Associate Professor Louis Rendina

BSc PhD ANU, FRSC, FRACI C.Chem.
Associate Head of School (Research)

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 4781
Fax 61 2 9351 3329

Website Research Group
Contact Details

Biographical details

  • B.Sc.(Hons I) ANU, 1988
  • Ph.D. ANU, 1991
  • ANU IAS Postdoctoral Fellow, 1991-1993
  • NSERC Canada International Fellow, 1993-1995
  • Lecturer, Senior Lecturer, The University of Adelaide, 1996-2003
  • Fellow of the Royal Australian Chemical Institute (FRACI, C. Chem.), 2005
  • Fellow of the Royal Society of Chemistry, UK (FRSC), 2007
  • Royal Society JWT Jones Fellow (Oxford University), 2008
  • Appointed to the ARC College of Experts, 2014-

Research interests

My research group is primarily interested in the medicinal chemistry of boron and the lanthanides, in particular gadolinium. We place a strong emphasis on the design and development of new drug classes and also medicinal agents with neutron and X-ray photon applications, particularly those involving the treatment of intractable and aggressive cancers such as those of the brain. We are heavily involved in the development of new boron and gadolinium agents for an exciting cancer treatment known as neutron capture therapy (NCT), one of the few groups in the world to be involved in this area of research. To date, we have discovered several new classes of DNA-, mitochondrial- and tumour-targeted compounds and we are currently exploring their use as potential BNCT and GdNCT agents. We are also interested in the use of boron clusters, in particular the carboranes, as unique classes of pharmacophore in drug design.

Our research is funded by organizations including the Australian Research Council, The Prostate Cancer Foundation of Australia, Cure Cancer Australia Foundation and The National Breast Cancer Foundation.

Current projects

For more information please visit http://sydney.edu.au/science/chemistry/~lmrgroup

Awards and honours

  • Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry, 2003
  • Royal Australian Chemical Institute Organometallic Chemistry Award, 2004
  • Selby Research Award, 2005
  • Fellow of the Royal Australian Chemical Institute (FRACI,C. Chem.), 2005
  • Fellow of the Royal Society of Chemistry, UK (FRSC), 2007
  • Royal Society JWT Jones Fellow (Oxford University), 2008

Selected grants

2014

  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • A CyTOF for the NSW Advanced Cytometry Facility - clean multidimensional multiparametric flow cytometry using single cell mass spectrometry; King N, Campbell I, Fazekas B, Cordwell S, Rendina L, Gunning P, Crossley M, Davenport M, Hogg P, Pimanda J, Goldys E, Jin D, Molloy M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2013

  • Perpetual Account code: Australian Synchrotron Access Program; Rendina L; Australian Synchrotron Company Limited/International Access Program.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • A unique class of tumour-specific drugs for the potential treatment and imaging of advanced prostate cancer; Rendina L; Prostate Cancer Foundation of Australia/Concept Grants.
  • GeneAtlas Personal Microarray System; Richardson D, Scolyer R, Stocker R, Weninger W, Black J, Allen D, Murray M, Mason R, Twigg S, King N, Horvath L, Lovicu F, Lee C, Halliday G, Lovejoy D, Joshua D, Sharland A, Roufogalis B, Hambly B, Morris B, Bao B, Bishop A, Hibbs D, Lane D, Zhou F, Hanrahan J, Dixon K, Rendina L, Byrne M, Naylor M, Cole N, Jansson P, Dong Q, Codd R, Payne R, Assinder S, Chadban S, Fraser S, McLennan S, Suryo Rahmanto A, Lai D, Yu Y, Ju Y, Buckland M, Kovacevic Z, Saletta F, Zreiqat H, Kalinowski D, Groundwater P, Simes R, Zhang D, Boyer M, Murphy C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • A unique class of tumour-specific drugs for the trearment of advanced metastatic cancer; Rendina L, Kassiou M; National Breast Cancer Foundation/Novel Concept Awards.
  • New Frontiers in the Therapeutic Application of Gadolinium; Rendina L; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • The Development of Carboranes as New Agents in the Diagnosis and Treatment of Brain Disease; Kassiou M, Rendina L; Australian Research Council (ARC)/Discovery Projects (DP).

