Dr Mark Larance

D17 - Charles Perkins Centre
The University of Sydney


Biographical details

Mark Larance received his undergraduate degree in biochemistry and microbiology from the University of New South Wales (UNSW) in Sydney, Australia. He was awarded a PhD in biochemistry in 2007 from UNSW, based on a collaborative project between the Garvan Institute (Prof David James) and UNSW (Prof Michael Guilhaus). During his PhD, he developed methods for the study of insulin signalling and vesicle trafficking using mass spectrometry-based proteomics. This work lead to a number of important discoveries on the interaction between insulin signalling and the downstream physiological actions of insulin. 
 
In 2009, he moved to the University of Dundee in Scotland to take up a post-doctoral position in the laboratory of Prof. Angus Lamond. During this time he continued to pursue his interest in proteome analysis using mass spectrometry and developed several novel quantitative methods including the adaptation of the Stable Isotope Labeling with Amino acids in Cell culture (SILAC) technique for use in C. elegans
 
In 2013, he was awarded a Royal Society of Edinburgh - Scottish Government Personal Research Fellowship, which allowed him to become an independent investigator at the University of Dundee. Using the quantitative methods he developed previously, he was able to provide novel insights into the protein-level changes in response to starvation of a whole model animal (C. elegans). During this period, he expanded his interest in starvation by examining these responses in mouse tissues.
 
In 2016, he was awarded a Cancer Institute NSW Future Research Leader fellowship, which allowed him to return to Australia from Scotland to investigate how programs of intermittent fasting can assist with the prevention and treatment of cancer. He is currently a senior lecturer in the School of Life and Environmental Sciences and is located in the Charles Perkins Centre (CPC), which is a multidisciplinary institute devoted to easing the global burden of obesity, diabetes, cardiovascular disease and related conditions.

Selected grants

2017

  • Identification of New Mechanisms in Insulin Resistance; Larance M, Chaudhuri R; National Health and Medical Research Council (NHMRC)/Project Grants.

2016

  • USYD Research Support- Start up funding; Larance M; Faculty of Science/Seed Funding.
  • Nutrient Deprivation and the Protective Proteome for the Prevention of Disease; Larance M, Larance M; Cancer Institute New South Wales/Future Research Leaders Grants.

Selected publications

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Journals

  • Harvald, E., Sprenger, R., Dall, K., Ejsing, C., Nielsen, R., Mandrup, S., Murillo, A., Larance, M., Gartner, A., Lamond, A., et al (2017). Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C.�elegans. Cell Systems, 5(1), 38-52. [More Information]
  • Larance, M., Kirkwood, K., Tinti, M., Murillo, A., Ferguson, M., Lamond, A. (2016). Global Membrane Protein Interactome Analysis using In vivo Crosslinking and Mass Spectrometry-based Protein Correlation Profiling. Molecular and Cellular Proteomics, 15(7), 2476-2490. [More Information]
  • Larance, M., Pourkarimi, E., Wang, B., Murillo, A., Kent, R., Lamond, A., Gartner, A. (2015). Global proteomics analysis of the response to starvation in C. Elegans. Molecular and Cellular Proteomics, 14(7), 1989-2001. [More Information]
  • Larance, M., Lamond, A. (2015). Multidimensional proteomics for cell biology. Nature Reviews Molecular Cell Biology, 16(5), 269-280. [More Information]
  • Kirkwood, K., Ahmad, Y., Larance, M., Lamond, A. (2013). Characterization of Native Protein Complexes and Protein Isoform Variation Using Sizefractionation-based Quantitative Proteomics. Molecular and Cellular Proteomics, 12(12), 3851-3873. [More Information]
  • Larance, M., Ahmad, Y., Kirkwood, K., Ly, T., Lamond, A. (2013). Global subcellular characterization of protein degradation using quantitative proteomics. Molecular and Cellular Proteomics, 12(3), 638-650. [More Information]
  • Akay, A., Craig, A., Lehrbach, N., Larance, M., Pourkarimi, E., Wright, J., Lamond, A., Miska, E., Gartner, A. (2013). RNA-binding protein GLD-1/ quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Open Biology, 3, 1-14. [More Information]
  • Larance, M., Kirkwood, K., Xirodimas, D., Lundberg, E., Uhlen, M., Lamond, A. (2012). Characterization of MRFAP1 Turnover and Interactions Downstream of the NEDD8 Pathway. Molecular and Cellular Proteomics, 11(3), 1-11. [More Information]
  • Rowland, A., Larance, M., Hughes, W., James, D. (2011). Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin. Molecular and Cellular Biology, 31(23), 4789-4800. [More Information]
  • Prior, M., Larance, M., Lawrence, R., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J., La-Borde, P., Buckley, M., James, D., et al (2011). Quantitative Proteomic Analysis of the Adipocyte Plasma Membrane. Journal of Proteome Research, 10(11), 4970-4982. [More Information]
  • Larance, M., Bailly, A., Pourkarimi, E., Hay, R., Buchanan, G., Coulthurst, S., Xirodimas, D., Gartner, A., Lamond, A. (2011). Stable-isotope labeling with amino acids in nematodes. Nature Methods, 8(10), 849-851. [More Information]
  • Bach, M., Larance, M., James, D., Ramm, G. (2011). The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. The Biochemical Journal, 440(2), 283-291. [More Information]
  • Larance, M., Rowland, A., Hoehn, K., Humphreys, D., Preiss, T., Guilhaus, M., James, D. (2010). Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Molecular and Cellular Proteomics, 9(4), 682-694. [More Information]
  • Pangon, L., Sigglekow, N., Larance, M., Al-Sohaily, S., Mladenova, D., Selinger, C., Musgrove, E., Kohonen-Corish, M. (2010). The "Mutated in Colorectal Cancer" Protein Is a Novel Target of the UV-Induced DNA Damage Checkpoint. Genes and Cancer, 1(9), 917-26. [More Information]
  • Yip, M., Ramm, G., Larance, M., Hoehn, K., Wagner, M., Guilhaus, M., James, D. (2008). CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c is required for Insulin-Stimulated GLUT4 Translocation in Adipocytes. Cell Metabolism, 8(5), 384-398. [More Information]
  • Brummer, T., Larance, M., Abreu, M., Lyons, R., Timpson, P., Emmerich, C., Fleuren, E., Lehrbach, G., Schramek, D., Guilhaus, M., et al (2008). Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. The EMBO Journal, 27(17), 2305-2316. [More Information]
  • Larance, M., Ramm, G., James, D. (2008). The GLUT4 Code. Molecular Endocrinology, 22(2), 226-233. [More Information]

