Disorder - Hepatic Encephalopathy, Portosystemic.Organ Systems Involved
Chronic Portosystemic HE.
Due to an abnormal blood vessel arrangement, blood from the intestinal tract bypasses the liver and enters the general circulation. This blood contains toxins that would normally be filtered out by the liver. These toxins affect the function of the brain.
The symptoms of this disorder include a variety of fluctuating nervous system signs. Many of the symptoms are present for a short period of time and then the animal seems normal for a variable period. Affected dogs are often stunted and have difficulty gaining weight. They often exhibit depression and listlessness and can have a range of behavioural changes such as hysteria and aggression. There may be involuntary movements such as circling, head pressing and ataxia (incoordination). Apparent blindness, abnormal swallowing and salivation, stupor and reduced response to stimuli are often seen. Affected dogs may have mild vomiting, diarrhoea and a poor appetite. In severe cases dogs may experience seizures and coma, or be completely non-responsive to stimuli.
American cocker spaniel
Australian cattle dog
Bernese mountain dog
English springer spaniel
Old English sheepdog
Hepatic Microvascular Dysplasia (HMD) Hepatic Arteriovenous Fistulas Cirrhosis Lobular Dissecting Hepatitis Portal Vein Thrombosis Portal Vein Hypoplasia
Hepatic Encephalopathy, Portosystemic.
Further Reference Material [OMIA Number]