Dr Lake-ee Quek

F07 - Carslaw Building
The University of Sydney


Research interests

Metabolomics, cancer metabolism, computational biology

Selected grants

2016

  • Targeting Glutamine metabolism to starve triple-negative breast cancer; Holst J, Beith J, Hoy A, Quek L; University of Sydney - Sydney Catalyst Translational Cancer Research/Pilot and Seed Funding.

Selected publications

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Book Chapters

  • Quek, L., Nielsen, L. (2014). Customization of 13C-MFA Strategy According to Cell Culture System. In Jens O. Kromer, Lars K. Nielsen, Lars M. Blank (Eds.), Methods in Molecular Biology: Metabolic Flux Analysis - Methods and Protocols, (pp. 81-90). New York: Humana Press. [More Information]
  • Quek, L., Nielsen, L. (2014). Steady-State 13C Fluxomics Using OpenFLUX. In Jens O. Kromer, Lars K. Nielsen, Lars M. Blank (Eds.), Methods in Molecular Biology: Metabolic Flux Analysis - Methods and Protocols, (pp. 209-224). New York: Humana Press. [More Information]
  • Quek, L., Nielsen, L. (2010). Metabolic Engineering of Mammalian Cells. In Christina D. Smolke (Eds.), The Metabolic Pathway Engineering Handbook: Fundamentals, (pp. 26-1-26-14). Florida, USA: CRC Press.

Journals

  • Quek, L., Liu, M., Joshi, S., Turner, N. (2016). Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment. Cancer and Metabolism, 4, 1-14. [More Information]
  • Couttas, T., Kain, N., Suchowerska, A., Quek, L., Turner, N., Fath, T., Garner, B., Don, A. (2016). Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of Aging, 43(July), 89-100. [More Information]
  • Marcellin, E., Behrendorff, J., Nagaraju, S., DeTissera, S., Segovia, S., Palfreyman, R., Daniell, J., Licona-Cassani, C., Quek, L., Speight, R., et al (2016). Low carbon fuels and commodity chemicals from waste gases-systematic approach to understand energy metabolism in a model acetogen. Green Chemistry, 18(10), 3020-3028. [More Information]
  • Swainston, N., Smallbone, K., Hefzi, H., Dobson, P., Brewer, J., Hanscho, M., Zielinski, D., Ang, K., Gardiner, N., Gutierrez, J., et al (2016). Recon 2.2: from reconstruction to model of human metabolism. Metabolomics, 12(7), 1-7. [More Information]
  • De Oliveira Dal'Molin, C., Quek, L., Saa, P., Nielsen, L. (2015). A multi-tissue genome-scale metabolic modeling framework for the analysis of whole plant systems. Frontiers in Plant Science, 6, 1-12. [More Information]
  • Martinez, V., Buchsteiner, M., Gray, P., Nielsen, L., Quek, L. (2015). Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism. Metabolic Engineering Communications, 2, 46-57. [More Information]
  • Quek, L., Nielsen, L. (2014). A depth-first search algorithm to compute elementary flux modes by linear programming. BMC Systems Biology, 8(1), 1-10. [More Information]
  • Arifin, Y., Archer, C., Lim, S., Quek, L., Sugiarto, H., Marcellin, E., Vickers, C., Kromer, J., Nielsen, L. (2014). Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation. Applied Microbiology and Biotechnology, 98(21), 9033-9044. [More Information]
  • Turner, J., Quek, L., Titmarsh, D., Kromer, J., Kao, L., Nielsen, L., Wolvetang, E., Cooper-White, J. (2014). Metabolic Profiling and Flux Analysis of MEL-2 Human Embryonic Stem Cells during Exponential Growth at Physiological and Atmospheric Oxygen Concentrations. PloS One, 9(11), 1-13. [More Information]
  • Martinez, V., Quek, L., Nielsen, L. (2014). Network Thermodynamic Curation of Human and Yeast Genome-Scale Metabolic Models. Biophysical Journal, 107(2), 493-503. [More Information]
  • Dal’Molin, C., Quek, L., Palfreyman, R., Nielsen, L. (2014). Plant genome-scale modeling and implementation. Methods in Molecular Biology, 1090, 317-332. [More Information]
  • Quek, L., Dietmair, S., Hanscho, M., Martinez, V., Borth, N., Nielsen, L. (2014). Reducing Recon 2 for steady-state flux analysis of HEK cell culture. Journal of Biotechnology, 184, 172-178. [More Information]
  • Martinez, V., Dietmair, S., Quek, L., Hodson, M., Gray, P., Nielsen, L. (2013). Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnology and Bioengineering, 110(2), 660-666. [More Information]
  • Dietmair, S., Hodson, M., Quek, L., Timmins, N., Gray, P., Nielsen, L. (2012). A multi-omics analysis of recombinant protein production in Hek293 cells. PloS One, 7(8), 1-15. [More Information]
  • Dietmair, S., Hodson, M., Quek, L., Timmins, N., Chrysanthopoulos, P., Jacob, S., Gray, P., Nielsen, L. (2012). Metabolite profiling of CHO cells with different growth characteristics. Biotechnology and Bioengineering, 109(6), 1404-1414. [More Information]
  • Licona-Cassani, C., Marcellin, E., Quek, L., Jacob, S., Nielsen, L. (2012). Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production. Antonie van Leeuwenhoek: international journal of general and molecular microbiology, 102(3), 493-502. [More Information]
  • Gomes de Oliveira Dal'Molin, C., Quek, L., Palfreyman, R., Nielsen, L. (2011). AlgaGEM--a genome-scale metabolic reconstruction of algae based on the Chlamydomonas reinhardtii genome. BMC Genomics, 12, 1-10. [More Information]
  • Gomes de Oliveira Dal'Molin, C., Quek, L., Palfreyman, R., Brumbley, S., Nielsen, L. (2010). AraGEM, a genome-scale reconstruction of the primary metabolic network in Arabidopsis. Australian Journal of Plant Physiology, 152(2), 579-589. [More Information]
  • Gomes de Oliveira Dal'Molin, C., Quek, L., Palfreyman, R., Brumbley, S., Nielsen, L. (2010). C4GEM, a genome-scale metabolic model to study C4 plant metabolism. Australian Journal of Plant Physiology, 154(4), 1871-1885. [More Information]
  • Quek, L., Dietmair, S., Kromer, J., Nielsen, L. (2010). Metabolic flux analysis in mammalian cell culture. Metabolic Engineering, 12(2), 161-171. [More Information]
  • Kromer, J., Quek, L., Nielsen, L. (2009). 13C-Fluxomics: A Tool for Measuring Metabolic Phenotypes. Australian Biochemist, 40(3), 17-20.
  • Quek, L., Wittmann, C., Nielsen, L., Kromer, J. (2009). OpenFLUX: Efficient modelling software for 13C-based metabolic flux analysis. Microbial Cell Factories, 8, 1-15. [More Information]
  • Quek, L., Nielsen, L. (2008). On the reconstruction of the Mus musculus genome-scale metabolic network model. Genome Informatics, 21, 89-100.

