Associate Professor Matthew Todd

BA PhD Cantab.
Associate Professor

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 2180
Fax 61 2 9351 3329

Website Contact Details
Research Group

Biographical details

  • School of Chemistry, The University of Sydney (2005-present)
  • Lecturer in Organic Chemistry, Department of Chemistry, Queen Mary, University of London (2001-2005)
  • Fellow in Chemistry, New Hall College, Cambridge (2000-2001)
  • Postdoctoral Fellow, University of California, Berkeley (1999-2000)
  • BA, PhD Queens' College, Cambridge

Research interests

For more details on the Group's research, please visit http://openwetware.org/wiki/Todd

Current research students

Project title Research student
Combating the Burgeoning Incidence of Drug-Resistant TB Jamie BATTEN

Current projects

For open source drug discovery projects, see Open Source Malaria and Open Source Pharma.

Awards and honours

In the media

Guardian article on the need for Open Source Pharma

Extensive worldwide media coverage of project with Sydney Grammar School to synthesise the drug Daraprim, which had been the subject of a 5500% price hike.

Research on schistosomiasis, Open Source Malaria and the Open Source Pharma Foundation featured in both The Lancet and Nature

Interviewed for Beilstein TV on whether the chemistry community is embracing open science and open data.

Article about openness vs. secrecy in drug development as part of a series on this topic at PLoS Blogs

Interviewed on Canadian and US Radio about Open Source Pharma and Ebola.

Selected grants

2017

  • Research Data Management: THE Generic Skill of the 21st Century (Open Learning Environment - Undergraduate); Denyer G, Todd M, Vervoort R, Karalis V, Yi X, Boddy A, Bridgeman A, Coleman R, Cruchley G, Faedo M, Hammond J, Ryan J; DVC Education/Small Educational Innovation Grant.

2016

  • Hitachi Social Innovation Forum 2016; Todd M, Williamson A; Hitachi Australia Pty Ltd/Social Innovation Award.
  • Australian Synchrotron - perpetual account; Todd M; Australian Synchrotron/Research Support.
  • Student-Led Laboratory Learning; Jordan M, Fleming S, Johnston J, Kepert C, Rutledge P, New E, Todd M; DVC Education/Large Educational Innovation Grant.

2015

  • An Open Source Approach to Understanding an Important Parasite Ion Pump; Todd M, Kirk K, Wells T; Australian Research Council (ARC)/Linkage Projects (LP).
  • Open Research in the Undergraduate Laboratory; Williamson A, Rendina L, Todd M, O'Byrne J, Rutledge P; DVC Education/Small Educational Innovation Grant.
  • A new class of inhibitors for the treatment of tuberculosis; Triccas J, Rutledge P, West N, Todd M; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • An Open Source Hit-to-Lead Campaign in Tuberculosis Drug Discovery; Todd M; GlaxoSmithKline (UK)/OpenLab Foundation.

2012

  • Open Source Drug Discovery for Malaria; Todd M, Wells T; Australian Research Council (ARC)/Linkage Projects (LP).
  • Charting Intercellular Space; Todd M, Rutledge P, Smith P; Australian Research Council (ARC)/Discovery Projects (DP).

2011

  • Australian Participation in European COST Action FY 2011-2012; Todd M; Australian Academy of Science/Australian participation in COST.

2010

  • Target Activated Therapeutics: A New Strategy for Monitoring and Treating Breast Cancer; Todd M, Rutledge P, Sutherland R, Butt A; National Breast Cancer Foundation/Pilot Study Grants.

2009

  • 2nd Indian-Australia Workshop on Plant Neutrachemicals; Todd M; Office of Global Engagement/IPDF Grant.
  • A Pilot Open Source Research Project for Undergraduates; Todd M; Office of Global Engagement/IPDF Grant.

2008

  • Plant Nutraceuticals and Bioactive Molecules: A growth opportunity for the pharmaceutical industry i; Roufogalis B, Todd M; Department of Industry, Innovation and Science/Australia-India Strategic Research Fund (AISRF).
  • Praziquantel: a unique pharmaceutical challenge; Best W, Streijffertch C, Olliaro P, Olliaro P, Todd M; Australian Research Council (ARC)/Linkage Projects (LP).

2007

  • Sydney-SIOC New Chemical Technologies Workshop; Todd M; Australian Academy of Technological Sciences and Engineering/Research Support.

2006

  • A New Chemical Route to an Important Antiparasitic Pharmaceutical; Todd M; University of Sydney/Early Career Researcher.
  • University of Sydney - Cancer Research Fund; Todd M; University of Sydney/Cancer Research Fund.

2005

  • MEARS (Molecularly Engineered Amperometric Recognition Scaffolds) in Electrode Composite Biosensor Materials; Todd M; Engineering and Physical Sciences Research Council (EPSRC)/Research Grant.

2004

  • Analytical Biomimetic Recognition Scaffolds as Ligands with Built-in Amplification for SPR Arrays; Watkinson M, Todd M; Biotechnology and Biological Sciences Research Council/Research Grants.
  • The Prediction of Nonlinear Effects in Asymmetric Catalysis; Todd M; Engineering and Physical Sciences Research Council (EPSRC)/Research Grant.

