Dr Leslie Caron

D17 - Charles Perkins Centre
The University of Sydney

Telephone 02 8627 5619

Biographical details

Leslie Caron received a Ph.D from the University of Nice-Sophia Antipolis in France where she worked on skeletal muscle differentiation of mouse embryonic stem cells. Following her degree, she joined Pr Ken Chien?s laboratory at Harvard Medical School in Boston, USA. Her postdoctoral studies focused on isolating cardiovascular progenitors from mouse and human ESCs and showed that a triple-marked Isl1+/Nkx2.5+/Flk1+ multipotent progenitor gives rise to the three major lineages of the heart: cardiac myocytes, smooth muscle, and endothelial cells. This study provided new insights into the lineage diversification during mammalian heart development and represents a new strategy for cardiac tissue regeneration. In 2011, Leslie Caron moved to Australia to join Genea, an IVF Clinic and Stem Cell Company based in Sydney, and was awarded a fellowship from FSHD Global Research Foundation to develop stem cell-based models for muscular dystrophies using affected human ESC lines. Lack of a suitable cellular model for muscle diseases was stunting research into muscle diseases, with very little known and no progress in therapeutics. The system she developed is now commercialized and being used by researchers in Europe and USA. In 2016, Leslie joined the Charles Perkins Centre to set up a human pluripotent stem cells platform for the study of various human diseases.

Teaching and supervision

Research mentoring

Leslie has supervised several undergraduates and two PhD students during her postdoctoral fellowships both in the United States and Australia.

Associations

ISSCR (International Society for Stem Cell Research)

ASSCR (Australasian Society for Stem Cell Research)

NSW Stem Cell Network

Awards and honours

2011-2014: Inaugural Bill Moss fellowship from FSHD Global Foundation, Australia.

2011: Winner of the international IN Cell Image Competition, GE Healthcare. 

2006: Postdoctoral fellowship from "Fondation pour la Recherche Medicale", France.

2004: Doctoral Fellowship from "Ligue Nationale contre le Cancer", France.

2001-2003: Doctoral Fellowship from INSERM / Region PACA, France. 

In the media

http://biotechin.asia/2016/06/06/donemuscle-dystrophy-model-created-using-pluripotent-stem-cells/

http://www.smh.com.au/world/science/portrait-of-a-stem-cell-artist-20120131-1qr8t.html

Selected publications

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Journals

  • Caron, L., Kher, D., Lee, K., McKernan, R., Dumevska, B., Hidalgo, A., Li, J., Yang, H., Main, H., et al (2016). A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles. Stem Cells Translational Medicine, 5(9), 1145-1161. [More Information]
  • Bost, F., Aouadi, M., Caron, L., Even, P., Belmonte, N., Prot, M., Dani, C., Hofman, P., Pages, G., Pouyssegur, J., et al (2016). The Extracellular Signal�Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis. Diabetes, 54, 402-411.
  • Leschik, J., Caron, L., Yang, H., Cowan, C., Puceat, M. (2015). A View of Bivalent Epigenetic Marks in Two Human Embryonic Stem Cell Lines Reveals a Different Cardiogenic Potentia. Stem Cells and Development, 24(3), 384-392. [More Information]
  • Buikema, J., Mady, A., Mittal, N., Atmanli, A., Caron, L., Doevendans, P., Sluijter, J., Domian, I. (2013). Wnt/Beta-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes. Development, 140(20), 4165-4176. [More Information]
  • Bu, L., Jiang, X., Martin-Puig, S., Caron, L., Zhu, S., Shao, Y., Roberts, D., Huang, P., Domian, I., Chien, K. (2009). Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature, 460(2), 113-118. [More Information]
  • Laugwitz, K., Moretti, A., Caron, L., Nakano, A., Chien, K. (2008). Islet1 cardiovascular progenitors: a single source for heart lineages? Development, 135, 193-205. [More Information]
  • Osafune, K., Caron, L., Borowiak, M., Martinez, R., Fitz-Gerald, C., Sato, Y., Cowan, C., Chien, K., Melton, D. (2008). Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology, 26(3), 313-315. [More Information]
  • Binetruy, B., Heasley, L., Bost, F., Caron, L., Aouadi, M. (2007). Regulation of ES Cell Lineage Commitment by Mitogen Activated Protein Kinases. Stem Cells, 25, 1090-1095. [More Information]
  • Qyang, Y., Martin-Puig, S., Chiravuri, M., Chen, S., Bu, L., Jiang, X., Lin, L., Granger, A., Moretti, A., Caron, L., et al (2007). The Renewal and Differentiation of Isl1+ Cardiovascular Progenitors Are Controlled by a Wnt/b-Catenin Pathway. Cell Stem Cell, 1, 165-179. [More Information]
  • Moretti, A., Caron, L., Nakano, A., Lam, J., Bernshausen, A., Chen, Y., Qyang, Y., Bu, L., Sasaki, M., Martin-Puig, S., et al (2006). Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification. Cell, 127, 1151-11665. [More Information]
  • Aouadi, M., Bost, F., Caron, L., Laurent, K., Le Marchand-Brustel, Y., Binetruy, B. (2006). p38 Mitogen-Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis. Stem Cells, 24, 1393-1406. [More Information]
  • Aouadi, M., Binetruy, B., Caron, L., Le Marchand-Brustel, Y., Bost, F. (2006). Role of MAPKs in development and differentiation: lessons from knockout mice. Biochimie, 88, 1091-1098. [More Information]
  • Caron, L., Bost, F., Prot, M., Hofman, P., Binetruy, B. (2005). A new role for the oncogenic high-mobility group A2 transcription factor in myogenesis of embryonic stem cells. Oncogene, 24, 6281-6291. [More Information]
  • Caron, L., Prot, M., Rouleau, M., Bost, F., Binetruy, B. (2005). The Lac repressor provides a reversible gene expression system in undifferentiated and differentiated embryonic stem cell. Cellular and Molecular Life Sciences, 62, 1605-1612. [More Information]
  • Bost, F., Aouadi, M., Caron, L., Binetruy, B. (2005). The role of MAPKs in adipocyte differentiation and obesity. Biochimie, 87, 51-56. [More Information]
  • Bost, F., Caron, L., Marchetti, I., Dani, C., Le Marchand-Brustel, Y., Binetruy, B. (2002). Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochemical Society Transactions, 361, 621-627.

