Paper in Australasian
- Naresh Mondraty, C. Laird Birmingham, Stephen
Touyz, Viktoria Sundakov, Lucy Chapman and Pierre Beumont
(2005). Radomized controlled trial of olanzapine in the treatment
of cognitions in anorexia nervosa. Australasian Psychiatry,
Objective: Recovery from anorexia nervosa is confounded
by intrusive anorectic cognitions and rituals. It has been observed
that olanzapine, an atypical antipsychotic, can reduce this anorexic
rumination. A pilot study was designed to test the effectiveness
of olanzapine in this role.
Methods: A randomized trial of olanzapine versus
chlorpromazine, with anorexic rumination as the primary outcome,
was conducted. Of the 26 patients who presented, 15 were randomized
in a balanced block design, eight to olanzapine and seven to chlorpromazine.
Results: Only the olanzapine group had a significant
reduction in the degree of rumination.
Conclusion: Olanzapine may be of benefit in anorexia
nervosa by causing a reduction in anorexic rumination.