Selected publications

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Edited Books

  • Todd, M., Maddani, M., Fiaud, J., Kagan, H., Pellissier, H., Humphrey, C., Ahmed, M., Ghanem, A., Turner, N., Nakano, K., et al (2014). Separation of Enantiomers: Synthetic Methods. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.

Book Chapters

  • Tsang, A., Park, S., Todd, M. (2015). Mechanisms of Cross-Dehydrogenative-Coupling Reactions. In Chao-Jun Li (Eds.), From C-H to C-C Bonds: Cross-Dehydrogenative-Coupling, (pp. 254-294). Cambridge: Royal Society of Chemistry.
  • Todd, M. (2014). Introduction: A Survey of How and Why to Separate Enantiomers. In Matthew Todd (Eds.), Separation of Enantiomers: Synthetic Methods, (pp. 1-11). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. [More Information]
  • Todd, M. (2014). Rare, Neglected and Potential Synthetic Methods for the Separation of Enantiomers. In Matthew Todd (Eds.), Separation of Enantiomers: Synthetic Methods, (pp. 267-290). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. [More Information]
  • Parker, P., Schwendimann, B., Thompson, K., Todd, M. (2014). The Synaptic Leap: Open science combating disease. In Lucila Carvalho, Peter Goodyear (Eds.), The architecture of productive learning networks, (pp. 193-208). New York: Routledge. [More Information]
  • Caffrey, C., Williams, D., Todd, M., Nelson, D., Keiser, J., Utzinger, J. (2009). Chemotherapeutic Development Strategies for Schistosomiasis. In Paul M. Selzer (Eds.), Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates, (pp. 301-321). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.

