Dr Neil Nosworthy

F13 - Anderson Stuart Building
The University of Sydney

Telephone +61 9351 6543

Research interests

Member of the Applied and Plasma Physics Research Group. Research projects in these areas are a stimulating mix of fundamental physics and practical applications, in areas which include materials physics, plasma deposition and processing, thin film materials, vacuum glazing, renewable and sustainable energy and cross-disciplinary research in the areas of biointerfaces and interactions of biosystems for medicine.

Selected grants

2003

  • Cofilin-actin bundles and their relation to disease; Nosworthy N; Alzheimers Australia/Research Grant.

Selected publications

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Book Chapters

  • dos Remedios, C., Nosworthy, N. (2008). The role of PIP2 in actin, actin-binding proteins and disease. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 290-297). New York: Springer Science + Business Media.
  • Kekic, M., Nosworthy, N., Dedova, I., Collyer, C., dos Remedios, C. (2001). Regulation of the cytoskeleton assembly: a role for a ternary complex of actin with two actin-binding proteins. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 165-177). Germany: Springer.

Journals

  • Nosworthy, N., Kondyurin, A., Bilek, M., McKenzie, D. (2014). Ion implantation treatment of beads for covalent binding of molecules: Application to bioethanol production using thermophilic beta-glucosidase. Enzyme and Microbial Technology, 54(1), 20-24-20-24. [More Information]
  • Tran, C., Nosworthy, N., Kondyurin, A., McKenzie, D., Bilek, M. (2013). CelB and B-glucosidase immobilization for carboxymethyl cellulose hydrolysis. RSC Advances, 3(45), 23604-23611. [More Information]
  • Hirsh, S., Bilek, M., Bax, D., Kondyurin, A., Kosobrodova, E., Tsoutas, K., Tran, C., Waterhouse, A., Yin, Y., Nosworthy, N., McKenzie, D., dos Remedios, C., Weiss, A., et al (2013). Ion Implanted, Radical-Rich Surfaces For The Rapid Covalent Immobilization Of Active Biomolecules. AIP Conference Proceedings, 1525, 364-369. [More Information]
  • Hirsh, S., McKenzie, D., Nosworthy, N., Denman, J., Sezerman, O., Bilek, M. (2013). The Vroman effect: Competitive protein exchange with dynamic multilayer protein aggregates. Colloids And Surfaces B: Biointerfaces, 103, 395-404. [More Information]
  • Yin, Y., Fisher, K., Nosworthy, N., Bax, D., Clarke, R., McKenzie, D., Bilek, M. (2012). Comparison on protein adsorption properties of diamond-like carbon and nitrogen-containing plasma polymer surfaces. Thin Solid Films, 520(7), 3021-3025. [More Information]
  • Kondyurin, A., Naseri, P., Tilley, J., Nosworthy, N., Bilek, M., McKenzie, D. (2012). Mechanisms for Covalent Immobilization of Horseradish Peroxidase on Ion-Beam-Treated Polyethylene. Scientifca, 2012, 1-28.
  • Kondyurin, A., Nosworthy, N., Bilek, M. (2011). Effect of Low Molecular Weight Additives on Immobilization Strength, Activity, and Conformation of Protein Immobilized on PVC and UHMWPE. Langmuir, 27(10), 6138-6148. [More Information]
  • Yin, Y., Nosworthy, N., McKenzie, D., Bilek, M. (2011). Ellipsometry analysis of conformational change of immobilized protein monolayer on plasma polymer surfaces. Thin Solid Films, 519(9), 2968-2971. [More Information]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., dos Remedios, C., McKenzie, D. (2011). Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences (PNAS), 108(35), 14405-14410. [More Information]
  • Hirsh, S., Nosworthy, N., Kondyurin, A., dos Remedios, C., McKenzie, D., Bilek, M. (2011). Linker-free covalent thermophilic b-glucosidase functionalized polymeric surfaces. Journal of Materials Chemistry, 21, 17832-17841. [More Information]
  • Kondyurin, A., Nosworthy, N., Bilek, M., Jones, R., Pigram, P. (2011). Surface Attachment of Horseradish Peroxidase to Nylon Modified by Plasma-Immersion Ion Implantation. Journal of Applied Polymer Science, 120(5), 2891-2903. [More Information]
  • Hirsch, S., Bilek, M., Nosworthy, N., Kondyurin, A., dos Remedios, C., McKenzie, D. (2010). A Comparison of Covalent Immobilization and Physical Adsorption of a Cellulase Enzyme Mixture. Langmuir, 26(17), 14380-14388. [More Information]
