Dr Jibran Wali

NHMRC Peter Doherty Biomedical Fellow
School of Life and Environmental Sciences

Member of the Charles Perkins Centre

D17 - Charles Perkins Centre
The University of Sydney

Telephone +61 2 9114 2199

Website Room 4E46, D17 - Charles Perkins Centre

Research interests

Metabolism, Nutrition, Obesity, Insulin Resistance, Type 2 Diabetes

Current projects

My research focuses on how dietary macronutrients (protein, fat and carbohydrate) interact and how this links to obesity, insulin resistance and type-2 diabetes. In particular, I am investigating the impact of consuming different types of carbohydrates (starch, sucrose, glucose, fructose and dietary fibre) on adiposity, insulin sensitivity, glucose homeostasis and nutrient signalling.

Associations

  1. Australian Diabetes Society (ADS)
  2. European Association for the Study of Diabetes (EASD)

Awards and honours

T J Martin Medal for the best PhD thesis (St Vincent's Hospital, Melbourne, Australia).

Themes

Biochemistry and metabolism

Selected grants

2017

  • Are Dietary Carbohydrates the key to a long, healthy life? : Determining the impact of dietary carbohydrate composition on lifespan and late-life health.; Wali J; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.
  • Determining the macronutrient composition of the optimum diet for the management of type 2 diabetes; Wali J, Simpson S, Le Couteur D, Cogger V; Diabetes Australia/Research Grant.

Selected publications

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Book Chapters

  • Wali, J., Trivedi, P., Kay, T., Thomas, H. (2015). Measuring death of pancreatic beta cells in response to stress and cytotoxic T cells. In C. M. Oslowski (Eds.), Stress Responses: Methods and Protocols, (pp. 165-176). New York: Springer. [More Information]

Journals

  • Wali, J., Galic, S., Tan, C., Gurzov, E., Frazier, A., Connor, T., Ge, J., Pappas, E., Stroud, D., Varanasi, L., et al (2018). Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice. Cell Death and Differentiation, 25, 217-225. [More Information]
  • Solon-Biet, S., Cogger, V., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A., Warren, A., Durrant-Whyte, J., Walters, K., Krycer, J., Ponton, F., Gokarn, R., Wali, J., Conigrave, A., James, D., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2016). Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Cell Metabolism, 24(4), 555-565. [More Information]
  • Litwak, S., Loh, K., Stanley, W., Pappas, E., Wali, J., Selck, C., Strasser, A., Thomas, H., Gurzov, E. (2016). P53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity. Scientific Reports, 6, 1-9. [More Information]
  • Krishnamurthy, B., Chee, J., Jhala, G., Trivedi, P., Catterall, T., Selck, C., Gurzov, E., Brodnicki, T., Graham, K., Wali, J., et al (2015). BIM deficiency protects NOD mice from diabetes by diverting thymocytes to regulatory T cells. Diabetes, 64(9), 3229-3238. [More Information]
  • Litwak, S., Wali, J., Pappas, E., Saadi, H., Stanley, W., Varanasi, L., Kay, T., Thomas, H., Gurzov, E. (2015). Lipotoxic Stress Induces Pancreatic (beta)-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System. Journal of Diabetes Research, 2015, 1-16. [More Information]
  • Wali, J., Trivedi, P., Kay, T., Thomas, H. (2015). Measuring death of pancreatic beta cells in response to stress and cytotoxic T cells. Methods in Molecular Biology, 1292, 165-176. [More Information]
  • Wali, J., Gurzov, E., Fynch, S., Elkerbout, L., Kay, T., Masters, S., Thomas, H. (2014). Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets. PloS One, 9(11), 1-9. [More Information]
  • Wali, J., Thomas, H., Sutherland, A. (2014). Linking obesity with type 2 diabetes: The role of T-bet. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 7, 331-340. [More Information]
  • Wali, J., Rondas, D., McKenzie, M., Zhao, Y., Elkerbout, L., Fynch, S., Gurzov, E., Akira, S., Mathieu, C., Kay, T., et al (2014). The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death and Disease, 5(3), 1-9. [More Information]
  • Wali, J., de Boo, H., Derraik, J., Phua, H., Oliver, M., Bloomfield, F., Harding, J. (2012). Weekly intra-amniotic igf-1 treatment increases growth of growth-restricted ovine fetuses and up-regulates placental amino acid transporters. PloS One, 7(5), 1-13. [More Information]
  • Mollah, Z., Wali, J., McKenzie, M., Krishnamurthy, B., Graham, K., Fynch, S., Szanyi, J., Santamaria, P., Brodnicki, T., et al (2011). The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse. Apoptosis, 16(8), 822-830. [More Information]