Journals

  • Balasegaram, M., Kolb, P., McKew, J., Menon, J., Olliaro, P., Sablinski, T., Thomas, Z., Todd, M., Torreele, E., Wilbanks, J. (2017). An open source pharma roadmap. PLoS Medicine, 14(4), e1002276-1-e1002276-7. [More Information]
  • Tsang, A., Hashmi, A., Comba, P., Kerscher, M., Chan, B., Todd, M. (2017). N-aryl groups are ubiquitous in cross-dehydrogenative couplings because they stabilize reactive intermediates. Chemistry: A European Journal, 23(39), 9313-9318. [More Information]
  • Wong, J., Todd, M., Rutledge, P. (2017). Recent advances in macrocyclic fluorescent probes for ion sensing. Molecules, 22(2), 1-28. [More Information]
  • Wong, J., Proschogo, N., Todd, M., Rutledge, P. (2017). Selective displacement of a scorpionand triazole ligand from metallocyclam complexes visualised with NMR spectroscopy. European Journal of Inorganic Chemistry, 2017 (7), 1075-1086. [More Information]
  • Counsell, A., Jones, A., Todd, M., Rutledge, P. (2016). A direct method for the N-tetraalkylation of azamacrocycles. Beilstein Journal of Organic Chemistry, 12, 2457-2461. [More Information]
  • Yu, M., Nagalingam, G., Ellis, S., Martinez, E., Sintchenko, V., Spain, M., Rutledge, P., Todd, M., Triccas, J. (2016). Nontoxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 59(12), 5917-5921. [More Information]
  • Williamson, A., Ylioja, P., Robertson, M., Antonova-Koch, Y., Avery, V., Baell, J., Batchu, H., Batra, S., Burrows, J., Bhattacharyya, S., Dean, M., Hungerford, Z., Tarnowski, M., Turner, P., White, L., Todd, M., et al (2016). Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. ACS Central Science, 2(10), 687-701. [More Information]
  • Smith, C., Todd, M., Patiny, L., Swain, C., Southan, C., Williamson, A., Clark, A. (2016). SCINDR - The SCience INtroDuction Robot that will Connect Open Scientists. Research Ideas and Outcomes, 2, 1-9. [More Information]
  • Wong, J., Ast, S., Yu, M., Flehr, R., Counsell, A., Turner, P., Crisologo, P., Todd, M., Rutledge, P. (2016). Synthesis and evaluation of 1,8-disubstituted-cyclam/naphthalimide conjugates as probes for metal ions. ChemistryOpen, 5(4), 375-385. [More Information]
  • Yu, M., Wong, J., Tang, C., Turner, P., Todd, M., Rutledge, P. (2015). Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Bronsted acids. Beilstein Journal of Organic Chemistry, 11, 37-41. [More Information]
  • Badiola, K., Bird, C., Brocklesby, W., Casson, J., Chapman, R., Coles, S., Cronshaw, J., Fisher, A., Frey, J., Gloria, D., Quinnell, R., Robertson, M., Robins, M., Todd, M., Williamson, A., Ylioja, P., et al (2015). Experiences with a researcher-centric ELN. Chemical Science, 6(3), 1614-1629. [More Information]
  • Todd, M. (2015). Using an open source model to accelerate schistosomiasis drug research. Future Medicinal Chemistry, 7(6), 689-692. [More Information]
  • Ast, S., Kuke, S., Rutledge, P., Todd, M. (2015). Using click chemistry to tune the properties and the fluorescence response mechanism of structurally similar probes for metal ions. European Journal of Inorganic Chemistry, 2015 (1), 58-66. [More Information]
  • Meister, I., Ingram-Sieber, K., Cowan, N., Todd, M., Robertson, M., Meli, C., Patra, M., Gasser, G., Keiser, J. (2014). Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 58(9), 5466-5472. [More Information]
  • Badiola, K., Quan, D., Triccas, J., Todd, M. (2014). Efficient synthesis and anti-tubercular activity of a series of spirocycles: An exercise in open science. PloS One, 9(12), 1-20. [More Information]
  • Yu, M., Ast, S., Yu, Q., Lo, A., Flehr, R., Todd, M., Rutledge, P. (2014). Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PloS One, 9(7), 1-12. [More Information]
  • Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
  • Robertson, M., Ylioja, P., Williamson, A., Woelfle, M., Robins, M., Badiola, K., Willis, P., Olliaro, P., Wells, T., Todd, M. (2014). Open source drug discovery - A limited tutorial. Parasitology, 141(1), 148-157. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2014). pH-Responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye. Physical Chemistry Chemical Physics, 16(46), 25255-25257. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2014). The properties and performance of a pH-responsive functionalised nanoparticle. Faraday Discussions, 175, 171-187. [More Information]
  • Yu, M., Yu, Q., Rutledge, P., Todd, M. (2013). A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem, 14(2), 224-229. [More Information]
  • Tsang, A., Ingram, K., Keiser, J., Hibbert, D., Todd, M. (2013). Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group. Organic and Biomolecular Chemistry, 11(30), 4921-4924. [More Information]
  • Patra, M., Ingram, K., Leonidova, A., Pierroz, V., Ferrari, S., Robertson, M., Todd, M., Keiser, J., Gasser, G. (2013). In Vitro Metabolic Profile and in Vivo Antischistosomal Activity Studies of (eta6-Praziquantel)Cr(CO)3 Derivatives. Journal of Medicinal Chemistry, 56(22), 9192-9198. [More Information]
  • Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
  • Csok, Z., Kegl, T., Li, Y., Skoda-Foldes, R., Kiss, L., Kunsagi-Mate, S., Todd, M., Kollar, L. (2013). Synthesis of elongated cavitands via click reactions and their use as chemosensors. Tetrahedron, 69(38), 8186-8190. [More Information]
  • Masum, H., Rao, A., Good, B., Todd, M., Edwards, A., Chan, L., Bunin, B., Su, A., Thomas, Z., Bourne, P. (2013). Ten simple rules for cultivating open science and collaborative R&D. PLoS Computational Biology, 9(9), e1003244-1-e1003244-4. [More Information]
  • Park, S., Price, J., Todd, M. (2012). Oxidative arylation of isochroman. The Journal of Organic Chemistry, 77(2), 949-955. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2012). Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn(2+) in aqueous solution. European Journal of Inorganic Chemistry, 2012 (34), 5611-5615. [More Information]
  • Amarasinghe, N., Turner, P., Todd, M. (2012). The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine. Advanced Synthesis and Catalysis, 354(16), 2954-2958. [More Information]
  • Ahamed, M., Chan, B., Jensen, P., Todd, M. (2012). The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions. PloS One, 7(10), 1-7. [More Information]
  • Lau, Y., Price, J., Todd, M., Rutledge, P. (2011). A Click Fluorophore Sensor that Can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation. Chemistry: A European Journal, 17(10), 2850-2858. [More Information]
