Canine Mast Cell Tumours
Canine mast cell tumours are the most common cutaneous cancer in dogs but up to 80% of them are biologically unpredictable, leading to over or under treatment and difficult prognostication. The capacity for the tumour to recur and metastasize rapidly with variable response to chemotherapy contributes to euthanasia. There has been limited success in using standard tumour classification systems or presence of c-Kit mutation to identify subgroups of patients with the same diagnosis but different clinical and therapeutic response.
My research investigates novel approaches to enhance prognostication and stratification of these tumours by means of molecular profiling, the use of biomarkers and revised grading system – techniques extrapolated from human biomedical oncology research.