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Emeritus Professor Alan Husband

BScAgr(Hons), PhD, DSc, FASM

B01 - J.D. Stewart Building
The University of Sydney

Research interests

Immunology, focussing on mucosal diseases and the role of behaviour, nutrition and stress in health maintenance.

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Teaching and supervision

Immunology, Pathology

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Selected grants

2003

  • Analysis of the sheep, Haemonchus contortus relationship; Sangster N, Husband A; Meat and Livestock Australia Ltd/MLA Livestock Production Research and Development Program.

2000

  • Enhancing mucosal immunity in chickens by novel in-ovo and postnatal vaccination techniques; Husband A; Rural Industries Research and Development Corporation/Research and Development Grants.
  • Growth gap Project 2; Husband A; Pig Research and Development Corporation/Research and Development Grants.
  • Development of veterinary applications of Beta 1,3 glucan technology; Husband A, Kelly G; Australian Research Council (ARC)/Spirt Grants.
  • Cytokine regulation of mucosal immunity - interactions between precursor subsets and cytokines; Husband A, Bao S; National Health and Medical Research Council/Project Grants.
  • Biological screening of phenolic hormones produced with synthetic derivatives; Husband A, Walker C, Kelly G; Novogen Limited/BLO Project.
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Selected publications

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Journals

  • Kelly, M., Mor, G., Husband, A., O'Malley, D., Baker, L., Azodi, M., Schwartz, P., Rutherford, T. (2011). Phase II Evaluation of Phenoxodiol in Combination with Cisplatin or Paclitaxel in Women with Platinum/Taxane-Refractory/Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers. International Journal Of Gynecological Cancer, 21(4), 633-639.
  • Brown, D., Heaton, A., Husband, A. (2008). Idronoxil. Proapoptotic agent, oncolytic. Drugs of the Future, 33(10), 844-860.
  • Alvaro, A., Rossi, P., Brown, D., Lelser, A., Kelly, M., Rutherford, T., Husband, A., Mor, G. (2008). Phenoxodiol-A Chemosensitizer in the Midst of Cancer Chemoresistance. US Oncology, 4, 39-41.
  • Haines, C., James, A., Sahota, D., Chen, Y., Panesar, N., Tomlinson, B., Chow, L., Benzie, I., Husband, A. (2006). Comparison between phytoestrogens and estradiol in the prevention of atheroma using either phytoestrogen or estradiol in ovariectomized cholesterol-fed rabbits. Climacteric, 9(6), 430-436.
  • Shen, J., White, M., Husband, A., Hambly, B., Bao, S. (2006). Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology, 548(1-3), 123-128.
  • Bao, S., Fei, J., Shen, J., Gong, S., Fang, H., Husband, A. (2006). Reserpine-induced model of stress suppresses mucosal immunity. Immunology and Cell Biology, 84(6), 537-542.
  • Cole, N., Hume, E., Khan, S., Madigan, M., Husband, A., Garthwaite, L., Willcox, M. (2005). Contribution of the cornea to cytokine in the whole eye induced during the early phase of Pseudomonas aeruginosa challage. Immunology and Cell Biology, 83(3), 301-306.
  • Cole, N., Hume, E., Khan, S., Krockenberger, M., Thakur, A., Husband, A., Willcox, M. (2005). Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection. Current Eye Research, 30, 535-542.
  • Widyarini, S., Husband, A., Reeve, V. (2005). Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with chemical cocarcinogen. Photochemistry and Photobiology, 81, 32-37.
  • Lam, A., Demasi, M., James, M., Husband, A., Walker, C. (2004). Effect Of Red Clover Isoflavones On Cox-2 Activity In Murine And Human Monocyte/Macrophage Cells. Nutrition and Cancer: an international journal, 49(1), 89-93.
  • Ling, S., Dai, A., Williams, M., Husband, A., Nestel, P., Komesaroff, P., Sudhir, K. (2004). The Isoflavone Metabolite Cis - Tetrahydrodaidzein Inhibits Erk-1 Activation And Proliferation In Human Vascular Smooth Muscle Cells. Journal of Cardiovascular Pharmacology, 43(5), 622-628.
  • Chin-Dusting, J., Boak, L., Husband, A., Nestel, P. (2004). The Isoflavone Metabolite Dehydroequol Produces Vasodilation In Human Resistance Ateries Via A Nitric Oxide Dependent Mechanism. Atherosclerosis, 176(1), 45-48.
  • Jiang, F., Jones, G., Husband, A., Dusting, G. (2003). Cardiovascular protective effects of synthetic Isoflavone derivatives in Apolipoprotein E-deficient mice. Journal of Vascular Research, 40(3), 276-284.
  • Cole, N., Krockenberger, M., Stapleton, F., Khan, S., Hume, E., Husband, A., Willcox, M. (2003). Experimental Pseudomonas aeruginosa keratitis in interleukin-10 gene knockout mice. Infection and Immunity, 71(3), 1328-1336.
  • Constantinou, A., Mehta, R., Husband, A. (2003). Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. European Journal of Cancer, 39(7), 1012-1018.
  • Cole, N., Bao, S., Stapleton, F., Thakur, A., Beagley, K., Husband, A., Willcox, M. (2003). Pseudomonas aeruginosa keratitis in IL-6-deficient mice. International Archives Of Allergy And Immunology, 130, 165-172.
  • Muir, W., Husband, A., Bryden, W. (2002). Dietary supplementation with vitamin E modulates avian intestinal immunity. The British Journal of Nutrition, 87(6), 579-585.
  • Slater, M., Brown, D., Husband, A. (2002). In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor B and E - cadherin expression decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Slater, M., Husband, A., Brown, D. (2002). In the prostatic epithelium, dietry isoflavones from red clover significantly increase estrogen receptorB and E-cadherin expression but decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Jarred, R., Keikha,, M., Dowling, C., McPherson, S., Clare, A., Husband, A., Pedersen, J., Frydenberg, M., Risbridger, G. (2002). Induction of Apoptosis in low to moderate grade human prostate Carcinoma by red clover derived dietary isoflavones. Cancer Epidemiology, Biomarkers and Prevention, 11, 1689-1696.
  • Husband, A. (2002). Mucosal memory ?x2013;2013; maintenance and recruitment. Veterinary Immunology and Immunopathology, 87, 131-136.
  • Krockenberger, M., Bao, S., Husband, A., Cole,, N., Beagley, K., Willcox, M. (2001). Effects of Exogenous Interleukin 6 during Pseudomonas aeruginosa Corneal Infection. Infection and Immunity, 69 (6), 4116-4119.
  • Husband, A., Risbridger, G., Wang, H., Frydenberg, M. (2001). The in vivo effect of red clover diet on ventral prostate growth in adult male mice. Reproduction, Fertility and Development, 13, 325-329.