  • Nosworthy, N., McKenzie, D., Bilek, M. (2009). A New Surface for Immobilizing and Maintaining the Function of Enzymes in a Freeze-Dried State. Biomacromolecules, 10(9), 2577-2583. [More Information]
  • Yin, Y., Nosworthy, N., Youssef, H., Gong, B., Bilek, M., McKenzie, D. (2009). Acetylene plasma coated surfaces for covalent immobilization of proteins. Thin Solid Films, 517(17), 5343-5346. [More Information]
  • Yin, Y., Bilek, M., McKenzie, D., Nosworthy, N., Kondyurin, A., Youssef, H., Byrom, M., Yang, W. (2009). Acetylene plasma polymerized surfaces for covalent immobilization of dense bioactive protein monolayers. Surface and Coatings Technology, 203(10-11), 1310-1316. [More Information]
  • Yin, Y., Wise, S., Nosworthy, N., Waterhouse, A., Bax, D., Youssef, H., Byrom, M., Bilek, M., McKenzie, D., Weiss, A., Ng, M. (2009). Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials, 30(9), 1675-1681. [More Information]
  • Yin, Y., Fisher, K., Nosworthy, N., Bax, D., Rubanov, S., Gong, B., Weiss, A., McKenzie, D., Bilek, M. (2009). Covalently Bound Biomimetic Layers on Plasma Polymers with Graded Metallic Interfaces for in vivo Implants. Plasma Processes and Polymers, 6(10), 658-666. [More Information]
  • Yin, Y., Nosworthy, N., Gong, B., Bax, D., Kondyurin, A., McKenzie, D., Bilek, M. (2009). Plasma Polymer Surfaces Compatible with a CMOS Process for Direct Covalent Enzyme Immobilization. Plasma Processes and Polymers, 6(1), 68-75.
  • Kondyurin, A., Nosworthy, N., Bilek, M. (2008). Attachment of horseradish peroxidise to polytetrafluorethylene (teflon) after plasma immersion ion implantation. Acta Biomaterialia, 4, 1218-1225. [More Information]
  • Kondyurin, A., Polonskyi, O., Nosworthy, N., Matousek, J., Hildek, P., Biederman, H., Bilek, M. (2008). Covalent Attachment and Bioactivity of Horseradish Peroxidase on Plasma-Polymerized Hexane Coatings. Plasma Processes and Polymers, 5(8), 727-736.
  • Gan, B., Nosworthy, N., McKenzie, D., dos Remedios, C., Bilek, M. (2007). Plasma immersion ion implantation treatment of polyethylene for enhanced binding of active horseradish peroxidase. Journal of Biomedical Materials Research. Part A, 85A(3), 605-610. [More Information]
  • Ho, J., Nosworthy, N., Bilek, M., Gan, B., McKenzie, D., Chu, P., dos Remedios, C. (2007). Plasma-treated polyethylene surfaces for improved binding of active protein. Plasma Processes and Polymers, 4(5), 583-590. [More Information]
  • Nosworthy, N., Ho, J., Kondyurin, A., McKenzie, D., Bilek, M. (2007). The attachment of catalase and poly-L-lysine to plasma immersion ion implantation-treated polyethylene. Acta Biomaterialia, 3(5), 695-704. [More Information]
  • Gorbatyuk, V., Nosworthy, N., Robson, S., Bains, N., Maciejewski, M., dos Remedios, C., King, G. (2006). Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Molecular Cell, 24(4), 511-522.
  • Steel, B., McKenzie, D., Bilek, M., Nosworthy, N., dos Remedios, C. (2006). Nanosecond responses of proteins to ultra-high temperature pulses. Biophysical Journal, 91(6), L66-L68. [More Information]
  • Chhabra, D., Nosworthy, N., dos Remedios, C. (2005). The N-terminal fragment of gelsolin inhibits the interaction of DNase I with isolated actin, but not with the cofilin-actin complex. Proteomics, 5(12), 3131-3136. [More Information]
  • dos Remedios, C., Chhabra, D., Kekic, M., Dedova, I., Tsubakihara, M., Berry, A., Nosworthy, N. (2003). Actin binding proteins: Regulation of cytoskeletal microfilaments. Physiological Reviews, 83, 433-473.
  • Dedova, I., Dedov, V., Nosworthy, N., Hambly, B., dos Remedios, C. (2002). Cofilin and DNase 1 affect the conformation of the small domain of actin. Biophysical Journal, 82, 3134-3143.
  • Bains, N., Gorbatyuk, V., Nosworthy, N., Robson, S., Maciejewski, M., dos Remedios, C., King, G. (2002). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular NMR, 22(2), 193-194.
  • Jiang, L., Tsubakihara, M., Heinke, M., Phillips, W., dos Remedios, C., Nosworthy, N., Yao, M. (2001). Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics, 1 (12), 1481-1488.
  • Nosworthy, N., Kekic, M., dos Remedios, C. (2001). The affinity of chick cofilin for actin increases when actin is complexed with DNase 1: Formation of a cofilin-actin-DNase 1 ternary complex. Proteomics, 1 (12), 1513-1518.