2010

  • NMR Spectroscopy Facilities for the Sydney Region; Jolliffe K, Messerle B, Hambley T, Rendina L, Payne R, Mackay J, Kuchel P, Messerle B, Ball G, Price W, Crossley M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • Selective Targeting of Breast Tumours for Boron Neutron Capture Therapy; Rendina L, Kassiou M; National Breast Cancer Foundation/Novel Concept Awards.
  • New Boron and Gadolinium Agents for Neutron Capture Therapy; Rendina L, Matsumura A; Australian Research Council (ARC)/Discovery Projects (DP).

2008

  • Selective Targeting of Breast Tumours for Boron Neutron Capture Therapy; Rendina L; National Breast Cancer Foundation/Novel Concept Awards.
  • The Targeting of Brain Tumours by a New Class of Agents for Boron Neutron Capture Therapy; Rendina L, Kassiou M; Cure Cancer Australia Foundation/Research Support.

2007

  • Total internal reflectance fluorescence microscope (TIRFM); Soon L, Rendina L, Braet F, Weiss A, Grau G, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • Tumour Specific Boronated Peptides as a New Class of Agents for Boron Neutron Capture Therapy; Rendina L; University of Sydney/Cancer Research Fund.

2005

  • DNA Nanoshuttles: A New class of DNA-Binding Molecules; Rendina L, Harding M; Australian Research Council (ARC)/Discovery Projects (DP).
  • Platinum-Carborane Complexes as New Agents for Boron Neutron Capture Therapy; Rendina L, Coderre J; Australian Research Council (ARC)/Discovery Projects (DP).

2004

  • DNA nanoshuttles: electrostatic models of toroidal proteins and potential topological probes of DNA structure and function; Rendina L; DVC Research/Research and Development Scheme: Newly Appointed Staff (NAS).

Selected publications

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Book Chapters

  • Issa, F., Ioppolo, J., Rendina, L. (2013). Boron and Gadolinium Neutron Capture Therapy. In Jan Reedijk, Kenneth Poeppelmeier (Eds.), Comprehensive Inorganic Chemistry II: From Elements to Applications, (pp. 877-900). Amsterdam, Netherlands: Elsevier.
  • Crossley, E., Ching, V., Ioppolo, J., Rendina, L. (2011). Boron and Gadolinium in the Neutron Capture Therapy of Cancer. In Professor Enzo Alessio (Eds.), Bioinorganic Medicinal Chemistry, (pp. 283-305). Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Rendina, L., Hambley, T. (2004). Platinum. In D. E. Fenton (Eds.), Comprehensive Coordination Chemistry II : From biology to nanotechnology. Volume 6: Transition Metal groups 9-12, (pp. 673-745). Amsterdam: Elsevier.

