Mr Tristan Reekie

Postdoctoral Research Associate

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 3951
Fax 61 2 9351 3329

Selected publications

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Journals

  • Sridharan, S., Lepelletier, F., Trigg, W., Banister, S., Reekie, T., Kassiou, M., Gerhard, A., Hinz, R., Boutin, H. (2017). Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats. Molecular Imaging and Biology, 19(1), 77-89. [More Information]
  • Sokias, R., Werry, E., Chua, S., Reekie, T., Munoz, L., Wong, E., Ittner, L., Kassiou, M. (2017). Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. MedChemComm (Medicinal Chemistry Communications), 8(1), 202-210. [More Information]
  • O'Brien-Brown, J., Jackson, A., Reekie, T., Barron, M., Werry, E., Schiavini, P., McDonnell, M., Munoz, L., Wilkinson, S., Noll, B., Kassiou, M., et al (2017). Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists. European Journal of Medicinal Chemistry, 130, 433-439. [More Information]
  • Katte, T., Reekie, T., Werry, E., Jorgensen, W., Boyd, R., Wong, E., Gulliver, D., Connor, M., Kassiou, M. (2017). Investigation of pyrazolo-sulfonamides as putative small molecule oxytocin receptor agonists. European Journal of Medicinal Chemistry, 136, 330-333. [More Information]
  • Wong, E., Reekie, T., Werry, E., O'Brien-Brown, J., Bowyer, S., Kassiou, M. (2017). Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X7 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 27(11), 2439-2442. [More Information]
  • Reekie, T., Wilkinson, S., Law, V., Hibbs, D., Ong, J., Kassiou, M. (2017). Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores. Organic and Biomolecular Chemistry, 15(3), 576-580. [More Information]
  • Moir, M., Chua, S., Reekie, T., Martin, A., Ittner, A., Ittner, L., Kassiou, M. (2017). Ring-opened aminothienopyridazines as novel tau aggregation inhibitors. MedChemComm (Medicinal Chemistry Communications), 8(6), 1275-1282. [More Information]
  • Zhou, Q., Phoa, A., Abbassi, R., Hoque, M., Reekie, T., Font Sadurni, J., Ryan, R., Stringer, B., Day, B., Johns, T., Munoz, L., Kassiou, M. (2017). Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastoma. Journal of Medicinal Chemistry, 60(5), 2052-2070. [More Information]
  • Conroy, T., Manohar, M., Gong, Y., Wilkinson, S., Webster, M., Lieberman, B., Banister, S., Reekie, T., Mach, R., Rendina, L., Kassiou, M. (2016). A systematic exploration of the effects of flexibility and basicity on sigma (sigma) receptor binding in a series of substituted diamines. Organic and Biomolecular Chemistry, 14(39), 9388-9405. [More Information]
  • Jorgensen, W., Gulliver, D., Werry, E., Reekie, T., Connor, M., Kassiou, M. (2016). Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors. European Journal of Medicinal Chemistry, 108, 730-740. [More Information]
  • Katte, T., Reekie, T., Jorgensen, W., Kassiou, M. (2016). The Formation of Seven-Membered Heterocycles under Mild Pictet-Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines. The Journal of Organic Chemistry, 81(11), 4883-4889. [More Information]
  • Beinat, C., Reekie, T., Banister, S., O'Brien-Brown, J., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Kassiou, M., et al (2015). Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at alpha7 nAChRs through incorporation of known structural motifs. European Journal of Medicinal Chemistry, 95, 277-301. [More Information]
  • Hicks, C., Ramos, L., Reekie, T., Misagh, G., Narlawar, R., Kassiou, M., McGregor, I. (2014). Body temperature and cardiac changes induced by peripherally administered oxytocin, vaspressin and the non-peptide oxytocin receptor agonist WAY 267, 464: a biotelemetry study in rats. British Journal of Pharmacology, 171(11), 2868-2887. [More Information]
  • Beinat, C., Reekie, T., Hibbs, D., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Tsanaktsidis, J., Kassiou, M. (2014). Investigations of amide bond variation and biaryl modification in analogues of alpha7 nAChR agonist SEN12333. European Journal of Medicinal Chemistry, 84, 200-205. [More Information]
  • Reekie, T., McGregor, I., Kassiou, M. (2014). Pyrazolo 1,4 diazepines as non-peptidic probes of the oxytocin and vasopressin receptors. Tetrahedron Letters, 55(33), 4568-4571. [More Information]
  • Reekie, T., Banwell, M., Willis, A. (2013). Intramolecular Cycloaddition Reactions of cis-1,2-dihydrocatechol Derivatives Incorporating C-3 Tethered Diazoketones, Nitrile Oxides and Azides: Stereocontrolled Routes to Enantiomerically Pure Spiro[5.5]undecanes and Related Systems. The Journal of Organic Chemistry, 78, 7100-7111.
  • Reekie, T., Kavanagh, M., Longworth, M., Kassiou, M. (2013). Synthesis of Biologically Active Seven-Membered-Ring Heterocycles. Synthesis: journal of synthetic organic chemistry, 45(23), 3211-3227. [More Information]
  • Reekie, T., Banwell, M., Willis, A. (2012). A Raney-Cobalt-Mediated Tandem Reductive Cyclization Route to the 1,5-Methanoazocino[4,3-b]indole Framework of the Uleine and Strychnos Alkaloids. The Journal of Organic Chemistry, 77(23), 10773-10781. [More Information]
  • Tan, S., Banwell, M., Willis, A., Reekie, T. (2012). Application of a Raney-Cobalt-Mediated Tandem Reductive Cyclization Protocol to Total Syntheses of the Aspidosperma Alkaloids (+-)-Limaspermidine and (+-)-1-Acetylaspidoalbidine. Organic Letters, 14(22), 5621-5623. [More Information]
  • Banwell, M., Jones, M., Reekie, T. (2011). The Palladium-Catalysed Ullmann Cross-Coupling Reaction. Chemistry in New Zealand, 75(3), 122-127.
  • Austin, K., Matveenko, M., Reekie, T., Banwell, M. (2008). Chemoenzymatic methods for the ennatioselective assembly of bioactive natural products. Chemistry in Australia, 75(11), 3-7.
  • Reekie, T., Austin, K., Banwell, M., Willis, A. (2008). The Chemoenzymatic Total Synthesis of Phellodonic Acid, a Biologically Active and Highly Functionalized Hirsutane Derivative Isolated from the Tasmanian Fungus Phellodon melaleucus. Australian Journal of Chemistry, 61(2), 94-106.