Conferences

  • Bilek, M., McKenzie, D., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Hirsh, S., Fisher, K., Weiss, A. (2011). Universal biomolecule binding interlayers created by energetic ion bombardment. 2011 Materials Research Society (MRS) Spring Meeting. Cambridge University Press. [More Information]
  • Thordarson, P., Bilek, M., McKenzie, D., Nosworthy, N., Davies, K., Morrow, R., Gan, B., dos Remedios, C. (2005). Functional Attachment of Horse Radish Peroxidase to Plasma Treated Surfaces. Smart Materials III, : SPIE Press.

2014

  • Nosworthy, N., Kondyurin, A., Bilek, M., McKenzie, D. (2014). Ion implantation treatment of beads for covalent binding of molecules: Application to bioethanol production using thermophilic beta-glucosidase. Enzyme and Microbial Technology, 54(1), 20-24-20-24. [More Information]

2013

  • Tran, C., Nosworthy, N., Kondyurin, A., McKenzie, D., Bilek, M. (2013). CelB and B-glucosidase immobilization for carboxymethyl cellulose hydrolysis. RSC Advances, 3(45), 23604-23611. [More Information]
  • Hirsh, S., Bilek, M., Bax, D., Kondyurin, A., Kosobrodova, E., Tsoutas, K., Tran, C., Waterhouse, A., Yin, Y., Nosworthy, N., McKenzie, D., dos Remedios, C., Weiss, A., et al (2013). Ion Implanted, Radical-Rich Surfaces For The Rapid Covalent Immobilization Of Active Biomolecules. AIP Conference Proceedings, 1525, 364-369. [More Information]
  • Hirsh, S., McKenzie, D., Nosworthy, N., Denman, J., Sezerman, O., Bilek, M. (2013). The Vroman effect: Competitive protein exchange with dynamic multilayer protein aggregates. Colloids And Surfaces B: Biointerfaces, 103, 395-404. [More Information]

2012

  • Yin, Y., Fisher, K., Nosworthy, N., Bax, D., Clarke, R., McKenzie, D., Bilek, M. (2012). Comparison on protein adsorption properties of diamond-like carbon and nitrogen-containing plasma polymer surfaces. Thin Solid Films, 520(7), 3021-3025. [More Information]
  • Kondyurin, A., Naseri, P., Tilley, J., Nosworthy, N., Bilek, M., McKenzie, D. (2012). Mechanisms for Covalent Immobilization of Horseradish Peroxidase on Ion-Beam-Treated Polyethylene. Scientifca, 2012, 1-28.