Journals

  • Kahlert, J., Rawal, A., Hook, J., Rendina, L., Choucair, M. (2014). Carborane functionalization of the aromatic network in chemically-synthesized graphene. Chemical Communications, 50(77), 11332-11334. [More Information]
  • Morrison, D., Aitken, J., De Jonge, M., Ioppolo, J., Harris, H., Rendina, L. (2014). High mitochondrial accumulation of new gadolinium(III) agents within tumour cells. Chemical Communications, 50(18), 2252-2254. [More Information]
  • Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information]
  • Austin, C., Kahlert, J., Issa, F., Reed, J., Smith, J., Ioppolo, J., Ong, J., Jamie, J., Hibbs, D., Rendina, L. (2014). The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane. Dalton Transactions, 43(28), 10719-10724. [More Information]
  • Ioppolo, J., Bhadbhade, M., Fox, M., Rendina, L. (2013). Remarkable cage deboronation and rearrangement of a closo-1,12-dicarbadodecaborane to form a neutral nido-7,9-dicarbaundecaborane. Chemical Communications, 49(32), 3312-3314. [More Information]
  • Ching, V., Clarke, R., Rendina, L. (2013). Supramolecular beta-cyclodextrin adducts of boron-rich DNA metallointercalators containing dicarba-closo-dodecaborane(12). Inorganic Chemistry, 52(18), 10356-10367. [More Information]
  • Ziolkowski (Sheridan), E., Austin, C., Aitken, J., Vogt, S., Jolliffe, K., Harris, H., Rendina, L. (2013). Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells. Journal of Synchrotron Radiation, 20(2), 226-233. [More Information]
  • Kahlert, J., Austin, C., Kassiou, M., Rendina, L. (2013). The fifth element in drug design: Boron in medicinal chemistry. Australian Journal of Chemistry: an international journal for chemical science, 66(10), 1118-1123. [More Information]
  • Austin, C., Kahlert, J., Kassiou, M., Rendina, L. (2013). The translocator protein (TSPO): A novel target for cancer chemotherapy. The International Journal of Biochemistry and Cell Biology, 45(7), 1212-1216. [More Information]
  • Banister, S., Rendina, L., Kassiou, M. (2012). 7-azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (sigma-2) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(12), 4059-4063. [More Information]
  • Ching, V., Buck, D., Bhadbhade, M., Collins, J., Rendina, L. (2012). A ternary supramolecular system containing a boronated DNA-metallointercalator, beta-cyclodextrin and the hexanucleotide d(GTCGAC)(2). Chemical Communications, 48(6), 880-882. [More Information]
  • Ching, V., Clifford, S., Bhadbhade, M., Clarke, R., Rendina, L. (2012). Synthesis and supramolecular studies of chiral boronated platinum(II) complexes: Insights into the molecular recognition of carboranes by beta-cyclodextrin. Chemistry: A European Journal, 18(45), 14413-14425. [More Information]
  • Issa, F., Kassiou, M., Rendina, L. (2011). Boron in drug discovery: Carboranes as unique pharmacophores in biologically active compounds. Chemical Reviews, 111(9), 5701-5722. [More Information]
  • Bloch, W., Derwent-Smith, S., Issa, F., Morris, J., Rendina, L., Sumby, C. (2011). Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties. Tetrahedron, 67(48), 9368-9375. [More Information]
  • Crossley, E., Issa, F., Scarf, A., Kassiou, M., Rendina, L. (2011). Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells. Chemical Communications, 47(44), 12179-12181. [More Information]
