Dr Melanie White

ARC DECRA Research Fellow

Member of the Charles Perkins Centre

D17 - Charles Perkins Centre
The University of Sydney

Telephone +61 2 9036 7918
Fax +61 2 9351 4726

Biographical details

Melanie's research interests are in how the heart behaves when faced with a physiological challenge. Some of the major challenges are in response to myocardial ischemia and when compounded by complications arising from Type 2 Diabetes Mellitus. She uses proteomic techniques including specialised enrichment techniques for post-translational modifications (e.g. phosphorylation and redox modified Cysteine) and high-resolution mass spectrometry to achieve these aims.

Having received a prestigious NHMRC CJ Martin Research Fellowship, Melanie worked at Johns Hopkins School of Medicine with Professors Jennifer Van Eyk and Brian O'Rourke investigating the mitochondrial response to myocardial ischemia. She joined the University of Sydney in the former School of Molecular Bioscience to complete this fellowship. In 2012 she was awarded an inaugural Australian Research Council (ARC) DECRA award. This allowed Melanie to establish her own group where they have developed an animal model of Type 2 diabetes. This has allowed Melanie to interrogate the diabetic phenotype using cutting edge proteomic and biochemical techniques.

Research interests

My group and I are interested in understanding more about how cells adapt to their changing environment by altering proteins using post-translational modifications. Sometimes referred to as "functional decorations", post-translations modifications have the ability to change the function, partners and location of proteins without requiring new protein.

Our work centres on asking these questions in clinically relevant models of myocardial ischemia (heart attack), type 2 diabetes and obesity. These are major contributors to the longevity of Australians and we are uncovering how different cells respond to these challenges.

Teaching and supervision

I currently teach to senior students through the Pathology discipline (The Pancreas and it's Endocrine and Exocrine Functions) and Biochemistry (Proteomics; Protein-Protein Interactions, Cardiovascular Proteomics and Validation Tools). I find these topics blend together with my research interests. Communicating these topics is really interesting and I hope to impart some of this interest to the students in my courses.

Current research students

Project title Research student
Impact of type 2 diabetes mellitus in protien post translational modifications with iscemia/reperfusion injury and post conditioning. Desmond LI

Current projects

Melanie and her team are working with SydneyMS to develop methods for the enrichment and quantification of post-translational modifications. We are particularly interested in transient modifiers including phosphorylation and redox modifications. We have applied these techniques to look at how cells reposnd and regulate under physiological and disease conditions.

Awards and honours

2014: Co-authored the ‘Paper of the Year 2014in ‘Genomics and Proteomicsby the Editors of the Journal of Biological Chemistry (>25,000 pages published each year and from >3000 articles)

2013: Closing Plenary 12th Annual HUPO Congress (Yokohama, JAPAN)

2012:Australian Research Council (ARC) Discovery Early Career Researcher Award (DECRA)

2011: Australian Proteomics Society Young Investigator Award (Lorne, VIC)

2010: China-NSW Collaborative Research Program (NSW State Government)

2008:Ramaciotti Establishment Grant

2007: Youngest ever editor of "Journal of Molecular and Celllular Cardiology"

2007:National Health and Medical Research Council (NHMRC) Overseas Biomedical (CJ Martin) Postdoctoral Researcher Award

2007:National Heart Foundation (NHF) Postdoctoral Researcher Award(Awarded but not accepted)

Keywords

Bioinformatics; Diabetes; Computational biology; Proteomics; Cardiovascular diseases

Honours project opportunities

  • Peptide biomarkers of myocardial ischemia
  • Why do diabetic hearts behave differently from normal hearts?
  • To what extent does Type 2 Diabetes influence the cellular environment?

Selected grants

2017

  • Identification of novel secretory factors from the heart as new targets for metabolic disease; McMullen J, White M; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • The influence of crosstalk between protein post-translational modifications on the propagation of molecular signals.; White M; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA).

2009

  • Efficacy biomarkers for traditional therapy in myocardial angina pectoris; Cordwell S, White M, Cao J; Office for Science and Medical Research (NSW)/China - NSW Collaborative Research Grant Program.
  • Identifying pathological signaling pathways in ischemia reperfusion injury in the heart following myocardial infarction.; White M; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Establishment Gifts.