Conferences

  • Muir, W., Bryden, W., Husband, A. (2003). Interleukin-6 cytokine enhances intestinal immunity. 15th Annual Australian Poultry Science Symposium, Sydney: University of Sydney.
  • Muir, W., Strom, A., Bryden, W., Husband, A. (2003). Interluukin-6 Cytokine enhances intestinal Immunity. Australian Poultry Science Symposium, Sydney: The Poultry Research Foundation University of Sydney and The World's Poultry Science Association.
  • Muir, W., Strom, A., Husband, A., Bryden, W. (2002). Exogenous IL-6 cytokines modulation of avian intestinal immunity and disease resistance. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.
  • Muir, W., Husband, A., Bryden, W. (2002). Vitamin E modulation of avian intestinal immunity. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.
  • Muir, W., Husband, A., Bryden, W. (2001). Dietary vitamin E modulates immune responses to Salmonella typhimurium in chickens. 30th Annual Nutrition Society of Australia Scientific Meeting. Nutrition Society of Australia.
  • Muir, W., Husband, A., Bryden, W. (2001). Dietary Vitamin E modulates intestinal immunity. Australian Poultry Science Symposium (2001).

2011

  • Kelly, M., Mor, G., Husband, A., O'Malley, D., Baker, L., Azodi, M., Schwartz, P., Rutherford, T. (2011). Phase II Evaluation of Phenoxodiol in Combination with Cisplatin or Paclitaxel in Women with Platinum/Taxane-Refractory/Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers. International Journal Of Gynecological Cancer, 21(4), 633-639.

2008

  • Brown, D., Heaton, A., Husband, A. (2008). Idronoxil. Proapoptotic agent, oncolytic. Drugs of the Future, 33(10), 844-860.
  • Alvaro, A., Rossi, P., Brown, D., Lelser, A., Kelly, M., Rutherford, T., Husband, A., Mor, G. (2008). Phenoxodiol-A Chemosensitizer in the Midst of Cancer Chemoresistance. US Oncology, 4, 39-41.

2006

  • Haines, C., James, A., Sahota, D., Chen, Y., Panesar, N., Tomlinson, B., Chow, L., Benzie, I., Husband, A. (2006). Comparison between phytoestrogens and estradiol in the prevention of atheroma using either phytoestrogen or estradiol in ovariectomized cholesterol-fed rabbits. Climacteric, 9(6), 430-436.
  • Shen, J., White, M., Husband, A., Hambly, B., Bao, S. (2006). Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology, 548(1-3), 123-128.
  • Bao, S., Fei, J., Shen, J., Gong, S., Fang, H., Husband, A. (2006). Reserpine-induced model of stress suppresses mucosal immunity. Immunology and Cell Biology, 84(6), 537-542.