  • Hosseini, S., Bhadbhade, M., Clarke, R., Rutledge, P., Rendina, L. (2011). Synthesis, carbohydrate- and DNA-binding studies of cationic 2,2':6',2"-terpyridineplatinum(II) complexes containing N- and S-donor boronic acid ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 40(2), 506-513.
  • Crossley, E., Aitken, J., Vogt, S., Harris, H., Rendina, L. (2011). Uptake and Distribution of a Platinum(II)-Carborane Complex Within a Tumour Cell Using Synchrotron XRF Imaging. Australian Journal of Chemistry: an international journal for chemical science, 64(3), 253-257. [More Information]
  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
  • Rendina, L. (2010). Can lithium salts herald a new era for neutron capture therapy? Journal of Medicinal Chemistry, 53(23), 8224-8227. [More Information]
  • Schilter, D., Urathamakul, T., Beck, J., Harding, M., Rendina, L. (2010). ESI-MS and thermal melting studies of nanoscale platinum(II) metallomacrocycles with DNA. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(46), 11263-11271.
  • Schilter, D., Clegg, J., Harding, M., Rendina, L. (2010). Platinum(II) and palladium(II) metallomacrocycles derived from cationic 4,4'-bipyridinium, 3-aminopyrazinium and 2-aminopyrimidinium ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(1), 239-247. [More Information]
  • Crossley, E., Aitken, J., Vogt, S., Harris, H., Rendina, L. (2010). Selective aggregation of a Platinum-Gadolinium complex within a tumor-cell nucleus. Angewandte Chemie (International Edition), 49(7), 1231-1233. [More Information]
  • Ioppolo, J., Clegg, J., Rendina, L. (2009). [1,2-bis(diphenylphosphino)-1,2-dicarba-closo-dodecaborane-kappa(2)P,P'][7,8-bis(diphenylphosphino)-7,8-dicarba nido-undecaborato-kappa(2)P,P']gold(I)-dichloro-methane-water (2/1/1). Acta Crystallographica. Section E: Structure Reports Online, E65(5), m603 (also sup-1 to sup-20)-m604.
  • Crisp, M., Rendina, L. (2009). Dinuclear organoplatinum(II) complexes containing N-methylbenzamide. Canadian Journal of Chemistry, 87(1), 212-216.
  • Ioppolo, J., Kassiou, M., Rendina, L. (2009). Water-soluble phosphonium salts containing 1,12-dicarba-closo-dodecaborane(12). Tetrahedron Letters, 50(47), 6457-6461. [More Information]
  • Crossley, E., Ziolkowski (Sheridan), E., Coderre, J., Rendina, L. (2007). Boronated DNA-binding compounds as potential agents for boron neutron capture therapy. Mini - Reviews in Medicinal Chemistry, 7, 303-313.
  • Ioppolo, J., Clegg, J., Rendina, L. (2007). Dicarba-closo-dodecaborane(12) derivatives of phosphonium salts: Easy formation of nido-carborane phosphonium zwitterions. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (20), 1982-1985.
  • Ioppolo, J., Kepert, C., Price, D., Rendina, L. (2007). Mono- and di-nuclear gold(I) complexes containing 1,12-dicarba-closo-dodecaborance(12). Australian Journal of Chemistry: an international journal for chemical science, 60(11), 816-820.
  • Ching, V., Clegg, J., Rendina, L. (2007). Synthesis and preliminary DNA-binding studies of diimineplatinum(II) complexes containing 3- or 4-pyridineboronic acid. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (21), 2121-2126.
  • Ziolkowski (Sheridan), E., Turner, P., Rendina, L. (2006). Mono- and di-nuclear platinum(II) complexes containing O- and N-bonded acetamide. Inorganic Chemistry Communications, 9(1), 53-56.
  • Lee, C., Groneman, J., Turner, P., Rendina, L., Harding, M. (2006). Synthesis and X-ray crystallographic analysis of chiral pyridyl substituted carbocyclic molecular clefts. Tetrahedron, 62(20), 4870-4878.