2007

  • NHMRC - C.J. Martin Fellowship; White M; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Book Chapters

  • Cordwell, S., Crossett, B., White, M. (2008). Gel-Based Approaches. In C.D. OConner and B D Hames (Eds.), Proteomics, (pp. 33-60). Oxfordshire, UK: Scion Publishing Limited.
  • Crossett, B., Edwards, A., White, M., Cordwell, S. (2008). Statistical analysis of image data provided by two-dimensional gel electrophoresis for discovery proteomics. In Ronald J.A. Trent (Eds.), Clinical Bioinformatics: Methods in Molecular Medicine, (pp. 271-285). New Jersey: Humana Press. [More Information]
  • White, M., Cordwell, S. (2005). Isoelectric focusing and proteomics. In S. Ahaja and D.E. Garfin (Eds.), Handbook of Isoelectric Focusing and Proteomics, (pp. 247-264). Burlington, MA USA: Academic Press.

Journals

  • Love, D., Barrett, T., White, M., Cordwell, S., Davies, M., Hawkins, C. (2016). Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages. Free Radical Biology and Medicine, 94, 88-98. [More Information]
  • Dinnes, D., White, M., Kockx, M., Traini, M., Hsieh, V., Kim, M., Hou, L., Jessup, W., Rye, K., Thaysen-Andersen, M., Cordwell, S., Kritharides, L. (2016). Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity. The FASEB Journal, 30(12), 4239-4255. [More Information]
  • Mohamad, M., Mitchell, S., Wu, L., White, M., Cordwell, S., Mach, J., Solon-Biet, S., Boyer, D., Nines, D., Das, A., Warren, A., Hilmer, S., Simpson, S., Le Couteur, D., Cogger, V., et al (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. [More Information]
  • Paulech, J., Liddy, K., Engholm-Keller, K., White, M., Cordwell, S. (2015). Global analysis of myocardial peptides containing cysteines with irreversible sulfinic and sulfonic acid post-translational modifications. Molecular and Cellular Proteomics, 14(3), 609-620. [More Information]
  • Parker, B., Shepherd, N., Trefely, S., Hoffman, N., White, M., Engholm-Keller, K., Hambly, B., Larsen, M., James, D., Cordwell, S. (2014). Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection. Journal of Biological Chemistry, 289(37), 25890-25906. [More Information]
  • Smith, L., White, M. (2014). The role of post-translational modifications in acute and chronic cardiovascular disease. Proteomics - Clinical Applications, 8(7-8), 506-521. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]
  • Liddy, K., White, M., Cordwell, S. (2013). Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics. Genome Medicine, 5(2), 1-12. [More Information]
  • Paulech, J., Solis, N., Edwards, A., Puckeridge, M., White, M., Cordwell, S. (2013). Large-scale capture of peptides containing reversibly oxidized cysteines by thiol-disulfide exchange applied to the myocardial redox proteome. Analytical Chemistry, 85(7), 3774-3780. [More Information]
  • Scott, N., Hare, N., White, M., Manos, J., Cordwell, S. (2013). Secretome of Transmissible Pseudomonas aeruginosa AES-1R Grown in a Cystic Fibrosis Lung-Like Environment. Journal of Proteome Research, 12(12), 5357-5369. [More Information]
  • White, M., Brown, D., Sheng, S., O'Rourke, B., van Eyk, J. (2012). Enriching for Mitochondrial Proteins to Identify Modifications Initiated during Myocardial Ischemic Preconditioning; Preferential Methodologies to Identify Protein Subclasses. Molecular and Cellular Proteomics, 5(10), S322-S322.
  • Cordwell, S., Edwards, A., Liddy, K., Moshkanbaryans, L., Solis, N., Parker, B., Yong, A., Wong, C., Kritharides, L., Hambly, B., White, M. (2012). Release of Tissue-specific Proteins into Coronary Perfusate as a Model for Biomarker Discovery in Myocardial Ischemia/Reperfusion Injury. Journal of Proteome Research, 11(4), 2114-2126. [More Information]
  • Cordwell, S., White, M. (2012). Targeted proteomics for determining phosphorylation site-specific associations in cardiovascular disease. Circulation, 126, 1803-1807. [More Information]
  • White, M., Brown, D., Sheng, S., Cole, R., O'Rourke, B., van Eyk, J. (2011). Parallel Proteomics to Improve Coverage and Confidence in the Partially Annotated Oryctolagus cuniculus Mitochondrial Proteome. Molecular and Cellular Proteomics, 10(2), 1-14. [More Information]
  • Edwards, A., Cordwell, S., White, M. (2011). Phosphoproteomic Profiling of the Myocyte. Circulation: Cardiovascular Genetics, 4(5), 575-575. [More Information]
  • Parker, B., Palmisano, G., Edwards, A., White, M., Engholm-Keller, K., Lee, A., Scott, N., Kolarich, D., Hambly, B., Packer, N., Cordwell, S., et al (2011). Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment. Molecular and Cellular Proteomics, 10(8), 1-13. [More Information]
  • Nguyen-Khuong, T., White, M., Hung, T., Seeto, S., Thomas, M., Fitzgerald, A., Martucci, C., Luk, S., Pang, S., Russell, P., et al (2009). Alterations to the protein profile of bladder carcinoma cell lines induced by plant extract MINA-05 in vitro. Proteomics, 9, 1883-1892. [More Information]
