Associate Professor Matthew Todd

BA PhD Cantab.
Associate Professor

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 2180
Fax 61 2 9351 3329

Website Contact Details
Research Group

Biographical details

  • School of Chemistry, The University of Sydney (2005-present)
  • Lecturer in Organic Chemistry, Department of Chemistry, Queen Mary, University of London (2001-2005)
  • Fellow in Chemistry, New Hall College, Cambridge (2000-2001)
  • Postdoctoral Fellow, University of California, Berkeley (1999-2000)
  • BA, PhD Queens' College, Cambridge

Research interests

For more details on the Group's research, please visit http://openwetware.org/wiki/Todd

Awards and honours

Selected grants

2015

  • A new class of inhibitors for the treatment of tuberculosis; Triccas J, Rutledge P, West N, Todd M; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • An Open Source Hit-to-Lead Campaign in Tuberculosis Drug Discovery; Todd M; GlaxoSmithKline (UK)/OpenLab Foundation.

2012

  • Charting Intercellular Space; Todd M, Rutledge P, Smith P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Open Source Drug Discovery for Malaria; Todd M, Wells T; Australian Research Council (ARC)/Linkage Projects (LP).

2011

  • Australian Participation in European COST Action FY 2011-2012; Todd M; Australian Academy of Science/Australian participation in COST.

2010

  • Target Activated Therapeutics: A New Strategy for Monitoring and Treating Breast Cancer; Todd M, Rutledge P, Sutherland R, Butt A; National Breast Cancer Foundation/Pilot Study Grants.

2009

  • 2nd Indian-Australia Workshop on Plant Neutrachemicals; Todd M; DVC International/IPDF Grant.
  • A Pilot Open Source Research Project for Undergraduates; Todd M; DVC International/IPDF Grant.

2008

  • Plant Nutraceuticals and Bioactive Molecules: A growth opportunity for the pharmaceutical industry i; Roufogalis B, Todd M; Department of Education, Science and Training (Federal)/Australia-India Strategic Research Fund (AISRF).
  • Praziquantel: a unique pharmaceutical challenge; Best W, Streijffertch C, Olliaro P, Olliaro P, Todd M; Australian Research Council (ARC)/Linkage Projects (LP).

2007

  • Sydney-SIOC New Chemical Technologies Workshop; Todd M; Australian Academy of Technological Sciences and Engineering/Research Support.

2006

  • University of Sydney - Cancer Research Fund; Todd M; University of Sydney/Cancer Research Fund.
  • A New Chemical Route to an Important Antiparasitic Pharmaceutical; Todd M; University of Sydney/Early Career Researcher.

2005

  • MEARS (Molecularly Engineered Amperometric Recognition Scaffolds) in Electrode Composite Biosensor Materials; Todd M; Engineering and Physical Sciences Research Council (EPSRC)/Research Grant.

2004

  • The Prediction of Nonlinear Effects in Asymmetric Catalysis; Todd M; Engineering and Physical Sciences Research Council (EPSRC)/Research Grant.
  • Analytical Biomimetic Recognition Scaffolds as Ligands with Built-in Amplification for SPR Arrays; Watkinson M, Todd M; Biotechnology and Biological Sciences Research Council/Research Grants.

Selected publications

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Book Chapters

  • Tsang, A., Park, S., Todd, M. (2015). Mechanisms of cross-dehydrogenative-coupling reactions. In Chao-Jun Li (Eds.), From C-H to C-C Bonds, (pp. 254-294). Cambridge, United Kingdom: Royal Society of Chemistry.
  • Parker, P., Schwendimann, B., Thompson, K., Todd, M. (2014). The Synaptic Leap: Open science combating disease. In Lucila Carvalho, Peter Goodyear (Eds.), The architecture of productive learning networks, (pp. 193-208). New York: Routledge.
  • Caffrey, C., Williams, D., Todd, M., Nelson, D., Keiser, J., Utzinger, J. (2009). Chemotherapeutic Development Strategies for Schistosomiasis. In Paul M. Selzer (Eds.), Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates, (pp. 301-321). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.