2011

  • Kondyurin, A., Nosworthy, N., Bilek, M. (2011). Effect of Low Molecular Weight Additives on Immobilization Strength, Activity, and Conformation of Protein Immobilized on PVC and UHMWPE. Langmuir, 27(10), 6138-6148. [More Information]
  • Yin, Y., Nosworthy, N., McKenzie, D., Bilek, M. (2011). Ellipsometry analysis of conformational change of immobilized protein monolayer on plasma polymer surfaces. Thin Solid Films, 519(9), 2968-2971. [More Information]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., dos Remedios, C., McKenzie, D. (2011). Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences (PNAS), 108(35), 14405-14410. [More Information]
  • Hirsh, S., Nosworthy, N., Kondyurin, A., dos Remedios, C., McKenzie, D., Bilek, M. (2011). Linker-free covalent thermophilic b-glucosidase functionalized polymeric surfaces. Journal of Materials Chemistry, 21, 17832-17841. [More Information]
  • Kondyurin, A., Nosworthy, N., Bilek, M., Jones, R., Pigram, P. (2011). Surface Attachment of Horseradish Peroxidase to Nylon Modified by Plasma-Immersion Ion Implantation. Journal of Applied Polymer Science, 120(5), 2891-2903. [More Information]
  • Bilek, M., McKenzie, D., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Hirsh, S., Fisher, K., Weiss, A. (2011). Universal biomolecule binding interlayers created by energetic ion bombardment. 2011 Materials Research Society (MRS) Spring Meeting. Cambridge University Press. [More Information]

2010

  • Hirsch, S., Bilek, M., Nosworthy, N., Kondyurin, A., dos Remedios, C., McKenzie, D. (2010). A Comparison of Covalent Immobilization and Physical Adsorption of a Cellulase Enzyme Mixture. Langmuir, 26(17), 14380-14388. [More Information]

2009

  • Nosworthy, N., McKenzie, D., Bilek, M. (2009). A New Surface for Immobilizing and Maintaining the Function of Enzymes in a Freeze-Dried State. Biomacromolecules, 10(9), 2577-2583. [More Information]
  • Yin, Y., Nosworthy, N., Youssef, H., Gong, B., Bilek, M., McKenzie, D. (2009). Acetylene plasma coated surfaces for covalent immobilization of proteins. Thin Solid Films, 517(17), 5343-5346. [More Information]
  • Yin, Y., Bilek, M., McKenzie, D., Nosworthy, N., Kondyurin, A., Youssef, H., Byrom, M., Yang, W. (2009). Acetylene plasma polymerized surfaces for covalent immobilization of dense bioactive protein monolayers. Surface and Coatings Technology, 203(10-11), 1310-1316. [More Information]
  • Yin, Y., Wise, S., Nosworthy, N., Waterhouse, A., Bax, D., Youssef, H., Byrom, M., Bilek, M., McKenzie, D., Weiss, A., Ng, M. (2009). Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials, 30(9), 1675-1681. [More Information]
  • Yin, Y., Fisher, K., Nosworthy, N., Bax, D., Rubanov, S., Gong, B., Weiss, A., McKenzie, D., Bilek, M. (2009). Covalently Bound Biomimetic Layers on Plasma Polymers with Graded Metallic Interfaces for in vivo Implants. Plasma Processes and Polymers, 6(10), 658-666. [More Information]
  • Yin, Y., Nosworthy, N., Gong, B., Bax, D., Kondyurin, A., McKenzie, D., Bilek, M. (2009). Plasma Polymer Surfaces Compatible with a CMOS Process for Direct Covalent Enzyme Immobilization. Plasma Processes and Polymers, 6(1), 68-75.

2008

  • Kondyurin, A., Nosworthy, N., Bilek, M. (2008). Attachment of horseradish peroxidise to polytetrafluorethylene (teflon) after plasma immersion ion implantation. Acta Biomaterialia, 4, 1218-1225. [More Information]
  • Kondyurin, A., Polonskyi, O., Nosworthy, N., Matousek, J., Hildek, P., Biederman, H., Bilek, M. (2008). Covalent Attachment and Bioactivity of Horseradish Peroxidase on Plasma-Polymerized Hexane Coatings. Plasma Processes and Polymers, 5(8), 727-736.
  • dos Remedios, C., Nosworthy, N. (2008). The role of PIP2 in actin, actin-binding proteins and disease. In C. dos Remedios and D. Chhabra (Eds.), Actin-Binding Proteins and Disease, (pp. 290-297). New York: Springer Science + Business Media.