  • Gundry, R., White, M., Nogee, L., Tchernyshyov, I., van Eyk, J. (2009). Assessment of Albumin Removal from an Immunoaffinity Spin Column: Critical Implications for Proteomic Examination of the Albuminome and Albumin-depleted Samples. Proteomics, 9(7), 2021-2028. [More Information]
  • Gundry, R., White, M., Murray, C., Kane, L., Fu, Q., Stanley, B., van Eyk, J. (2009). Preparation of Proteins and Peptides for Mass Spectrometry Analysis in a Bottom-Up Proteomics Workflow. Current Protocols in Molecular Biology, 88, 10.25.1-10.25.23. [More Information]
  • White, M., Edwards, A., Cordwell, S., van Eyk, J. (2008). Mitochondria: A mirror into cellular dysfunction in heart disease. Proteomics - Clinical Applications, 2(6), 845-861. [More Information]
  • Warburton, S., White, M., van Eyk, J., Cotter, R., Ping, P., Dunn, M., Vondriska, T. (2008). Report: Cardiovascular Initiative of the Human Proteome Organisation, 5th Workshop October 2007, Seoul, Korea. Proteomics, 8(5), 924-926. [More Information]
  • Edwards, A., White, M., Cordwell, S. (2008). The role of proteomics in clinical cardiovascular biomarker discovery. Molecular and Cellular Proteomics, 7(10), 1824-1837. [More Information]
  • White, M., van Eyk, J. (2007). Cardiovascular proteomics: Past, present, and future. Molecular Diagnosis and Therapy, 11(2), 83-95. [More Information]
  • White, M. (2007). Molecular evidence for the role of gap junctions in the antiarrhythmic effect of preconditioning. Journal of Molecular and Cellular Cardiology, 42(1), S174-S174.
  • Vandyke, K., White, M., Nguyen-Khuong, T., Ow, K., Luk, S., Kingsley, E., Rowe, A., Pang, S., Walsh, B., Russell, P. (2007). Plant-Derived MINA-05 Inhibits Human Prostate Cancer Proliferation In Vitro and Lymph Node Spread In Vivo. NeoPlasia: an international journal of oncology research, 9(4), 322-331. [More Information]
  • White, M. (2007). Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo. NeoPlasia: an international journal of oncology research, 9(4), 322-31. [More Information]
  • Matt, P., Carrel, T., White, M., Lefkovits, I., van Eyk, J. (2007). Proteomics in cardiovascular surgery. The Journal of Thoracic and Cardiovascular Surgery, 133(1), 210-214.e1. [More Information]
  • White, M., Hambly, B., Jeremy, R., Cordwell, S. (2006). Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. Journal of Molecular and Cellular Cardiology, 40(6), 761-774. [More Information]
  • Shen, J., White, M., Husband, A., Hambly, B., Bao, B. (2006). Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology, 548(1-3), 123-128. [More Information]
  • White, M., Tchen, A., McCarron, H., Hambly, B., Jeremy, R., Cordwell, S. (2006). Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger. Proteomics, 6(23), 6221-6233. [More Information]
  • White, M., Gundry, R., Cordwell, S. (2006). When does a fingerprint constitute a diagnostic? The Lancet, 368(9540), 971-973. [More Information]
  • Hambly, B., Jeremy, R., White, M., McCarron, H., Prasan, A., Craft, G., Cordwell, S. (2005). Proteomics of ischemia/reperfusion injury in rabbit myocardium reveals alterations to proteins of essential functional systems. Proteomics, 5(5), 1395-410. [More Information]
  • Cordwell, S., Slyker, T., Paulus, A., Len, A., White, M., Djordjevic, S. (2004). Comparative proteomics of the human pathogen Campylobacter jejuni. The F A S E B Journal, 18(8), C63-C63.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2004). Oxygen Free Radical Damage To Essential Components Of The Oxidative Phosphorylation Pathway. Journal of the American College of Cardiology, 43(ABSTRACTS - Myocardial Ischemia and Infarction), 254A-254A.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2004). Oxygen Free Radical Scavengers Prevent Damage To Proteins Of The Sarcomere Initiated By Reversible Ischemia/Reperfusion Injury. Journal of the American College of Cardiology, 43(ABSTRACTS - Myocardial Ischemia and Infarction), 255A-255A.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2003). Alterations to proteins of the electron transport chain in reperfused myocardium. Circulation, 108(17), 127-127.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2003). Modifications of myosin-regulatory light chain correlate with function of stunned myocardium. Journal of Molecular and Cellular Cardiology, 35(7), 833-840. [More Information]
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2003). Oxygen free radical scavengers reverse alterations to multiple proteins observed following myocardial stunning. Journal of the American College of Cardiology, 41(6), 373A-373A.
  • Prasan, A., McCarron, H., White, M., McLennan, S., Tchen, A., Hambly, B., Jeremy, R. (2002). Duration of ischaemia determines matrix metalloproteinase-2 activation in the reperfused rabbit heart. Proteomics, 2, 1204-1210.