Journals

  • Meister, I., Ingram-Sieber, K., Cowan, N., Todd, M., Robertson, M., Meli, C., Patra, M., Gasser, G., Keiser, J. (2014). Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 58(9), 5466-5472. [More Information]
  • Yu, M., Ast, S., Yu, Q., Lo, A., Flehr, R., Todd, M., Rutledge, P. (2014). Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PloS One, 9(7), e100761-1-e100761-12. [More Information]
  • Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
  • Robertson, M., Ylioja, P., Williamson, A., Woelfle, M., Robins, M., Badiola, K., Willis, P., Olliaro, P., Wells, T., Todd, M. (2014). Open source drug discovery - A limited tutorial. Parasitology (Cambridge), 141(1), 148-157. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2014). pH-responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye. Physical Chemistry Chemical Physics, 16(46), 25255-25257. [More Information]
  • Yu, M., Yu, Q., Rutledge, P., Todd, M. (2013). A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem: a European journal of chemical biology, 14(2), 224-229. [More Information]
  • Tsang, A., Ingram, K., Keiser, J., Hibbert, D., Todd, M. (2013). Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group. Organic and Biomolecular Chemistry, 11(30), 4921-4924. [More Information]
  • Patra, M., Ingram, K., Leonidova, A., Pierroz, V., Ferrari, S., Robertson, M., Todd, M., Keiser, J., Gasser, G. (2013). In Vitro Metabolic Profile and in Vivo Antischistosomal Activity Studies of (eta6-Praziquantel)Cr(CO)3 Derivatives. Journal of Medicinal Chemistry, 56(22), 9192-9198. [More Information]
  • Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
  • Csok, Z., Kegl, T., Li, Y., Skoda-Foldes, R., Kiss, L., Kunsagi-Mate, S., Todd, M., Kollar, L. (2013). Synthesis of elongated cavitands via click reactions and their use as chemosensors. Tetrahedron, 69(38), 8186-8190. [More Information]
  • Masum, H., Rao, A., Good, B., Todd, M., Edwards, A., Chan, L., Bunin, B., Su, A., Thomas, Z., Bourne, P. (2013). Ten simple rules for cultivating open science and collaborative R&D. PLoS Computational Biology, 9(9), e1003244-1-e1003244-4. [More Information]
  • Park, S., Price, J., Todd, M. (2012). Oxidative arylation of isochroman. The Journal of Organic Chemistry, 77(2), 949-955. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2012). Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn(2+) in aqueous solution. European Journal of Inorganic Chemistry, 2012 (34), 5611-5615. [More Information]
  • Amarasinghe, N., Turner, P., Todd, M. (2012). The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine. Advanced Synthesis and Catalysis, 354(16), 2954-2958. [More Information]
  • Ahamed, M., Chan, B., Jensen, P., Todd, M. (2012). The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions. PloS One, 7(10), 1-7. [More Information]
  • Lau, N., Price, J., Todd, M., Rutledge, P. (2011). A Click Fluorophore Sensor that Can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation. Chemistry: A European Journal, 17(10), 2850-2858. [More Information]
  • Bridgeman, A., Rutledge, P., Todd, M., Connor, R. (2011). A treasure hunt for chemistry. Journal of Chemical Education, 88(4), 437-439. [More Information]
  • Tsang, A., Jensen, P., Hook, J., Hashmi, A., Todd, M. (2011). An oxidative carbon-carbon bond-forming reaction proceeds via an isolable iminium ion. Pure and Applied Chemistry, 83(3), 655-665. [More Information]
  • Lau, N., Rutledge, P., Watkinson, M., Todd, M. (2011). Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40(5), 2848-2866. [More Information]
  • Yu, M., Price, J., Jensen, P., Lovitt, C., Shelper, T., Duffy, S., Windus, L., Avery, V., Rutledge, P., Todd, M. (2011). Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic. Inorganic Chemistry, 50(24), 12823-12835. [More Information]
  • Woelfle, M., Olliaro, P., Todd, M. (2011). Open science is a research accelerator. Nature Chemistry, 3(10), 745-748. [More Information]
  • Lo, A., Salam, N., Hibbs, D., Rutledge, P., Todd, M. (2011). Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal. PloS One, 6(5), e17446-1-e17446-13. [More Information]
  • Woelfle, M., Seerden, J., de Gooijer, J., Pouwer, K., Olliaro, P., Todd, M. (2011). Resolution of praziquantel. PLoS Neglected Tropical Diseases, 5(9), 1-7. [More Information]
  • Ahamed, M., Thirukkumaran, T., Leung, W., Jensen, P., Schroers, J., Todd, M. (2010). Aza-Henry reactions of 3,4-dihydroisoquinoline. European Journal of Organic Chemistry, 2010 (31), 5980-5988.
  • Ahamed, M., Todd, M. (2010). Catalytic asymmetric additions of carbon-centered nucleophiles to nitrogen-containing aromatic heterocycles. European Journal of Organic Chemistry, 2010 (31), 5935-5942.
