Dr Auriol Purdie

BSc (Hons) MSc PhD
Post Doctoral Fellow Farm Animal &
Veterinary Public Health  

C01A - Jl Shute - Camden
The University of Sydney

Telephone +61 2 9036 7743
Fax +61 2 9351 1618

Biographical details

Auriol holds a Bachelor of Science in Molecular Genetics from Kings College, London (UK), a Masters degree in the Immunology of Infectious Disease from the London School of Hygiene and Tropical Medicine (UK) and a Doctorate of Philosophy looking at the immunomodulatory effects of the antibiotics Ciprofloxacin and Moxifloxacin on healthy humans. The PhD was granted from the University of Aberdeen (UK). Prior to joining the faculty at the University of Sydney, Auriol completed two Post Doctoral Fellowships at The Roslin Institute (Edinburgh, UK).

The first looked at the pathogenesis of bovine spongiform encephalopathy in bovine and murine models and the second Fellowship studied the potential to utilise gene transduction to obtain proteins of medical interest from a chicken model. Auriol¿s research interest pertains to the pathogenesis of disease in host organisms with particular reference to the immune response and she is working within the Johne¿s research team.

Selected grants

2013

  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2011

  • OJD/BJD: Diagnostic, predictive and preventative tools for Johnes disease in sheep and cattle; Whittington R, Begg D, de Silva K, Plain K, Purdie (Williams) A, Dhand N; Meat and Livestock Australia Ltd/Livestock Production Research and Development Program: Strategic and Applied Research Funding.

Selected publications

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Journals

  • Whittington, R., Begg, D., de Silva, K., Plain, K., Purdie (Williams), A. (2012). Comparative immunological and microbiological aspects of paratuberculosis as a model mycobacterial infection. Veterinary Immunology and Immunopathology, 148(1-2), 29-47.
  • Plain, K., Begg, D., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Enhancement of the interferon gamma assay to detect paratuberculosis using interleukin-7 and interleukin-12 potentiation. Veterinary Immunology and Immunopathology, 149(1-2), 28-37. [More Information]
  • Purdie (Williams), A., Plain, K., Begg, D., de Silva, K., Whittington, R. (2012). Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection. Comparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners, 35(2), 151-162. [More Information]
  • Gurung, R., Purdie (Williams), A., Begg, D., Whittington, R. (2012). In silico identification of epitopes in Mycobacterium avium subsp paratuberculosis proteins that were upregulated under stress conditions. Clinical and Vaccine Immunology, 19(6), 855-864. [More Information]
  • Gurung, R., Purdie (Williams), A., Begg, D., Whittington, R. (2012). In silico screened Mycobacterium avium subsp. paratuberculosis (MAP) recombinant proteins upregulated under stress conditions are immunogenic in sheep. Veterinary Immunology and Immunopathology, 149(3-4), 186-196. [More Information]
  • Purdie (Williams), A., Plain, K., Begg, D., de Silva, K., Whittington, R. (2011). Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: A review. Comparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners, 34(3), 197-208. [More Information]
  • Begg, D., de Silva, K., Carter, N., Plain, K., Purdie (Williams), A., Whittington, R. (2011). Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections? Immunobiology, 216(7), 840-846. [More Information]
  • Plain, K., de Silva, K., Earl, J., Begg, D., Purdie (Williams), A., Whittington, R. (2011). Indoleamine 2,3-Dioxygenase, Tryptophan Catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for Chronic Mycobacterial Infection. Infection and Immunity, 79(9), 3821-3832. [More Information]
  • Lyall, J., Irvine, R., Sherman, A., McKinley, T., Nunez, A., Purdie, A., Outtrim, L., Brown, I., Rolleston-Smith, G., Sang, H., et al (2011). Suppression of Avian Influenza Transmission in Genetically Modified Chickens. Science, 331(6014), 223-226. [More Information]
  • Plain, K., Purdie (Williams), A., Begg, D., de Silva, K., Whittington, R. (2010). Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease. Veterinary Immunology and Immunopathology, 137(1-2), 142-148. [More Information]
  • Purdie (Williams), A., Galley, H., Watt, A., Webster, N. (2005). Differential effects of three antibiotics on T helper cell cytokine expression. Journal of Antimicrobial Chemotherapy, 56(3), 502-506. [More Information]