  • Bridgeman, A., Rutledge, P., Todd, M., Connor, R. (2011). A treasure hunt for chemistry. Journal of Chemical Education, 88(4), 437-439. [More Information]
  • Tsang, A., Jensen, P., Hook, J., Hashmi, A., Todd, M. (2011). An oxidative carbon-carbon bond-forming reaction proceeds via an isolable iminium ion. Pure and Applied Chemistry, 83(3), 655-665. [More Information]
  • Lau, Y., Rutledge, P., Watkinson, M., Todd, M. (2011). Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40(5), 2848-2866. [More Information]
  • Yu, M., Price, J., Jensen, P., Lovitt, C., Shelper, T., Duffy, S., Windus, L., Avery, V., Rutledge, P., Todd, M. (2011). Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic. Inorganic Chemistry, 50(24), 12823-12835. [More Information]
  • Woelfle, M., Olliaro, P., Todd, M. (2011). Open science is a research accelerator. Nature Chemistry, 3(10), 745-748. [More Information]
  • Lo, A., Salam, N., Hibbs, D., Rutledge, P., Todd, M. (2011). Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal. PloS One, 6(5), e17446-1-e17446-13. [More Information]
  • Woelfle, M., Seerden, J., de Gooijer, J., Pouwer, K., Olliaro, P., Todd, M. (2011). Resolution of praziquantel. PLoS Neglected Tropical Diseases, 5(9), 1-7. [More Information]
  • Ahamed, M., Thirukkumaran, T., Leung, W., Jensen, P., Schroers, J., Todd, M. (2010). Aza-Henry reactions of 3,4-dihydroisoquinoline. European Journal of Organic Chemistry, 2010 (31), 5980-5988. [More Information]
  • Ahamed, M., Todd, M. (2010). Catalytic asymmetric additions of carbon-centered nucleophiles to nitrogen-containing aromatic heterocycles. European Journal of Organic Chemistry, 2010 (31), 5935-5942. [More Information]
  • Tamanini, E., Flavin, K., Motevalli, M., Piperno, S., Gheber, L., Todd, M., Watkinson, M. (2010). Cyclam-based "clickates":┬áHomogeneous and heterogeneous fluorescent sensors for Zn(II). Inorganic Chemistry, 49(8), 3789-3800. [More Information]
  • Hashmi, A., Ramamurthi, T., Todd, M., Tsang, A., Graf, K. (2010). Gold-catalysis: Reactions of organogold compounds with electrophiles. Australian Journal of Chemistry, 63(12), 1619-1626. [More Information]
  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for open source drug discovery in tropical diseases. PLoS Neglected Tropical Diseases, 3(4), e418-1-e418-10. [More Information]
  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for the tropical disease initiative. Nature Biotechnology, 27(4), 320-321. [More Information]
  • Tamanini, E., Katewa, A., Sedger, L., Todd, M., Watkinson, M. (2009). A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorganic Chemistry, 48(1), 319-324. [More Information]
  • El-Fayyoumy, S., Todd, M., Richards, C. (2009). Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach. Beilstein Journal of Organic Chemistry, 5, A67-1-A67-5. [More Information]
  • Tsang, A., Todd, M. (2009). Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ. Tetrahedron Letters, 50(11), 1199-1202. [More Information]
  • Tamanini, E., Rigby, S., Motevalli, M., Todd, M., Watkinson, M. (2009). Responsive metal complexes: A click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry: A European Journal, 15(15), 3720-3728. [More Information]
  • Ramana, A., Watkinson, M., Todd, M. (2008). Synthesis and DNA binding ability of cyclam-amino acid conjugates. Bioorganic and Medicinal Chemistry Letters, 18(9), 3007-3010. [More Information]
  • Krivickas, S., Tamanini, E., Todd, M., Watkinson, M. (2007). Effective methods for the biotinylation of azamacrocycles. The Journal of Organic Chemistry, 72(22), 8280-8289. [More Information]
  • Troiani, A., Pica-Mattoccia, L., Valle, C., Cioli, D., Mignogna, G., Ronketti, F., Todd, M. (2007). Is actin the praziquantel receptor? International Journal of Antimicrobial Agents, 30(3), 280-281. [More Information]
  • Todd, M. (2007). Open access and open source in chemistry. Chemistry Central Journal, 1(3), 1-4. [More Information]
  • Ronketti, F., Adi, V., Chao-Ming, X., Pica-Mattoccia, L., Cioli, D., Todd, M. (2007). Praziquantel derivatives I: Modification of the aromatic ring. Bioorganic and Medicinal Chemistry Letters, 17(15), 4154-4157. [More Information]
  • Todd, M., Motevalli, M., El-Fayyoumy, S., Richards, C. (2006). (R)-2-ferrocenyl-4-hydroxymethyl-4,5-dihydro-1,3-oxazole. Acta Crystallographica. Section E: Structure Reports Online, 62, M719-M720. [More Information]
  • Ismail, M., Barker, S., Abou El Ella, D., Abouzid, K., Toubar, R., Todd, M. (2006). Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT(1) receptor antagonists. Journal of Medicinal Chemistry, 49(5), 1526-1535. [More Information]
  • Tamanini, E., Watkinson, M., Todd, M. (2006). Improved synthesis of the valuable peptidomimetic intermediate 3-azido-4-hydroxy cyclopentanoic acid. Tetrahedron-Asymmetry, 17(15), 2235-2239. [More Information]
  • Kepler, T., Marti-Renom, M., Maurer, S., Rai, A., Taylor, G., Todd, M. (2006). Open source research - the power of us. Australian Journal of Chemistry, 59(5), 291-294. [More Information]
  • El-Fayyoumy, S., Mansour, W., Todd, M. (2006). Solid phase synthesis of praziquantel. Tetrahedron Letters, 47(8), 1287-1290. [More Information]
  • Kusel, J., Oliveira, F., Todd, M., Ronketti, F., Lima, S., Mattos, A., Reis, K., Coelho, P., Thornhill, J., Ribeiro, F. (2006). The effects of drugs, ions, and poly-l-lysine on the exretory system of Schistosoma mansoni. Instituto Oswaldo Cruz, Rio de Janeiro. Memorias, 101(1), 293-298. [More Information]
  • Todd, M. (2005). Computer-aided organic synthesis. Chemical Society Reviews, 34(3), 247-266. [More Information]
  • Fenwick, A., Savioli, L., Engels, D., Bergquist, N., Todd, M. (2003). Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends in Parasitology, 19(11), 509-515. [More Information]
  • Todd, M., Ndubaku, C., Bartlett, P. (2002). Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals. The Journal of Organic Chemistry, 67(12), 3985-3988. [More Information]
  • Todd, M. (2002). Asymmetric autocatalysis: product recruitment for the increase in the chiral environment (PRICE). Chemical Society Reviews, 31(4), 211-222. [More Information]
  • Todd, M., Abell, C. (2002). The use of FTICR-MS to detect chemical tags from a combinatorial library. The Analyst, 127(11), 1399-1406. [More Information]
  • Todd, M., Abell, C. (2001). Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry. ACS Combinatorial Science, 3(3), 319-327.

