Disorder - Reduced Glutathione Deficiency, unclassified

Organ Systems Involved
Cardiovascular

Alternative Names
Glutathionine deficiency
Reduced GSH deficiency

Brief Description

A deficiency in a protein in red blood cells causes increased fragility and rupture of the cells, resulting in anaemia.

Presenting Signs

Red blood cells are responsible for carrying oxygen around the body to the organs and other tissues. When there is a lack of red blood cells (anaemia) the dog displays fatigue, pale mucous membranes (the moist linings of the body such as the gums, skin between the toes and the skin of the vulva and penis), lethargy, a reduced ability to exercise and decreased overall activity. Haemoglobin (a substance within red blood cells) is released from the ruptured blood cells and enters the circulation, causing red-brown urine. The dog may also have jaundice, with yellowish eyes and gums. Liver function may be impaired causing loss of appetite, fatigue and weakness.

Related Disorders

Pyroglutamic acidemia
Glutathione Synthetase (GS) Deficiency
Defects in the Hexose-monophosphate shunt
Defects in the Embden-Meyerhof pathway

PubMed References
Reduced Glutathione Deficiency, unclassified

Further Reference Material [OMIA Number]
1235


Contributor
Rina Harun