Conferences

  • Purdie (Williams), A., Begg, D., de Silva, K., Plain, K., Whittington, R. (2012). Differential gene expression changes associated with sub-clinical Mycobacterium avium subspecies paratuberculosis infection in cattle: a transcriptomic study. Immunology 2012, usa: N/A.
  • de Silva, K., Begg, D., Plain, K., Purdie (Williams), A., Kawaji, S., Dhand, N., Whittington, R. (2012). Early biomarkers of resistance and susceptibility to mycobacterial disease. Immunology 2012, usa: N/A.
  • Begg, D., Plain, K., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Extension of the storage time of blood in interferon gamma assays to diagnose paratuberculosis: combination of IL-7 and IL-12 stimulation. 6th International Veterinary Vaccines and Diagnostics Conference, N/A: N/A.
  • Begg, D., Plain, K., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Extension of the storage time of blood in interferon gamma assays to disgnose paratuberculosis: combination of II-7 and II-12 stimulation. 4th European Veterinary Immunology Workshop (EVIW), N/A: N/A.
  • Begg, D., Plain, K., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Extension of the storgage time of blood in interferon gamma assay to diagnose paratuberculosis: reporting guidelines. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • de Silva, K., Begg, D., Plain, K., Purdie (Williams), A., Kawaji, S., Whittington, R. (2012). Immune profiles and faecal shedding of Mycobacterium avium paratuberculosis indicate eventual severity of Johne's Disease. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Gurung, R., Purdie (Williams), A., Begg, D., Whittington, R. (2012). Immunogenicity evaluation of in silico identified MAP recombinant proteins that were upregulated under stress conditions. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Gurung, R., Begg, D., Purdie (Williams), A., Whittington, R. (2012). Immunogenicity evaluation of in silico Mycobacterium avium subsp paratuberculosis recombinant proteins that were upregulated under stress conditions. IVVDC 2012, Queensland: N/A.
  • Thirunavukkarasu, S., Purdie (Williams), A., Plain, K., de Silva, K., Whittington, R. (2012). Novel gene expression profile in the blood cells of cattle experimentally exposed to Mycobacterium avium subspecies paratuberculosis. IMMUNOLOGY2012™ The 99th AAI Annual Meeting!, USA: N/A.
  • Purdie (Williams), A. (2012). Technology Glossary session: Pathogenomics. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Plain, K., de Silva, K., Earl, J., Begg, D., Purdie (Williams), A., Whittington, R. (2012). The role of indoleamine 2,3-dioxygenase (IDO) and tryptophan catabolism in paratuberculosis disease progression. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Purdie (Williams), A., Begg, D., de Silva, K., Plain, K., Whittington, R. (2012). Transcriptomic analysis of sub clinical mycobacterium avium subsp.paratuberculosis infection in cattle. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Begg, D., de Silva, K., Plain, K., Purdie (Williams), A., Whittington, R. (2010). Does a Th1 over Th2 dominance exist in the early stages of Mycobacterium avium subsp. paratuberculosis infections? 9th IVIS International Veterinary Immunology Symposium, Amsterdam: Elsevier.
  • de Silva, K., Begg, D., Plain, K., Purdie (Williams), A., Kawaji, S., Whittington, R. (2010). Immune correlates of protection and susceptibility to mycobacterial disease. 41st Australasian Society for Immunology Annual Meeting, N/A: N/A.
  • Whittington, R., Begg, D., de Silva, K., Plain, K., Purdie (Williams), A. (2010). Immunological characteristics of paratuberculosis as a mycobacterial infection. 9th IVIS International Veterinary Immunology Symposium, Amsterdam: Elsevier.
  • Whittington, R., Begg, D., de Silva, K., Plain, K., Purdie (Williams), A. (2010). Mycobacterial infection – lessons from tuberculosis and paratuberculosis. 9th IVIS International Veterinary Immunology Symposium, Amsterdam: Elsevier.
  • Plain, K., de Silva, K., Earl, J., Begg, D., Purdie (Williams), A., Whittington, R. (2010). Role of IDO and tryptophan catabolism in chronic mycobacterial disease pathogenesis. 41st Australasian Society for Immunology Annual Meeting, N/A: N/A.

