The University of Sydney
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From Test Tube to Treatment – 29 June 2006

Members of the Bosch Institute named below provided the following presentations based on their current work on the listed topics for this seminar morning.

Diabetes
Role of growth factors in diabetic complications
Concern about diabetes reaching epidemic proportions relates to the organ and tissue damage it causes. Improved understanding of the role of growth factors in these complications is also suggesting ways in which growth factors might be manipulated to prevent and treat such complications.

Presenter: Associate Professor Stephen Twigg, Endocrinologist & Medical Head of Endocrinology Research Laboratories, RPA Hospital & Bosch Institute University of Sydney

Pharmacology
The science that underpins drug discovery
Successful drug development requires collaboration between academic institutions, clinical units and pharmaceutical companies to assess the effects of medications on patients. Research identifies new targets for treating disease and new molecules directed specifically towards these targets.

Presenter: Professor Paul Seale, Professor of Clinical Pharmacology & Deputy Director, Woolcock Institute of Medical Research, RPA Hospital

Chronic Pain
"Goodness speaks in a whisper. Evil shouts"
For approximately 1 in 5 Australians, even after healing has occurred, the pain never goes away. Pain neurobiologists are now examining key areas in the nervous system to uncover new targets for pain therapies

Presenter: Dr Michelle Gerke, Lecturer, Laboratory of Neuroglycobiology & Sensation, Department of Anatomy & Histology, University of Sydney

Motor Neurone Disease
Is MND different in the Southern Hemisphere?
The cause of MND is unknown. No effective treatment is available. About 1,000 Australians have MND at any one time. Population studies of other disorders suggest environmental influences on diseases can differ between the hemispheres. A large-scale southern hemisphere study of environmental and genetic factors in MND is finally underway.

Presenter: Associate Professor Roger Pamphlett, Neurologist, Neuropathologist Department of Pathology, University of Sydney