Conferences

  • Reekie, T., Austin, K., Banwell, M. (2012). A Chemoenzymatic Total Synthesis of (-)- Phellodonic Acid. 28th Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Sydney: RACI.
  • Reekie, T., Banwell, M. (2012). A Concise Synthesis of the ABCDE Ring-system of Strychnine. 19th International Conference on Organic Synthesis, Melbourne: Arinex.
  • Reekie, T., Banwell, M. (2011). A Cascade Approach to the Synthesis of the ABCDE Ring-system of Strychnine. Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Natural Products Group, Australia: Royal Australian Chemical Institute.
  • Reekie, T., Banwell, M. (2011). A Synthesis of the ABCDE Ring-system of Strychnine. 23rd International Congress on Heterocyclic Chemistry, Scotland.
  • Reekie, T., Banwell, M. (2010). A Synthesis of the ABCDE Ring-system of Strychnine. 31st Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Australia: Royal Australian Chemical Institute.
  • Reekie, T., Banwell, M. (2009). Strychnine Synthesis Support Studies: A Novel Approach to the ABCDE Ring-system. 30th Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Australia: Royal Australian Chemical Institute.
  • Reekie, T., Austin, K., Banwell, M. (2008). A Chemoenzymatic Total Synthesis of (-)-Phellodonic Acid. 5th SINO-Australia Organic Chemistry Symposium, Australia: Australian National University (ANU).
  • Reekie, T., Austin, K., Banwell, M. (2008). A Chemoenzymatic Total Synthesis of (-)-Phellodonic Acid. 29th Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Australia: Royal Australian Chemical Institute.
  • Reekie, T., Banwell, M. (2008). The Enantioselective Construction of a Key Intermediate for the Synthesis of Biologically Active Sesquiterpenoids Incorporating Novel Ring Systems. 23rd Royal Australian Chemical Institute Organic Chemistry Conference, Australia: RACI.

