Emeritus Professor Alan Husband

BScAgr(Hons), PhD, DSc, FASM

B01 - J.D. Stewart Building
The University of Sydney


Research interests

Immunology, focussing on mucosal diseases and the role of behaviour, nutrition and stress in health maintenance.

Teaching and supervision

Immunology, Pathology

Selected grants

2003

  • Analysis of the sheep, Haemonchus contortus relationship; Sangster N, Husband A; Meat and Livestock Australia Ltd/MLA Livestock Production Research and Development Program.

2000

  • Enhancing mucosal immunity in chickens by novel in-ovo and postnatal vaccination techniques; Husband A; Rural Industries Research and Development Corporation/Research and Development Projects.
  • Growth gap Project 2; Husband A; Pig Research and Development Corporation/Research and Development Grants.
  • Development of veterinary applications of Beta 1,3 glucan technology; Husband A, Kelly G; Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT).
  • Cytokine regulation of mucosal immunity - interactions between precursor subsets and cytokines; Husband A, Bao B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Biological screening of phenolic hormones produced with synthetic derivatives; Husband A, Walker C, Kelly G; Novogen Limited/Research Grants.

Selected publications

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Journals

  • Kelly, M., Mor, G., Husband, A., O'Malley, D., Baker, L., Azodi, M., Schwartz, P., Rutherford, T. (2011). Phase II Evaluation of Phenoxodiol in Combination with Cisplatin or Paclitaxel in Women with Platinum/Taxane-Refractory/Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers. International Journal Of Gynecological Cancer, 21(4), 633-639. [More Information]
  • Brown, D., Heaton, A., Husband, A. (2008). Idronoxil. Proapoptotic agent, oncolytic. Drugs of the Future, 33(10), 844-860.
  • Alvaro, A., Rossi, P., Brown, D., Lelser, A., Kelly, M., Rutherford, T., Husband, A., Mor, G. (2008). Phenoxodiol-A Chemosensitizer in the Midst of Cancer Chemoresistance. US Oncology, 4, 39-41.
  • Haines, C., James, A., Sahota, D., Chen, Y., Panesar, N., Tomlinson, B., Chow, L., Benzie, I., Husband, A. (2006). Comparison between phytoestrogens and estradiol in the prevention of atheroma using either phytoestrogen or estradiol in ovariectomized cholesterol-fed rabbits. Climacteric, 9(6), 430-436.
  • Shen, J., White, M., Husband, A., Hambly, B., Bao, B. (2006). Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology, 548(1-3), 123-128. [More Information]
  • Bao, B., Fei, J., Shen, J., Gong, S., Fang, H., Husband, A. (2006). Reserpine-induced model of stress suppresses mucosal immunity. Immunology and Cell Biology, 84(6), 537-542. [More Information]
  • Cole, N., Hume, E., Khan, S., Madigan, M., Husband, A., Garthwaite, L., Willcox, M. (2005). Contribution of the cornea to cytokine in the whole eye induced during the early phase of Pseudomonas aeruginosa challage. Immunology and Cell Biology, 83(3), 301-306. [More Information]
  • Cole, N., Hume, E., Khan, S., Krockenberger, M., Thakur, A., Husband, A., Willcox, M. (2005). Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection. Current Eye Research, 30, 535-542.
  • Widyarini, S., Husband, A., Reeve, V. (2005). Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with chemical cocarcinogen. Photochemistry and Photobiology, 81, 32-37. [More Information]
  • Lam, A., Demasi, M., James, M., Husband, A., Walker, C. (2004). Effect Of Red Clover Isoflavones On Cox-2 Activity In Murine And Human Monocyte/Macrophage Cells. Nutrition and Cancer: an international journal, 49(1), 89-93.
  • Ling, S., Dai, A., Williams, M., Husband, A., Nestel, P., Komesaroff, P., Sudhir, K. (2004). The Isoflavone Metabolite Cis - Tetrahydrodaidzein Inhibits Erk-1 Activation And Proliferation In Human Vascular Smooth Muscle Cells. Journal of Cardiovascular Pharmacology, 43(5), 622-628.
  • Chin-Dusting, J., Boak, L., Husband, A., Nestel, P. (2004). The Isoflavone Metabolite Dehydroequol Produces Vasodilation In Human Resistance Ateries Via A Nitric Oxide Dependent Mechanism. Atherosclerosis, 176(1), 45-48. [More Information]
  • Jiang, F., Jones, G., Husband, A., Dusting, G. (2003). Cardiovascular protective effects of synthetic Isoflavone derivatives in Apolipoprotein E-deficient mice. Journal of Vascular Research, 40(3), 276-284.
  • Cole, N., Krockenberger, M., Stapleton, F., Khan, S., Hume, E., Husband, A., Willcox, M. (2003). Experimental Pseudomonas aeruginosa keratitis in interleukin-10 gene knockout mice. Infection and Immunity, 71(3), 1328-1336.
  • Constantinou, A., Mehta, R., Husband, A. (2003). Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. European Journal of Cancer, 39(7), 1012-1018.
  • Cole, N., Bao, B., Stapleton, F., Thakur, A., Beagley, K., Husband, A., Willcox, M. (2003). Pseudomonas aeruginosa keratitis in IL-6-deficient mice. International Archives Of Allergy And Immunology, 130, 165-172.
  • Muir, W., Husband, A., Bryden, W. (2002). Dietary supplementation with vitamin E modulates avian intestinal immunity. British Journal of Nutrition, 87(6), 579-585.
  • Slater, M., Brown, D., Husband, A. (2002). In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor B and E - cadherin expression decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Slater, M., Husband, A., Brown, D. (2002). In the prostatic epithelium, dietry isoflavones from red clover significantly increase estrogen receptorB and E-cadherin expression but decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Jarred, R., Keikha,, M., Dowling, C., McPherson, S., Clare, A., Husband, A., Pedersen, J., Frydenberg, M., Risbridger, G. (2002). Induction of Apoptosis in low to moderate grade human prostate Carcinoma by red clover derived dietary isoflavones. Cancer Epidemiology, Biomarkers and Prevention, 11, 1689-1696.
  • Husband, A. (2002). Mucosal memory ?x2013;2013; maintenance and recruitment. Veterinary Immunology and Immunopathology, 87, 131-136.
  • Krockenberger, M., Bao, B., Husband, A., Cole,, N., Beagley, K., Willcox, M. (2001). Effects of Exogenous Interleukin 6 during Pseudomonas aeruginosa Corneal Infection. Infection and Immunity, 69 (6), 4116-4119.
  • Husband, A., Risbridger, G., Wang, H., Frydenberg, M. (2001). The in vivo effect of red clover diet on ventral prostate growth in adult male mice. Reproduction, Fertility and Development, 13, 325-329.