Conferences

  • White, M. (2013). Protein post-translational modification and their regulation of cardiovascular disease. 12th Annual HUPO Congress, Yokohama.
  • White, M. (2011). Phosphoproteomic profiling of the myocardium. 60th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2012, Brisbane, Queensland, Australia.
  • White, M. (2011). Quantitative myocardial phosphoproteomics to investigate signal cascades initiated with ischemia. 16th Annual Lorne Proteomics Symposium, Australia: Australasian Proteomics Society.
  • White, M. (2009). Discovery tools for phosphorylation: chromatographic enrichment and mass spectrometry. American Heart Association Scientific Sessions, Not published: Not Published.
  • White, M. (2008). Alterations to mitochondrial proteins initiated during myocardial preconditioning. 13th Annual Lorne Proteomics Symposium, Australia: Australasian Proteomics Society.
  • White, M. (2008). Expanding the mitochondrial proteome to explore ischemic preconditioning. 32nd Annual Conference of the Australian Society for Biophysicists, Canberra, Australia: Australian Society for Biophysicists.
  • White, M. (2007). Biomarker discovery: advantages of extensive intact protein fractionation. 6th Annual HUPO Congress, Australia: HUPO.
  • White, M. (2007). Targeted CV biomarker discovery: tissue vs biofluid. HUPO Cardiovascular Initiative Workshop, Australia: HUPO.
  • White, M. (2006). Enriching for mitochondrial proteins to identify modifications initiated during myocardial ischemic preconditioning. HUPO 2006. HUPO.
  • White, M., Tchen, A., McCarron, H., Hambly, B., Jeremy, R., Cordwell, S. (2006). Ischemia-induced protein modifications that occur independently of reactive oxygen species in stunned myocardium. AHA Scientific Sessions 2006, United States: Lippincott Williams & Wilkins.
  • Hambly, B., White, M., Cordwell, S., Tchen, A., McCarron, H., Jeremy, R. (2005). Reversible ischemia/reperfusion injury correlates with troponin C modification. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.
  • White, M. (2004). Alterations to Proteins of the Electron Transport Chain in Reperfused Myocardium. 9th Annual Lorne Proteomics Symposium, Australia: Australasian Proteomics Society.
  • White, M. (2004). Modifications to troponin C associated with brief ischemia/reperfusion injury. American Heart Association Scientific Sessions, Not published: Not Published.
  • White, M., Cordwell, S., Tchen, A., McCarron, H., Hambly, B., Jeremy, R. (2004). Modifications to troponin C with brief ischemia/reperfusion injury. CIRCULATION 110 (17): 321-321 1540 Suppl. S, OCT 26 2004, United States: Lippincott Williams & Wilkins.
  • White, M., Cordwell, S., Tchen, A., McCarron, H., Hambly, B., Jeremy, R. (2004). Oxygen free radical damage to essential components of the oxidative phosphorylation pathway. American College of Cardiology, United States: Elsevier.
  • White, M., Cordwell, S., Tchen, A., McCarron, H., Hambly, B., Jeremy, R. (2004). Oxygen free radical scavengers prevent damage to proteins of the sarcomere initiated by reversible ischemia/reperfusion injury. American College of Cardiology, United States: Elsevier.
  • White, M. (2004). Proteomic applcations for the identification of potential biomarkers of ischemia/reperfusion injury. COMBIO 2004. University of Melbourne.
  • White, M. (2003). Alterations to proteins of the electron transport chain in reperfused myocardium. American Heart Association Scientific Sessions, Not published: Not Published.
  • White, M. (2002). Alterations to the myocardial protein profile as a consequence of ischemia/reperfusion injury. 8th Australian Electrophoresis and Proteomics Society, Australia: Australian Electrophoresis and Proteomics Society.

