Recent Publications

• K Whitmont, I Reid, S Tritton, L March, M Xue, M Lee, G Fulcher, P Sambrook, E Slobedman, A Cooper and C Jackson, Treatment of chronic leg ulcers with topical activated protein C.  Arch Derm,  2008, in press (accepted 1st Feb 2008) (No 2 in Dermatology)

• M Xue and C Jackson, Autocrine actions of matrix metalloproteinase (MMP)-2 counter the effects of MMP-9 to promote survival and prevent terminal differentiation of cultured human keratinocytes, J Invest Derm, 2008, in press (accepted 4th April 2008) (No 1 in Dermatology)

• A. Xue, C. Scarlett, C J Jackson and R Smith, Diagnostic and prognostic significance of uPAR and PAI-2 in pancreatic ductal adenocarcinoma using multigene assay, Pancreas, 2008;36:160-167 (IF 2.337).

• M Xue, M Smith, C Little, P Sambrook,  L March and C J Jackson,   Activated protein C mediates a healing phenotype in cultured tenocytes,  J Cell Mol Med, 2008, in press (accepted 30th  April) . (IF 6.7)

• Chris Jackson, Kaley Whitmont, Alan Cooper, Sara Tritton, Lyn March, Philip Sambrook and Meilang Xue, New therapeutic applications for the anticoagulant, activated protein C, Expert Opin Biol Ther,  2008, in press (accepted April), (IF

• Seeho S, Park, J, Jackson CJ, Morris JM, Gallery EDG. Villous explant culture using early gestation tissue from ongoing pregnancies with known normal outcomes: the effect of oxygen on trophoblast outgrowth and migration. Hum Reprod (in press, accepted Feb 2008 (IF 3.769, No. 2 in Human Reproduction)

• G Gallagher, S Menzie, Y Huang, C Jackson and S N Hunyor. Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction, Basic Res Cardiology, 2007 Jan;102(1):63-72. Epub  2006 Jul 4. (IF 2.993).

• Gallagher G, Jackson C, Hunyor SN. Myocardial extracellular matrix remodelling in ischemic heart failure. Front Bioscience,  2007; Jan 1, 12:1410-19 (IF 3.603)

• M Xue, D Campbell  and C J Jackson, Activated protein C is an autocrine growth factor for human skin keratinocytes, J Biol Chem, 2007 May 4;282(18):13610-6. Epub 2007 Feb 9. PMID: 17293597 (IF 5.854)

• N Le, M Xue, L Castelnoble and C Jackson, The dual personalities of matrix metalloproteinases in inflammation, Front Bioscience, 2007; Jan 1, 12:1475-87. (IF 3.603)

• M Xue, D Campbell, L March, P N Sambrook, and C J Jackson, Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Ann Rheum Dis, 2007 Dec;66(12):1574-80. Epub 2007 May 9. PMID: 17491095 (IF 5.767)

• L Xie, A Galettis, J Morris, C Jackson, S M Twigg, E DM Gallery, Intercellular adhesion molecule-1 (ICAM-1) is required for monocyte adhesion to the placental bed endothelium in diabetic human pregnancy, Diabetes/Metabolism Research and Reviews, 2007 Nov 7 [Epub ahead of print] (IF 2.453)

•  Yiwei Wang, Hsin-I Chang, Allan Jones, Chris Jackson, Allan Coombes. Polycaprolactone-based bicomposite scaffolds for tissue regeneration. Biomaterials, 2007 Nov;28(31):4619-27. (IF 5.196)

• M Xue, L March, P N Sambrook and C J Jackson, Differential regulation of matrix metalloproteinase (MMP)-2 and MMP-9 by activated protein C - relevance to inflammation in rheumatoid arthritis,  Arthr Rheum, 2007 Sep;56(9):2864-74. PMID: 17763449 (IF 7.621) (No 1 in Rheumatology)

• C Jackson and M Xue, Activated protein C – an anticoagulant that does more than stop clots, Int J Biochem Cell Biol, doi:10.1016/j.biocel.2007.12.013 (in press, accepted Dec 20th 2007)

• M Xue, P Thompson, P Sambrook, L March and C Jackson Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clin Hemorheol Micro, 2006, 34 (1-2), 155-161.)

• M. Xue, N. Le and C. Jackson, Targetting matrix metalloproteinases to improve wound healing, Exp Opin Ther Targets, 2006, 10 (1), 143-155.

• C. Jackson and M. Xue, Activated protein C as a novel agent to promote wound healing, Primary Intention, 2006, 14 (1), 31-34. .

• Cheuk Man Au, Sze Ki Luk, Christopher John Jackson , Ho Keung Ng, Christine Miu Ngan Yow, Shing Shun Tony To, Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells, J Photochem Photobiol B: Biology 85, 2006, 92–101.

• Jackson C and Xue M. Activated protein C as a novel agent to promote wound healing. Primary Intention, 14, 31-34, 2006.

• Xue M, Le N and Jackson C. Targetting matrix metalloproteinases to improve wound healing. Exp Opin Ther Targets 10, 143-155, 2006.

• Le N, Xue M, Castelnoble L and Jackson C. The dual personalities of matrix metalloproteinases in inflammation, Front Biosc, in press, 2006.

• Xue M, Thompson P, Clifton-Bligh R, Gallery E and Jackson C. MMP-9 is elevated in diabetic leukocytes and contributes to T cell activation, Int J Cell Biol Biochem 37, 2406-2416, 2005.