Conferences

  • Muir, W., Bryden, W., Husband, A. (2003). Interleukin-6 cytokine enhances intestinal immunity. 15th Annual Australian Poultry Science Symposium, Sydney: University of Sydney.
  • Muir, W., Strom, A., Bryden, W., Husband, A. (2003). Interluukin-6 Cytokine enhances intestinal Immunity. Australian Poultry Science Symposium, Sydney: The Poultry Research Foundation University of Sydney and The Worlds Poultry Science Association.
  • Muir, W., Strom, A., Husband, A., Bryden, W. (2002). Exogenous IL-6 cytokines modulation of avian intestinal immunity and disease resistance. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.
  • Muir, W., Husband, A., Bryden, W. (2002). Vitamin E modulation of avian intestinal immunity. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.
  • Muir, W., Husband, A., Bryden, W. (2001). Dietary vitamin E modulates immune responses to Salmonella typhimurium in chickens. 30th Annual Nutrition Society of Australia Scientific Meeting. Nutrition Society of Australia.
  • Muir, W., Husband, A., Bryden, W. (2001). Dietary Vitamin E modulates intestinal immunity. Australian Poultry Science Symposium (2001).

2011

  • Kelly, M., Mor, G., Husband, A., O'Malley, D., Baker, L., Azodi, M., Schwartz, P., Rutherford, T. (2011). Phase II Evaluation of Phenoxodiol in Combination with Cisplatin or Paclitaxel in Women with Platinum/Taxane-Refractory/Resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers. International Journal Of Gynecological Cancer, 21(4), 633-639. [More Information]

2008

  • Brown, D., Heaton, A., Husband, A. (2008). Idronoxil. Proapoptotic agent, oncolytic. Drugs of the Future, 33(10), 844-860.
  • Alvaro, A., Rossi, P., Brown, D., Lelser, A., Kelly, M., Rutherford, T., Husband, A., Mor, G. (2008). Phenoxodiol-A Chemosensitizer in the Midst of Cancer Chemoresistance. US Oncology, 4, 39-41.

2006

  • Haines, C., James, A., Sahota, D., Chen, Y., Panesar, N., Tomlinson, B., Chow, L., Benzie, I., Husband, A. (2006). Comparison between phytoestrogens and estradiol in the prevention of atheroma using either phytoestrogen or estradiol in ovariectomized cholesterol-fed rabbits. Climacteric, 9(6), 430-436.
  • Shen, J., White, M., Husband, A., Hambly, B., Bao, B. (2006). Phytoestrogen derivatives differentially inhibit arterial neointimal proliferation in a mouse model. European Journal of Pharmacology, 548(1-3), 123-128. [More Information]
  • Bao, B., Fei, J., Shen, J., Gong, S., Fang, H., Husband, A. (2006). Reserpine-induced model of stress suppresses mucosal immunity. Immunology and Cell Biology, 84(6), 537-542. [More Information]

2005

  • Cole, N., Hume, E., Khan, S., Madigan, M., Husband, A., Garthwaite, L., Willcox, M. (2005). Contribution of the cornea to cytokine in the whole eye induced during the early phase of Pseudomonas aeruginosa challage. Immunology and Cell Biology, 83(3), 301-306. [More Information]
  • Cole, N., Hume, E., Khan, S., Krockenberger, M., Thakur, A., Husband, A., Willcox, M. (2005). Interleukin-4 is not critical to pathogenesis in a mouse model of Pseudomonas aeruginosa corneal infection. Current Eye Research, 30, 535-542.
  • Widyarini, S., Husband, A., Reeve, V. (2005). Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with chemical cocarcinogen. Photochemistry and Photobiology, 81, 32-37. [More Information]