Other

  • White, M., Vieluf, K. (2004), Improved high-throughput mass spectrometry with concentration and desalting of peptide samples using PerfectPure(R) C-18 Tips and Research pro multi-channel pipette.
  • White, M., Cordwell, S. (2004), Removal of Abundant Myofilament Proteins From Rabbit Myocardium Using the ReadyPrepTM Protein Extraction Kit (Membrane I).

2016

  • Love, D., Barrett, T., White, M., Cordwell, S., Davies, M., Hawkins, C. (2016). Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages. Free Radical Biology and Medicine, 94, 88-98. [More Information]
  • Dinnes, D., White, M., Kockx, M., Traini, M., Hsieh, V., Kim, M., Hou, L., Jessup, W., Rye, K., Thaysen-Andersen, M., Cordwell, S., Kritharides, L. (2016). Human macrophage cathepsin B-mediated C-terminal cleavage of apolipoprotein A-I at Ser228 severely impairs antiatherogenic capacity. The FASEB Journal, 30(12), 4239-4255. [More Information]
  • Mohamad, M., Mitchell, S., Wu, L., White, M., Cordwell, S., Mach, J., Solon-Biet, S., Boyer, D., Nines, D., Das, A., Warren, A., Hilmer, S., Simpson, S., Le Couteur, D., Cogger, V., et al (2016). Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance. Aging Cell, 15(4), 706-715. [More Information]

2015

  • Paulech, J., Liddy, K., Engholm-Keller, K., White, M., Cordwell, S. (2015). Global analysis of myocardial peptides containing cysteines with irreversible sulfinic and sulfonic acid post-translational modifications. Molecular and Cellular Proteomics, 14(3), 609-620. [More Information]

2014

  • Parker, B., Shepherd, N., Trefely, S., Hoffman, N., White, M., Engholm-Keller, K., Hambly, B., Larsen, M., James, D., Cordwell, S. (2014). Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection. Journal of Biological Chemistry, 289(37), 25890-25906. [More Information]
  • Smith, L., White, M. (2014). The role of post-translational modifications in acute and chronic cardiovascular disease. Proteomics - Clinical Applications, 8(7-8), 506-521. [More Information]
  • Getts, D., Terry, R., Getts, M., Deffrasnes, C., Müller, M., Van Vreden, C., Ashhurst, T., Chami, B., McCarthy, D., Wu, H., Ma, J., Witting, P., Campbell, I., Reilly, D., White, M., Cordwell, S., Chadban, S., Bao, B., King, N., et al (2014). Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Science Translational Medicine, 6(219), 1-14. [More Information]

2013

  • Liddy, K., White, M., Cordwell, S. (2013). Functional decorations: post-translational modifications and heart disease delineated by targeted proteomics. Genome Medicine, 5(2), 1-12. [More Information]
  • Paulech, J., Solis, N., Edwards, A., Puckeridge, M., White, M., Cordwell, S. (2013). Large-scale capture of peptides containing reversibly oxidized cysteines by thiol-disulfide exchange applied to the myocardial redox proteome. Analytical Chemistry, 85(7), 3774-3780. [More Information]
  • White, M. (2013). Protein post-translational modification and their regulation of cardiovascular disease. 12th Annual HUPO Congress, Yokohama.
  • Scott, N., Hare, N., White, M., Manos, J., Cordwell, S. (2013). Secretome of Transmissible Pseudomonas aeruginosa AES-1R Grown in a Cystic Fibrosis Lung-Like Environment. Journal of Proteome Research, 12(12), 5357-5369. [More Information]

