Disorder - Amyloidosis, AA

Organ Systems Involved
Systemic

Alternative disorders described within LIDA

Amyloidosis, lambda, Renal amyloidosis

Alternative Names
Secondary amyloidosis

Presenting Signs

Amyloidosis AA is the result of an autosomal recessive genetic defect causing progressive deposition of abnormal AA subunit proteins in multiple organs. The protein deposits also cause inflammation of the affected organs. The disease results in the inability of affected organs to function effectively. Presenting signs are variable depending on the organ systems affected by the deposition of AA amyloid. Most commonly the kidneys and liver are affected. Presenting signs include increased urination and thirst, jaundice, vomiting, diarrhoea, and even heart disease. Other organs that may be affected by deposits are the thyroid, spleen, adrenal gland, and pancreas. The end point of the disease may be organ failure and even spontaneous liver rupture.

Cats at Risk

Oriental cats are most at risk of AA Amyloidosis. Cats that show signs of the disease early in life are usually affected by the disease more rapidly. Cats with a family history of the disease are also more likely to have AA amyloidosis.

Treatment

At the moment there are very few options for treatment of AA Amyoidosis. Transplants of affected organs are possible, and there are medical treatments being developed in human medicine which may be used for treatment of cats in the future.

PubMed References
Amyloidosis, AA

Contributor
Lauren Porter