Disorder - Fucosidosis, alpha

Organ Systems Involved
Systemic

Alternative disorders described within LIDA

Gangliosidosis, GM1; Gangliosidosis, GM2; Glycogen Storage disease II; Glycogen storage disease IV; Krabbe disease; Mannosidosis, alpha; Mucolipidosis II; Mucopolysaccharidosis I; Mucopolysaccharidosis VI; Mucopolysaccharidosis VII; Neuronal Ceroid Lipofuscinosis, Ceriod Lipofuscinosis; Niemann-Pick disease, type C

Presenting Signs

Fucosidosis, alpha is a storage disease. This means that a substance that is normally broken down is instead stored in the cells, causing damage. The condition occurs when a protein (alpha-L-fucosidase) responsible for breaking down a carbohydrate (fucose) is deficient. The fucose then accumulates within cells of the nervous system, kidneys, pancreas, lymph nodes and lungs. Due to the nature of the disease, it is reasonable to expect that a cat with this disease would show neurological symptoms.

While the gene responsible for alpha-L-fucosidase has been mapped in cats, this disease has not been documented in the cat. It is seen in dogs.

Cats at Risk

Young animals

PubMed References
Fucosidosis, alpha

Contributor
Dharshinee Rajkumar