2017

  • Sridharan, S., Lepelletier, F., Trigg, W., Banister, S., Reekie, T., Kassiou, M., Gerhard, A., Hinz, R., Boutin, H. (2017). Comparative evaluation of three TSPO PET radiotracers in a LPS-induced model of mild neuroinflammation in rats. Molecular Imaging and Biology, 19(1), 77-89. [More Information]
  • Sokias, R., Werry, E., Chua, S., Reekie, T., Munoz, L., Wong, E., Ittner, L., Kassiou, M. (2017). Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination. MedChemComm (Medicinal Chemistry Communications), 8(1), 202-210. [More Information]
  • O'Brien-Brown, J., Jackson, A., Reekie, T., Barron, M., Werry, E., Schiavini, P., McDonnell, M., Munoz, L., Wilkinson, S., Noll, B., Kassiou, M., et al (2017). Discovery and pharmacological evaluation of a novel series of adamantyl cyanoguanidines as P2X7 receptor antagonists. European Journal of Medicinal Chemistry, 130, 433-439. [More Information]
  • Katte, T., Reekie, T., Werry, E., Jorgensen, W., Boyd, R., Wong, E., Gulliver, D., Connor, M., Kassiou, M. (2017). Investigation of pyrazolo-sulfonamides as putative small molecule oxytocin receptor agonists. European Journal of Medicinal Chemistry, 136, 330-333. [More Information]
  • Wong, E., Reekie, T., Werry, E., O'Brien-Brown, J., Bowyer, S., Kassiou, M. (2017). Pharmacological evaluation of a novel series of urea, thiourea and guanidine derivatives as P2X7 receptor antagonists. Bioorganic and Medicinal Chemistry Letters, 27(11), 2439-2442. [More Information]
  • Reekie, T., Wilkinson, S., Law, V., Hibbs, D., Ong, J., Kassiou, M. (2017). Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores. Organic and Biomolecular Chemistry, 15(3), 576-580. [More Information]
  • Moir, M., Chua, S., Reekie, T., Martin, A., Ittner, A., Ittner, L., Kassiou, M. (2017). Ring-opened aminothienopyridazines as novel tau aggregation inhibitors. MedChemComm (Medicinal Chemistry Communications), 8(6), 1275-1282. [More Information]
  • Zhou, Q., Phoa, A., Abbassi, R., Hoque, M., Reekie, T., Font Sadurni, J., Ryan, R., Stringer, B., Day, B., Johns, T., Munoz, L., Kassiou, M. (2017). Structural optimization and pharmacological evaluation of inhibitors targeting dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) and CDC-like kinases (CLK) inglioblastoma. Journal of Medicinal Chemistry, 60(5), 2052-2070. [More Information]

2016

  • Conroy, T., Manohar, M., Gong, Y., Wilkinson, S., Webster, M., Lieberman, B., Banister, S., Reekie, T., Mach, R., Rendina, L., Kassiou, M. (2016). A systematic exploration of the effects of flexibility and basicity on sigma (sigma) receptor binding in a series of substituted diamines. Organic and Biomolecular Chemistry, 14(39), 9388-9405. [More Information]
  • Jorgensen, W., Gulliver, D., Werry, E., Reekie, T., Connor, M., Kassiou, M. (2016). Flexible analogues of WAY-267,464: Synthesis and pharmacology at the human oxytocin and vasopressin 1a receptors. European Journal of Medicinal Chemistry, 108, 730-740. [More Information]
  • Katte, T., Reekie, T., Jorgensen, W., Kassiou, M. (2016). The Formation of Seven-Membered Heterocycles under Mild Pictet-Spengler Conditions: A Route to Pyrazolo[3,4]benzodiazepines. The Journal of Organic Chemistry, 81(11), 4883-4889. [More Information]

2015

  • Beinat, C., Reekie, T., Banister, S., O'Brien-Brown, J., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Kassiou, M., et al (2015). Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at alpha7 nAChRs through incorporation of known structural motifs. European Journal of Medicinal Chemistry, 95, 277-301. [More Information]

2014

  • Hicks, C., Ramos, L., Reekie, T., Misagh, G., Narlawar, R., Kassiou, M., McGregor, I. (2014). Body temperature and cardiac changes induced by peripherally administered oxytocin, vaspressin and the non-peptide oxytocin receptor agonist WAY 267, 464: a biotelemetry study in rats. British Journal of Pharmacology, 171(11), 2868-2887. [More Information]
  • Beinat, C., Reekie, T., Hibbs, D., Xie, T., Olson, T., Xiao, Y., Harvey, A., O'Connor, S., Coles, C., Tsanaktsidis, J., Kassiou, M. (2014). Investigations of amide bond variation and biaryl modification in analogues of alpha7 nAChR agonist SEN12333. European Journal of Medicinal Chemistry, 84, 200-205. [More Information]
  • Reekie, T., McGregor, I., Kassiou, M. (2014). Pyrazolo 1,4 diazepines as non-peptidic probes of the oxytocin and vasopressin receptors. Tetrahedron Letters, 55(33), 4568-4571. [More Information]