  • Tamanini, E., Flavin, K., Motevalli, M., Piperno, S., Gheber, L., Todd, M., Watkinson, M. (2010). Cyclam-based "clickates":┬áHomogeneous and heterogeneous fluorescent sensors for Zn(II). Inorganic Chemistry, 49(8), 3789-3800. [More Information]
  • Hashmi, A., Ramamurthi, T., Todd, M., Tsang, A., Graf, K. (2010). Gold-catalysis: Reactions of organogold compounds with electrophiles. Australian Journal of Chemistry: an international journal for chemical science, 63(12), 1619-1626. [More Information]
  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for open source drug discovery in tropical diseases. PLoS Neglected Tropical Diseases, 3(4), e418-1-e418-10.
  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for the tropical disease initiative. Nature Biotechnology, 27(4), 320-321.
  • Tamanini, E., Katewa, A., Sedger, L., Todd, M., Watkinson, M. (2009). A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorganic Chemistry, 48(1), 319-324. [More Information]
  • El-Fayyoumy, S., Todd, M., Richards, C. (2009). Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach. Beilstein Journal of Organic Chemistry, 5, A67-1-A67-5. [More Information]
  • Tsang, A., Todd, M. (2009). Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ. Tetrahedron Letters, 50(11), 1199-1202.
  • Tamanini, E., Rigby, S., Motevalli, M., Todd, M., Watkinson, M. (2009). Responsive metal complexes: A click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry: A European Journal, 15(15), 3720-3728. [More Information]
  • Ramana, A., Watkinson, M., Todd, M. (2008). Synthesis and DNA binding ability of cyclam-amino acid conjugates. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(9), 3007-3010. [More Information]
  • Krivickas, S., Tamanini, E., Todd, M., Watkinson, M. (2007). Effective methods for the biotinylation of azamacrocycles. The Journal of Organic Chemistry, 72(22), 8280-8289.
  • Troiani, A., Pica-Mattoccia, L., Valle, C., Cioli, D., Mignogna, G., Ronketti, F., Todd, M. (2007). Is actin the praziquantel receptor? International Journal of Antimicrobial Agents, 30(3), 280-281. [More Information]
  • Todd, M. (2007). Open access and open source in chemistry. Chemistry Central Journal, 1(3), 1-4.
  • Ronketti, F., Adi, V., Chao-Ming, X., Pica-Mattoccia, L., Cioli, D., Todd, M. (2007). Praziquantel derivatives I: Modification of the aromatic ring. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 17(15), 4154-4157. [More Information]
  • Todd, M., Motevalli, M., El-Fayyoumy, S., Richards, C. (2006). (R)-2-ferrocenyl-4-hydroxymethyl-4,5-dihydro-1,3-oxazole. Acta Crystallographica. Section E: Structure Reports Online, 62, M719-M720.
  • Ismail, M., Barker, S., Abou El Ella, D., Abouzid, K., Toubar, R., Todd, M. (2006). Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT(1) receptor antagonists. Journal of Medicinal Chemistry, 49(5), 1526-1535.
  • Tamanini, E., Watkinson, M., Todd, M. (2006). Improved synthesis of the valuable peptidomimetic intermediate 3-azido-4-hydroxy cyclopentanoic acid. Tetrahedron-Asymmetry, 17(15), 2235-2239.
  • Kepler, T., Marti-Renom, M., Maurer, S., Rai, A., Taylor, G., Todd, M. (2006). Open source research - the power of us. Australian Journal of Chemistry: an international journal for chemical science, 59(5), 291-294.
  • El-Fayyoumy, S., Mansour, W., Todd, M. (2006). Solid phase synthesis of praziquantel. Tetrahedron Letters, 47(8), 1287-1290.
  • Kusel, J., Oliveira, F., Todd, M., Ronketti, F., Lima, S., Mattos, A., Reis, K., Coelho, P., Thornhill, J., Ribeiro, F. (2006). The effects of drugs, ions, and poly-l-lysine on the exretory system of Schistosoma mansoni. Instituto Oswaldo Cruz, Rio de Janeiro. Memorias, 101(1), 293-298.
  • Todd, M. (2005). Computer-aided organic synthesis. Chemical Society Reviews, 34(3), 247-266.
  • Fenwick, A., Savioli, L., Engels, D., Bergquist, N., Todd, M. (2003). Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends in Parasitology, 19(11), 509-515.
  • Todd, M., Ndubaku, C., Bartlett, P. (2002). Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals. The Journal of Organic Chemistry, 67(12), 3985-3988.
  • Todd, M. (2002). Asymmetric autocatalysis: product recruitment for the increase in the chiral environment (PRICE). Chemical Society Reviews, 31(4), 211-222.
  • Todd, M., Abell, C. (2002). The use of FTICR-MS to detect chemical tags from a combinatorial library. The Analyst, 127(11), 1399-1406.
  • Todd, M., Abell, C. (2001). Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry. ACS Combinatorial Science, 3(3), 319-327.