  • Todd, J., Turner, P., Ziolkowski (Sheridan), E., Rendina, L. (2005). (2,2 ': 6 ',2 ''-Terpyridine)platinum(II) complexes (thioalkyl)dicarba-closo-dodecaborane(12) containing ligands. Inorganic Chemistry, 44(18), 6401-6408.
  • Crossley, E., Caiazza, D., Rendina, L. (2005). A highly water-soluble platinum(II) complex containing a thiopropyl-1,2-dicarba-closo-dodecaborane(12) ligand functionalised with a pendant glycerol group. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2005 (17), 2825-2826.
  • Woodhouse, S., Ziolkowski (Sheridan), E., Rendina, L. (2005). Synthesis and anti-cancer activity of dinuclear platinum(II) complexes containing bis(thioalkyl)dicarba-closo-dodecaborane(12) ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2005 (17), 2827-2829.
  • Woodhouse, S., Rendina, L. (2004). Multinuclear Platinum(Ii) -Amine Complexes Containing Bis (Aminopropyl)Dicarba-Closo-Dodecaborane(12)Ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 21, 3669-3677.
  • Gallasch, D., Woodhouse, S., Rendina, L. (2004). Synthesis And Redistribution Reactions Of Asymmetric Sigma-Arylplatinum(Ii) Complexes Containing 4,7-Phenanthroline. Journal of Organometallic Chemistry, 689(7), 1288-1294.
  • Rendina, L., Todd, J. (2004). The First Examples Of Platinum(Ii)-Amine Complexes Containing 1,2-Dicarba-Closo-Dodecaborane(12). Inorganic Chemistry Communications, 7(2), 289-291.
  • Crisp, M., Tiekink, E., Rendina, L. (2003). Cationic sigma-phenylplatinum(II) complexes with carboxylic acid functionality: pKa determinations and X-ray structures. Inorganic Chemistry, 42(4), 1057-1063.
  • Wenger, E., Rendina, L. (2003). Protagonists in chemistry. Inorganica Chimica Acta, 352, 1-3.
  • Todd, J., Caiazza, D., Tiekink, E., Rendina, L. (2003). Synthesis of diimineplatinum(II) complexes containing the 1,2-dicarba-closo-dodecaborane(12)-1-thiolato ligand. Inorganica Chimica Acta, 352, 208-212.
  • Janzen, M., Jenkins, H., Jennings, M., Rendina, L., Puddephatt, R. (2002). Ring expansion and contraction in reactions of an alkyne with stannylplatinum(IV) metallacycles: Formation of an alkyl(alkenyl)(alkynyl)platinum(IV) complex. Organometallics, 21(6), 1257-1261.
  • Todd, J., Rendina, L. (2002). Synthesis and DNA-binding properties of cationic 2,2':6',2"-terpyridineplatinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12). Inorganic Chemistry, 41(13), 3331-3333.
  • Gallasch, D., Tiekink, E., Rendina, L. (2001). A new methodology for the preparation of cationic organoplatinum(II) complexes with hydrogen-bonding functionality. Organometallics, 20(16), 3373-3382.
  • Crisp, M., Rendina, L., Tiekink, E. (2001). Crystal structure of trans-bis(diethylhydroxyphosphine)diethylphosphinito(iodo)platinum(II) triethylphosphineoxide solvate (1/1), [(Et2(OH)P)2(Et2PO)IPt] · Et3PO. Zeitschrift fuer Kristallographie - New Crystal Structures, 216(2), 243-244.
  • Crisp, M., Rendina, L., Tiekink, E. (2001). Refinement of the crystal structure of trans-chloro-phenyl-bis(triphenylphosphine)platinum(II) at 173 K, C42H35ClP2Pt. Zeitschrift fuer Kristallographie - New Crystal Structures, 216, 249-250.
  • Woodhouse, S., Rendina, L. (2001). Synthesis and DNA-binding properties of dinuclear platinum(II)-amine complexes of 1,7-dicarba-closo-dodecaborane(12). Chemical Communications, (23), 2464-2465.

