Disorder - Vitamin D dependent rickets, type II

Organ Systems Involved
Musculoskeletal

Alternative disorders described within LIDA

Bone lesion; Fibrodysplasia ossificans; Hip dysplasia; Metabolic disorder

Alternative Names
Rickets, Hereditary vitamin D-resistent rickets

Presenting Signs

Rickets is a disorder of the bones normally caused by a deficiency in vitamin D. Many animals present with no symptoms. However, some may have a hunched appearance, swollen limbs, a reluctance to jump and a decreased appetite. Affected animals show no response to supplementation with vitamin D. A blood sample from these cats may show abnormal calcium and phosphate levels. If the animal has low calcium levels, it may also present with vomiting, diarrhoea, muscle tremors and dilated pupils. If X-rays are taken they will show multiple deformities of the bone and a decrease in bone 'whiteness' or density. This means there is a low level of mineral being deposited in the bone.

Cats at Risk

Kittens under four months old. There is no gender predilection.

Treatment

Medical: management involves supplementation with calcium and vitamin D (calcitriol).

PubMed References
Vitamin D dependent rickets, type II

Contributor
Prue McClenaughan