2012

  • Whittington, R., Begg, D., de Silva, K., Plain, K., Purdie (Williams), A. (2012). Comparative immunological and microbiological aspects of paratuberculosis as a model mycobacterial infection. Veterinary Immunology and Immunopathology, 148(1-2), 29-47.
  • Purdie (Williams), A., Begg, D., de Silva, K., Plain, K., Whittington, R. (2012). Differential gene expression changes associated with sub-clinical Mycobacterium avium subspecies paratuberculosis infection in cattle: a transcriptomic study. Immunology 2012, usa: N/A.
  • de Silva, K., Begg, D., Plain, K., Purdie (Williams), A., Kawaji, S., Dhand, N., Whittington, R. (2012). Early biomarkers of resistance and susceptibility to mycobacterial disease. Immunology 2012, usa: N/A.
  • Plain, K., Begg, D., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Enhancement of the interferon gamma assay to detect paratuberculosis using interleukin-7 and interleukin-12 potentiation. Veterinary Immunology and Immunopathology, 149(1-2), 28-37. [More Information]
  • Purdie (Williams), A., Plain, K., Begg, D., de Silva, K., Whittington, R. (2012). Expression of genes associated with the antigen presentation and processing pathway are consistently regulated in early Mycobacterium avium subsp. paratuberculosis infection. Comparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners, 35(2), 151-162. [More Information]
  • Begg, D., Plain, K., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Extension of the storage time of blood in interferon gamma assays to diagnose paratuberculosis: combination of IL-7 and IL-12 stimulation. 6th International Veterinary Vaccines and Diagnostics Conference, N/A: N/A.
  • Begg, D., Plain, K., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Extension of the storage time of blood in interferon gamma assays to disgnose paratuberculosis: combination of II-7 and II-12 stimulation. 4th European Veterinary Immunology Workshop (EVIW), N/A: N/A.
  • Begg, D., Plain, K., de Silva, K., Purdie (Williams), A., Whittington, R. (2012). Extension of the storgage time of blood in interferon gamma assay to diagnose paratuberculosis: reporting guidelines. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • de Silva, K., Begg, D., Plain, K., Purdie (Williams), A., Kawaji, S., Whittington, R. (2012). Immune profiles and faecal shedding of Mycobacterium avium paratuberculosis indicate eventual severity of Johne's Disease. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Gurung, R., Purdie (Williams), A., Begg, D., Whittington, R. (2012). Immunogenicity evaluation of in silico identified MAP recombinant proteins that were upregulated under stress conditions. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Gurung, R., Begg, D., Purdie (Williams), A., Whittington, R. (2012). Immunogenicity evaluation of in silico Mycobacterium avium subsp paratuberculosis recombinant proteins that were upregulated under stress conditions. IVVDC 2012, Queensland: N/A.
  • Gurung, R., Purdie (Williams), A., Begg, D., Whittington, R. (2012). In silico identification of epitopes in Mycobacterium avium subsp paratuberculosis proteins that were upregulated under stress conditions. Clinical and Vaccine Immunology, 19(6), 855-864. [More Information]
  • Gurung, R., Purdie (Williams), A., Begg, D., Whittington, R. (2012). In silico screened Mycobacterium avium subsp. paratuberculosis (MAP) recombinant proteins upregulated under stress conditions are immunogenic in sheep. Veterinary Immunology and Immunopathology, 149(3-4), 186-196. [More Information]
  • Thirunavukkarasu, S., Purdie (Williams), A., Plain, K., de Silva, K., Whittington, R. (2012). Novel gene expression profile in the blood cells of cattle experimentally exposed to Mycobacterium avium subspecies paratuberculosis. IMMUNOLOGY2012™ The 99th AAI Annual Meeting!, USA: N/A.
  • Purdie (Williams), A. (2012). Technology Glossary session: Pathogenomics. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Plain, K., de Silva, K., Earl, J., Begg, D., Purdie (Williams), A., Whittington, R. (2012). The role of indoleamine 2,3-dioxygenase (IDO) and tryptophan catabolism in paratuberculosis disease progression. 11th International Colloquium on Paratuberculosis, N/A: N/A.
  • Purdie (Williams), A., Begg, D., de Silva, K., Plain, K., Whittington, R. (2012). Transcriptomic analysis of sub clinical mycobacterium avium subsp.paratuberculosis infection in cattle. 11th International Colloquium on Paratuberculosis, N/A: N/A.