Conferences

  • Todd, M., Wells, T., Willis, P., Olliaro, P., Avery, V., Ralph, S., Gamo, J., Charman, S., Ylioja, P., Robertson, M., Williamson, A., et al (2013). Open source drug discovery for malaria. 8th European Congress on Tropical Medicine and International Health and 5th Conference of the Scandinavian-Baltic Society for Parasitology, Europe: John Wiley & Sons.
  • Anam, S., Todd, M. (2011). Target-activated metal complex (TaMC) as a new strategy for artificial metallonucleases. 242nd National Meeting of the American Chemical Society (ACS), USA: American Chemical Society.
  • Quinnell, R., Hibbert, D., Frey, J., Duffy, N., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Extending the science curriculum: teaching instrumental science at a distance in a global laboratory using a collaborative Electronic Laboratory Notebook. Learning Technology Research Fest 2010, Not published: Centre for Research on Computer Supported Learning and Cognition, University of Sydney.
  • Hibbert, D., Frey, J., Quinnell, R., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Teaching instrumental science globally using a collaborative electronic laboratory notebook. 16th UniServe Science Annual Conference 2010, Sydney: University of Sydney.
  • Todd, M. (2009). Drug discovery and synthesis using an open source approach. Plant Nutraceuticals and Bioactive Molecules: A Growth Opportunity for the Pharmaceutical Industry in Australia and India, N/A: N/A.
  • Luck, I., Bova, F., Todd, M. (2009). Dynamic NMR studies of the hindered amide bond rotation of Enediamides. SMASH 2009 Small Molecule NMR Conference.
  • Todd, M. (2009). The chemical tale of a flawed wonder drug and how we can all make it better. 2nd Sino-Australian Symposium, N/A: N/A.
  • Todd, M. (2009). Towards a low-cost, sustainable synthesis of an important drug with an open source approach. Catalysis: A Major Key to Sustainability 2005, N/A: N/A.

Other

  • Todd, M. (2005), The synaptic leap - an open source collaborative biomedical research portal.

2017

  • Balasegaram, M., Kolb, P., McKew, J., Menon, J., Olliaro, P., Sablinski, T., Thomas, Z., Todd, M., Torreele, E., Wilbanks, J. (2017). An open source pharma roadmap. PLoS Medicine, 14(4), e1002276-1-e1002276-7. [More Information]
  • Tsang, A., Hashmi, A., Comba, P., Kerscher, M., Chan, B., Todd, M. (2017). N-aryl groups are ubiquitous in cross-dehydrogenative couplings because they stabilize reactive intermediates. Chemistry: A European Journal, 23(39), 9313-9318. [More Information]
  • Wong, J., Todd, M., Rutledge, P. (2017). Recent advances in macrocyclic fluorescent probes for ion sensing. Molecules, 22(2), 1-28. [More Information]
  • Wong, J., Proschogo, N., Todd, M., Rutledge, P. (2017). Selective displacement of a scorpionand triazole ligand from metallocyclam complexes visualised with NMR spectroscopy. European Journal of Inorganic Chemistry, 2017 (7), 1075-1086. [More Information]

2016

  • Counsell, A., Jones, A., Todd, M., Rutledge, P. (2016). A direct method for the N-tetraalkylation of azamacrocycles. Beilstein Journal of Organic Chemistry, 12, 2457-2461. [More Information]
  • Yu, M., Nagalingam, G., Ellis, S., Martinez, E., Sintchenko, V., Spain, M., Rutledge, P., Todd, M., Triccas, J. (2016). Nontoxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 59(12), 5917-5921. [More Information]
  • Williamson, A., Ylioja, P., Robertson, M., Antonova-Koch, Y., Avery, V., Baell, J., Batchu, H., Batra, S., Burrows, J., Bhattacharyya, S., Dean, M., Hungerford, Z., Tarnowski, M., Turner, P., White, L., Todd, M., et al (2016). Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. ACS Central Science, 2(10), 687-701. [More Information]
  • Smith, C., Todd, M., Patiny, L., Swain, C., Southan, C., Williamson, A., Clark, A. (2016). SCINDR - The SCience INtroDuction Robot that will Connect Open Scientists. Research Ideas and Outcomes, 2, 1-9. [More Information]
  • Wong, J., Ast, S., Yu, M., Flehr, R., Counsell, A., Turner, P., Crisologo, P., Todd, M., Rutledge, P. (2016). Synthesis and evaluation of 1,8-disubstituted-cyclam/naphthalimide conjugates as probes for metal ions. ChemistryOpen, 5(4), 375-385. [More Information]

2015

  • Yu, M., Wong, J., Tang, C., Turner, P., Todd, M., Rutledge, P. (2015). Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Bronsted acids. Beilstein Journal of Organic Chemistry, 11, 37-41. [More Information]
  • Badiola, K., Bird, C., Brocklesby, W., Casson, J., Chapman, R., Coles, S., Cronshaw, J., Fisher, A., Frey, J., Gloria, D., Quinnell, R., Robertson, M., Robins, M., Todd, M., Williamson, A., Ylioja, P., et al (2015). Experiences with a researcher-centric ELN. Chemical Science, 6(3), 1614-1629. [More Information]
  • Tsang, A., Park, S., Todd, M. (2015). Mechanisms of Cross-Dehydrogenative-Coupling Reactions. In Chao-Jun Li (Eds.), From C-H to C-C Bonds: Cross-Dehydrogenative-Coupling, (pp. 254-294). Cambridge: Royal Society of Chemistry.
  • Todd, M. (2015). Using an open source model to accelerate schistosomiasis drug research. Future Medicinal Chemistry, 7(6), 689-692. [More Information]
  • Ast, S., Kuke, S., Rutledge, P., Todd, M. (2015). Using click chemistry to tune the properties and the fluorescence response mechanism of structurally similar probes for metal ions. European Journal of Inorganic Chemistry, 2015 (1), 58-66. [More Information]

