This unit of study will explore the responses of cells to changes in their environment in both health and disease. The lecture course consists of four integrated modules. The first will provide an overview of the role of signalling mechanisms in the control of human cell biology and then focus on cell surface receptors and the downstream signal transduction events that they initiate. The second will examine how cells detect and respond to pathogenic molecular patterns displayed by infectious agents and injured cells by discussing the roles of relevant cell surface receptors, cytokines and signal transduction pathways. The third and fourth will focus on the life, death and differentiation of human cells in response to intra-cellular and extra-cellular signals by discussing the eukaryotic cell cycle under normal and pathological circumstances and programmed cell death in response to abnormal extra-cellular and intra-cellular signals. In all modules emphasis will be placed on the molecular processes involved in human cell biology, how modern molecular and cell biology methods have led to our current understanding of them and the implications of them for pathologies such as cancer. The practical component is designed to complement the lecture course, providing students with experience in a wide range of techniques used in modern molecular cell biology. The lecture component of this unit of study is the same as BCHM3072. Qualified students will attend seminars/practical classes in which more sophisticated topics in modern molecular cell biology will be covered.
Two 1-hour lectures per week; two 3-hours practicals per fortnight
One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%)
Alberts, B. et al. Molecular Biology of the Cell. 6th edition. Garland Science. 2014.
BMedSc degree students: You must have successfully completed BMED2401 and an additional 12cp from BMED240X before enrolling in this unit.
[An average mark of 75 in 12cp from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MBLG2X71)] OR [BMED2401 and a mark of 75 or above in BMED2405 and a mark of 75 or above in 6cp from (BCHM2X71 or BCMB2X02 or MBLG2X71)]Prohibitions