Dr Vivienne E. Reeve
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Principal Research Fellow in Photobiology and Skin Cancer Research |
| Qualifications | BSc PhD |
| Career History | 2009-current Honorary Associate Professor, Faculty of Veterinary Science 2007-2008 Principal Research Fellow, Faculty of Veterinary Science 1990-2006 Senior Research Fellow, Faculty of Veterinary Science 1990-current Senior Research Fellow, Faculty of Veterinary Science 1980-1989 Research Fellow, Department of Veterinary Pathology 1966–1979 Research Assistant, Department of Veterinary Pathology, University of Sydney |
| Administration | Laboratory Animal Management Advisory Committee, Faculty representative Research Advisory Committee, member Post-Graduate Education and Research Training Committee, Student co-ordinator |
| Research | Photobiology and Skin Cancer Research |
| Contribution to the Profession and the Community | President, Mutagenesis and Experimental Pathology Society of Australasia (MEPSA) Member American Society for Photobiology; European Society for Photobiology; Society for Free Radical Research, Australasia. |
| Research Interests |
Vivienne has developed an active research group in Photobiology and Skin Cancer in the Faculty. The focus of her research has been in understanding the mechanisms that regulate skin carcinogenesis, particularly the immune suppression induced by chronic exposure to UV radiation, which is a prerequisite for skin cancer development in humans and animals. This immune impairment appears to be sensitive to different wavebands of the UV spectrum, to antioxidants, to the level and nature of the dietary fat, and to steroid hormone receptors, and can be modified by sunscreen application. Using a specific mutant mouse, the Skh:hr hairless mouse, which is produced in the Faculty, a relevant model of solar UV radiation and skin photodamage is utilised in studies of chemoprevention by a variety of phytochemicals or immune modulators, attempting to correlate the immune function with the skin damage, and to develop new strategies for the prevention of solar UV-induced skin carcinogenesis in humans and animals. |
| Selected Publications |
1. Nishimura, N., Reeve, V.E., Nishimura, H., Satoh, M. and Tohyama, C. (2000) Cutaneous metallothionein induction by ultraviolet B irradiation in interleukin-6-null mice. J. Invest. Dermatol. 114:343-348. 2. Reeve, V.E., Nishimura, N., Bosnic, M., Michalska, A.E. and Choo, K.H.A. (2000) Lack of metallothionein-I and -II exacerbates the immunosuppressive effects of UVB radiation and cis-urocanic acid in mice. Immunology 100:399-404. 3. Domanski, D., Bosnic, M. and Reeve, V.E. (1999) Does sunscreen protection from immunosuppression by solar UV radiation predict protection from photocarcinogenesis? Redox Rep. 4:309-310. 4. Reeve, V.E. (2001) Chemoprevention of photocarcinogenesis. In Photobiology for the 21st Century, Eds. Coohill, T.P. and Valenzeno, D.P., Valdenmar Publ. Co., Kansas, USA. pp. 41-51. 5. Widyarini, S., Spinks, N., Husband, A.J. and Reeve, V.E. (2001) Isoflavonoid compounds from red clover (Trifolium pratense) protect from inflammation and immune suppression induced by UV radiation. Photochem. Photobiol. 74:465-470. 6. Reeve, V.E., Bosnic, M. and Domanski, D. (2001) Interaction of UVB-absorbing sunscreen ingredients with cutaneous molecules may alter photoimmune protection. Photochem. Photobiol. 74:765-770. |