2012

  • White, M., Brown, D., Sheng, S., O'Rourke, B., van Eyk, J. (2012). Enriching for Mitochondrial Proteins to Identify Modifications Initiated during Myocardial Ischemic Preconditioning; Preferential Methodologies to Identify Protein Subclasses. Molecular and Cellular Proteomics, 5(10), S322-S322.
  • Cordwell, S., Edwards, A., Liddy, K., Moshkanbaryans, L., Solis, N., Parker, B., Yong, A., Wong, C., Kritharides, L., Hambly, B., White, M. (2012). Release of Tissue-specific Proteins into Coronary Perfusate as a Model for Biomarker Discovery in Myocardial Ischemia/Reperfusion Injury. Journal of Proteome Research, 11(4), 2114-2126. [More Information]
  • Cordwell, S., White, M. (2012). Targeted proteomics for determining phosphorylation site-specific associations in cardiovascular disease. Circulation, 126, 1803-1807. [More Information]

2011

  • White, M., Brown, D., Sheng, S., Cole, R., O'Rourke, B., van Eyk, J. (2011). Parallel Proteomics to Improve Coverage and Confidence in the Partially Annotated Oryctolagus cuniculus Mitochondrial Proteome. Molecular and Cellular Proteomics, 10(2), 1-14. [More Information]
  • White, M. (2011). Phosphoproteomic profiling of the myocardium. 60th Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand (CSANZ) 2012, Brisbane, Queensland, Australia.
  • Edwards, A., Cordwell, S., White, M. (2011). Phosphoproteomic Profiling of the Myocyte. Circulation: Cardiovascular Genetics, 4(5), 575-575. [More Information]
  • White, M. (2011). Quantitative myocardial phosphoproteomics to investigate signal cascades initiated with ischemia. 16th Annual Lorne Proteomics Symposium, Australia: Australasian Proteomics Society.
  • Parker, B., Palmisano, G., Edwards, A., White, M., Engholm-Keller, K., Lee, A., Scott, N., Kolarich, D., Hambly, B., Packer, N., Cordwell, S., et al (2011). Quantitative N-linked glycoproteomics of myocardial ischemia and reperfusion injury reveals early remodeling in the extracellular environment. Molecular and Cellular Proteomics, 10(8), 1-13. [More Information]

2009

  • Nguyen-Khuong, T., White, M., Hung, T., Seeto, S., Thomas, M., Fitzgerald, A., Martucci, C., Luk, S., Pang, S., Russell, P., et al (2009). Alterations to the protein profile of bladder carcinoma cell lines induced by plant extract MINA-05 in vitro. Proteomics, 9, 1883-1892. [More Information]
  • Gundry, R., White, M., Nogee, L., Tchernyshyov, I., van Eyk, J. (2009). Assessment of Albumin Removal from an Immunoaffinity Spin Column: Critical Implications for Proteomic Examination of the Albuminome and Albumin-depleted Samples. Proteomics, 9(7), 2021-2028. [More Information]
  • White, M. (2009). Discovery tools for phosphorylation: chromatographic enrichment and mass spectrometry. American Heart Association Scientific Sessions, Not published: Not Published.
  • Gundry, R., White, M., Murray, C., Kane, L., Fu, Q., Stanley, B., van Eyk, J. (2009). Preparation of Proteins and Peptides for Mass Spectrometry Analysis in a Bottom-Up Proteomics Workflow. Current Protocols in Molecular Biology, 88, 10.25.1-10.25.23. [More Information]

