Dr John-Sebastian Eden

A12 - Macleay Building
The University of Sydney

Telephone +61 2 8627 1817

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Viral Evolution

Biographical details

Currently, I am a postdoctoral fellow in the School of Biological Sciences researching the mechanisms and processes driving the emergence of viruses in new hosts under the supervision of Professor Eddie Holmes. Before this, I completed my PhD and undergraduate degree at the University of New South Wales in the School of Biotechnology and Biomolecular Sciences. In addition to my basic training in virology, I also have a diploma and graduate certificate in research management and commercialisation.

Research interests

RNA viruses are ubiquitous in nature, infecting plants, animals, bacteria and, of course, humans. This widespread abundance throughout the domains of life demonstrates an immense genetic diversity that allows RNA viruses to adapt and evolve in the face of ever changing environments and hosts. The ultimate aim of my research is to explain and identify the source of genetic diversity in RNA viruses.

This work has led me to examine the patterns of genetic variation, evolution and molecular epidemiology of RNA viruses with a specific focus on the mechanisms of viral emergence. I have a strong background in viral genome sequencing and analysis, including the application of next-generation sequencing protocols and state-of-the-art bioinformatics methods. I have also been involved in a number of studies describing the molecular epidemiology of clinically important pathogens such as norovirus and have published extensively in this area.

Associations

  • Westmead Millennium Institute
  • Marie Bashir Institute for Infectious Diseases and Biosecurity
  • Charles Perkins Centre

Awards and honours

  • NHMRC Early Career Fellowship (2014-18)

Selected grants

2014

  • Integrating genotype and phenotype in clinical molecular epidemiology; Eden J; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Eltahla, A., Lim, K., Eden, J., Kelly, A., Mackenzie, J., White, P. (2014). Nonnucleoside Inhibitors of Norovirus RNA Polymerase: Scaffolds for Rational Drug Design. Antimicrobial Agents and Chemotherapy, 58(6), 3115-3123. [More Information]
  • Eden, J., Hewitt, J., Lim, K., Boni, M., Merif, J., Greening, G., Ratcliff, R., Holmes, E., Tanaka, M., Rawlinson, W., et al (2014). The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. Virology, 450-451, 106-113. [More Information]
  • Eltahla, A., Lackovic, K., Marquis, C., Eden, J., White, P. (2013). A fluorescence-based high-throughput screen to identify small compound inhibitors of the genotype 3a hepatitis c virus RNA polymerase. Journal of Biomolecular Screening, 18(9), 1027-1034. [More Information]
  • Cui, J., Eden, J., Holmes, E., Wang, L. (2013). Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): Implications for the origin and emergence of Middle East Respiratory Syndrome Coronavirus. Virology Journal, 10, 1-5. [More Information]
  • Eden, J., Kun, L., Lynette, L., White, P. (2013). Molecular epidemiology of norovirus in Singapore, 2004-2011. Journal of Medical Virology, 85(10), 1842-1851. [More Information]
  • Eden, J., Tanaka, M., Boni, M., Rawlinson, W., White, P. (2013). Recombination within the pandemic norovirus GII.4 lineage. Journal of Virology, 87(11), 6270-6282. [More Information]
  • Eden, J., Lim, K., White, P. (2012). Complete genome of the human norovirus GIV.1 strain Lake Macquarie virus. Journal of Virology, 86(18), 10251-10252. [More Information]
  • Bull, R., Eden, J., Luciani, F., McElroy, K., Rawlinson, W., White, P. (2012). Contribution of intra- and interhost dynamics to norovirus evolution. Journal of Virology, 86(6), 3219-3229. [More Information]
  • White, P., Eden, J., Hansman, G. (2012). Molecular epidemiology of noroviruses and sapoviruses and their role in Australian outbreaks of acute gastroenteritis. Microbiology Australia, 33(2), 70-73.
  • Eden, J., Sharpe, L., White, P., Brown, A. (2011). Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. Journal of Virology, 85(20), 10894-10898. [More Information]
  • Eden, J., Bull, R., Tu, E., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., White, P. (2010). Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008. Journal Of Clinical Virology, 49(4), 265-271. [More Information]
  • Bull, R., Eden, J., Rawlinson, W., White, P. (2010). Rapid evolution of pandemic noroviruses of the GII.4 lineage. PLoS Pathogens, 6(3), e1000831. [More Information]

Conferences

  • Eden, J., Lim, K., Ballouk, R., Rawlinson, W., Tanaka, M., White, P. (2012). Complex patterns of evolution led to the emergence of the current norovirus pandemic GII.4 variant, termed New Orleans 2010. 2012 Asia-Pacific Congress of Medical Virology, Adelaide, South Australia, Australia.
  • Eden, J., Bull, R., White, P. (2011). Evidence of intra-genotype recombination in the evolution of a novel norovirus GII.4 variant associated with outbreaks in NSW, Australia during 2009. Australian Microbiology Society Annual Scientific Meeting.
  • Eden, J., Bull, R., White, P. (2010). Evolution of a novel GII.4 associated with outbreaks of gastroenteritis in NSW, Australia during 2009. International Calicivirus Conference.
  • Eden, J., Bull, R., Tu, E., Lim, H., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., et al (2009). Norovirus GII.4 variant, 2006b, continues to cause gastroenteritis epidemics across Australia in 2007 and 2008. Australian Virology Group Meeting.