2014

  • Meister, I., Ingram-Sieber, K., Cowan, N., Todd, M., Robertson, M., Meli, C., Patra, M., Gasser, G., Keiser, J. (2014). Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni. Antimicrobial Agents and Chemotherapy, 58(9), 5466-5472. [More Information]
  • Badiola, K., Quan, D., Triccas, J., Todd, M. (2014). Efficient synthesis and anti-tubercular activity of a series of spirocycles: An exercise in open science. PloS One, 9(12), 1-20. [More Information]
  • Yu, M., Ast, S., Yu, Q., Lo, A., Flehr, R., Todd, M., Rutledge, P. (2014). Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PloS One, 9(7), 1-12. [More Information]
  • Todd, M. (2014). Introduction: A Survey of How and Why to Separate Enantiomers. In Matthew Todd (Eds.), Separation of Enantiomers: Synthetic Methods, (pp. 1-11). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. [More Information]
  • Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
  • Robertson, M., Ylioja, P., Williamson, A., Woelfle, M., Robins, M., Badiola, K., Willis, P., Olliaro, P., Wells, T., Todd, M. (2014). Open source drug discovery - A limited tutorial. Parasitology, 141(1), 148-157. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2014). pH-Responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye. Physical Chemistry Chemical Physics, 16(46), 25255-25257. [More Information]
  • Todd, M. (2014). Rare, Neglected and Potential Synthetic Methods for the Separation of Enantiomers. In Matthew Todd (Eds.), Separation of Enantiomers: Synthetic Methods, (pp. 267-290). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA. [More Information]
  • Todd, M., Maddani, M., Fiaud, J., Kagan, H., Pellissier, H., Humphrey, C., Ahmed, M., Ghanem, A., Turner, N., Nakano, K., et al (2014). Separation of Enantiomers: Synthetic Methods. Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Ast, S., Rutledge, P., Todd, M. (2014). The properties and performance of a pH-responsive functionalised nanoparticle. Faraday Discussions, 175, 171-187. [More Information]
  • Parker, P., Schwendimann, B., Thompson, K., Todd, M. (2014). The Synaptic Leap: Open science combating disease. In Lucila Carvalho, Peter Goodyear (Eds.), The architecture of productive learning networks, (pp. 193-208). New York: Routledge. [More Information]

2013

  • Yu, M., Yu, Q., Rutledge, P., Todd, M. (2013). A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem, 14(2), 224-229. [More Information]
  • Tsang, A., Ingram, K., Keiser, J., Hibbert, D., Todd, M. (2013). Enhancing the usefulness of cross dehydrogenative coupling reactions with a removable protecting group. Organic and Biomolecular Chemistry, 11(30), 4921-4924. [More Information]
  • Patra, M., Ingram, K., Leonidova, A., Pierroz, V., Ferrari, S., Robertson, M., Todd, M., Keiser, J., Gasser, G. (2013). In Vitro Metabolic Profile and in Vivo Antischistosomal Activity Studies of (eta6-Praziquantel)Cr(CO)3 Derivatives. Journal of Medicinal Chemistry, 56(22), 9192-9198. [More Information]
  • Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
  • Todd, M., Wells, T., Willis, P., Olliaro, P., Avery, V., Ralph, S., Gamo, J., Charman, S., Ylioja, P., Robertson, M., Williamson, A., et al (2013). Open source drug discovery for malaria. 8th European Congress on Tropical Medicine and International Health and 5th Conference of the Scandinavian-Baltic Society for Parasitology, Europe: John Wiley & Sons.
  • Csok, Z., Kegl, T., Li, Y., Skoda-Foldes, R., Kiss, L., Kunsagi-Mate, S., Todd, M., Kollar, L. (2013). Synthesis of elongated cavitands via click reactions and their use as chemosensors. Tetrahedron, 69(38), 8186-8190. [More Information]
  • Masum, H., Rao, A., Good, B., Todd, M., Edwards, A., Chan, L., Bunin, B., Su, A., Thomas, Z., Bourne, P. (2013). Ten simple rules for cultivating open science and collaborative R&D. PLoS Computational Biology, 9(9), e1003244-1-e1003244-4. [More Information]

2012

  • Park, S., Price, J., Todd, M. (2012). Oxidative arylation of isochroman. The Journal of Organic Chemistry, 77(2), 949-955. [More Information]
  • Ast, S., Rutledge, P., Todd, M. (2012). Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn(2+) in aqueous solution. European Journal of Inorganic Chemistry, 2012 (34), 5611-5615. [More Information]
  • Amarasinghe, N., Turner, P., Todd, M. (2012). The first catalytic, enantioselective aza-Henry reaction of an unactivated cyclic imine. Advanced Synthesis and Catalysis, 354(16), 2954-2958. [More Information]
  • Ahamed, M., Chan, B., Jensen, P., Todd, M. (2012). The outcome of the oxidations of unusual enediamide motifs is governed by the stabilities of the intermediate iminium ions. PloS One, 7(10), 1-7. [More Information]

