Dr Timothy Newsome

Lecturer

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 2907
Fax +61 2 9351 4571

Website Related website

Biographical details

Dr Tim Newsome was appointed Lecturer in the School of Molecular Bioscience in 2007, with key leadership responsibilities in the areas of virology research and teaching.

Dr Newsome was awarded his PhD from the University of Zurich in 2000, and moved to Cancer Research UK, London shortly after to work as a Post-doc, successfully managing to publish his work in the highest international journals, and developing novel strategies in advanced light microscopy, genetic manilpulation of vial genomes, and tandem affinity approach for the purification of protein complezes to address new questions in host/pathogen interactions using vaccinia virus. In 2008 Tim was awarded the Selby Research Award, and later was the proud recipient of the Faculty of Science Citations for Excellence in Teaching award, recognising his contribution to enhancing the student learning environment by innovations to the online delivery of courses, integrating imaging into the undergraduate syllabus via a successful TIES application, and good practise in teaching.

Research interests

Infection and Immunological Conditions;

Vaccines and vaccinology; Virus diseases; Virology

Keywords

Vaccines and vaccinology; Virus diseases; Virology

Selected grants

2013

  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.
  • Regulation of F-actin during HIV spread; Turville S, Newsome T; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • The fate of single virus particles during infection; Newsome T, Diefenbach R; Australian Research Council (ARC)/Discovery Projects (DP).
  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The role of actin-based motility as a virulence mechanism and potential as an antiviral target; Newsome T, Karupiah G, Marty A; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Microbial and Cellular Imaging and Analysis Facility; Whitchurch C, Harry E, Phillips M, Ford M, Dalton J, Ralph P, Doblin M, Smith N, Firth N, Trewhella J, Cox G, Braet F, Carter D, Newsome T, Dixon N, Walker M, Mackenzie J, Hanssen E, Tilley L, Mak J, Murphy R, Ryan M, Stephenson D, Vaux D, Tang C, Fisher P, Gendall A, Crewther S, Smith T, Robins-Browne R, Hartland E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

Selected publications

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Book Chapters

  • Newsome, T., Marty, A., Lynn, H., Procter, D. (2011). Navigating the subcellular space: Lessons from vaccinia virus. In Russell J Diefenbach & Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 155-177). Kerala, India: Research Signpost.

Journals

  • Horsington, J., Lynn, H., Turnbull, L., Cheng, D., Braet, F., Diefenbach, R., Whitchurch, C., Karupiah, G., Newsome, T. (2013). A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus. PLoS Pathogens, 9(3), 1-15. [More Information]
  • Lynn, H., Horsington, J., Ter, L., Han, S., Chew, Y., Diefenbach, R., Way, M., Chaudhri, G., Karupiah, G., Newsome, T. (2012). Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo. Journal of Virology, 86(13), 7427-7443. [More Information]
  • Aggarwal, A., Iemma, T., Shih, I., Newsome, T., McAllery, S., Cunningham, A., Turville, S. (2012). Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells. PLoS Pathogens, 8(6), 1-20. [More Information]
  • Horsington, J., Turnbull, L., Whitchurch, C., Newsome, T. (2012). Sub-viral imaging of vaccinia virus using super-resolution microscopy. Journal of Virological Methods, 186(1-2), 132-136. [More Information]
  • Dodding, M., Newsome, T., Collinson, L., Edwards, C., Way, M. (2009). An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection. Cellular Microbiology, 11(5), 808-824. [More Information]
  • Stelzer-Braid, S., Oliver, B., Blazey, A., Argent, E., Newsome, T., Rawlinson, W., Tovey, E. (2009). Exhalation of respiratory viruses by breathing, coughing, and talking. Journal of Medical Virology, 81(9), 1674-1679. [More Information]
  • Weisswange, I., Newsome, T., Schleich, S., Way, M. (2009). The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature, 458(5), 87-91. [More Information]
  • Berger, J., Senti, K., Senti, G., Newsome, T., Asling, B., Dickson, B., Suzuki, T. (2008). Systematic Identification of Genes that Regulate Neuronal Wiring in the Drosophila Visual System. PLoS Genetics, 4(5), e1000085-1-e1000085-14. [More Information]
  • Bracale, A., Cesca, F., Neubrand, V., Newsome, T., Way, M., Schiavo, G. (2007). Kidins220/ARMS Is Transported by a Kinesin-1-based Mechanism Likely to be Involved in Neuronal Differentiation. Molecular Biology of the Cell, 18(1), 142-152. [More Information]
  • Arakawa, Y., Cordeiro, J., Schleich, S., Newsome, T., Way, M. (2007). The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host and Microbe, 1(3), 227-240. [More Information]
  • Newsome, T., Weisswange, I., Frischknecht, F., Way, M. (2006). Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cellular Microbiology, 8(2), 233-241. [More Information]
  • Newsome, T., Scaplehorn, N., Way, M. (2004). Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus. Science, 306(5693), 124-129. [More Information]
  • Grosse, R., Copeland, J., Newsome, T., Way, M., Treisman, R. (2003). A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity. The EMBO Journal, 22(12), 3050-3061. [More Information]
  • Newsome, T., Asling, B., Dickson, B. (2000). Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development (Cambridge), 127, 851-860.
  • Newsome, T., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A., Dickson, B. (2000). Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila. Cell, 101, 283-294.