2004

  • Lam, A., Demasi, M., James, M., Husband, A., Walker, C. (2004). Effect Of Red Clover Isoflavones On Cox-2 Activity In Murine And Human Monocyte/Macrophage Cells. Nutrition and Cancer: an international journal, 49(1), 89-93.
  • Ling, S., Dai, A., Williams, M., Husband, A., Nestel, P., Komesaroff, P., Sudhir, K. (2004). The Isoflavone Metabolite Cis - Tetrahydrodaidzein Inhibits Erk-1 Activation And Proliferation In Human Vascular Smooth Muscle Cells. Journal of Cardiovascular Pharmacology, 43(5), 622-628.
  • Chin-Dusting, J., Boak, L., Husband, A., Nestel, P. (2004). The Isoflavone Metabolite Dehydroequol Produces Vasodilation In Human Resistance Ateries Via A Nitric Oxide Dependent Mechanism. Atherosclerosis, 176(1), 45-48. [More Information]

2003

  • Jiang, F., Jones, G., Husband, A., Dusting, G. (2003). Cardiovascular protective effects of synthetic Isoflavone derivatives in Apolipoprotein E-deficient mice. Journal of Vascular Research, 40(3), 276-284.
  • Cole, N., Krockenberger, M., Stapleton, F., Khan, S., Hume, E., Husband, A., Willcox, M. (2003). Experimental Pseudomonas aeruginosa keratitis in interleukin-10 gene knockout mice. Infection and Immunity, 71(3), 1328-1336.
  • Muir, W., Bryden, W., Husband, A. (2003). Interleukin-6 cytokine enhances intestinal immunity. 15th Annual Australian Poultry Science Symposium, Sydney: University of Sydney.
  • Muir, W., Strom, A., Bryden, W., Husband, A. (2003). Interluukin-6 Cytokine enhances intestinal Immunity. Australian Poultry Science Symposium, Sydney: The Poultry Research Foundation University of Sydney and The Worlds Poultry Science Association.
  • Constantinou, A., Mehta, R., Husband, A. (2003). Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague-Dawley rats. European Journal of Cancer, 39(7), 1012-1018.
  • Cole, N., Bao, B., Stapleton, F., Thakur, A., Beagley, K., Husband, A., Willcox, M. (2003). Pseudomonas aeruginosa keratitis in IL-6-deficient mice. International Archives Of Allergy And Immunology, 130, 165-172.

2002

  • Muir, W., Husband, A., Bryden, W. (2002). Dietary supplementation with vitamin E modulates avian intestinal immunity. British Journal of Nutrition, 87(6), 579-585.
  • Muir, W., Strom, A., Husband, A., Bryden, W. (2002). Exogenous IL-6 cytokines modulation of avian intestinal immunity and disease resistance. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.
  • Slater, M., Brown, D., Husband, A. (2002). In the prostatic epithelium, dietary isoflavones from red clover significantly increase estrogen receptor B and E - cadherin expression decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Slater, M., Husband, A., Brown, D. (2002). In the prostatic epithelium, dietry isoflavones from red clover significantly increase estrogen receptorB and E-cadherin expression but decrease transforming growth factor B1. Prostate Cancer and Prostatic Diseases, 5(1), 16-21.
  • Jarred, R., Keikha,, M., Dowling, C., McPherson, S., Clare, A., Husband, A., Pedersen, J., Frydenberg, M., Risbridger, G. (2002). Induction of Apoptosis in low to moderate grade human prostate Carcinoma by red clover derived dietary isoflavones. Cancer Epidemiology, Biomarkers and Prevention, 11, 1689-1696.
  • Husband, A. (2002). Mucosal memory ?x2013;2013; maintenance and recruitment. Veterinary Immunology and Immunopathology, 87, 131-136.
  • Muir, W., Husband, A., Bryden, W. (2002). Vitamin E modulation of avian intestinal immunity. 11th International Congress of Mucosal Immunology, Bethesda, USA: Society for Mucosal Immunology.

2001

  • Muir, W., Husband, A., Bryden, W. (2001). Dietary vitamin E modulates immune responses to Salmonella typhimurium in chickens. 30th Annual Nutrition Society of Australia Scientific Meeting. Nutrition Society of Australia.
  • Muir, W., Husband, A., Bryden, W. (2001). Dietary Vitamin E modulates intestinal immunity. Australian Poultry Science Symposium (2001).
  • Krockenberger, M., Bao, B., Husband, A., Cole,, N., Beagley, K., Willcox, M. (2001). Effects of Exogenous Interleukin 6 during Pseudomonas aeruginosa Corneal Infection. Infection and Immunity, 69 (6), 4116-4119.
  • Husband, A., Risbridger, G., Wang, H., Frydenberg, M. (2001). The in vivo effect of red clover diet on ventral prostate growth in adult male mice. Reproduction, Fertility and Development, 13, 325-329.

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