2008

  • White, M. (2008). Alterations to mitochondrial proteins initiated during myocardial preconditioning. 13th Annual Lorne Proteomics Symposium, Australia: Australasian Proteomics Society.
  • White, M. (2008). Expanding the mitochondrial proteome to explore ischemic preconditioning. 32nd Annual Conference of the Australian Society for Biophysicists, Canberra, Australia: Australian Society for Biophysicists.
  • Cordwell, S., Crossett, B., White, M. (2008). Gel-Based Approaches. In C.D. OConner and B D Hames (Eds.), Proteomics, (pp. 33-60). Oxfordshire, UK: Scion Publishing Limited.
  • White, M., Edwards, A., Cordwell, S., van Eyk, J. (2008). Mitochondria: A mirror into cellular dysfunction in heart disease. Proteomics - Clinical Applications, 2(6), 845-861. [More Information]
  • Warburton, S., White, M., van Eyk, J., Cotter, R., Ping, P., Dunn, M., Vondriska, T. (2008). Report: Cardiovascular Initiative of the Human Proteome Organisation, 5th Workshop October 2007, Seoul, Korea. Proteomics, 8(5), 924-926. [More Information]
  • Crossett, B., Edwards, A., White, M., Cordwell, S. (2008). Statistical analysis of image data provided by two-dimensional gel electrophoresis for discovery proteomics. In Ronald J.A. Trent (Eds.), Clinical Bioinformatics: Methods in Molecular Medicine, (pp. 271-285). New Jersey: Humana Press. [More Information]
  • Edwards, A., White, M., Cordwell, S. (2008). The role of proteomics in clinical cardiovascular biomarker discovery. Molecular and Cellular Proteomics, 7(10), 1824-1837. [More Information]

2007

  • White, M. (2007). Biomarker discovery: advantages of extensive intact protein fractionation. 6th Annual HUPO Congress, Australia: HUPO.
  • White, M., van Eyk, J. (2007). Cardiovascular proteomics: Past, present, and future. Molecular Diagnosis and Therapy, 11(2), 83-95. [More Information]
  • White, M. (2007). Molecular evidence for the role of gap junctions in the antiarrhythmic effect of preconditioning. Journal of Molecular and Cellular Cardiology, 42(1), S174-S174.
  • Vandyke, K., White, M., Nguyen-Khuong, T., Ow, K., Luk, S., Kingsley, E., Rowe, A., Pang, S., Walsh, B., Russell, P. (2007). Plant-Derived MINA-05 Inhibits Human Prostate Cancer Proliferation In Vitro and Lymph Node Spread In Vivo. NeoPlasia: an international journal of oncology research, 9(4), 322-331. [More Information]
  • White, M. (2007). Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo. NeoPlasia: an international journal of oncology research, 9(4), 322-31. [More Information]
  • Matt, P., Carrel, T., White, M., Lefkovits, I., van Eyk, J. (2007). Proteomics in cardiovascular surgery. The Journal of Thoracic and Cardiovascular Surgery, 133(1), 210-214.e1. [More Information]
  • White, M. (2007). Targeted CV biomarker discovery: tissue vs biofluid. HUPO Cardiovascular Initiative Workshop, Australia: HUPO.

2006

  • White, M. (2006). Enriching for mitochondrial proteins to identify modifications initiated during myocardial ischemic preconditioning. HUPO 2006. HUPO.
  • White, M., Tchen, A., McCarron, H., Hambly, B., Jeremy, R., Cordwell, S. (2006). Ischemia-induced protein modifications that occur independently of reactive oxygen species in stunned myocardium. AHA Scientific Sessions 2006, United States: Lippincott Williams & Wilkins.
  • White, M., Hambly, B., Jeremy, R., Cordwell, S. (2006). Ischemia-specific phosphorylation and myofilament translocation of heat shock protein 27 precedes alpha B-crystallin and occurs independently of reactive oxygen species in rabbit myocardium. Journal of Molecular and Cellular Cardiology, 40(6), 761-774. [More Information]
  • Shen, J., White, M., Husband, A., Hambly, B., Bao, B. (2006). Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology, 548(1-3), 123-128. [More Information]
  • White, M., Tchen, A., McCarron, H., Hambly, B., Jeremy, R., Cordwell, S. (2006). Proteomics of ischemia and reperfusion injuries in rabbit myocardium with and without intervention by an oxygen-free radical scavenger. Proteomics, 6(23), 6221-6233. [More Information]
  • White, M., Gundry, R., Cordwell, S. (2006). When does a fingerprint constitute a diagnostic? The Lancet, 368(9540), 971-973. [More Information]

2005

  • White, M., Cordwell, S. (2005). Isoelectric focusing and proteomics. In S. Ahaja and D.E. Garfin (Eds.), Handbook of Isoelectric Focusing and Proteomics, (pp. 247-264). Burlington, MA USA: Academic Press.
  • Hambly, B., Jeremy, R., White, M., McCarron, H., Prasan, A., Craft, G., Cordwell, S. (2005). Proteomics of ischemia/reperfusion injury in rabbit myocardium reveals alterations to proteins of essential functional systems. Proteomics, 5(5), 1395-410. [More Information]
  • Hambly, B., White, M., Cordwell, S., Tchen, A., McCarron, H., Jeremy, R. (2005). Reversible ischemia/reperfusion injury correlates with troponin C modification. Biophysical Society 49th Annual Meeting, Bethesda, MD: Biophysical Society.