2017

  • Harvald, E., Sprenger, R., Dall, K., Ejsing, C., Nielsen, R., Mandrup, S., Murillo, A., Larance, M., Gartner, A., Lamond, A., et al (2017). Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C.�elegans. Cell Systems, 5(1), 38-52. [More Information]

2016

  • Larance, M., Kirkwood, K., Tinti, M., Murillo, A., Ferguson, M., Lamond, A. (2016). Global Membrane Protein Interactome Analysis using In vivo Crosslinking and Mass Spectrometry-based Protein Correlation Profiling. Molecular and Cellular Proteomics, 15(7), 2476-2490. [More Information]

2015

  • Larance, M., Pourkarimi, E., Wang, B., Murillo, A., Kent, R., Lamond, A., Gartner, A. (2015). Global proteomics analysis of the response to starvation in C. Elegans. Molecular and Cellular Proteomics, 14(7), 1989-2001. [More Information]
  • Larance, M., Lamond, A. (2015). Multidimensional proteomics for cell biology. Nature Reviews Molecular Cell Biology, 16(5), 269-280. [More Information]

2013

  • Kirkwood, K., Ahmad, Y., Larance, M., Lamond, A. (2013). Characterization of Native Protein Complexes and Protein Isoform Variation Using Sizefractionation-based Quantitative Proteomics. Molecular and Cellular Proteomics, 12(12), 3851-3873. [More Information]
  • Larance, M., Ahmad, Y., Kirkwood, K., Ly, T., Lamond, A. (2013). Global subcellular characterization of protein degradation using quantitative proteomics. Molecular and Cellular Proteomics, 12(3), 638-650. [More Information]
  • Akay, A., Craig, A., Lehrbach, N., Larance, M., Pourkarimi, E., Wright, J., Lamond, A., Miska, E., Gartner, A. (2013). RNA-binding protein GLD-1/ quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans. Open Biology, 3, 1-14. [More Information]

2012

  • Larance, M., Kirkwood, K., Xirodimas, D., Lundberg, E., Uhlen, M., Lamond, A. (2012). Characterization of MRFAP1 Turnover and Interactions Downstream of the NEDD8 Pathway. Molecular and Cellular Proteomics, 11(3), 1-11. [More Information]

2011

  • Rowland, A., Larance, M., Hughes, W., James, D. (2011). Identification of RhoGAP22 as an Akt-Dependent Regulator of Cell Motility in Response to Insulin. Molecular and Cellular Biology, 31(23), 4789-4800. [More Information]
  • Prior, M., Larance, M., Lawrence, R., Soul, J., Humphrey, S., Burchfield, J., Kistler, C., Davey, J., La-Borde, P., Buckley, M., James, D., et al (2011). Quantitative Proteomic Analysis of the Adipocyte Plasma Membrane. Journal of Proteome Research, 10(11), 4970-4982. [More Information]
  • Larance, M., Bailly, A., Pourkarimi, E., Hay, R., Buchanan, G., Coulthurst, S., Xirodimas, D., Gartner, A., Lamond, A. (2011). Stable-isotope labeling with amino acids in nematodes. Nature Methods, 8(10), 849-851. [More Information]
  • Bach, M., Larance, M., James, D., Ramm, G. (2011). The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. The Biochemical Journal, 440(2), 283-291. [More Information]

2010

  • Larance, M., Rowland, A., Hoehn, K., Humphreys, D., Preiss, T., Guilhaus, M., James, D. (2010). Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Molecular and Cellular Proteomics, 9(4), 682-694. [More Information]
  • Pangon, L., Sigglekow, N., Larance, M., Al-Sohaily, S., Mladenova, D., Selinger, C., Musgrove, E., Kohonen-Corish, M. (2010). The "Mutated in Colorectal Cancer" Protein Is a Novel Target of the UV-Induced DNA Damage Checkpoint. Genes and Cancer, 1(9), 917-26. [More Information]

2008

  • Yip, M., Ramm, G., Larance, M., Hoehn, K., Wagner, M., Guilhaus, M., James, D. (2008). CaMKII-Mediated Phosphorylation of the Myosin Motor Myo1c is required for Insulin-Stimulated GLUT4 Translocation in Adipocytes. Cell Metabolism, 8(5), 384-398. [More Information]
  • Brummer, T., Larance, M., Abreu, M., Lyons, R., Timpson, P., Emmerich, C., Fleuren, E., Lehrbach, G., Schramek, D., Guilhaus, M., et al (2008). Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. The EMBO Journal, 27(17), 2305-2316. [More Information]
  • Larance, M., Ramm, G., James, D. (2008). The GLUT4 Code. Molecular Endocrinology, 22(2), 226-233. [More Information]

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