Conferences

  • Todd, M., Wells, T., Willis, P., Olliaro, P., Avery, V., Ralph, S., Gamo, J., Charman, S., Ylioja, P., Robertson, M., Williamson, A., et al (2013). Open source drug discovery for malaria. 8th European Congress on Tropical Medicine and International Health and 5th Conference of the Scandinavian-Baltic Society for Parasitology, Europe: John Wiley & Sons.
  • Anam, S., Todd, M. (2011). Target-activated metal complex (TaMC) as a new strategy for artificial metallonucleases. 242nd National Meeting of the American Chemical Society (ACS), USA: American Chemical Society.
  • Quinnell, R., Hibbert, D., Frey, J., Duffy, N., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Extending the science curriculum: teaching instrumental science at a distance in a global laboratory using a collaborative Electronic Laboratory Notebook. Learning Technology Research Fest 2010, Not published: Centre for Research on Computer Supported Learning and Cognition, University of Sydney.
  • Hibbert, D., Frey, J., Quinnell, R., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Teaching instrumental science globally using a collaborative electronic laboratory notebook. 16th UniServe Science Annual Conference 2010, Sydney: University of Sydney.
  • Todd, M. (2009). Drug discovery and synthesis using an open source approach. Plant Nutraceuticals and Bioactive Molecules: A Growth Opportunity for the Pharmaceutical Industry in Australia and India, N/A: N/A.
  • Luck, I., Bova, F., Todd, M. (2009). Dynamic NMR studies of the hindered amide bond rotation of Enediamides. SMASH 2009 Small Molecule NMR Conference.
  • Todd, M. (2009). The chemical tale of a flawed wonder drug and how we can all make it better. 2nd Sino-Australian Symposium, N/A: N/A.
  • Todd, M. (2009). Towards a low-cost, sustainable synthesis of an important drug with an open source approach. Catalysis: A Major Key to Sustainability 2005, N/A: N/A.

Other

  • Todd, M. (2005), The synaptic leap - an open source collaborative biomedical research portal.

2015

  • Tsang, A., Park, S., Todd, M. (2015). Mechanisms of cross-dehydrogenative-coupling reactions. In Chao-Jun Li (Eds.), From C-H to C-C Bonds, (pp. 254-294). Cambridge, United Kingdom: Royal Society of Chemistry.