2013

  • Horsington, J., Lynn, H., Turnbull, L., Cheng, D., Braet, F., Diefenbach, R., Whitchurch, C., Karupiah, G., Newsome, T. (2013). A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus. PLoS Pathogens, 9(3), 1-15. [More Information]

2012

  • Lynn, H., Horsington, J., Ter, L., Han, S., Chew, Y., Diefenbach, R., Way, M., Chaudhri, G., Karupiah, G., Newsome, T. (2012). Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo. Journal of Virology, 86(13), 7427-7443. [More Information]
  • Aggarwal, A., Iemma, T., Shih, I., Newsome, T., McAllery, S., Cunningham, A., Turville, S. (2012). Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells. PLoS Pathogens, 8(6), 1-20. [More Information]
  • Horsington, J., Turnbull, L., Whitchurch, C., Newsome, T. (2012). Sub-viral imaging of vaccinia virus using super-resolution microscopy. Journal of Virological Methods, 186(1-2), 132-136. [More Information]

2011

  • Newsome, T., Marty, A., Lynn, H., Procter, D. (2011). Navigating the subcellular space: Lessons from vaccinia virus. In Russell J Diefenbach & Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 155-177). Kerala, India: Research Signpost.

2009

  • Dodding, M., Newsome, T., Collinson, L., Edwards, C., Way, M. (2009). An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection. Cellular Microbiology, 11(5), 808-824. [More Information]
  • Stelzer-Braid, S., Oliver, B., Blazey, A., Argent, E., Newsome, T., Rawlinson, W., Tovey, E. (2009). Exhalation of respiratory viruses by breathing, coughing, and talking. Journal of Medical Virology, 81(9), 1674-1679. [More Information]
  • Weisswange, I., Newsome, T., Schleich, S., Way, M. (2009). The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature, 458(5), 87-91. [More Information]

2008

  • Berger, J., Senti, K., Senti, G., Newsome, T., Asling, B., Dickson, B., Suzuki, T. (2008). Systematic Identification of Genes that Regulate Neuronal Wiring in the Drosophila Visual System. PLoS Genetics, 4(5), e1000085-1-e1000085-14. [More Information]

2007

  • Bracale, A., Cesca, F., Neubrand, V., Newsome, T., Way, M., Schiavo, G. (2007). Kidins220/ARMS Is Transported by a Kinesin-1-based Mechanism Likely to be Involved in Neuronal Differentiation. Molecular Biology of the Cell, 18(1), 142-152. [More Information]
  • Arakawa, Y., Cordeiro, J., Schleich, S., Newsome, T., Way, M. (2007). The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host and Microbe, 1(3), 227-240. [More Information]

2006

  • Newsome, T., Weisswange, I., Frischknecht, F., Way, M. (2006). Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cellular Microbiology, 8(2), 233-241. [More Information]

2004

  • Newsome, T., Scaplehorn, N., Way, M. (2004). Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus. Science, 306(5693), 124-129. [More Information]

2003

  • Grosse, R., Copeland, J., Newsome, T., Way, M., Treisman, R. (2003). A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity. The EMBO Journal, 22(12), 3050-3061. [More Information]

2000

  • Newsome, T., Asling, B., Dickson, B. (2000). Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development (Cambridge), 127, 851-860.
  • Newsome, T., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A., Dickson, B. (2000). Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila. Cell, 101, 283-294.

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