissociation Mass Spectrometry. Journal of the American Society for Mass Spectrometry, 23(8), 1376-1389. [More Information]
  • Low, J., Wilkins, M. (2012). Protein arginine methylation in Saccharomyces cerevisiae. The FEBS Journal, 279(24), 4423-4443. [More Information]

2010

  • Erce, M., Low, J., Wilkins, M. (2010). Analysis of the RNA degradosome complex in Vibrio angustum S14. The FEBS Journal, 277, 5161-5173. [More Information]

2009

  • Erce, M., Low, J., March, P., Wilkins, M., Takayama, K. (2009). Identification and functional analysis of RNase E of Vibrio angustum S14 and two-hybrid analysis of its interaction partners. Biochimica et Biophysica Acta. Proteins and Proteomics, 1794, 1107-1114. [More Information]

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