2014

  • Meister, I., Ingram-Sieber, K., Cowan, N., Todd, M., Robertson, M., Meli, C., Patra, M., Gasser, G., Keiser, J. (2014). Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 58(9), 5466-5472. [More Information]
  • Yu, M., Ast, S., Yu, Q., Lo, A., Flehr, R., Todd, M., Rutledge, P. (2014). Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PloS One, 9(7), e100761-1-e100761-12. [More Information]
  • Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
  • Robertson, M., Ylioja, P., Williamson, A., Woelfle, M., Robins, M., Badiola, K., Willis, P., Olliaro, P., Wells, T., Todd, M. (2014). Open source drug discovery - A limited tutorial. Parasitology (Cambridge), 141(1), 148-157. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2014). pH-responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye. Physical Chemistry Chemical Physics, 16(46), 25255-25257. [More Information]
  • Parker, P., Schwendimann, B., Thompson, K., Todd, M. (2014). The Synaptic Leap: Open science combating disease. In Lucila Carvalho, Peter Goodyear (Eds.), The architecture of productive learning networks, (pp. 193-208). New York: Routledge.

2013

  • Yu, M., Yu, Q., Rutledge, P., Todd, M. (2013). A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem: a European journal of chemical biology, 14(2), 224-229. [More Information]
  • Tsang, A., Ingram, K., Keiser, J., Hibbert, D., Todd, M. (2013). Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group. Organic and Biomolecular Chemistry, 11(30), 4921-4924. [More Information]
  • Patra, M., Ingram, K., Leonidova, A., Pierroz, V., Ferrari, S., Robertson, M., Todd, M., Keiser, J., Gasser, G. (2013). In Vitro Metabolic Profile and in Vivo Antischistosomal Activity Studies of (eta6-Praziquantel)Cr(CO)3 Derivatives. Journal of Medicinal Chemistry, 56(22), 9192-9198. [More Information]
  • Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
  • Todd, M., Wells, T., Willis, P., Olliaro, P., Avery, V., Ralph, S., Gamo, J., Charman, S., Ylioja, P., Robertson, M., Williamson, A., et al (2013). Open source drug discovery for malaria. 8th European Congress on Tropical Medicine and International Health and 5th Conference of the Scandinavian-Baltic Society for Parasitology, Europe: John Wiley & Sons.
  • Csok, Z., Kegl, T., Li, Y., Skoda-Foldes, R., Kiss, L., Kunsagi-Mate, S., Todd, M., Kollar, L. (2013). Synthesis of elongated cavitands via click reactions and their use as chemosensors. Tetrahedron, 69(38), 8186-8190. [More Information]
  • Masum, H., Rao, A., Good, B., Todd, M., Edwards, A., Chan, L., Bunin, B., Su, A., Thomas, Z., Bourne, P. (2013). Ten simple rules for cultivating open science and collaborative R&D. PLoS Computational Biology, 9(9), e1003244-1-e1003244-4. [More Information]

2012

  • Park, S., Price, J., Todd, M. (2012). Oxidative arylation of isochroman. The Journal of Organic Chemistry, 77(2), 949-955. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2012). Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn(2+) in aqueous solution. European Journal of Inorganic Chemistry, 2012 (34), 5611-5615. [More Information]
  • Amarasinghe, N., Turner, P., Todd, M. (2012). The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine. Advanced Synthesis and Catalysis, 354(16), 2954-2958. [More Information]
  • Ahamed, M., Chan, B., Jensen, P., Todd, M. (2012). The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions. PloS One, 7(10), 1-7. [More Information]