2004

  • White, M. (2004). Alterations to Proteins of the Electron Transport Chain in Reperfused Myocardium. 9th Annual Lorne Proteomics Symposium, Australia: Australasian Proteomics Society.
  • Cordwell, S., Slyker, T., Paulus, A., Len, A., White, M., Djordjevic, S. (2004). Comparative proteomics of the human pathogen Campylobacter jejuni. The F A S E B Journal, 18(8), C63-C63.
  • White, M., Vieluf, K. (2004), Improved high-throughput mass spectrometry with concentration and desalting of peptide samples using PerfectPure(R) C-18 Tips and Research pro multi-channel pipette.
  • White, M. (2004). Modifications to troponin C associated with brief ischemia/reperfusion injury. American Heart Association Scientific Sessions, Not published: Not Published.
  • White, M., Cordwell, S., Tchen, A., McCarron, H., Hambly, B., Jeremy, R. (2004). Modifications to troponin C with brief ischemia/reperfusion injury. CIRCULATION 110 (17): 321-321 1540 Suppl. S, OCT 26 2004, United States: Lippincott Williams & Wilkins.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2004). Oxygen Free Radical Damage To Essential Components Of The Oxidative Phosphorylation Pathway. Journal of the American College of Cardiology, 43(ABSTRACTS - Myocardial Ischemia and Infarction), 254A-254A.
  • White, M., Cordwell, S., Tchen, A., McCarron, H., Hambly, B., Jeremy, R. (2004). Oxygen free radical damage to essential components of the oxidative phosphorylation pathway. American College of Cardiology, United States: Elsevier.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2004). Oxygen Free Radical Scavengers Prevent Damage To Proteins Of The Sarcomere Initiated By Reversible Ischemia/Reperfusion Injury. Journal of the American College of Cardiology, 43(ABSTRACTS - Myocardial Ischemia and Infarction), 255A-255A.
  • White, M., Cordwell, S., Tchen, A., McCarron, H., Hambly, B., Jeremy, R. (2004). Oxygen free radical scavengers prevent damage to proteins of the sarcomere initiated by reversible ischemia/reperfusion injury. American College of Cardiology, United States: Elsevier.
  • White, M. (2004). Proteomic applcations for the identification of potential biomarkers of ischemia/reperfusion injury. COMBIO 2004. University of Melbourne.
  • White, M., Cordwell, S. (2004), Removal of Abundant Myofilament Proteins From Rabbit Myocardium Using the ReadyPrepTM Protein Extraction Kit (Membrane I).

2003

  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2003). Alterations to proteins of the electron transport chain in reperfused myocardium. Circulation, 108(17), 127-127.
  • White, M. (2003). Alterations to proteins of the electron transport chain in reperfused myocardium. American Heart Association Scientific Sessions, Not published: Not Published.
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2003). Modifications of myosin-regulatory light chain correlate with function of stunned myocardium. Journal of Molecular and Cellular Cardiology, 35(7), 833-840. [More Information]
  • White, M., Cordwell, S., McCarron, H., Tchen, A., Hambly, B., Jeremy, R. (2003). Oxygen free radical scavengers reverse alterations to multiple proteins observed following myocardial stunning. Journal of the American College of Cardiology, 41(6), 373A-373A.

2002

  • White, M. (2002). Alterations to the myocardial protein profile as a consequence of ischemia/reperfusion injury. 8th Australian Electrophoresis and Proteomics Society, Australia: Australian Electrophoresis and Proteomics Society.
  • Prasan, A., McCarron, H., White, M., McLennan, S., Tchen, A., Hambly, B., Jeremy, R. (2002). Duration of ischaemia determines matrix metalloproteinase-2 activation in the reperfused rabbit heart. Proteomics, 2, 1204-1210.

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