2014

  • Kahlert, J., Rawal, A., Hook, J., Rendina, L., Choucair, M. (2014). Carborane functionalization of the aromatic network in chemically-synthesized graphene. Chemical Communications, 50(77), 11332-11334. [More Information]
  • Morrison, D., Aitken, J., De Jonge, M., Ioppolo, J., Harris, H., Rendina, L. (2014). High mitochondrial accumulation of new gadolinium(III) agents within tumour cells. Chemical Communications, 50(18), 2252-2254. [More Information]
  • Wilkinson, S., Gunosewoyo, H., Barron, M., Boucher, A., McDonnell, M., Turner, P., Morrison, D., Bennett, M., McGregor, I., Rendina, L., Kassiou, M. (2014). The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity. ACS Chemical Neuroscience, 5(5), 335-339. [More Information]
  • Austin, C., Kahlert, J., Issa, F., Reed, J., Smith, J., Ioppolo, J., Ong, J., Jamie, J., Hibbs, D., Rendina, L. (2014). The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane. Dalton Transactions, 43(28), 10719-10724. [More Information]

2013

  • Issa, F., Ioppolo, J., Rendina, L. (2013). Boron and Gadolinium Neutron Capture Therapy. In Jan Reedijk, Kenneth Poeppelmeier (Eds.), Comprehensive Inorganic Chemistry II: From Elements to Applications, (pp. 877-900). Amsterdam, Netherlands: Elsevier.
  • Ioppolo, J., Bhadbhade, M., Fox, M., Rendina, L. (2013). Remarkable cage deboronation and rearrangement of a closo-1,12-dicarbadodecaborane to form a neutral nido-7,9-dicarbaundecaborane. Chemical Communications, 49(32), 3312-3314. [More Information]
  • Ching, V., Clarke, R., Rendina, L. (2013). Supramolecular beta-cyclodextrin adducts of boron-rich DNA metallointercalators containing dicarba-closo-dodecaborane(12). Inorganic Chemistry, 52(18), 10356-10367. [More Information]
  • Ziolkowski (Sheridan), E., Austin, C., Aitken, J., Vogt, S., Jolliffe, K., Harris, H., Rendina, L. (2013). Synchrotron X-ray fluorescence studies of a bromine-labelled cyclic RGD peptide interacting with individual tumor cells. Journal of Synchrotron Radiation, 20(2), 226-233. [More Information]
  • Kahlert, J., Austin, C., Kassiou, M., Rendina, L. (2013). The fifth element in drug design: Boron in medicinal chemistry. Australian Journal of Chemistry: an international journal for chemical science, 66(10), 1118-1123. [More Information]
  • Austin, C., Kahlert, J., Kassiou, M., Rendina, L. (2013). The translocator protein (TSPO): A novel target for cancer chemotherapy. The International Journal of Biochemistry and Cell Biology, 45(7), 1212-1216. [More Information]

2012

  • Banister, S., Rendina, L., Kassiou, M. (2012). 7-azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (sigma-2) receptor ligands. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 22(12), 4059-4063. [More Information]
  • Ching, V., Buck, D., Bhadbhade, M., Collins, J., Rendina, L. (2012). A ternary supramolecular system containing a boronated DNA-metallointercalator, beta-cyclodextrin and the hexanucleotide d(GTCGAC)(2). Chemical Communications, 48(6), 880-882. [More Information]
  • Ching, V., Clifford, S., Bhadbhade, M., Clarke, R., Rendina, L. (2012). Synthesis and supramolecular studies of chiral boronated platinum(II) complexes: Insights into the molecular recognition of carboranes by beta-cyclodextrin. Chemistry: A European Journal, 18(45), 14413-14425. [More Information]

2011

  • Crossley, E., Ching, V., Ioppolo, J., Rendina, L. (2011). Boron and Gadolinium in the Neutron Capture Therapy of Cancer. In Professor Enzo Alessio (Eds.), Bioinorganic Medicinal Chemistry, (pp. 283-305). Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Issa, F., Kassiou, M., Rendina, L. (2011). Boron in drug discovery: Carboranes as unique pharmacophores in biologically active compounds. Chemical Reviews, 111(9), 5701-5722. [More Information]
  • Bloch, W., Derwent-Smith, S., Issa, F., Morris, J., Rendina, L., Sumby, C. (2011). Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties. Tetrahedron, 67(48), 9368-9375. [More Information]
  • Crossley, E., Issa, F., Scarf, A., Kassiou, M., Rendina, L. (2011). Synthesis and cellular uptake of boron-rich pyrazolopyrimidines: exploitation of the translocator protein for the efficient delivery of boron into human glioma cells. Chemical Communications, 47(44), 12179-12181. [More Information]
  • Hosseini, S., Bhadbhade, M., Clarke, R., Rutledge, P., Rendina, L. (2011). Synthesis, carbohydrate- and DNA-binding studies of cationic 2,2':6',2"-terpyridineplatinum(II) complexes containing N- and S-donor boronic acid ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 40(2), 506-513.
  • Crossley, E., Aitken, J., Vogt, S., Harris, H., Rendina, L. (2011). Uptake and Distribution of a Platinum(II)-Carborane Complex Within a Tumour Cell Using Synchrotron XRF Imaging. Australian Journal of Chemistry: an international journal for chemical science, 64(3), 253-257. [More Information]