2011

  • Lau, N., Price, J., Todd, M., Rutledge, P. (2011). A Click Fluorophore Sensor that Can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation. Chemistry: A European Journal, 17(10), 2850-2858. [More Information]
  • Bridgeman, A., Rutledge, P., Todd, M., Connor, R. (2011). A treasure hunt for chemistry. Journal of Chemical Education, 88(4), 437-439. [More Information]
  • Tsang, A., Jensen, P., Hook, J., Hashmi, A., Todd, M. (2011). An oxidative carbon-carbon bond-forming reaction proceeds via an isolable iminium ion. Pure and Applied Chemistry, 83(3), 655-665. [More Information]
  • Lau, N., Rutledge, P., Watkinson, M., Todd, M. (2011). Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40(5), 2848-2866. [More Information]
  • Yu, M., Price, J., Jensen, P., Lovitt, C., Shelper, T., Duffy, S., Windus, L., Avery, V., Rutledge, P., Todd, M. (2011). Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic. Inorganic Chemistry, 50(24), 12823-12835. [More Information]
  • Woelfle, M., Olliaro, P., Todd, M. (2011). Open science is a research accelerator. Nature Chemistry, 3(10), 745-748. [More Information]
  • Lo, A., Salam, N., Hibbs, D., Rutledge, P., Todd, M. (2011). Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal. PloS One, 6(5), e17446-1-e17446-13. [More Information]
  • Woelfle, M., Seerden, J., de Gooijer, J., Pouwer, K., Olliaro, P., Todd, M. (2011). Resolution of praziquantel. PLoS Neglected Tropical Diseases, 5(9), 1-7. [More Information]
  • Anam, S., Todd, M. (2011). Target-activated metal complex (TaMC) as a new strategy for artificial metallonucleases. 242nd National Meeting of the American Chemical Society (ACS), USA: American Chemical Society.

2010

  • Ahamed, M., Thirukkumaran, T., Leung, W., Jensen, P., Schroers, J., Todd, M. (2010). Aza-Henry reactions of 3,4-dihydroisoquinoline. European Journal of Organic Chemistry, 2010 (31), 5980-5988.
  • Ahamed, M., Todd, M. (2010). Catalytic asymmetric additions of carbon-centered nucleophiles to nitrogen-containing aromatic heterocycles. European Journal of Organic Chemistry, 2010 (31), 5935-5942.
  • Tamanini, E., Flavin, K., Motevalli, M., Piperno, S., Gheber, L., Todd, M., Watkinson, M. (2010). Cyclam-based "clickates":┬áHomogeneous and heterogeneous fluorescent sensors for Zn(II). Inorganic Chemistry, 49(8), 3789-3800. [More Information]
  • Quinnell, R., Hibbert, D., Frey, J., Duffy, N., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Extending the science curriculum: teaching instrumental science at a distance in a global laboratory using a collaborative Electronic Laboratory Notebook. Learning Technology Research Fest 2010, Not published: Centre for Research on Computer Supported Learning and Cognition, University of Sydney.
  • Hashmi, A., Ramamurthi, T., Todd, M., Tsang, A., Graf, K. (2010). Gold-catalysis: Reactions of organogold compounds with electrophiles. Australian Journal of Chemistry: an international journal for chemical science, 63(12), 1619-1626. [More Information]
  • Hibbert, D., Frey, J., Quinnell, R., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Teaching instrumental science globally using a collaborative electronic laboratory notebook. 16th UniServe Science Annual Conference 2010, Sydney: University of Sydney.

2009

  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for open source drug discovery in tropical diseases. PLoS Neglected Tropical Diseases, 3(4), e418-1-e418-10.
  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for the tropical disease initiative. Nature Biotechnology, 27(4), 320-321.
  • Tamanini, E., Katewa, A., Sedger, L., Todd, M., Watkinson, M. (2009). A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorganic Chemistry, 48(1), 319-324. [More Information]
  • El-Fayyoumy, S., Todd, M., Richards, C. (2009). Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach. Beilstein Journal of Organic Chemistry, 5, A67-1-A67-5. [More Information]
  • Caffrey, C., Williams, D., Todd, M., Nelson, D., Keiser, J., Utzinger, J. (2009). Chemotherapeutic Development Strategies for Schistosomiasis. In Paul M. Selzer (Eds.), Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates, (pp. 301-321). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Todd, M. (2009). Drug discovery and synthesis using an open source approach. Plant Nutraceuticals and Bioactive Molecules: A Growth Opportunity for the Pharmaceutical Industry in Australia and India, N/A: N/A.
  • Luck, I., Bova, F., Todd, M. (2009). Dynamic NMR studies of the hindered amide bond rotation of Enediamides. SMASH 2009 Small Molecule NMR Conference.
  • Tsang, A., Todd, M. (2009). Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ. Tetrahedron Letters, 50(11), 1199-1202.
  • Tamanini, E., Rigby, S., Motevalli, M., Todd, M., Watkinson, M. (2009). Responsive metal complexes: A click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry: A European Journal, 15(15), 3720-3728. [More Information]
  • Todd, M. (2009). The chemical tale of a flawed wonder drug and how we can all make it better. 2nd Sino-Australian Symposium, N/A: N/A.
  • Todd, M. (2009). Towards a low-cost, sustainable synthesis of an important drug with an open source approach. Catalysis: A Major Key to Sustainability 2005, N/A: N/A.