• Xue M, Campbell D, Sambrook P, Fukudom K and Jackson C. Endothelial protein C receptor and protease activated receptor-1 mediate induction of a wound healing phenotype in human keratinocytes by activated protein C. J Invest Derm 125, 1279-85, 2005

• Xue M, Thompson P, Sambrook P, March L and Jackson C. Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clin Hemorheol Micro 34, 155-161, 2006.

• Jackson C, Xue M, Thompson P, Davey R, Whitmont K, Smith S, Buisson-Legendre N, Sztynda T, Jackson L, Cooper A, Sambrook P, and March L, Activated protein C stimulates angiogenesis and prevents inflammation to promote cutaneous wound healing. Wound Repair Regeneration 13, 284-294, 2005

• Xue M, Thompson P, Kelso I, Jackson C.Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes. Exp Cell Res. 299, 119-27, 2004. Download

• Galettis A, Campbell S, Morris JM, Jackson CJ, Twigg SM, Gallery EDM, Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27, 2514-2515, 2004.

• Qi W, Poronnik P, Young B, Jackson C, Field M, Pollock C, Human cortical fibroblast responses to high glucose and hypoxia, Nephron Physiol, 96, 121-9, 2004.

• Campbell S, Rowe J, Jackson C, and Gallery EDM, Cellular interactions between co-cultured decidual endothelial cells and cytotrophoblasts from pre-eclamptic pregnancies,  Biol Reprod 71, 244–252, 2004,

• Buisson-Legendre N, Smith S, March L and Jackson C, Activated protein C (APC) is elevated in rheumatoid arthritic synovial joints and correlates with matrix metalloproteinase-2 (MMP-2), Arthritis and Rheumatism, 2004, 50 (7), 2151-2156

• Campbell S, Rowe J, Jackson C, and Gallery EDM, Cytotrophoblast and decidual endothelial cell interactions in pre-eclampsia: the role of matrix metalloproteinases and hypoxia in trophoblast migration, Placenta, 2003, 24(4): 306-15.

• Arkell J, Jackson CJ. Constitutive secretion of MMP9 by early-passage cultured human endothelial cells. Cell Biochem Funct. 21, 381-6, 2003. Download

• Jackson C and Schrieber L, Angiogenesis in arthritis, in Rheumatology eds M. Hochberg,A Silman, J. Smolen, M Weinblatt and M Weisman, Mosby, 3^rd Edition, 2003, 76, 851-854.

• Jackson C. Matrix metalloproteinases and angiogenesis. Curr Opin Nephrol Hypertens. 11, 295-9, 2002. Download

• Nguyen M, Arkell J, Jackson CJ. Human endothelial gelatinases and angiogenesis. Int J Biochem Cell Biol. 33, 960-70, 2001. Download

• Jackson C, Nguyen M, Arkell J, Sambrook P. Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis-targetting gelatinase A activation. Inflamm Res. 50, 183-6, 2001. Download

• Gallery EDM, Campbell S, Ilkovski B, Sinosich MJ, and Jackson C, A novel in-vitro co-culture system for the study of maternal decidual endothelial cell-trophoblast interactions in human pregnancy. Brit J Obstet Gynaecol, 108, 651-653 2001.

• Nguyen M, Arkell J, Jackson CJ. Three-dimensional collagen matrices induce delayed but sustained activation of gelatinase A in human endothelial cells via MT1-MMP. Int J Biochem Cell Biol. 32, 621-31, 2000. Download

• Nguyen M, Arkell J, Jackson CJ. Activated protein C directly activates human endothelial gelatinase A. J Biol Chem. 275, 9095-8, 2000. Download

• Nguyen M, Arkell J, Jackson CJ.Thrombin rapidly and efficiently activates gelatinase A in human microvascular endothelial cells via a mechanism independent of active MT1 matrix metalloproteinase. Lab Invest. 79, 467-75, 1999.

• Gallery EDM, Cambell S, Arkell J, Nguyen M and Jackson C, Pre-eclamptic decidual microvascular endothelial cells express lower levels of matrix metalloproteinase-1 than normals. Microvasc. Res. 57:340-346, 1999.

• Jackson CJ, Arkell J, Nguyen M. Rheumatoid synovial endothelial cells secrete decreased levels of tissue inhibitor of MMP (TIMP1), Ann Rheum Dis, 57, 158-61, 1998.

• Nguyen M, Arkell J, Jackson CJ. Active and tissue inhibitor of matrix metalloproteinase-free gelatinase B accumulates within human microvascular endothelial vesicles, J Biol Chem, 273, 5400-4, 1998.

• Jackson C, Endothelial Cell Culture, book review in Trends in Cell Biology, 8, 130-131, 1998.

• Jackson CJ, Nguyen M. Human microvascular endothelial cells differ from macrovascular endothelial cells in their expression of matrix metalloproteinases, Int J Biochem Cell Biol, 29, 1167-77, 1997

• Preston S, Clifton-Bligh P, Laurent R, Jackson C and Mason R,  Effect of methotrexate and sulphasalasine on UMR 106 rat osteoblast-like osteosarcoma cells, Br.J. Rheum, 36, 178-184, 1997.

• Jackson C, Epithelial cell culture, book review in Trends in Cell Biology, 7, 417, 1997.

• Schrieber L and Jackson C, Angiogenesis in Arthritis in ‘Rheumatology’ ed  J. Klippel and P. Dieppe, 2nd edition, Mosby, London,Vol 1,12, 1-4, 1997.