2018

  • Wali, J., Galic, S., Tan, C., Gurzov, E., Frazier, A., Connor, T., Ge, J., Pappas, E., Stroud, D., Varanasi, L., et al (2018). Loss of BIM increases mitochondrial oxygen consumption and lipid oxidation, reduces adiposity and improves insulin sensitivity in mice. Cell Death and Differentiation, 25, 217-225. [More Information]

2016

  • Solon-Biet, S., Cogger, V., Pulpitel, T., Heblinski, M., Wahl, D., McMahon, A., Warren, A., Durrant-Whyte, J., Walters, K., Krycer, J., Ponton, F., Gokarn, R., Wali, J., Conigrave, A., James, D., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2016). Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework. Cell Metabolism, 24(4), 555-565. [More Information]
  • Litwak, S., Loh, K., Stanley, W., Pappas, E., Wali, J., Selck, C., Strasser, A., Thomas, H., Gurzov, E. (2016). P53-upregulated-modulator-of-apoptosis (PUMA) deficiency affects food intake but does not impact on body weight or glucose homeostasis in diet-induced obesity. Scientific Reports, 6, 1-9. [More Information]

2015

  • Krishnamurthy, B., Chee, J., Jhala, G., Trivedi, P., Catterall, T., Selck, C., Gurzov, E., Brodnicki, T., Graham, K., Wali, J., et al (2015). BIM deficiency protects NOD mice from diabetes by diverting thymocytes to regulatory T cells. Diabetes, 64(9), 3229-3238. [More Information]
  • Litwak, S., Wali, J., Pappas, E., Saadi, H., Stanley, W., Varanasi, L., Kay, T., Thomas, H., Gurzov, E. (2015). Lipotoxic Stress Induces Pancreatic (beta)-Cell Apoptosis through Modulation of Bcl-2 Proteins by the Ubiquitin-Proteasome System. Journal of Diabetes Research, 2015, 1-16. [More Information]
  • Wali, J., Trivedi, P., Kay, T., Thomas, H. (2015). Measuring death of pancreatic beta cells in response to stress and cytotoxic T cells. In C. M. Oslowski (Eds.), Stress Responses: Methods and Protocols, (pp. 165-176). New York: Springer. [More Information]
  • Wali, J., Trivedi, P., Kay, T., Thomas, H. (2015). Measuring death of pancreatic beta cells in response to stress and cytotoxic T cells. Methods in Molecular Biology, 1292, 165-176. [More Information]

2014

  • Wali, J., Gurzov, E., Fynch, S., Elkerbout, L., Kay, T., Masters, S., Thomas, H. (2014). Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets. PloS One, 9(11), 1-9. [More Information]
  • Wali, J., Thomas, H., Sutherland, A. (2014). Linking obesity with type 2 diabetes: The role of T-bet. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 7, 331-340. [More Information]
  • Wali, J., Rondas, D., McKenzie, M., Zhao, Y., Elkerbout, L., Fynch, S., Gurzov, E., Akira, S., Mathieu, C., Kay, T., et al (2014). The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity. Cell Death and Disease, 5(3), 1-9. [More Information]

2012

  • Wali, J., de Boo, H., Derraik, J., Phua, H., Oliver, M., Bloomfield, F., Harding, J. (2012). Weekly intra-amniotic igf-1 treatment increases growth of growth-restricted ovine fetuses and up-regulates placental amino acid transporters. PloS One, 7(5), 1-13. [More Information]

2011

  • Mollah, Z., Wali, J., McKenzie, M., Krishnamurthy, B., Graham, K., Fynch, S., Szanyi, J., Santamaria, P., Brodnicki, T., et al (2011). The pro-apoptotic BH3-only protein Bid is dispensable for development of insulitis and diabetes in the non-obese diabetic mouse. Apoptosis, 16(8), 822-830. [More Information]

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