Dr Kevin Aquino

F09 - Madsen Building
The University of Sydney

Telephone +61 2 9036 7966
Fax +61 2 9351 7726

Research interests

Currently my research interest is in the field of theoretical biology, namely within the field of theoretical neuroscience. My PhD was on the spatiotemporal dynamics of the Blood oxygenated-level dependent signal, measured with fMRI. In this field there is little attention paid to the spatiotemporal nature of blood flow in the cortex. My work strives to uncover the spatial nature of blood flow by building a theoretical model and testing this through highly resolved fMRI in humans. From a physics point of view: a way to tackle this is to use a mean-field approximation of the underlying cortical vasculature. This involves averaging over the dense vessels, then treating cortical tissue as a porous structure. In this framework the vessels penetrate cortical tissue which form the pores of the system. Applying physical laws to this system we derived our spatiotemporal model for hemodynamics. Along with our experimental findings, we provide support for our physical intuition: that the cortical vasculature can supports a patiotemporal oversupply of blood flow. Kevin Aquino is a member of the Complex Systems Research Group.

Selected publications

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Journals

  • Aquino, K., Robinson, P., Schira, M., Breakspear, M. (2014). Deconvolution of neural dynamics from fMRI data using a spatiotemporal hemodynamic response function. NeuroImage, 94, 203-215-203-215. [More Information]
  • Aquino, K., Robinson, P., Drysdale, P. (2014). Spatiotemporal hemodynamic response functions derived from physiology. Journal of Theoretical Biology, 347(1), 118-136. [More Information]
  • Aquino, K., Schira, M., Robinson, P., Drysdale, P., Breakspear, M. (2012). Hemodynamic traveling waves in human visual cortex. PLoS Computational Biology, 8(3), 1-12. [More Information]
  • Drysdale, P., Huber, J., Robinson, P., Aquino, K. (2010). Spatiotemporal BOLD dynamics from a poroelastic hemodynamic model. Journal of Theoretical Biology, 265(4), 524-534. [More Information]
  • Freyer, F., Aquino, K., Robinson, P., Ritter, P., Breakspear, M. (2009). Bistability and Non-Gaussian Fluctuations in Spontaneous Cortical Activity. The Journal of Neuroscience, 29(26), 8512-8524.
  • Breakspear, M., Bullmore, E., Aquino, K., Das, P., Williams, L. (2006). The multiscale character of evoked cortical activity. NeuroImage, 30(4), 1230-1242.

2014

  • Aquino, K., Robinson, P., Schira, M., Breakspear, M. (2014). Deconvolution of neural dynamics from fMRI data using a spatiotemporal hemodynamic response function. NeuroImage, 94, 203-215-203-215. [More Information]
  • Aquino, K., Robinson, P., Drysdale, P. (2014). Spatiotemporal hemodynamic response functions derived from physiology. Journal of Theoretical Biology, 347(1), 118-136. [More Information]

2012

  • Aquino, K., Schira, M., Robinson, P., Drysdale, P., Breakspear, M. (2012). Hemodynamic traveling waves in human visual cortex. PLoS Computational Biology, 8(3), 1-12. [More Information]

2010

  • Drysdale, P., Huber, J., Robinson, P., Aquino, K. (2010). Spatiotemporal BOLD dynamics from a poroelastic hemodynamic model. Journal of Theoretical Biology, 265(4), 524-534. [More Information]

2009

  • Freyer, F., Aquino, K., Robinson, P., Ritter, P., Breakspear, M. (2009). Bistability and Non-Gaussian Fluctuations in Spontaneous Cortical Activity. The Journal of Neuroscience, 29(26), 8512-8524.

2006

  • Breakspear, M., Bullmore, E., Aquino, K., Das, P., Williams, L. (2006). The multiscale character of evoked cortical activity. NeuroImage, 30(4), 1230-1242.

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