Wen-Meng (Monica) Liu
Lymphomas are common aggressive tumours of the haematopoietic system in dogs. Diffuse large B cell lymphoma is the most common histopathological subtype in both human and dogs. Gene expression studies of the human diffuse large B cell lymphoma showed prognostic subtypes which can be determined using immunohistochemistry in combination with algorithms.
In our study of canine diffuse large B cell lymphoma, immunohistochemical algorithms composing of FOXP1, MUM1 and BCL6 antibodies were found to be predictive of patient overall survival. The clinical applicability of these algorithms await for further investigations in prospective studies.