2016

  • Quek, L., Liu, M., Joshi, S., Turner, N. (2016). Fast exchange fluxes around the pyruvate node: a leaky cell model to explain the gain and loss of unlabelled and labelled metabolites in a tracer experiment. Cancer and Metabolism, 4, 1-14. [More Information]
  • Couttas, T., Kain, N., Suchowerska, A., Quek, L., Turner, N., Fath, T., Garner, B., Don, A. (2016). Loss of ceramide synthase 2 activity, necessary for myelin biosynthesis, precedes tau pathology in the cortical pathogenesis of Alzheimer's disease. Neurobiology of Aging, 43(July), 89-100. [More Information]
  • Marcellin, E., Behrendorff, J., Nagaraju, S., DeTissera, S., Segovia, S., Palfreyman, R., Daniell, J., Licona-Cassani, C., Quek, L., Speight, R., et al (2016). Low carbon fuels and commodity chemicals from waste gases-systematic approach to understand energy metabolism in a model acetogen. Green Chemistry, 18(10), 3020-3028. [More Information]
  • Swainston, N., Smallbone, K., Hefzi, H., Dobson, P., Brewer, J., Hanscho, M., Zielinski, D., Ang, K., Gardiner, N., Gutierrez, J., et al (2016). Recon 2.2: from reconstruction to model of human metabolism. Metabolomics, 12(7), 1-7. [More Information]

2015

  • De Oliveira Dal'Molin, C., Quek, L., Saa, P., Nielsen, L. (2015). A multi-tissue genome-scale metabolic modeling framework for the analysis of whole plant systems. Frontiers in Plant Science, 6, 1-12. [More Information]
  • Martinez, V., Buchsteiner, M., Gray, P., Nielsen, L., Quek, L. (2015). Dynamic metabolic flux analysis using B-splines to study the effects of temperature shift on CHO cell metabolism. Metabolic Engineering Communications, 2, 46-57. [More Information]