2010

  • Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
  • Rendina, L. (2010). Can lithium salts herald a new era for neutron capture therapy? Journal of Medicinal Chemistry, 53(23), 8224-8227. [More Information]
  • Schilter, D., Urathamakul, T., Beck, J., Harding, M., Rendina, L. (2010). ESI-MS and thermal melting studies of nanoscale platinum(II) metallomacrocycles with DNA. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(46), 11263-11271.
  • Schilter, D., Clegg, J., Harding, M., Rendina, L. (2010). Platinum(II) and palladium(II) metallomacrocycles derived from cationic 4,4'-bipyridinium, 3-aminopyrazinium and 2-aminopyrimidinium ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 39(1), 239-247. [More Information]
  • Crossley, E., Aitken, J., Vogt, S., Harris, H., Rendina, L. (2010). Selective aggregation of a Platinum-Gadolinium complex within a tumor-cell nucleus. Angewandte Chemie (International Edition), 49(7), 1231-1233. [More Information]

2009

  • Ioppolo, J., Clegg, J., Rendina, L. (2009). [1,2-bis(diphenylphosphino)-1,2-dicarba-closo-dodecaborane-kappa(2)P,P'][7,8-bis(diphenylphosphino)-7,8-dicarba nido-undecaborato-kappa(2)P,P']gold(I)-dichloro-methane-water (2/1/1). Acta Crystallographica. Section E: Structure Reports Online, E65(5), m603 (also sup-1 to sup-20)-m604.
  • Crisp, M., Rendina, L. (2009). Dinuclear organoplatinum(II) complexes containing N-methylbenzamide. Canadian Journal of Chemistry, 87(1), 212-216.
  • Ioppolo, J., Kassiou, M., Rendina, L. (2009). Water-soluble phosphonium salts containing 1,12-dicarba-closo-dodecaborane(12). Tetrahedron Letters, 50(47), 6457-6461. [More Information]

2007

  • Crossley, E., Ziolkowski (Sheridan), E., Coderre, J., Rendina, L. (2007). Boronated DNA-binding compounds as potential agents for boron neutron capture therapy. Mini - Reviews in Medicinal Chemistry, 7, 303-313.
  • Ioppolo, J., Clegg, J., Rendina, L. (2007). Dicarba-closo-dodecaborane(12) derivatives of phosphonium salts: Easy formation of nido-carborane phosphonium zwitterions. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (20), 1982-1985.
  • Ioppolo, J., Kepert, C., Price, D., Rendina, L. (2007). Mono- and di-nuclear gold(I) complexes containing 1,12-dicarba-closo-dodecaborance(12). Australian Journal of Chemistry: an international journal for chemical science, 60(11), 816-820.
  • Ching, V., Clegg, J., Rendina, L. (2007). Synthesis and preliminary DNA-binding studies of diimineplatinum(II) complexes containing 3- or 4-pyridineboronic acid. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (21), 2121-2126.

2006

  • Ziolkowski (Sheridan), E., Turner, P., Rendina, L. (2006). Mono- and di-nuclear platinum(II) complexes containing O- and N-bonded acetamide. Inorganic Chemistry Communications, 9(1), 53-56.
  • Lee, C., Groneman, J., Turner, P., Rendina, L., Harding, M. (2006). Synthesis and X-ray crystallographic analysis of chiral pyridyl substituted carbocyclic molecular clefts. Tetrahedron, 62(20), 4870-4878.

2005

  • Todd, J., Turner, P., Ziolkowski (Sheridan), E., Rendina, L. (2005). (2,2 ': 6 ',2 ''-Terpyridine)platinum(II) complexes (thioalkyl)dicarba-closo-dodecaborane(12) containing ligands. Inorganic Chemistry, 44(18), 6401-6408.
  • Crossley, E., Caiazza, D., Rendina, L. (2005). A highly water-soluble platinum(II) complex containing a thiopropyl-1,2-dicarba-closo-dodecaborane(12) ligand functionalised with a pendant glycerol group. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2005 (17), 2825-2826.
  • Woodhouse, S., Ziolkowski (Sheridan), E., Rendina, L. (2005). Synthesis and anti-cancer activity of dinuclear platinum(II) complexes containing bis(thioalkyl)dicarba-closo-dodecaborane(12) ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2005 (17), 2827-2829.

