Disorder - Polycystic kidney disease

Organ Systems Involved
Urogenital

Alternative Names
PKD; Autosomal dominant polycystic kidney disease

Presenting Signs

Polycystic kidney disease is an inherited dominant genetic disorder where there are multiple cysts present in one or both kidneys from birth. These cysts gradually enlarge as the cat becomes older, and enlarged kidneys may be felt when manipulating the abdomen. Affected cats can remain clinically normal until the cysts become large enough to interfere with kidney function, and the cat ultimately develops kidney failure. Signs of kidney disease include excessive urination and drinking, weight loss, lethargy, reduced appetite and depressed behaviour. Kidney failure can occur from three years of age, although it is usually not apparent until over seven years. Occasionally, some cats will also have cysts in the liver and pancreas.

Cats at Risk

Cats with either parent of Persian or Persian-related breed.

Breeds Affected
Bengal
Burmilla
Exotic
Persian


Treatment

Medical

PubMed References
Polycystic kidney disease

Contributor
Joyce Fong