2011

  • Purdie (Williams), A., Plain, K., Begg, D., de Silva, K., Whittington, R. (2011). Candidate gene and genome-wide association studies of Mycobacterium avium subsp. paratuberculosis infection in cattle and sheep: A review. Comparative Immunology, Microbiology and Infectious Diseases: the international journal for medical and veterinary researchers and practitioners, 34(3), 197-208. [More Information]
  • Begg, D., de Silva, K., Carter, N., Plain, K., Purdie (Williams), A., Whittington, R. (2011). Does a Th1 over Th2 dominancy really exist in the early stages of Mycobacterium avium subspecies paratuberculosis infections? Immunobiology, 216(7), 840-846. [More Information]
  • Plain, K., de Silva, K., Earl, J., Begg, D., Purdie (Williams), A., Whittington, R. (2011). Indoleamine 2,3-Dioxygenase, Tryptophan Catabolism, and Mycobacterium avium subsp. paratuberculosis: a model for Chronic Mycobacterial Infection. Infection and Immunity, 79(9), 3821-3832. [More Information]
  • Lyall, J., Irvine, R., Sherman, A., McKinley, T., Nunez, A., Purdie, A., Outtrim, L., Brown, I., Rolleston-Smith, G., Sang, H., et al (2011). Suppression of Avian Influenza Transmission in Genetically Modified Chickens. Science, 331(6014), 223-226. [More Information]

2010

  • Begg, D., de Silva, K., Plain, K., Purdie (Williams), A., Whittington, R. (2010). Does a Th1 over Th2 dominance exist in the early stages of Mycobacterium avium subsp. paratuberculosis infections? 9th IVIS International Veterinary Immunology Symposium, Amsterdam: Elsevier.
  • de Silva, K., Begg, D., Plain, K., Purdie (Williams), A., Kawaji, S., Whittington, R. (2010). Immune correlates of protection and susceptibility to mycobacterial disease. 41st Australasian Society for Immunology Annual Meeting, N/A: N/A.
  • Whittington, R., Begg, D., de Silva, K., Plain, K., Purdie (Williams), A. (2010). Immunological characteristics of paratuberculosis as a mycobacterial infection. 9th IVIS International Veterinary Immunology Symposium, Amsterdam: Elsevier.
  • Whittington, R., Begg, D., de Silva, K., Plain, K., Purdie (Williams), A. (2010). Mycobacterial infection – lessons from tuberculosis and paratuberculosis. 9th IVIS International Veterinary Immunology Symposium, Amsterdam: Elsevier.
  • Plain, K., de Silva, K., Earl, J., Begg, D., Purdie (Williams), A., Whittington, R. (2010). Role of IDO and tryptophan catabolism in chronic mycobacterial disease pathogenesis. 41st Australasian Society for Immunology Annual Meeting, N/A: N/A.
  • Plain, K., Purdie (Williams), A., Begg, D., de Silva, K., Whittington, R. (2010). Toll-like receptor (TLR)6 and TLR1 differentiation in gene expression studies of Johne's disease. Veterinary Immunology and Immunopathology, 137(1-2), 142-148. [More Information]

2005

  • Purdie (Williams), A., Galley, H., Watt, A., Webster, N. (2005). Differential effects of three antibiotics on T helper cell cytokine expression. Journal of Antimicrobial Chemotherapy, 56(3), 502-506. [More Information]

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