2004

  • Woodhouse, S., Rendina, L. (2004). Multinuclear Platinum(Ii) -Amine Complexes Containing Bis (Aminopropyl)Dicarba-Closo-Dodecaborane(12)Ligands. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 21, 3669-3677.
  • Rendina, L., Hambley, T. (2004). Platinum. In D. E. Fenton (Eds.), Comprehensive Coordination Chemistry II : From biology to nanotechnology. Volume 6: Transition Metal groups 9-12, (pp. 673-745). Amsterdam: Elsevier.
  • Gallasch, D., Woodhouse, S., Rendina, L. (2004). Synthesis And Redistribution Reactions Of Asymmetric Sigma-Arylplatinum(Ii) Complexes Containing 4,7-Phenanthroline. Journal of Organometallic Chemistry, 689(7), 1288-1294.
  • Rendina, L., Todd, J. (2004). The First Examples Of Platinum(Ii)-Amine Complexes Containing 1,2-Dicarba-Closo-Dodecaborane(12). Inorganic Chemistry Communications, 7(2), 289-291.

2003

  • Crisp, M., Tiekink, E., Rendina, L. (2003). Cationic sigma-phenylplatinum(II) complexes with carboxylic acid functionality: pKa determinations and X-ray structures. Inorganic Chemistry, 42(4), 1057-1063.
  • Wenger, E., Rendina, L. (2003). Protagonists in chemistry. Inorganica Chimica Acta, 352, 1-3.
  • Todd, J., Caiazza, D., Tiekink, E., Rendina, L. (2003). Synthesis of diimineplatinum(II) complexes containing the 1,2-dicarba-closo-dodecaborane(12)-1-thiolato ligand. Inorganica Chimica Acta, 352, 208-212.

2002

  • Janzen, M., Jenkins, H., Jennings, M., Rendina, L., Puddephatt, R. (2002). Ring expansion and contraction in reactions of an alkyne with stannylplatinum(IV) metallacycles: Formation of an alkyl(alkenyl)(alkynyl)platinum(IV) complex. Organometallics, 21(6), 1257-1261.
  • Todd, J., Rendina, L. (2002). Synthesis and DNA-binding properties of cationic 2,2':6',2"-terpyridineplatinum(II) complexes containing 1,2- and 1,7-dicarba-closo-dodecaborane(12). Inorganic Chemistry, 41(13), 3331-3333.

2001

  • Gallasch, D., Tiekink, E., Rendina, L. (2001). A new methodology for the preparation of cationic organoplatinum(II) complexes with hydrogen-bonding functionality. Organometallics, 20(16), 3373-3382.
  • Crisp, M., Rendina, L., Tiekink, E. (2001). Crystal structure of trans-bis(diethylhydroxyphosphine)diethylphosphinito(iodo)platinum(II) triethylphosphineoxide solvate (1/1), [(Et2(OH)P)2(Et2PO)IPt] · Et3PO. Zeitschrift fuer Kristallographie - New Crystal Structures, 216(2), 243-244.
  • Crisp, M., Rendina, L., Tiekink, E. (2001). Refinement of the crystal structure of trans-chloro-phenyl-bis(triphenylphosphine)platinum(II) at 173 K, C42H35ClP2Pt. Zeitschrift fuer Kristallographie - New Crystal Structures, 216, 249-250.
  • Woodhouse, S., Rendina, L. (2001). Synthesis and DNA-binding properties of dinuclear platinum(II)-amine complexes of 1,7-dicarba-closo-dodecaborane(12). Chemical Communications, (23), 2464-2465.

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