Canine Squamous Cell Carcinoma

Seung Hee Woo

telomerase stained canine SCC

Telomerase Stained Canine SCC

Squamous cell carcinomas are common skin tumours in dogs, particularly short, light coated dogs, with Dalmations and Bull Terriers having the highest incidence. UV exposure (sunbaking), Papilloma virus and host surveillance factors are implicated in human SCC.

While these were identified in our study of canine SCC, some but not all tumours showed high telomerase activity and loss of P53 tumour suppressor control, while Papilloma virus was rarely identified. There are other factors at play in canine SCC that await further investigation.