Disorder - Factor VIII DeficiencyOrgan Systems Involved
Factor VIII Antihaemolytic Factor Deficiency
A bleeding disorder in which there is a permanent tendency to haemorrhage, because of a deficiency in the clotting factor VIII necessary for blood clots to form. The severity of this disorder can range from mild to extreme.
Mild forms of Haemophilia A may not be detected until trauma or routine surgery (particularly castration) causes excessive haemorrhage and bleeding under the skin. Extreme bleeding from the umbilical cord and/or tail or feet (at tail-docking and dew-claw removal time) is common. Prolonged bleeding in severe cases can be fatal. Problems often arise after vaccination, as live vaccines effect the number and function of clotting cells for a period of 10-14 days after vaccination. There may be excessive bleeding during teething and puppies may suffer from bloody diarrhoea. Affected dogs typically have episodes of lameness caused by ongoing bleeding into joints due to the normal impact of everyday motion. Larger weight-bearing joints such as the elbow and stifles are more likely to be involved, and may develop a form of arthritis.
Dogs at Risk
Male dogs are most commonly affected. Females are usually classified as 'carriers' (passing the disorder onto their offspring without suffering clinically from the disorder themselves) but can also present with symptoms.
American cocker spaniel
Australian cattle dog
Collie (Rough and Smooth)
English springer spaniel
German shepherd dog
Factor VIII Deficiency
Further Reference Material [OMIA Number]
Emma Jane Hughes