2011

  • Lau, Y., Price, J., Todd, M., Rutledge, P. (2011). A Click Fluorophore Sensor that Can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation. Chemistry: A European Journal, 17(10), 2850-2858. [More Information]
  • Bridgeman, A., Rutledge, P., Todd, M., Connor, R. (2011). A treasure hunt for chemistry. Journal of Chemical Education, 88(4), 437-439. [More Information]
  • Tsang, A., Jensen, P., Hook, J., Hashmi, A., Todd, M. (2011). An oxidative carbon-carbon bond-forming reaction proceeds via an isolable iminium ion. Pure and Applied Chemistry, 83(3), 655-665. [More Information]
  • Lau, Y., Rutledge, P., Watkinson, M., Todd, M. (2011). Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40(5), 2848-2866. [More Information]
  • Yu, M., Price, J., Jensen, P., Lovitt, C., Shelper, T., Duffy, S., Windus, L., Avery, V., Rutledge, P., Todd, M. (2011). Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic. Inorganic Chemistry, 50(24), 12823-12835. [More Information]
  • Woelfle, M., Olliaro, P., Todd, M. (2011). Open science is a research accelerator. Nature Chemistry, 3(10), 745-748. [More Information]
  • Lo, A., Salam, N., Hibbs, D., Rutledge, P., Todd, M. (2011). Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal. PloS One, 6(5), e17446-1-e17446-13. [More Information]
  • Woelfle, M., Seerden, J., de Gooijer, J., Pouwer, K., Olliaro, P., Todd, M. (2011). Resolution of praziquantel. PLoS Neglected Tropical Diseases, 5(9), 1-7. [More Information]
  • Anam, S., Todd, M. (2011). Target-activated metal complex (TaMC) as a new strategy for artificial metallonucleases. 242nd National Meeting of the American Chemical Society (ACS), USA: American Chemical Society.

2010

  • Ahamed, M., Thirukkumaran, T., Leung, W., Jensen, P., Schroers, J., Todd, M. (2010). Aza-Henry reactions of 3,4-dihydroisoquinoline. European Journal of Organic Chemistry, 2010 (31), 5980-5988. [More Information]
  • Ahamed, M., Todd, M. (2010). Catalytic asymmetric additions of carbon-centered nucleophiles to nitrogen-containing aromatic heterocycles. European Journal of Organic Chemistry, 2010 (31), 5935-5942. [More Information]
  • Tamanini, E., Flavin, K., Motevalli, M., Piperno, S., Gheber, L., Todd, M., Watkinson, M. (2010). Cyclam-based "clickates":┬áHomogeneous and heterogeneous fluorescent sensors for Zn(II). Inorganic Chemistry, 49(8), 3789-3800. [More Information]
  • Quinnell, R., Hibbert, D., Frey, J., Duffy, N., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Extending the science curriculum: teaching instrumental science at a distance in a global laboratory using a collaborative Electronic Laboratory Notebook. Learning Technology Research Fest 2010, Not published: Centre for Research on Computer Supported Learning and Cognition, University of Sydney.
  • Hashmi, A., Ramamurthi, T., Todd, M., Tsang, A., Graf, K. (2010). Gold-catalysis: Reactions of organogold compounds with electrophiles. Australian Journal of Chemistry, 63(12), 1619-1626. [More Information]
  • Hibbert, D., Frey, J., Quinnell, R., Mocerino, M., Todd, M., Niamsup, P., Plummer, A., Milsted, A. (2010). Teaching instrumental science globally using a collaborative electronic laboratory notebook. 16th UniServe Science Annual Conference 2010, Sydney: University of Sydney.

2009

  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for open source drug discovery in tropical diseases. PLoS Neglected Tropical Diseases, 3(4), e418-1-e418-10. [More Information]
  • Orti, L., Carbajo, R., Pieper, U., Eswar, N., Maurer, S., Rai, A., Taylor, G., Todd, M., Pineda-Lucena, A., Sali, A., et al (2009). A kernel for the tropical disease initiative. Nature Biotechnology, 27(4), 320-321. [More Information]
  • Tamanini, E., Katewa, A., Sedger, L., Todd, M., Watkinson, M. (2009). A synthetically simple, click-generated cyclam-based zinc(II) sensor. Inorganic Chemistry, 48(1), 319-324. [More Information]
  • El-Fayyoumy, S., Todd, M., Richards, C. (2009). Can we measure catalyst efficiency in asymmetric chemical reactions? A theoretical approach. Beilstein Journal of Organic Chemistry, 5, A67-1-A67-5. [More Information]
  • Caffrey, C., Williams, D., Todd, M., Nelson, D., Keiser, J., Utzinger, J. (2009). Chemotherapeutic Development Strategies for Schistosomiasis. In Paul M. Selzer (Eds.), Antiparasitic and Antibacterial Drug Discovery: From Molecular Targets to Drug Candidates, (pp. 301-321). Weinheim, Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Todd, M. (2009). Drug discovery and synthesis using an open source approach. Plant Nutraceuticals and Bioactive Molecules: A Growth Opportunity for the Pharmaceutical Industry in Australia and India, N/A: N/A.
  • Luck, I., Bova, F., Todd, M. (2009). Dynamic NMR studies of the hindered amide bond rotation of Enediamides. SMASH 2009 Small Molecule NMR Conference.
  • Tsang, A., Todd, M. (2009). Facile synthesis of vicinal diamines via oxidation of N-phenyltetrahydroisoquinolines with DDQ. Tetrahedron Letters, 50(11), 1199-1202. [More Information]
  • Tamanini, E., Rigby, S., Motevalli, M., Todd, M., Watkinson, M. (2009). Responsive metal complexes: A click-based "allosteric scorpionate" complex permits the detection of a biological recognition event by EPR/ENDOR spectroscopy. Chemistry: A European Journal, 15(15), 3720-3728. [More Information]
  • Todd, M. (2009). The chemical tale of a flawed wonder drug and how we can all make it better. 2nd Sino-Australian Symposium, N/A: N/A.
  • Todd, M. (2009). Towards a low-cost, sustainable synthesis of an important drug with an open source approach. Catalysis: A Major Key to Sustainability 2005, N/A: N/A.