2007

  • Gan, B., Nosworthy, N., McKenzie, D., dos Remedios, C., Bilek, M. (2007). Plasma immersion ion implantation treatment of polyethylene for enhanced binding of active horseradish peroxidase. Journal of Biomedical Materials Research. Part A, 85A(3), 605-610. [More Information]
  • Ho, J., Nosworthy, N., Bilek, M., Gan, B., McKenzie, D., Chu, P., dos Remedios, C. (2007). Plasma-treated polyethylene surfaces for improved binding of active protein. Plasma Processes and Polymers, 4(5), 583-590. [More Information]
  • Nosworthy, N., Ho, J., Kondyurin, A., McKenzie, D., Bilek, M. (2007). The attachment of catalase and poly-L-lysine to plasma immersion ion implantation-treated polyethylene. Acta Biomaterialia, 3(5), 695-704. [More Information]

2006

  • Gorbatyuk, V., Nosworthy, N., Robson, S., Bains, N., Maciejewski, M., dos Remedios, C., King, G. (2006). Mapping the phosphoinositide-binding site on chick cofilin explains how PIP2 regulates the cofilin-actin interaction. Molecular Cell, 24(4), 511-522.
  • Steel, B., McKenzie, D., Bilek, M., Nosworthy, N., dos Remedios, C. (2006). Nanosecond responses of proteins to ultra-high temperature pulses. Biophysical Journal, 91(6), L66-L68. [More Information]

2005

  • Thordarson, P., Bilek, M., McKenzie, D., Nosworthy, N., Davies, K., Morrow, R., Gan, B., dos Remedios, C. (2005). Functional Attachment of Horse Radish Peroxidase to Plasma Treated Surfaces. Smart Materials III, : SPIE Press.
  • Chhabra, D., Nosworthy, N., dos Remedios, C. (2005). The N-terminal fragment of gelsolin inhibits the interaction of DNase I with isolated actin, but not with the cofilin-actin complex. Proteomics, 5(12), 3131-3136. [More Information]

2003

  • dos Remedios, C., Chhabra, D., Kekic, M., Dedova, I., Tsubakihara, M., Berry, A., Nosworthy, N. (2003). Actin binding proteins: Regulation of cytoskeletal microfilaments. Physiological Reviews, 83, 433-473.

2002

  • Dedova, I., Dedov, V., Nosworthy, N., Hambly, B., dos Remedios, C. (2002). Cofilin and DNase 1 affect the conformation of the small domain of actin. Biophysical Journal, 82, 3134-3143.
  • Bains, N., Gorbatyuk, V., Nosworthy, N., Robson, S., Maciejewski, M., dos Remedios, C., King, G. (2002). Letter to the Editor: Backbone and side-chain 1H, 15N, and 13C assignments for chick cofilin. Journal of Biomolecular NMR, 22(2), 193-194.

2001

  • Jiang, L., Tsubakihara, M., Heinke, M., Phillips, W., dos Remedios, C., Nosworthy, N., Yao, M. (2001). Heart failure and apoptosis: Electrophoretic methods support data from micro- and macro-arrays. A critical review of genomics and proteomics. Proteomics, 1 (12), 1481-1488.
  • Kekic, M., Nosworthy, N., Dedova, I., Collyer, C., dos Remedios, C. (2001). Regulation of the cytoskeleton assembly: a role for a ternary complex of actin with two actin-binding proteins. In Cristobal G. Dos Remedios & David D. Thomas (Eds.), Molecular Interactions of Actin: Actin Structure and Actin-Binding Proteins, (pp. 165-177). Germany: Springer.
  • Nosworthy, N., Kekic, M., dos Remedios, C. (2001). The affinity of chick cofilin for actin increases when actin is complexed with DNase 1: Formation of a cofilin-actin-DNase 1 ternary complex. Proteomics, 1 (12), 1513-1518.

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