2008

  • Ramana, A., Watkinson, M., Todd, M. (2008). Synthesis and DNA binding ability of cyclam-amino acid conjugates. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 18(9), 3007-3010. [More Information]

2007

  • Krivickas, S., Tamanini, E., Todd, M., Watkinson, M. (2007). Effective methods for the biotinylation of azamacrocycles. The Journal of Organic Chemistry, 72(22), 8280-8289.
  • Troiani, A., Pica-Mattoccia, L., Valle, C., Cioli, D., Mignogna, G., Ronketti, F., Todd, M. (2007). Is actin the praziquantel receptor? International Journal of Antimicrobial Agents, 30(3), 280-281. [More Information]
  • Todd, M. (2007). Open access and open source in chemistry. Chemistry Central Journal, 1(3), 1-4.
  • Ronketti, F., Adi, V., Chao-Ming, X., Pica-Mattoccia, L., Cioli, D., Todd, M. (2007). Praziquantel derivatives I: Modification of the aromatic ring. Bioorganic and Medicinal Chemistry Letters: the tetrahedron journal for research at the interface of chemistry and biology, 17(15), 4154-4157. [More Information]

2006

  • Todd, M., Motevalli, M., El-Fayyoumy, S., Richards, C. (2006). (R)-2-ferrocenyl-4-hydroxymethyl-4,5-dihydro-1,3-oxazole. Acta Crystallographica. Section E: Structure Reports Online, 62, M719-M720.
  • Ismail, M., Barker, S., Abou El Ella, D., Abouzid, K., Toubar, R., Todd, M. (2006). Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT(1) receptor antagonists. Journal of Medicinal Chemistry, 49(5), 1526-1535.
  • Tamanini, E., Watkinson, M., Todd, M. (2006). Improved synthesis of the valuable peptidomimetic intermediate 3-azido-4-hydroxy cyclopentanoic acid. Tetrahedron-Asymmetry, 17(15), 2235-2239.
  • Kepler, T., Marti-Renom, M., Maurer, S., Rai, A., Taylor, G., Todd, M. (2006). Open source research - the power of us. Australian Journal of Chemistry: an international journal for chemical science, 59(5), 291-294.
  • El-Fayyoumy, S., Mansour, W., Todd, M. (2006). Solid phase synthesis of praziquantel. Tetrahedron Letters, 47(8), 1287-1290.
  • Kusel, J., Oliveira, F., Todd, M., Ronketti, F., Lima, S., Mattos, A., Reis, K., Coelho, P., Thornhill, J., Ribeiro, F. (2006). The effects of drugs, ions, and poly-l-lysine on the exretory system of Schistosoma mansoni. Instituto Oswaldo Cruz, Rio de Janeiro. Memorias, 101(1), 293-298.

2005

  • Todd, M. (2005). Computer-aided organic synthesis. Chemical Society Reviews, 34(3), 247-266.
  • Todd, M. (2005), The synaptic leap - an open source collaborative biomedical research portal.

2003

  • Fenwick, A., Savioli, L., Engels, D., Bergquist, N., Todd, M. (2003). Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends in Parasitology, 19(11), 509-515.

2002

  • Todd, M., Ndubaku, C., Bartlett, P. (2002). Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals. The Journal of Organic Chemistry, 67(12), 3985-3988.
  • Todd, M. (2002). Asymmetric autocatalysis: product recruitment for the increase in the chiral environment (PRICE). Chemical Society Reviews, 31(4), 211-222.
  • Todd, M., Abell, C. (2002). The use of FTICR-MS to detect chemical tags from a combinatorial library. The Analyst, 127(11), 1399-1406.

2001

  • Todd, M., Abell, C. (2001). Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry. ACS Combinatorial Science, 3(3), 319-327.

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