2005

  • Cole, N., Hume, E., Khan, S., Madigan, M., Husband, A., Garthwaite, L., Willcox, M. (2005). Contribution of the cornea to cytokine in the whole eye induced during the early phase of Pseudomonas aeruginosa challage. Immunology and Cell Biology, 83(3), 301-306.
  • Cole, N., Hume, E., Khan, S., Krockenberger, M., Thakur, A., Husband, A., Willcox, M. (2005). Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection. Current Eye Research, 30, 535-542.
  • Widyarini, S., Husband, A., Reeve, V. (2005). Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with chemical cocarcinogen. Photochemistry and Photobiology, 81, 32-37.

2004

  • Lam, A., Demasi, M., James, M., Husband, A., Walker, C. (2004). Effect Of Red Clover Isoflavones On Cox-2 Activity In Murine And Human Monocyte/Macrophage Cells. Nutrition and Cancer: an international journal, 49(1), 89-93.
  • Ling, S., Dai, A., Williams, M., Husband, A., Nestel, P., Komesaroff, P., Sudhir, K. (2004). The Isoflavone Metabolite Cis - Tetrahydrodaidzein Inhibits Erk-1 Activation And Proliferation In Human Vascular Smooth Muscle Cells. Journal of Cardiovascular Pharmacology, 43(5), 622-628.
  • Chin-Dusting, J., Boak, L., Husband, A., Nestel, P. (2004). The Isoflavone Metabolite Dehydroequol Produces Vasodilation In Human Resistance Ateries Via A Nitric Oxide Dependent Mechanism. Atherosclerosis, 176(1), 45-48.

2003

  • Jiang, F., Jones, G., Husband, A., Dusting, G. (2003). Cardiovascular protective effects of synthetic Isoflavone derivatives in Apolipoprotein E-deficient mice. Journal of Vascular Research, 40(3), 276-284.
  • Cole, N., Krockenberger, M., Stapleton, F., Khan, S., Hume, E., Husband, A., Willcox, M. (2003). Experimental Pseudomonas aeruginosa keratitis in interleukin-10 gene knockout mice. Infection and Immunity, 71(3), 1328-1336.
  • Muir, W., Bryden, W., Husband, A. (2003). Interleukin-6 cytokine enhances intestinal immunity. 15th Annual Australian Poultry Science Symposium, Sydney: University of Sydney.
  • Muir, W., Strom, A., Bryden, W., Husband, A. (2003). Interluukin-6 Cytokine enhances intestinal Immunity. Australian Poultry Science Symposium, Sydney: The Poultry Research Foundation University of Sydney and The World's Poultry Science Association.
  • Constantinou, A., Mehta, R., Husband, A. (2003). Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. European Journal of Cancer, 39(7), 1012-1018.
  • Cole, N., Bao, S., Stapleton, F., Thakur, A., Beagley, K., Husband, A., Willcox, M. (2003). Pseudomonas aeruginosa keratitis in IL-6-deficient mice. International Archives Of Allergy And Immunology, 130, 165-172.

2002

  • Muir, W., Husband, A., Bryden, W. (2002). Dietary supplementation with vitamin E modulates avian intestinal immunity. The British Journal of Nutrition, 87(6), 579-585.
  • Muir, W., Strom, A., Husband, A., Bryden, W. (2002). Exogenous IL-6 cytokines modulation of avian intestinal immunity and disease resistance. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.
  • Slater, M., Brown, D., Husband, A. (2002). In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor B and E - cadherin expression decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Slater, M., Husband, A., Brown, D. (2002). In the prostatic epithelium, dietry isoflavones from red clover significantly increase estrogen receptorB and E-cadherin expression but decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Jarred, R., Keikha,, M., Dowling, C., McPherson, S., Clare, A., Husband, A., Pedersen, J., Frydenberg, M., Risbridger, G. (2002). Induction of Apoptosis in low to moderate grade human prostate Carcinoma by red clover derived dietary isoflavones. Cancer Epidemiology, Biomarkers and Prevention, 11, 1689-1696.
  • Husband, A. (2002). Mucosal memory ?x2013;2013; maintenance and recruitment. Veterinary Immunology and Immunopathology, 87, 131-136.
  • Muir, W., Husband, A., Bryden, W. (2002). Vitamin E modulation of avian intestinal immunity. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.

2001

  • Muir, W., Husband, A., Bryden, W. (2001). Dietary vitamin E modulates immune responses to Salmonella typhimurium in chickens. 30th Annual Nutrition Society of Australia Scientific Meeting. Nutrition Society of Australia.
  • Muir, W., Husband, A., Bryden, W. (2001). Dietary Vitamin E modulates intestinal immunity. Australian Poultry Science Symposium (2001).
  • Krockenberger, M., Bao, S., Husband, A., Cole,, N., Beagley, K., Willcox, M. (2001). Effects of Exogenous Interleukin 6 during Pseudomonas aeruginosa Corneal Infection. Infection and Immunity, 69 (6), 4116-4119.
  • Husband, A., Risbridger, G., Wang, H., Frydenberg, M. (2001). The in vivo effect of red clover diet on ventral prostate growth in adult male mice. Reproduction, Fertility and Development, 13, 325-329.
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