student profile: Mr Mitchell O'brien


Thesis work

Thesis title: Genetic exploration of Congestive Heart Failure and other complex phenotypes in Canines

Supervisors: Niek BEIJERINK , Claire WADE

Thesis abstract:

The broader basis of the proposed thesis is to improve the current knowledge of Congestive Heart failure (CHF) and its association with the endocrine system through the use of genetic studies using canines as a disease model. For the proposed thesis we plan to further study the genetics of CHF in Cavalier King Charles Spaniels (CKCS) with Myxomatous Mitral Valve Disease (MMVD) through the use of previously collected blood samples, (175 biobanked and phenotyped in 2015). The current hypothesis is that due to genetic abnormalities the endocrine system in CKCS specifically (but in dogs in general) with CHF is severely impaired and that in CKCS and other breeds a dysfunctional endocrine system is associated with CHF. A better understanding of the genetic and endocrine system may allow the identification of dogs more likely to develop CHF. 

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