2016

  • Caron, L., Kher, D., Lee, K., McKernan, R., Dumevska, B., Hidalgo, A., Li, J., Yang, H., Main, H., et al (2016). A Human Pluripotent Stem Cell Model of Facioscapulohumeral Muscular Dystrophy-Affected Skeletal Muscles. Stem Cells Translational Medicine, 5(9), 1145-1161. [More Information]
  • Bost, F., Aouadi, M., Caron, L., Even, P., Belmonte, N., Prot, M., Dani, C., Hofman, P., Pages, G., Pouyssegur, J., et al (2016). The Extracellular Signal�Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis. Diabetes, 54, 402-411.

2015

  • Leschik, J., Caron, L., Yang, H., Cowan, C., Puceat, M. (2015). A View of Bivalent Epigenetic Marks in Two Human Embryonic Stem Cell Lines Reveals a Different Cardiogenic Potentia. Stem Cells and Development, 24(3), 384-392. [More Information]

2013

  • Buikema, J., Mady, A., Mittal, N., Atmanli, A., Caron, L., Doevendans, P., Sluijter, J., Domian, I. (2013). Wnt/Beta-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes. Development, 140(20), 4165-4176. [More Information]

2009

  • Bu, L., Jiang, X., Martin-Puig, S., Caron, L., Zhu, S., Shao, Y., Roberts, D., Huang, P., Domian, I., Chien, K. (2009). Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature, 460(2), 113-118. [More Information]

2008

  • Laugwitz, K., Moretti, A., Caron, L., Nakano, A., Chien, K. (2008). Islet1 cardiovascular progenitors: a single source for heart lineages? Development, 135, 193-205. [More Information]
  • Osafune, K., Caron, L., Borowiak, M., Martinez, R., Fitz-Gerald, C., Sato, Y., Cowan, C., Chien, K., Melton, D. (2008). Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology, 26(3), 313-315. [More Information]

2007

  • Binetruy, B., Heasley, L., Bost, F., Caron, L., Aouadi, M. (2007). Regulation of ES Cell Lineage Commitment by Mitogen Activated Protein Kinases. Stem Cells, 25, 1090-1095. [More Information]
  • Qyang, Y., Martin-Puig, S., Chiravuri, M., Chen, S., Bu, L., Jiang, X., Lin, L., Granger, A., Moretti, A., Caron, L., et al (2007). The Renewal and Differentiation of Isl1+ Cardiovascular Progenitors Are Controlled by a Wnt/b-Catenin Pathway. Cell Stem Cell, 1, 165-179. [More Information]

2006

  • Moretti, A., Caron, L., Nakano, A., Lam, J., Bernshausen, A., Chen, Y., Qyang, Y., Bu, L., Sasaki, M., Martin-Puig, S., et al (2006). Multipotent Embryonic Isl1+ Progenitor Cells Lead to Cardiac, Smooth Muscle, and Endothelial Cell Diversification. Cell, 127, 1151-11665. [More Information]
  • Aouadi, M., Bost, F., Caron, L., Laurent, K., Le Marchand-Brustel, Y., Binetruy, B. (2006). p38 Mitogen-Activated Protein Kinase Activity Commits Embryonic Stem Cells to Either Neurogenesis or Cardiomyogenesis. Stem Cells, 24, 1393-1406. [More Information]
  • Aouadi, M., Binetruy, B., Caron, L., Le Marchand-Brustel, Y., Bost, F. (2006). Role of MAPKs in development and differentiation: lessons from knockout mice. Biochimie, 88, 1091-1098. [More Information]

2005

  • Caron, L., Bost, F., Prot, M., Hofman, P., Binetruy, B. (2005). A new role for the oncogenic high-mobility group A2 transcription factor in myogenesis of embryonic stem cells. Oncogene, 24, 6281-6291. [More Information]
  • Caron, L., Prot, M., Rouleau, M., Bost, F., Binetruy, B. (2005). The Lac repressor provides a reversible gene expression system in undifferentiated and differentiated embryonic stem cell. Cellular and Molecular Life Sciences, 62, 1605-1612. [More Information]
  • Bost, F., Aouadi, M., Caron, L., Binetruy, B. (2005). The role of MAPKs in adipocyte differentiation and obesity. Biochimie, 87, 51-56. [More Information]

2002

  • Bost, F., Caron, L., Marchetti, I., Dani, C., Le Marchand-Brustel, Y., Binetruy, B. (2002). Retinoic acid activation of the ERK pathway is required for embryonic stem cell commitment into the adipocyte lineage. Biochemical Society Transactions, 361, 621-627.

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