This unit of study is designed to provide a comprehensive coverage of the functions of proteins in living organisms, with a focus on eukaryotic and particularly human systems. Its lecture component deals with how proteins adopt their biologically active forms, including discussions of protein structure, protein folding and how recombinant DNA technology can be used to design novel proteins with potential medical or biotechnology applications. Particular emphasis is placed on how modern molecular biology and biochemical methods have led to our current understanding of the structure and functions of proteins. It also covers physiologically and medically important aspects of proteins in living systems, including the roles of chaperones in protein folding inside cells, the pathological consequences of misfolding of proteins, how proteins are sorted to different cellular compartments and how the biological activities of proteins can be controlled by regulated protein degradation. The practical course is designed to complement the lecture course and will provide students with experience in a wide range of techniques used in molecular biology and protein biochemistry laboratories. The lecture component of this unit of study is the same as BCHM3081. Qualified students will attend seminars/practical classes in which more sophisticated topics in protein biochemistry will be covered.
Two 1-hour lectures per week; two 3-hours practicals per fortnight
One 2.5-hour exam (theory and theory of prac 70%), in-semester (practical work and assignments 30%)
Williamson M. How Proteins Work. Garland. 2012.
BMedSc degree students: You must have successfully completed BMED2401 and an additional 12cp from BMED240X before enrolling in this unit.
[An average mark of 75 in 12cp from (BCHM2X71 or BCHM2X72 or BCMB2X01 or BCMB2X02 or MBLG2X71)] OR [BMED2401 and a mark of 75 or above in BMED2405 and a mark of 75 or above in 6cp from (BCHM2X71 or BCMB2X02 or MBLG2X71)]Prohibitions