2013

  • Reekie, T., Banwell, M., Willis, A. (2013). Intramolecular Cycloaddition Reactions of cis-1,2-dihydrocatechol Derivatives Incorporating C-3 Tethered Diazoketones, Nitrile Oxides and Azides: Stereocontrolled Routes to Enantiomerically Pure Spiro[5.5]undecanes and Related Systems. The Journal of Organic Chemistry, 78, 7100-7111.
  • Reekie, T., Kavanagh, M., Longworth, M., Kassiou, M. (2013). Synthesis of Biologically Active Seven-Membered-Ring Heterocycles. Synthesis: journal of synthetic organic chemistry, 45(23), 3211-3227. [More Information]

2012

  • Reekie, T., Austin, K., Banwell, M. (2012). A Chemoenzymatic Total Synthesis of (-)- Phellodonic Acid. 28th Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Sydney: RACI.
  • Reekie, T., Banwell, M. (2012). A Concise Synthesis of the ABCDE Ring-system of Strychnine. 19th International Conference on Organic Synthesis, Melbourne: Arinex.
  • Reekie, T., Banwell, M., Willis, A. (2012). A Raney-Cobalt-Mediated Tandem Reductive Cyclization Route to the 1,5-Methanoazocino[4,3-b]indole Framework of the Uleine and Strychnos Alkaloids. The Journal of Organic Chemistry, 77(23), 10773-10781. [More Information]
  • Tan, S., Banwell, M., Willis, A., Reekie, T. (2012). Application of a Raney-Cobalt-Mediated Tandem Reductive Cyclization Protocol to Total Syntheses of the Aspidosperma Alkaloids (+-)-Limaspermidine and (+-)-1-Acetylaspidoalbidine. Organic Letters, 14(22), 5621-5623. [More Information]

2011

  • Reekie, T., Banwell, M. (2011). A Cascade Approach to the Synthesis of the ABCDE Ring-system of Strychnine. Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Natural Products Group, Australia: Royal Australian Chemical Institute.
  • Reekie, T., Banwell, M. (2011). A Synthesis of the ABCDE Ring-system of Strychnine. 23rd International Congress on Heterocyclic Chemistry, Scotland.
  • Banwell, M., Jones, M., Reekie, T. (2011). The Palladium-Catalysed Ullmann Cross-Coupling Reaction. Chemistry in New Zealand, 75(3), 122-127.

2010

  • Reekie, T., Banwell, M. (2010). A Synthesis of the ABCDE Ring-system of Strychnine. 31st Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Australia: Royal Australian Chemical Institute.

2009

  • Reekie, T., Banwell, M. (2009). Strychnine Synthesis Support Studies: A Novel Approach to the ABCDE Ring-system. 30th Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Australia: Royal Australian Chemical Institute.

2008

  • Reekie, T., Austin, K., Banwell, M. (2008). A Chemoenzymatic Total Synthesis of (-)-Phellodonic Acid. 5th SINO-Australia Organic Chemistry Symposium, Australia: Australian National University (ANU).
  • Reekie, T., Austin, K., Banwell, M. (2008). A Chemoenzymatic Total Synthesis of (-)-Phellodonic Acid. 29th Annual One-Day Symposium, Royal Australian Chemical Institute, NSW Organic Chemistry Group, Australia: Royal Australian Chemical Institute.
  • Austin, K., Matveenko, M., Reekie, T., Banwell, M. (2008). Chemoenzymatic methods for the ennatioselective assembly of bioactive natural products. Chemistry in Australia, 75(11), 3-7.
  • Reekie, T., Austin, K., Banwell, M., Willis, A. (2008). The Chemoenzymatic Total Synthesis of Phellodonic Acid, a Biologically Active and Highly Functionalized Hirsutane Derivative Isolated from the Tasmanian Fungus Phellodon melaleucus. Australian Journal of Chemistry, 61(2), 94-106.
  • Reekie, T., Banwell, M. (2008). The Enantioselective Construction of a Key Intermediate for the Synthesis of Biologically Active Sesquiterpenoids Incorporating Novel Ring Systems. 23rd Royal Australian Chemical Institute Organic Chemistry Conference, Australia: RACI.

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