2008

  • Ramana, A., Watkinson, M., Todd, M. (2008). Synthesis and DNA binding ability of cyclam-amino acid conjugates. Bioorganic and Medicinal Chemistry Letters, 18(9), 3007-3010. [More Information]

2007

  • Krivickas, S., Tamanini, E., Todd, M., Watkinson, M. (2007). Effective methods for the biotinylation of azamacrocycles. The Journal of Organic Chemistry, 72(22), 8280-8289. [More Information]
  • Troiani, A., Pica-Mattoccia, L., Valle, C., Cioli, D., Mignogna, G., Ronketti, F., Todd, M. (2007). Is actin the praziquantel receptor? International Journal of Antimicrobial Agents, 30(3), 280-281. [More Information]
  • Todd, M. (2007). Open access and open source in chemistry. Chemistry Central Journal, 1(3), 1-4. [More Information]
  • Ronketti, F., Adi, V., Chao-Ming, X., Pica-Mattoccia, L., Cioli, D., Todd, M. (2007). Praziquantel derivatives I: Modification of the aromatic ring. Bioorganic and Medicinal Chemistry Letters, 17(15), 4154-4157. [More Information]

2006

  • Todd, M., Motevalli, M., El-Fayyoumy, S., Richards, C. (2006). (R)-2-ferrocenyl-4-hydroxymethyl-4,5-dihydro-1,3-oxazole. Acta Crystallographica. Section E: Structure Reports Online, 62, M719-M720. [More Information]
  • Ismail, M., Barker, S., Abou El Ella, D., Abouzid, K., Toubar, R., Todd, M. (2006). Design and synthesis of new tetrazolyl- and carboxy-biphenylylmethyl-quinazolin-4-one derivatives as angiotensin II AT(1) receptor antagonists. Journal of Medicinal Chemistry, 49(5), 1526-1535. [More Information]
  • Tamanini, E., Watkinson, M., Todd, M. (2006). Improved synthesis of the valuable peptidomimetic intermediate 3-azido-4-hydroxy cyclopentanoic acid. Tetrahedron-Asymmetry, 17(15), 2235-2239. [More Information]
  • Kepler, T., Marti-Renom, M., Maurer, S., Rai, A., Taylor, G., Todd, M. (2006). Open source research - the power of us. Australian Journal of Chemistry, 59(5), 291-294. [More Information]
  • El-Fayyoumy, S., Mansour, W., Todd, M. (2006). Solid phase synthesis of praziquantel. Tetrahedron Letters, 47(8), 1287-1290. [More Information]
  • Kusel, J., Oliveira, F., Todd, M., Ronketti, F., Lima, S., Mattos, A., Reis, K., Coelho, P., Thornhill, J., Ribeiro, F. (2006). The effects of drugs, ions, and poly-l-lysine on the exretory system of Schistosoma mansoni. Instituto Oswaldo Cruz, Rio de Janeiro. Memorias, 101(1), 293-298. [More Information]

2005

  • Todd, M. (2005). Computer-aided organic synthesis. Chemical Society Reviews, 34(3), 247-266. [More Information]
  • Todd, M. (2005), The synaptic leap - an open source collaborative biomedical research portal.

2003

  • Fenwick, A., Savioli, L., Engels, D., Bergquist, N., Todd, M. (2003). Drugs for the control of parasitic diseases: current status and development in schistosomiasis. Trends in Parasitology, 19(11), 509-515. [More Information]

2002

  • Todd, M., Ndubaku, C., Bartlett, P. (2002). Amino acid derived heterocycles: Lewis acid catalyzed and radical cyclizations from peptide acetals. The Journal of Organic Chemistry, 67(12), 3985-3988. [More Information]
  • Todd, M. (2002). Asymmetric autocatalysis: product recruitment for the increase in the chiral environment (PRICE). Chemical Society Reviews, 31(4), 211-222. [More Information]
  • Todd, M., Abell, C. (2002). The use of FTICR-MS to detect chemical tags from a combinatorial library. The Analyst, 127(11), 1399-1406. [More Information]

2001

  • Todd, M., Abell, C. (2001). Novel chemical tagging method for combinatorial synthesis utilizing Suzuki chemistry and Fourier transform ion cyclotron resonance mass spectrometry. ACS Combinatorial Science, 3(3), 319-327.

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