2014

  • Eltahla, A., Lim, K., Eden, J., Kelly, A., Mackenzie, J., White, P. (2014). Nonnucleoside Inhibitors of Norovirus RNA Polymerase: Scaffolds for Rational Drug Design. Antimicrobial Agents and Chemotherapy, 58(6), 3115-3123. [More Information]
  • Eden, J., Hewitt, J., Lim, K., Boni, M., Merif, J., Greening, G., Ratcliff, R., Holmes, E., Tanaka, M., Rawlinson, W., et al (2014). The emergence and evolution of the novel epidemic norovirus GII.4 variant Sydney 2012. Virology, 450-451, 106-113. [More Information]

2013

  • Eltahla, A., Lackovic, K., Marquis, C., Eden, J., White, P. (2013). A fluorescence-based high-throughput screen to identify small compound inhibitors of the genotype 3a hepatitis c virus RNA polymerase. Journal of Biomolecular Screening, 18(9), 1027-1034. [More Information]
  • Cui, J., Eden, J., Holmes, E., Wang, L. (2013). Adaptive evolution of bat dipeptidyl peptidase 4 (dpp4): Implications for the origin and emergence of Middle East Respiratory Syndrome Coronavirus. Virology Journal, 10, 1-5. [More Information]
  • Eden, J., Kun, L., Lynette, L., White, P. (2013). Molecular epidemiology of norovirus in Singapore, 2004-2011. Journal of Medical Virology, 85(10), 1842-1851. [More Information]
  • Eden, J., Tanaka, M., Boni, M., Rawlinson, W., White, P. (2013). Recombination within the pandemic norovirus GII.4 lineage. Journal of Virology, 87(11), 6270-6282. [More Information]

2012

  • Eden, J., Lim, K., White, P. (2012). Complete genome of the human norovirus GIV.1 strain Lake Macquarie virus. Journal of Virology, 86(18), 10251-10252. [More Information]
  • Eden, J., Lim, K., Ballouk, R., Rawlinson, W., Tanaka, M., White, P. (2012). Complex patterns of evolution led to the emergence of the current norovirus pandemic GII.4 variant, termed New Orleans 2010. 2012 Asia-Pacific Congress of Medical Virology, Adelaide, South Australia, Australia.
  • Bull, R., Eden, J., Luciani, F., McElroy, K., Rawlinson, W., White, P. (2012). Contribution of intra- and interhost dynamics to norovirus evolution. Journal of Virology, 86(6), 3219-3229. [More Information]
  • White, P., Eden, J., Hansman, G. (2012). Molecular epidemiology of noroviruses and sapoviruses and their role in Australian outbreaks of acute gastroenteritis. Microbiology Australia, 33(2), 70-73.

2011

  • Eden, J., Bull, R., White, P. (2011). Evidence of intra-genotype recombination in the evolution of a novel norovirus GII.4 variant associated with outbreaks in NSW, Australia during 2009. Australian Microbiology Society Annual Scientific Meeting.
  • Eden, J., Sharpe, L., White, P., Brown, A. (2011). Norovirus RNA-dependent RNA polymerase is phosphorylated by an important survival kinase, Akt. Journal of Virology, 85(20), 10894-10898. [More Information]

2010

  • Eden, J., Bull, R., White, P. (2010). Evolution of a novel GII.4 associated with outbreaks of gastroenteritis in NSW, Australia during 2009. International Calicivirus Conference.
  • Eden, J., Bull, R., Tu, E., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., White, P. (2010). Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008. Journal Of Clinical Virology, 49(4), 265-271. [More Information]
  • Bull, R., Eden, J., Rawlinson, W., White, P. (2010). Rapid evolution of pandemic noroviruses of the GII.4 lineage. PLoS Pathogens, 6(3), e1000831. [More Information]

2009

  • Eden, J., Bull, R., Tu, E., Lim, H., McIver, C., Lyon, M., Marshall, J., Smith, D., Musto, J., Rawlinson, W., et al (2009). Norovirus GII.4 variant, 2006b, continues to cause gastroenteritis epidemics across Australia in 2007 and 2008. Australian Virology Group Meeting.

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