2014

  • Quek, L., Nielsen, L. (2014). A depth-first search algorithm to compute elementary flux modes by linear programming. BMC Systems Biology, 8(1), 1-10. [More Information]
  • Quek, L., Nielsen, L. (2014). Customization of 13C-MFA Strategy According to Cell Culture System. In Jens O. Kromer, Lars K. Nielsen, Lars M. Blank (Eds.), Methods in Molecular Biology: Metabolic Flux Analysis - Methods and Protocols, (pp. 81-90). New York: Humana Press. [More Information]
  • Arifin, Y., Archer, C., Lim, S., Quek, L., Sugiarto, H., Marcellin, E., Vickers, C., Kromer, J., Nielsen, L. (2014). Escherichia coli W shows fast, highly oxidative sucrose metabolism and low acetate formation. Applied Microbiology and Biotechnology, 98(21), 9033-9044. [More Information]
  • Turner, J., Quek, L., Titmarsh, D., Kromer, J., Kao, L., Nielsen, L., Wolvetang, E., Cooper-White, J. (2014). Metabolic Profiling and Flux Analysis of MEL-2 Human Embryonic Stem Cells during Exponential Growth at Physiological and Atmospheric Oxygen Concentrations. PloS One, 9(11), 1-13. [More Information]
  • Martinez, V., Quek, L., Nielsen, L. (2014). Network Thermodynamic Curation of Human and Yeast Genome-Scale Metabolic Models. Biophysical Journal, 107(2), 493-503. [More Information]
  • Dal’Molin, C., Quek, L., Palfreyman, R., Nielsen, L. (2014). Plant genome-scale modeling and implementation. Methods in Molecular Biology, 1090, 317-332. [More Information]
  • Quek, L., Dietmair, S., Hanscho, M., Martinez, V., Borth, N., Nielsen, L. (2014). Reducing Recon 2 for steady-state flux analysis of HEK cell culture. Journal of Biotechnology, 184, 172-178. [More Information]
  • Quek, L., Nielsen, L. (2014). Steady-State 13C Fluxomics Using OpenFLUX. In Jens O. Kromer, Lars K. Nielsen, Lars M. Blank (Eds.), Methods in Molecular Biology: Metabolic Flux Analysis - Methods and Protocols, (pp. 209-224). New York: Humana Press. [More Information]

2013

  • Martinez, V., Dietmair, S., Quek, L., Hodson, M., Gray, P., Nielsen, L. (2013). Flux balance analysis of CHO cells before and after a metabolic switch from lactate production to consumption. Biotechnology and Bioengineering, 110(2), 660-666. [More Information]

2012

  • Dietmair, S., Hodson, M., Quek, L., Timmins, N., Gray, P., Nielsen, L. (2012). A multi-omics analysis of recombinant protein production in Hek293 cells. PloS One, 7(8), 1-15. [More Information]
  • Dietmair, S., Hodson, M., Quek, L., Timmins, N., Chrysanthopoulos, P., Jacob, S., Gray, P., Nielsen, L. (2012). Metabolite profiling of CHO cells with different growth characteristics. Biotechnology and Bioengineering, 109(6), 1404-1414. [More Information]
  • Licona-Cassani, C., Marcellin, E., Quek, L., Jacob, S., Nielsen, L. (2012). Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production. Antonie van Leeuwenhoek: international journal of general and molecular microbiology, 102(3), 493-502. [More Information]

2011

  • Gomes de Oliveira Dal'Molin, C., Quek, L., Palfreyman, R., Nielsen, L. (2011). AlgaGEM--a genome-scale metabolic reconstruction of algae based on the Chlamydomonas reinhardtii genome. BMC Genomics, 12, 1-10. [More Information]

2010

  • Gomes de Oliveira Dal'Molin, C., Quek, L., Palfreyman, R., Brumbley, S., Nielsen, L. (2010). AraGEM, a genome-scale reconstruction of the primary metabolic network in Arabidopsis. Australian Journal of Plant Physiology, 152(2), 579-589. [More Information]
  • Gomes de Oliveira Dal'Molin, C., Quek, L., Palfreyman, R., Brumbley, S., Nielsen, L. (2010). C4GEM, a genome-scale metabolic model to study C4 plant metabolism. Australian Journal of Plant Physiology, 154(4), 1871-1885. [More Information]
  • Quek, L., Nielsen, L. (2010). Metabolic Engineering of Mammalian Cells. In Christina D. Smolke (Eds.), The Metabolic Pathway Engineering Handbook: Fundamentals, (pp. 26-1-26-14). Florida, USA: CRC Press.
  • Quek, L., Dietmair, S., Kromer, J., Nielsen, L. (2010). Metabolic flux analysis in mammalian cell culture. Metabolic Engineering, 12(2), 161-171. [More Information]

2009

  • Kromer, J., Quek, L., Nielsen, L. (2009). 13C-Fluxomics: A Tool for Measuring Metabolic Phenotypes. Australian Biochemist, 40(3), 17-20.
  • Quek, L., Wittmann, C., Nielsen, L., Kromer, J. (2009). OpenFLUX: Efficient modelling software for 13C-based metabolic flux analysis. Microbial Cell Factories, 8, 1-15. [More Information]

2008

  • Quek, L., Nielsen, L. (2008). On the reconstruction of the Mus musculus genome-scale metabolic network model. Genome Informatics, 21, 89-100.

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